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Jin, Young Ju,Kang, Sunah,Park, Pona,Choi, Dongkil,Kim, Dae Woo,Jung, Dongwook,Koh, Jaemoon,Jeon, Joohee,Lee, Myoungjin,Ham, Jiyeon,Seo, Ji-Hun,Jin, Hong-Ryul,Lee, Yan American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.22
<P>Expanded polytetrafluoroethylene (ePTFE), also known as Gore-Tex, is widely used as an implantable biomaterial in biomedical applications because of its favorable mechanical properties and biochemical inertness. However, infection and inflammation are two major complications with ePTFE implantations, because pathogenic bacteria can inhabit the microsized pores, without clearance by host immune cells, and the limited biocompatibility can induce foreign body reactions. To minimize these complications, we covalently grafted a biomembrane-mimic polymer, poly(2-methacryloyloxylethyl phosphorylcholine) (PMPC), by partial defluorination followed by UV-induced polymerization with cross-linkers on the ePTFE surface. PMPC grafting greatly reduced serum protein adsorption as well as fibroblast adhesion on the ePTFE surface. Moreover, the PMPC-grafted ePTFE surface exhibited a dramatic inhibition of the adhesion and growth of Staphylococcus aureus, a typical pathogenic bacterium in ePTFE implants, in the porous network. On the basis of an analysis of immune cells and inflammation-related factors, i.e., transforming growth factor-beta (TGF-beta) and myeloperoxidase (MPO), we confirmed that inflammation was efficiently alleviated in tissues around PMPC-grafted ePTFE plates implanted in the backs of rats. Covalent PMPC may be an effective strategy for promoting anti-inflammatory and antibacterial functions in ePTFE implants and to reduce side effects in biomedical applications of ePTFE.</P>
Ginsenosides Rg5 and Rk1, the skin-whitening agents in black ginseng
Jin, Yan,Kim, Ji Hye,Hong, Hee-Do,Kwon, Jeonghun,Lee, Eun Jung,Jang, Mi,Lee, Sung-Young,Han, Ah-Ram,Nam, Tae Gyu,Hong, Seok Kyu,Huh, Tae-Lin,Kang, Nam Joo,Lim, Tae-Gyu Elsevier 2018 Journal of Functional Foods Vol.45 No.-
<P><B>Abstract</B></P> <P>Ginseng (<I>Panax ginseng</I> Meyer) is widely used to treat various chronic disorders. Black ginseng is obtained by repeated steaming and drying of raw ginseng, which turn it black and convert the ginsenoside compounds present into more potent bioactive ingredients. The effects of a black ginseng extract on melanin production and skin whitening were evaluated in vitro as well as <I>in vivo</I> using human skin and zebrafish embryos. Tyrosinase activity decreased when steamed and dried ginseng was used. A pronounced skin-whitening effect was observed in our clinical study, and inhibition of melanin activity and tyrosinase levels was confirmed in zebrafish embryos. Two ginsenosides specific to black ginseng activate the MEK-ERK signaling pathway and are the main factors responsible for skin whitening. The skin-whitening effects of black ginseng are associated with the formation of two ginsenosides, indicating that black ginseng can be used as a novel skin-whitening agent in cosmetic products.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Inhibitory effect of black ginseng extract on melanin production on B16F10 and zebrafish model. </LI> <LI> Skin whitening activity of black ginseng extract on human skin. </LI> <LI> Ginsenoside Rg5 and Rk1, bioactive compounds in black ginseng extract for skin whitening activity. </LI> <LI> Activation MEK-ERK signaling pathway, a underlying mechanism for skin whitening activity of black ginseng extract. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
ROS1 gene rearrangement and copy number gain in non-small cell lung cancer.
Jin, Yan,Sun, Ping-Li,Kim, Hyojin,Park, Eunhyang,Shim, Hyo Sup,Jheon, Sanghoon,Kim, Kwhanmien,Lee, Choon-Taek,Chung, Jin-Haeng Springer International 2015 Virchows Archiv Vol.466 No.1
<P>ROS1 has attracted much attention as a possible oncogenic driver and ROS1-rearranged tumors show sensitivity to most ALK inhibitors. We aimed to clarify the prevalence of ROS1 gene rearrangement and investigate the clinical implications of ROS1 gene copy number gain (CNG) in non-small cell lung cancer (NSCLC) patients. We carried out fluorescent in situ hybridization with ROS1 and centromere enumeration 6 probes and immunohistochemistry for ROS1 protein expression. ROS1 rearrangement was detected in 3 of 375 samples (0.8 %); all of whom were female, never-smokers, and harbored an adenocarcinoma component. ROS1 gene CNG was found in 18 cases (4.8 %). ROS1 gene CNG was significantly associated with shorter disease-free survival (DFS, 12 vs. 58 months; p = 0.003) and shorter overall survival (OS, 40 vs. 67 months; p <0.001) than the group without CNG. Multivariate analysis confirmed that ROS1 gene CNG was significantly associated with poorer DFS (hazard ratio [HR]=2.16, 95 % confidence interval [CI] = 1.22-3.81, p = 0.008), and OS ([HR] = 2.53, 95 % [CI] = 1.31-4.89, p = 0.006). ROS1 protein overexpression was observed in 5.0 % (18 out of 357), of which 2 cases harbored ROS1 gene rearrangement. There was no statistically significant correlation between ROS1 gene CNG and protein overexpression. This study demonstrated ROS1 gene rearrangement was detected in 0.8 % of surgically resected NSCLC; and ROS1 gene CNG is an independent poor prognostic factor. This survival analyses may contribute to future studies on the utility of ROS1-targeted therapy for patients.</P>
Lee, Jungwoon,Xia, Yan,Son, Mi‐,Young,Jin, Guanghai,Seol, Binna,Kim, Min‐,Jeong,Son, Myung Jin,Do, Misol,Lee, Minho,Kim, Dongsup,Lee, Kyeong,Cho, Yee Sook WILEY‐VCH Verlag 2012 Angewandte Chemie Vol.124 No.50
<P><B>Pluripotenz‐Booster</B>: RSC133, ein neues synthetisches Derivat von Indolacrylsäure/Indolpropionsäure, zeigt zweifache Aktivität, indem es Histondeacetylase und DNA‐Methyltransferase inhibiert. Außerdem verbessert es wirksam die Reprogrammierung von menschlichen somatischen Zellen in einen pluripotenten Zustand und unterstützt Wachstum und Erhaltung von humanen pluripotenten Stammzellen (hPSCs).</P>