Dose-Dependent Associations between Wine Drinking and Breast Cancer Risk - Meta-Analysis Findings

Chen, Jia-Yan,Zhu, Hong-Cheng,Guo, Qing,Shu, Zheng,Bao, Xu-Hui,Sun, Feng,Qin, Qin,Yang, Xi,Zhang, Chi,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3

Purpose: To investigate any potential association between wine and breast cancer risk. Materials and Methods: We quantitatively assessed associations by conducting a meta-analysis based on evidence from observational studies. In May 2014, we performed electronic searches in PubMed, EmBase and the Cochrane Library to identify studies examining the effect of wine drinking on breast cancer incidence. The relative risk (RR) or odds ratio (OR) were used to measure any such association. Results: The analysis was further stratified by confounding factors that could influence the results. A total of twenty-six studies (eight case-control and eighteen cohort studies) involving 21,149 cases were included in our meta-analysis. Our study demonstrated that wine drinking was associated with breast cancer risk. A 36% increase in breast cancer risk was observed across overall studies based on the highest versus lowest model, with a combined RR of 1.0059 (95%CI 0.97-1.05) in dose-response analysis. However, 5 g/d ethanol from wine seemed to have protective value from our non-linear model. Conclusions: Our findings indicate that wine drinking is associated with breast cancer risk in a dose-dependent manner. High consumption of wine contributes to breast cancer risk with protection exerted by low doses. Further investigations are needed for clarification.

Time-Dependent Reliability Analysis of Oil Derrick Structures in Mechanism Failure Mode

Yan Zheng,Dongsheng He,Yue Cheng,Li Mo 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.3

Most research studies on the reliability of oil derrick structures have focused on static reliability analysis. Strength degradation with time of oil derrick structures and mechanism failure should also be considered in reliability analysis. In order to address this issue, we propose a new time-dependent reliability analysis method for oil derrick structures in mechanism failure mode and apply it to a tower derrick structure. We used the Monte Carlo fi nite element method to compute the static failure probability of each derrick component, and steps were employed to determine the main failure mechanisms. The time-dependent failure probabilities of each derrick component in the main failure mechanisms were calculated by the total probability theorem. The time-dependent reliability of a derrick structure system was obtained by considering the system as a series of parallel subsystems. A tower derrick example was used to demonstrate the accuracy and applicability of the proposed method. The results revealed that the proposed method is accurate and reliable.

Plasma metabolites associated with physiological and biochemical indexes indicate the effect of caging stress on mallard ducks (Anas platyrhynchos)

Zheng Chao,Wu Yan,Liang Zhen Hua,Pi Jin Song,Cheng Shi Bin,Wei Wen Zhuo,Liu Jing Bo,Lu Li Zhi,Zhang Hao 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.2

Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been extensively studied, but no detailed information is available about the comprehensive changes in plasma metabolites at different stages of caging stress in ducks. We designed this experiment to analyze the effects of caging stress on performance parameters and oxidative stress indexes in ducks. Methods: Liquid chromatography tandem mass spectrometry (LC/MS-MS) was used to determine the changes in metabolites in duck plasma at 5 (CR5), 10 (CR10), and 15 (CR15) days after cage rearing and traditional breeding (TB). The associated pathways of differentially altered metabolites were analyzed using Kyoto encyclopedia of genes and genomes (KEGG) database. Results: The results of this study indicate that caging stress decreased performance parameters, and the plasma total superoxide dismutase levels were increased in the CR10 group compared with the other groups. In addition, 1,431 metabolites were detected. Compared with the TB group, 134, 381, and 190 differentially produced metabolites were identified in the CR5, CR10, and CR15 groups, respectively. The results of principal component analysis (PCA) show that the selected components sufficiently distinguish the TB group and CR10 group. KEGG analysis results revealed that the differentially altered metabolites in duck plasma from the CR5 and TB groups were mainly associated with ovarian steroidogenesis, biosynthesis of unsaturated fatty acids, and phenylalanine metabolism. Conclusion: In this study, the production performance, blood indexes, number of metabolites and PCA were compared to determine effect of the caging stress stage on ducks. We inferred from the experimental results that caging-stressed ducks were in the sensitive phase in the first 5 days after caging, caging for approximately 10 days was an important transition phase, and then the duck continually adapted. Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been extensively studied, but no detailed information is available about the comprehensive changes in plasma metabolites at different stages of caging stress in ducks. We designed this experiment to analyze the effects of caging stress on performance parameters and oxidative stress indexes in ducks.Methods: Liquid chromatography tandem mass spectrometry (LC/MS-MS) was used to determine the changes in metabolites in duck plasma at 5 (CR5), 10 (CR10), and 15 (CR15) days after cage rearing and traditional breeding (TB). The associated pathways of differentially altered metabolites were analyzed using Kyoto encyclopedia of genes and genomes (KEGG) database.Results: The results of this study indicate that caging stress decreased performance parameters, and the plasma total superoxide dismutase levels were increased in the CR10 group compared with the other groups. In addition, 1,431 metabolites were detected. Compared with the TB group, 134, 381, and 190 differentially produced metabolites were identified in the CR5, CR10, and CR15 groups, respectively. The results of principal component analysis (PCA) show that the selected components sufficiently distinguish the TB group and CR10 group. KEGG analysis results revealed that the differentially altered metabolites in duck plasma from the CR5 and TB groups were mainly associated with ovarian steroidogenesis, biosynthesis of unsaturated fatty acids, and phenylalanine metabolism.Conclusion: In this study, the production performance, blood indexes, number of metabolites and PCA were compared to determine effect of the caging stress stage on ducks. We inferred from the experimental results that caging-stressed ducks were in the sensitive phase in the first 5 days after caging, caging for approximately 10 days was an important transition phase, and then the duck continually adapted.

Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera

Cheng-Qin Liang,Rong-Hua Luo,Ju-Ming Yan,Yan Li,Xiao-Nian Li,Yi-Ming Shi,Shan-Zhai Shang,Zhong-Hua Gao,Liu-Meng Yang,Yong-Tang Zheng,Wei-Lie Xiao,Hong-Bin Zhang,Han Dong Sun 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.2

Two new triterpenoids, schisphendilactoneA and B (1 and 2), together with three known triterpenoids,were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods,and the absolute configuration of 1 was determined bysingle-crystal X-ray diffraction. Compound 2 showedmoderate inhibitory activity against SW480 cancer cellline, and compound 5 exhibited promising anti-HIV-1activity with EC50 value of 0.52 lg ml-1 and therapeuticindex value of 117.12.

Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions

Zhihua Zheng,Jiasi Chen,Keping Wu,Yan Lei,Mingcheng Huang,Lokyu Cheng,Hui Guan,Jiawen Lin,Ming Zhong,Xiaohua Wang 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.2

Background: Ferroptosis, which is caused by an iron-dependent accumulation of lipid hydroperoxides, is a type of cell death linked todiabetic kidney disease (DKD). Previous research has shown that fatty acid binding protein 4 (FABP4) is involved in the regulation of ferroptosis in diabetic retinopathy. The present study was constructed to explore the role of FABP4 in the regulation of ferroptosis in DKD. Methods: We first detected the expression of FABP4 and proteins related to ferroptosis in renal biopsies of patients with DKD. Then, we used a FABP4 inhibitor and small interfering RNA to investigate the role of FABP4 in ferroptosis induced by high glucosein human renal proximal tubular epithelial (HG-HK2) cells. Results: In kidney biopsies of DKD patients, the expression of FABP4 was elevated, whereas carnitine palmitoyltransferase-1A (CPT1A), glutathione peroxidase 4, ferritin heavy chain, and ferritin light chain showed reduced expression. In HG-HK2 cells, the induction of ferroptosis was accompanied by an increase in FABP4. Inhibition of FABP4 in HG-HK2 cells changed the redox state, suppressing the production of reactive oxygen species, ferrous iron (Fe2+), and malondialdehyde, increasing superoxide dismutase, and reversing ferroptosis-associated mitochondrial damage. The inhibition of FABP4 also increased the expression of CPT1A, reversed lipiddeposition, and restored impaired fatty acid β-oxidation. In addition, the inhibition of CPT1A could induce ferroptosis in HK2 cells. Conclusion: Our results suggest that FABP4 mediates ferroptosis in HG-HK2 cells by inhibiting fatty acid β-oxidation.

Energy-Saving Design and Research of High-Speed Permanent Magnetic Synchronous Motor Under the Development of Rare Earth Resources

Li Zheng,Yan Zhi-Bang,Zhang Lu-Cheng,Liu Yu,Zhang Hong-Jie,Sun He-Xu 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3

In recent years, under the background of low carbonization and industrial intelligence, with the rise of new energy sources such as wind energy and solar energy, rare earth permanent magnets have begun to be widely used in generators of these new energy sources. From the perspective of green and sustainable development, permanent magnet motor can reduce energy loss and meet the requirements of sustainable development through the reasonable selection and utilization of permanent magnet materials, the design of motor structures, and advanced transmission control technology. In this paper, a 225 kW/34,000 rpm high speed permanent magnet motor (HSPMSM) is designed. Firstly, the electromagnetic design of the motor is carried out, and the fnite element model is established. The rotor temperature rise under diferent materials is analyzed by comparing the electromagnetic characteristics and loss of diferent permanent magnet materials and using the principle of electrothermal coupling. Combined with the thermal performance of the material, the advantages of rare earth permanent magnet are analyzed, and SmCo permanent magnet material is selected to be more suitable for the motor. Due to the motor's high speed and high frequency harmonic rate, an improved proportional resonant algorithm based on active disturbance rejection is studied and analyzed. Compared with the traditional PI control, the algorithm further reduces the harmonic content of the motor's stator current while improving the motor's running state, thereby reducing the overall loss of the motor. The prototype and experimental platform are made, and the experimental results verify the correctness of the simulation analysis.

연구논문 : 동절기 고층건물 풍하면의 기온역전에 관한 연구

정해연 ( Hai Yan Zheng ),김문성 ( Wen Cheng Jin ),오성남 ( Sung Nam Oh ),이규석 ( Kyoo Seock Lee ) 한국환경영향평가학회 2010 환경영향평가 Vol.19 No.6

To determine nocturnal inversion characteristics at the leeward side of high-rise building, air temperature data were observed at 10 minute interval from February 22, 2010 to April 15, 2010. The observed data were compared, analyzed and examined to illustrate air temperature differences between the roof (XAR) and surface (XAG) of X apartment. The wind speed, wind direction and precipitation data were also observed at XAR and YJL (Yangjae Stream) sites at the same time. After the analysis, the maximum nocturnal inversion was observed by 4.0˚C at 3:40, 3:50, 4:10 on February 24th 2010, at that time the weather condition was clear and weak wind. Air temperature inversions at the leeward side of high-rise building were observed on whole day in wintertime and air temperature inversion intensity was also higher than other nearby area (SMG).

도시상업업무중심지구와 산기슭마을의 기온차

정해연 ( Hai Yan Zheng ),김문성 ( Wen Cheng Jin ),이규석 ( Kyoo Seock Lee ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2011 한국환경복원기술학회지 Vol.14 No.1

도시화로 인해 도심지와 도시외곽간의 기온차가 더욱 심해지는 열섬현상은 폭염과 더불어 도시민의 쾌적한 삶을 저해하는 요소로 작용하여 이를 저감하기 위한 노력이 시행되고 있다. 도시 기온은 도시의 지형적 특성, 도시 수체의 규모와 위치 등에 의해 영향을 받고 있는 것으로 알려져 있어 도시외곽에 산림이 존재하는 도시에서는 이들 지역과 도심지와의 기온차이를 측정하여 바람길을 이용한 기후응용도시계획에 활용할 필요가 있다. 허나, 아직 국내에서는 이들 기온 차에 대한 특성을 조사한 연구가 많지 않다. 이를 위해 본 연구에서는 서울시 강남 지역을 대상으로 도심지 상업업무중심지구 두 곳(GNS, SLS)과 도시외곽 산기슭 마을 두 곳(YGD, GPT) 간의 기온 차를 2008년 4월 14일부터 2009년 4월 13일까지 1년간 관측한 자료를 대상으로 일 변동, 계절별 변동을 비교, 분석하였다. 분석결과 관측 기간 동안 YGD는 연평균기온이 GNS보다 2.8℃ 낮았으며 열대야는 GNS, SLS가 16일인데 비해 GPT는 2일, YGD는 하루도 관측되지 않아 도시외곽의 산림이 도시기온 저감효과가 있음을 확인하였다.

도시 기온차이의 주간 변동에 관한 연구

정해연 ( Hai Yan Zheng ),김일 ( Ri Jin ),김문성 ( Wen Cheng Jin ),이규석 ( Kyoo Seock Lee ) 한국환경복원기술학회 2012 한국환경복원기술학회지 Vol.15 No.4

도시화, 산업화로 인해 도시는 그 주변지역보다 기온이 높은 도시열섬 현상이 발생하고 있으며 이는 인간 활동에 의한 인공폐열 배출량의 증가에 기인한다. 이러한 인간 활동에 의한 도시기온의 변화는 도심과 농촌지역의 차이로 인한 공간적 변이와 아울러 주중과 주간에 기온 차이가 발생하는 시간적변이를 포함하고 있으나 도시열섬현상의 공간적 변이에 의한 연구에 비해 시간적 변이에 의한 연구는 많이 수행되고 있지 않다. 본 연구에서는 서울 도심의 주중과 주말의 기온차이를 다년간 관측을 통하여 주중과 주말의 주간 변동의 특성을 파악하여 도시 기온의 시간적 변이를 파악하기 위하여 서울시강남구를 사례로 2007년 10월 31일부터 2010년 12월 11일까지 약 3년간 관측한 자료를 이용하여 분석한 결과 5개 관측지점 모두 주중(weekday)이 주말보다 1.6~1.7℃ 기온이 더 높았으며 이는 주중에 도시 내에서 방출하는 인공폐열의 양이 더 많음을 의미하며 고밀도지역은 냉난방수요가 많아 토지이용에 따라 기온의 차가 크므로 이를 저감시키기 위한 도시 및 조경계획이 필요하다.

고층건물 도로협곡의 바람특성

정해연 ( Hai Yan Zheng ),김문성 ( Wen Cheng Jin ),이성희 ( Sung Hee Lee ),이규석 ( Kyoo Seock Lee ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2012 한국환경복원기술학회지 Vol.15 No.2

The street canyon forms the geometric unit of the built environment. The geometry makes up urban canyons and it influences the urban climate. In order to investigate the wind characteristics of urban street canyon at Dogok-dong, Gangnam-gu in Seoul, the wind direction and wind speed data were observed and analyzed by using 2-D ultra sonic and propeller wind monitor from May 5, 2010 to May 4, 2011. The results show that the prevailing wind direction was west at Station A(Military Mutual Aid Association Building), southwest at Station B(Sookmyung Girls`` High School) and the wind speed of Station B was higher than Station A. There were diurnal differences about prevailing wind direction between two stations:it was westerly wind at Station A for a whole day, but at Station B only from 22:00 to 04:00. However, Station B is different from Station A at other time. At Station B, it was easterly wind from 04:00 to 12:00, southwesterly wind from 12:00 to 22:00. In terms of seasonal (except winter) frequency, the spring shows the highest frequency and fall was the next.