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Liu Xiaoyi,Wei Qinglv,Yang Chenyue,Zhao Hongyan,Xu Jie,Mobet Youchaou,Luo Qingya,Yang Dan,Zuo Xinzhao,Chen Ningxuan,Yang Yu,Li Li,Wang Wei,Yu Jianhua,Xu Jing,Liu Tao,Yi Ping 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional regulation, in ovarian cancer, is poorly understood. In this study, we revealed that the RNA methyltransferase NSUN2 facilitates mRNA m5C modification and forms a positive feedback regulatory loop with the transcription factor E2F1 in ovarian cancer. Specifically, NSUN2 promotes m5C modification of E2F1 mRNA and increases its stability, and E2F1 binds to the NSUN2 promoter, subsequently reciprocally activating NSUN2 transcription. The RNA binding protein YBX1 functions as the m5C reader and is involved in NSUN2-mediated E2F1 regulation. m5C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the expression of the oncogenes MYBL2 and RAD54L, driving ovarian cancer progression. Thus, our study delineates a NSUN2-E2F1-NSUN2 loop regulated by m5C modification in a manner dependent on YBX1 phase separation, and this previously unidentified pathway could be a promising target for ovarian cancer treatment.
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Guo Huilin,Yu Tingting,Zhao Lei,Qian Jun,Yu Jiahe,Zhang Yu,Teng Yongyue,Zhu Chunshui,Yang Tao,Chen Wenbin,Gong Picheng,Jiang Cuishuang,Gao Changfei,Yang Bing,Yang Chenyu 한국탄소학회 2023 Carbon Letters Vol.33 No.3
In this study, a bipolar visible light responsive photocatalytic fuel cell (PFC) was constructed by loading a Z-scheme g-C3N4/carbon black/BiOBr and a Ti3C2/MoS2 Schottky heterojunction on the carbon brush to prepare the photoanode and photocathode, respectively. It greatly improved the electron transfer and achieved efficient degradation of organic pollutants such as antibiotics and dyes simultaneously in two chambers of the PFC system. The Z-scheme g-C3N4/carbon black/BiOBr formed by adding highly conductive carbon black to g-C3N4/BiOBr not only effectively separates the photogenerated carriers, but also simultaneously retains the high reduction of the conduction band of g-C3N4 and the high oxidation of the valence band of BiOBr, improving the photocatalytic performance. The exceptional performance of Ti3C2/MoS2 Schottky heterojunction originated from the superior electrical conductivity of Ti3C2 MXene, which facilitated the separation of photogenerated electron–hole pairs. Meanwhile, the synergistic effect of the two photoelectrodes further improved the photocatalytic performance of the PFC system, with degradation rates of 90.9% and 99.9% for 50 mg L−1 tetracycline hydrochloride (TCH) and 50 mg L−1 rhodamine-B (RhB), respectively, within 180 min. In addition, it was found that the PFC also exhibited excellent pollutant degradation rates under dark conditions (79.7%, TCH and 97.9%, RhB). This novel pollutant degradation system is expected to provide a new idea for efficient degradation of multiple pollutant simultaneously even in the dark.
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Lianzhou Yang,Yuchen Cai,Dongsheng Zhang,Jian Sun,Chenyu Xu,Wenli Zhao,Wenqi Jiang,Chunhua Pan 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7 family members that were able to predict the immune status of patients, and which may serve as potential targets for the treatment of breast cancer. We also aimed to identify microRNAs that may regulate the expression of B7 family members. Methods: The Cancer Genome Atlas data from 1,092 patients with breast cancer, including gene expression, microRNA expression and survival data, were used for statistical and survival analyses. Polymerase chain reaction and Western blot were used to measure messenger RNA and protein expression, respectively. Luciferase assay was used to investigate direct microRNA target. Results: Bioinformatic analysis predicted that microRNA (miR)-93, miR-195, miR-497, and miR-340 are potential regulators of the immune evasion of breast cancer cells, and that they exert this function by targeting CD274, PDCD1LG2, and NCR3LG1. We chose CD274 for further investigations. We found that miR-195, miR-497, and CD274 expression levels were inversely correlated in MDA-MB-231 cells, and miR-195 and miR-497 expressions mimic inhibited CD274 expression in vitro. Mechanistic investigations demonstrated that miR-195 and miR-497 directly target CD274 3´ untranslated region. Conclusion: Our data indicated that the level of B7 family members can predict the prognosis of breast cancer patients, and miR-195/miR-497 regulate CD274 expression in triple negative breast cancer. This regulation may further influence tumor progression and the immune tolerance mechanism in breast cancer and may be able to predict the effect of immunotherapy on patients.
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Tribological Properties of PAO40@SiO2/UHMWPE Composites Subjected to Heavy-loading Conditions
Yao Chenyu,Jia Dan,Wan Changxin,Li Jian,Zhan Shengpeng,Yang Tian,Qi Xiaowen,Liu Changxin,Duan Haitao 한국고분자학회 2022 폴리머 Vol.46 No.5
In the present study, the ballistic impact resistance of kevlar reinforced polymer composites and shape memoryalloy sheet reinforced kevlar epoxy polymer composites have been compared numerically and experimentally. The testspecimens have been fabricated by the hand layup method, and the ballistic impact test has been conducted accordingto NIJ Level IIIA. In the current research, a new method has been proposed to measure the ballistic impact resistanceof the material by using Image J software. From the test results, it has been observed that reinforcement of shape memoryalloy in kevlar epoxy polymer composites has increased the ballistic impact resistance by 89-145% for the damaged areacompared with plain kevlar reinforced epoxy polymer composite. Also, the damaged area observed in the numerical andthe experimental results is almost the same.
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A Geometric Method for Kinematics of Delta Robot and its Path Tracking Control
Xuewen Yang,Zuren Feng,Chenyu Liu,Xiaodong Ren 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
This paper presents a geometric method for solving the inverse and forward kinematics of Delta robot, and then investigated the problem of path tracking control. The forward kinematics is most commonly solved by various iterative methods, which may suffer from slow convergence rate and strict initial value conditions. In this paper, this problem is simplified as solving the intersection point of two circles and then transforming the coordinates system to get the final solution. This method has advantages in its simplicity, accuracy and efficiency. Based on the solution to kinematics and the derivation of Jacobian matrix, the path tracking control is studied from two parts: the superior trajectory planning and the lower control system. Trajectory planning aims to define a temporal motion law along a given geometric path. A method for trajectory planning is presented which is based on a modified trapezoidal velocity profile (TVP) of which initial and final velocities could be nonzero depending on its movement model, whether continuous path (CP) or point to point (PTP). A velocity control method is proposed using a nonlinear PD controller to ensure the end effector tracking the desired path with high precision. At last, a demo trajectory is generated to verify the feasibility of the method experimentally.
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Qingshao Liang,Jingchun Tian,Xiang Zhang,Xiao Sun,Chenyu Yang 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.1
The paleo-sedimentary environment can be restored qualitatively or semiqualitatively using elements or combinations of elements that are sensitive to the depositional environment. Through the analysis and testing of the main elements, trace elements and rare earth elements of twenty-one Lower–Middle Permian coal-bearing strata mudstone samples in Taikang Uplift, southern North China Basin, this study explored the FOUR-PALEO conditions (paleo-water depth, paleo-redox conditions, paleoclimate and paleo-provenance). The La and Co contents indicate that the water depth of the northern margin of the southern North China Basin became gradually shallower during the Lower–Middle Permian period. According to the U/Th, Uau, V/Cr, Ni/Co and V/Sc ratios, it is known that this section of the basin is in an oxidizing environment, and the oxidation is gradually enhanced from the Taiyuan Formation to the Lower Shihezi Formation. Paleoclimate from bivariate plot diagrams of C-value and Sr/Cu versus Ga/Rb shows that the Taikang Uplift was characterized by a warm and arid climate during the depositional period of Permian Taiyuan Formation and a warm and humid climate during the Lower Shihezi Formation and shows that the depositional period of Permian Shanxi Formation was in a transitional period of humid and arid. CIA, PIA, ICV, Th/U and K/Rb reflect the tectonic settings of the source area. From the Taiyuan Formation to the Lower Shihezi Formation, the CIA and PIA gradually increase, and the ICV gradually decreases, indicating enhanced chemical weathering and the transition from arid to humid in the source area, the arid and humid frequent change in the Taiyuan Formation, and a sudden climate change in the Shanxi Formation. Additionally, the provenance discriminant function, Zr/Sc-Th/Sr, REEs ratios, Th versus Hf-Co, Hf versus La/Th and ΣREE vs. La/Yb indicate that the type of provenance is associated with magmatic differentiation. Moreover, discriminant diagrams, consisting of K2O/Na2O versus SiO2, La-Th-Sc, Th-Sc-Zr/10 and Th-Co-Zr/10, suggest that the mudstones of Lower–Middle Permian were deposited in active continental margin tectonic settings.
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