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Ye-Ji Lee,Ju Ik Moon,In-Seok Choi,Sang-Eok Lee,Nak-Song Sung,Seong-Wook Kwon,Dae-Sung Yoon,Won-Jun Choi,Si-Min Park 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4
Backgrounds/Aims: This study was conducted to verify and compare the safety and feasibility of single incision laparoscopic cholecystectomy (SILC) and conventional laparoscopic cholecystectomy (CLC). Methods: A total of 2,080 patients underwent laparoscopic cholecystectomy in a single center, Konyang University Hospital, between 2010 and 2016. We retrospectively compared the demographics, perioperative outcome, and postoperative complication results between the CLC and SILC groups. Results: Among the 2,080 patients who underwent laparoscopic cholecystectomy, 1,080 had CLC and 1,000 had SILC. When retrospectively reviewed, the SILC group had significantly higher percentages of patients who were aged under 80 years, who were women, and had the American Society of Anesthesiologist score of lower than 3 points compared to those of the CLC group. Furthermore, the CLC group had a higher percentage of patients with acute cholecystitis or empyema, whereas the SILC group had a higher percentage of patients with chronic cholecystitis. Preoperative percutaneous transhepatic gallbladder drainage insertion or H-vac insertion was more frequently conducted, bleeding loss was more common, and hospital stay was longer in the CLC group. Postoperative complications such as wound infection, biloma, bile duct injury, and duodenal perforation were not significantly different between the two groups. Conclusions: In conclusion, if performed after preoperative patient selection such as in younger and female patients with no abdominal operation history at the time of benign gallbladder surgery, SILC can be considered feasible and safe without additional complications when compared with CLC.
Ye-Seul Kwan,Hye-Kyung Song,Hyun-Jung Lee,Wan-Ok Lee,Yong-Jin Won 한국동물분류학회 2012 Animal Systematics, Evolution and Diversity Vol.28 No.4
Plecoglossus altivelis (ayu) is an amphidromous fish widely distributed in Northeastern Asia from the East China Sea to the northern Japanese coastal waters, encompassing the Korean Peninsula within its range. The shore lines of northeastern region in Asia have severely fluctuated following glaciations in the Quaternary. In the present study, we investigate the population genetic structure and historical demographic change of P. altivelis at a population level in East Asia. Analysis of molecular variance (AMOVA) based on 244 mitochondrial control region DNA sequences clearly showed that as the sampling scope extended to a larger geographic area, genetic differentiation began to become significant, particularly among Northeastern populations. A series of hierarchical AMOVA could detect the genetic relationship of three closely located islands between Korea and Japan that might have been tightly connected by the regional Tsushima current. Neutrality and mismatch distribution analyses revealed a strong signature of a recent population expansion of P. altivelis in East Asia, estimated at 126 to 391 thousand years ago during the late Pleistocene. Therefore it suggests that the present population of P. altivelis traces back to its approximate demographic change long before the last glacial maximum. This contrasts our a priori expectation that the most recent glacial event might have the most crucial effect on the present day demography of marine organisms through bottleneck and subsequent increase of effective population size in this region.
( Song I Bae ),( You Sun Kim ),( Jong Pil Im ),( Jae Hee Cheon ),( Byong Duk Ye ),( Ji Won Kim ),( Young Ho Kim ),( Kang Moon Lee ),( Joo Sung Kim ),( Dong Soo Han ),( Won Ho Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Anti-tumor necrosis factor-alpha (anti-TNF-a) agents have been known to alter the natural course of Crohn`s disease (CD). Therefore, we aimed to compare the changes in clinical features and disease course according to the time of introduction of anti-TNF-a agent in Korea. Methods: We performed a retrospective analysis on 1,382 Korean CD patients diagnosed between 1982 and 2008 who were enrolled in the retrospective cohort of CrOhn`s disease cliNical NEtwork and CohorT (CONNECT) study. The anti-TNF-a agent has been applied to national medical insurance in 2005, and more widely used since 2007 in Korea. Accordingly the patients were divided into 3 groups [Group A (1981-2004): 656 patients, Group B (2005-2006): 282 patients, Group C (2007-2008): 362 patients]. Results: The average age (p=0.251), disease location (p=0.941) and behavior (p=0.813) at the time of diagnosis were not different among 3 groups. The anti-TNF-a agent was administered in a total of 31.0% of the patients (n=403), and showed no difference among groups (p=0.124). However, the 3- and 5-year cumulative probabilities of administration of anti-TNF-a agent were significantly higher in group C (p Conclusions: After the introduction of anti-TNF-a agent to the treatment of Korean CD patients, natural history of the CD has been changed. We found that early administration of an anti-TNF-a agent can help delay the occurrence of perianal fistula and the need for surgery in Korean CD patients.
InGaAs/GaAs quantum well intermixing using proton irradiation for non-absorbing mirror
Ye Seul Yun,SangHyeon Kim,Han-Youl Ryu,Min-Su Park,Hojin Jang,Jonghan Song,Weon Cheol Lim,Young Jun Chang,Won Jun Choi 한국물리학회 2016 Current Applied Physics Vol.16 No.9
We report a proton irradiation-induced intermixing on InGaAs/GaAs quantum well (QW) heterostructures with thick upper cladding layers. Proton irradiation was performed with different dose, followed with annealing. Proton irradiated and annealed sample shows the blue-shift of the photoluminescence (PL) spectra and the blue-shift energy was increased up to about 30 meV with increasing dose, but was insensitive to the annealing temperature. Finally, we calculated that the relative absorption coefficient at the laser wavelength for the irradiated sample with dose of 1 1016/cm2 was 0.045, suggesting such proton irradiation-induced intermixing is a promising approach for fabricating non-absorbing mirror.
( Won Jai Jung ),( Byung Hoon Park ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-
Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.
Song, Insun,Choi, Yong Jun,Jin, Yilan,Kim, Jung-Woo,Koh, Jeong-Tae,Ji, Hyung Min,Jeong, Seon-Yong,Won, Ye-Yeon,Kim, Won,Chung, Yoon-Sok D.A. Spandidos 2017 MOLECULAR MEDICINE REPORTS Vol.16 No.4
<P>To identify novel candidate genes associated with osteoporosis, RNA-sequence analysis of human mesenchymal stem cells (hMSCs) from patients with osteoporosis (G3) and osteopenia (G2), and healthy controls (G1) was performed. Differentially expressed genes (DEGs) from among the three groups were identified. DEGs were separated into nine groups according to their gene expression patterns: UU (up and up), UF (up and flat), UD (up and down), FU (flat and up), FF (flat and flat), FD (flat and down), DU (down and up), DF (down and flat), and DD (down and down). Among the 42 DEGs between G3 and G1, eight candidate genes, namely stimulated by retinoic acid 6 (STRA6), melanophilin, neurotrophic receptor tyrosine kinase 2, cartilage oligomeric matrix protein, collagen type XI α 1 chain, integrin subunit β 2, monooxygenase DBH-like 1 and selenoprotein P, were selected, as they demonstrated consistent gene expression patterns of UU, FU, FD, and DD. Among these eight genes, STRA6 was highly expressed in the osteoporosis group and based on additional data from quantitative polymerase chain reaction analysis, it was selected for further study. In order to investigate whether STRA6 served a functional role in osteoblast or adipocyte differentiation, the effects of STRA6 expression changes in pluripotent stem cell C3H10T1/2, preosteoblast MC3T3-E1 and stromal ST2 cell lines were examined. Bone morphogenetic protein 2 enhanced STRA6 expression only at the early stage of osteoblast differentiation, and overexpression of STRA6 temporally inhibited the expression of osteoblastogenesis markers, including runt related transcription factor 2, bone sialoprotein and osteocalcin. Furthermore, the knockdown of STRA6 slightly enhanced nodule formation at the late stage of osteoblast differentiation, and overexpression of STRA6 in ST2 cells enhanced adipocyte differentiation. Taken together, STRA6 expression could be associated with the pathogenesis of osteoporosis by promoting adipocyte differentiation over osteoblast differentiation in the hMSC population.</P>