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YU-Ming GUO(곽육명),Rae-Hyun Yu(유래현),Pil-Kyo Kim(김필교),Kyung-Ho Kim(김경호) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10
In this paper, blood pressure was estimated using the time difference between the R peak of Electrocardiography and the peak of Photoplethysmogram. The feature point detection algorithm is improved, the R-wave of ECG is detected by the adaptive threshold method, and the peak of PPG is detected by relative position, which greatly improves the efficiency of the improved algorithm and the accuracy of PTT(Pulse Transit Time) detection. And on this basis, the vascular elasticity variable is added. Through the correlation analysis of the data, the strong correlation between PTT and systolic blood pressure(SBP) can be obtained, and there is a moderate correlation between PTT and diastolic blood pressure(DBP).
Research on the temperature characteristics of SiPM-based LaBr3(Ce) detectors
Yu Tao,Guo Siming,Wu Jinjie,An Zhenghua,Qie Xiaoyu,Guo Kaiyue 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.1
When a satellite-borne detector is being ground calibrated, a standard detector is required to determine the monochromatic X-ray beam energy and intensity. For this purpose, a SiPM-based LaBr3(Ce) detector has been developed. The environmental temperature change may substantially afect the performance of the detector, thus afecting the accuracy of the ground calibration results. To study the efect of temperature change on the performance of the LaBr3(Ce) detector, the performance of the LaBr3(Ce) detector was tested with 241Am and 137Cs γ-ray sources in the high- and low-temperature test chambers. The results showed that within the range of – 20 to 40 °C, the energy resolution of the LaBr3(Ce) detector does not change by more than 1%, nor does the peak-to-total ratio of 241Am and 137Cs. The temperature change has little efect on the performance of the LaBr3(Ce) detector, which meets the requirements for use as a beam monitor. However, the peak location of the radioactive source varies signifcantly with temperature, and the diference with the peak location at room temperature is within 17%. To reduce the variation in the gain of the LaBr3(Ce) detector with temperature, it is necessary to optimize the compensation design of the temperature gain to ensure the stability of the detector gain at various temperatures.
Guo Huilin,Yu Tingting,Zhao Lei,Qian Jun,Yu Jiahe,Zhang Yu,Teng Yongyue,Zhu Chunshui,Yang Tao,Chen Wenbin,Gong Picheng,Jiang Cuishuang,Gao Changfei,Yang Bing,Yang Chenyu 한국탄소학회 2023 Carbon Letters Vol.33 No.3
In this study, a bipolar visible light responsive photocatalytic fuel cell (PFC) was constructed by loading a Z-scheme g-C3N4/carbon black/BiOBr and a Ti3C2/MoS2 Schottky heterojunction on the carbon brush to prepare the photoanode and photocathode, respectively. It greatly improved the electron transfer and achieved efficient degradation of organic pollutants such as antibiotics and dyes simultaneously in two chambers of the PFC system. The Z-scheme g-C3N4/carbon black/BiOBr formed by adding highly conductive carbon black to g-C3N4/BiOBr not only effectively separates the photogenerated carriers, but also simultaneously retains the high reduction of the conduction band of g-C3N4 and the high oxidation of the valence band of BiOBr, improving the photocatalytic performance. The exceptional performance of Ti3C2/MoS2 Schottky heterojunction originated from the superior electrical conductivity of Ti3C2 MXene, which facilitated the separation of photogenerated electron–hole pairs. Meanwhile, the synergistic effect of the two photoelectrodes further improved the photocatalytic performance of the PFC system, with degradation rates of 90.9% and 99.9% for 50 mg L−1 tetracycline hydrochloride (TCH) and 50 mg L−1 rhodamine-B (RhB), respectively, within 180 min. In addition, it was found that the PFC also exhibited excellent pollutant degradation rates under dark conditions (79.7%, TCH and 97.9%, RhB). This novel pollutant degradation system is expected to provide a new idea for efficient degradation of multiple pollutant simultaneously even in the dark.
Protective Effect of Sodium Ferulate on Acetaldehyde-Treated Precision-Cut Rat Liver Slices
Yu Guo,Xiao-Qian Wu,Chun Zhang,Zhang-Xiu Liao,Yong Wu,Hui Wang 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.6
Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis, and inhibition of HSC activation may prevent liver fibrosis. Acetaldehyde, the most deleterious metabolite of alcohol, triggers HSC activation in alcoholic liver injury. In the present study, we investigated the protective effect of sodium ferulate (SF), a sodium salt of ferulic acid that is rich in fruits and vegetables, on acetaldehyde-stimulated HSC activation using precision-cut liver slices (PCLSs). Rat PCLSs were co-incubated with 700 lM acetaldehyde and different concentrations of SF. Hepatotoxicity was assessed by measuring enzyme leakage and malondialdehyde content in tissue. a-Smooth muscle actin, transforming growth factor-b1, and hydroxyproline were determined to assess the activation of HSCs. In addition, matrix metalloproteinase (MMP)-1 and the tissue inhibitor of metalloproteinase (TIMP-1) were determined to evaluate collagen degradation. SF prominently prevented the enzyme leakage in acetaldehyde-treated slices and also inhibited HSC activation and collagen production stimulated by acetaldehyde. In addition, SF increased MMP-1 expression and decreased TIMP-1 expression. These results showed that SF protected PCLSs from acetaldehyde-stimulated HSC activation and liver injury, which may be associated with the attenuation of oxidative injury and acceleration of collagen degradation
Yu Xiaoyu,Mao Yinhe,Li Guangbo,Wu Xianwei,Xuan Qiankun,Yang Simin,Chen Xiaoqing,Cao Qi,Guo Jian,Guo Jinhu,Wu Wenjuan 한국미생물학회 2023 The journal of microbiology Vol.61 No.2
The use of antibiotics can disrupt the body’s natural balance and increase the susteptibility of patients towards fungal infections. Candida albicans is a dimorphic opportunistic fungal pathogen with niches similar to those of bacteria. Our aim was to study the interaction between this pathogen and bacteria to facilitate the control of C. albicans infection. Alpha-hemolysin (Hla), a protein secreted from Staphylococcus aureus, causes cell wall damage and impedes the yeast–hyphae transition in C. albicans. Mechanistically, Hla stimulation triggered the formation of reactive oxygen species that damaged the cell wall and mitochondria of C. albicans. The cell cycle was arrested in the G0/G1 phase, CDC42 was downregulated, and Ywp1 was upregulated, disrupting yeast hyphae switching. Subsequently, hyphae development was inhibited. In mouse models, C. albicans pretreated with Hla reduced the C. albicans burden in skin and vaginal mucosal infections, suggesting that S. aureus Hla can inhibit hyphal development and reduce the pathogenicity of candidiasis in vivo.
Chebyshev Pseudospectral-Finite Element Method for Navier-Stokes Equation
Guo, Ben-yu,Hou, Jing-yu CHOSUN UNIVERSITY 1997 Basic Science and Engineering Vol.1 No.1
Abstract-A Chebyshev pseudospectral-finite element method is proposed for two-dimensional unsteady Navier-Stokes equation. The generalized stability and the convergence are given. The numerical results show the advantages of this method.
Guo, Qi,Shen, Zhiyang,Yu, Hongxia,Lu, Gaofeng,Yu, Yong,Liu, Xia,Zheng, Pengyuan The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were reduced by CA treatment. Moreover, CA treatment significantly inhibited APAP-induced hepatocytes necrosis and lactate dehydrogenase (LDH) releasing. Western blot analysis showed that CA abrogated APAP-induced cleaved caspase-3, Bax and phosphorylated JNK protein expression. Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated $I{\kappa}B{\alpha}$ and p65 protein in the liver. In addition, CA treatment reduced APAP- induced hepatic malondialdehyde (MDA) contents and reactive oxygen species (ROS) accumulation. Conversely, hepatic glutathione (GSH) level was increased by administration of CA in APAP-treated mice. Mechanistically, CA facilitated Nrf2 translocation into nuclear through blocking the interaction between Nrf2 and Keap1, which, in turn, upregulated anti-oxidant genes mRNA expression. Taken together, our results indicate that CA facilitates Nrf2 nuclear translocation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.