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RISS 인기검색어
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- 저자 : Yanan Hao (검색결과 5 건)
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Hao Wang,Yinuo Liu,Yanan Wang,Xiumin Shang,Zhongxin Yan,Shengli Li,Wei Bao 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.2
Objective: We previously elucidated that long non-coding RNA Promoter of CDKN1A AntisenseDNA damage Activated RNA (PANDAR) as a p53-dependent oncogene to promote cisplatinresistance in ovarian cancer (OC). Intriguingly, high level of p53-independent PANDAR wasfound in cisplatin-resistant patients with p53 mutation. Here, our study probed the new rolesand the underlying mechanisms of PANDAR in p53-mutant OC cisplatin-resistance. Methods: A2780 and A2780-DDP cells were ser ved as OC cisplatin-sensitive and cisplatin-resistant cells. HO-8910PM cells were subjected to construct chemotherapy-inducedextracellular vesicles (Chemo-EVs). Transmission electron microscopy (TEM) and nanoparticletracking analysis were employed to evaluate Chemo-EVs. Cell viability was assessed using cellcounting kit-8 and colony formation assays. Cell apoptosis was assessed using Annexin V andpropidium iodide staining. The relationships between PANDAR, serine and arginine-rich pre-mRNA splicing factor 9 (SRSF9) were verified by RNA immunoprecipitation and fluorescencein situ hybridization. Tumor xenograft experiment was employed to evaluate the effects ofPANDAR-Chemo-EVs on OC cisplatin-resistance in vivo. Immunofluorescent staining andimmunohistochemistr y were performed in tumor tissue. Results: PANDAR level increased in OC patients with p53-mutation. PANDAR efflux enactedvia exosomes under cisplatin conditions. Additionally, exosomes from OC cell lines carriedPANDAR, which significantly increased cell sur vival and chemoresistance in vitro and tumorprogression and metastasis in vivo. During cisplatin-induced stress, SRSF9 was recruited tonuclear bodies by increased PANDAR and muted apoptosis in response to cisplatin. Besides,SRSF9 significantly increased the ratio of SIRT4/SIRT6 mRNA in OC. Conclusion: Cisplatin-induced exosomes transfer PANDAR and lead to a rapid adaptation ofOC cell sur vival through accumulating SRSF9 following cisplatin stress exposure.
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Shuai He,Lin Wang,Hao Dong,Pei Liu,Peiyu Shi,Xuemin Li,Xingchen Ren,Ning Lv,Yanan Liu,Changhu Xue,Hong Lin,Xiangzhao Mao 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
A new production bioprocess for sea cucumberrice wine (SCRW) was established. The traditional productiontechnology of Chinese rice wine was combined with additionof sea cucumber hydrosylates. The optimal enzymaticconditions of sea cucumber and the fermentation process ofSCRW were determined. The weight of sea cucumberenzymatic hydrolysates was 2.5% of millet while cookingthe millet. SCRW contained abundant free amino acids (30total at 1,681.216 mg/L), oligosaccharides (4 total at10,999.380 mg/L), total phenols (658.850 mg/L), andmineral elements (9 total at 1,911.353 mg/kg), and anantioxidant activity, all of which were higher than forcontrol rice wine (CRW). Galactosamine and glucuronicacid, both sea cucumber polysaccharides, were present inSCRW, but not in CRW.
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Yuan Zhao,JingXiu Li,Ling Wang,Yanan Hao,Lin Yang,Pingting He,JianJun Xue 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.10
Sulfated TiO2 nanoparticles were successfully immobilized on zeolite through improving hydrolysis-deposition method. Microstructure, crystallization, surface state and surface area of composite catalysts were characterized by SEM, XRD, FTIR spectra, XPS and BET and the photocatalytic activity was evaluated by degradation of methyl orange under UV irradiation. We optimized these factors (SO4 -2) ions, calcination temperature and loading amount of sulfated TiO2) on photocatalytic activity and crystallization of composite photocatalysts. The results indicated that the SO4 -2 ) ions are successfully immobilized on the surface of TiO2, and sulfated TiO2/zeolite show the highest photocatalytic activity for methyl orange at the [SO4 -2]/[Ti4+] molar rate of 1:1, calcination temperature of 600 ℃ for 2 h, and sulfated TiO2 loading amount of 40%, respectively.
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Recent progress of continuous crystallization
Ting Wang,Haijiao Lu,Jingkang Wang,Yan Xiao,Yanan Zhou,Ying Bao,Hongxun Hao 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-
Continuous crystallization has always been a hot topic in industrial crystallization. Many efforts have been made to improve the continuous crystallization, either by designing novel continuous crystallizers or by proposing improved design and operation of conventional continuous crystallizers. Some new models for continuous crystallization processes have also been proposed and tested in recent years. In this work, the development of continuous crystallization in recent years, including novel crystallizers, control strategies, models and some assistive technologies, is summarized. Promising as it is, continuous crystallization is still not as universal as batch crystallization due to the existence of the drawbacks, such as blockage and encrustation. Therefore, further efforts are needed before wider application of continuous crystallization.
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Xiaoshan Zhang,Yu Huan,Yuanna Zhu,Hui Tian,Kai Li,Yanan Hao,Tao Wei 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.12
Ferroelectric particles have been applied in the photocatalytic field because the spontaneous polarization results in the internal electric field, which can accelerate the separation and migration of photogenerated carriers. In this study, the BaTiO3 (BT) fibers are synthesized by electrospinning. The BT fibers calcined above 800 ℃ exhibit a strong ferroelectric property, which is verified by a typical butterfly-shaped displacement-voltage loop. It is found that the BT fibers with the single-domain structure exhibit better photocatalytic performance than that with the multi-domain configuration. When the single-domain transforms into multi-domain, the integrated internal electric field correspondingly breaks up, inducing that the internal electric field might cancel each other out and diminish the separation of photogenerated carriers. Also, the Au nanoparticles can improve the photocatalytic activity further on account of the surface plasmon resonance. Therefore, it is suggested that Au nanoparticles decorated on ferroelectric BT nanomaterials are promising photocatalysts.
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