반응매체로써 용융염을 사용한 연소가스로부터 NO의 제거에 관한 연구(Ⅱ)

배성렬,김희택 漢陽大學校 環境科學硏究所 1989 環境科學論文集 Vol.10 No.-

기포탑내에서 용융염(50mol% NH₄HSO₄, 50mol% NaHSO₄)과 V₂??계 촉매를 사용하여 온도범위 150∼180℃ O₂존재하에서 NH₃에 의한 NO의 환원반응에 대하여 조사하였다. NO의 환원속도는 NO의 농도에 대하여 1차 나타내었고 V₂??와 V₂??-NH₄Br-TiO₂-SiO₂촉매계에서1차 속도상수를 결정하였다. 또한 같은 온도범위내에서 용융염중의 NO에 대한 Henry 상수를 결정하였다. The kinetics of the reduction of NO by NH₃in the presence of O₂ in molten salts of 50mol% NH₄HSO₄and 50mol% NaHSO₄with V₂O as catalyst were investigated by chemical absorption method using a bubble column reactor at temperatures ranging from 150 to 180℃. The rate of the reduction of NO could be expressed as first-order with respect to the concentration of NO. The first-order reaction rate constants with V₂?? and V₂??-NH₄Br-TiO₂-SiO₂as catalyst were determined. The Henry's law constants of NO in the molten salts were determined in the same range of temperature.

마우스 단위법에 의한 테트로도톡신 중독사 판정사례(제2보)

정희선,김은미,김인숙,양자열 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

발치후 임프란트 매식 시기에 따른 골유착에 관한 연구 : Histomorphometric and Biomechanical Studies 조직형태계측학적 및 생역학적 연구

오희균,류선열 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.4

The purpose of this study was to investigate the effect of timing of implant insertion on osseointegration after tooth extraction. Fifteen mongrel dogs, weighing 15kg or more, were used. The lower right 1st, 2nd, 3rd, 4th premolars and 1st molar were extracted under general anesthesia. Implants were inserted at 2, 4, and 8 weeks after extraction of the teeth, being designated as 2-, 4-, and 8-week groups, respectively. Results obtained were as follows. 1. Macroscopically there was neither an infection at the implant site nor an exposure of the implant. 2. Histologically the surrounding bone of the implant was less mature in the 2-week group than in the 4- and 8-week groups. 3. The implant-bone contact ranged from 75 to 82%, with no significant differences among the groups. No increase in the implant-bone contact was found with increasing healing periods from 4 to 12 weeks after implant insertions. 4. The average depth (0.64mm) of the fibrous connective tissue ingrowth in the 2-week group was slightly deeper than those in the 4- (0.51mm) and 8-week (0.53mm) groups at 12 weeks after implant insertion. 5. the implant-bone interfacial bond strengths were 73.05kgf in the 2-week group, 69.71 kgf in the 4-week group and 73.76 kgf in the 8-week group. No significant difference was noted in pullout force among the groups. The degree of confidence of interfacial bone strength was highest in the 8-week group, followed by the 4- and 2-week groups. These results indicate that at least 4 weeks of healing period will be required before implant is to be inserted following tooth extraction.

대형물의 RP 작업을 위한 절단 알고리즘의 개발

채희창,강희용,유상훈,이승현,문홍렬 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.2

Nowadays, as the development period of new products becomes shorter and consumer's requirement is more various, the importance of Rapid Prototyping Technology has been rapidly increased. Rapid Prototyping makes prototypes or functional parts directly using the 3D CAD data. But RP machines can make protypes in limit size. For making large size prototype, we slice solid, which is made of STL file, and then glue sliced solid. And if contact area of part is small, union solid will be easily destroyed for going down of adhesion. So we need to expand contact area, I suggest making a section into stair shape. This paper is concerned with slicing solid on STL file and improving on adhesion.

미세혈관문합시 헤파린의 국소 및 전신 투여가 혈전 형성에 미치는 영향

김성열,오희균 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.2

The need of microvascular anastomosis or vascular graft has been increased gradually to reconstruct the maxillofacial defects. Despite advances in microsurgical technique, instrumentation and experience gained in clinical microvascular surgery, thrombosis of small veins may lead to the failure of microvascular surgery. A variety of anticoagulant agents have been used in either experimental or clinical microvascular surgery in order to decrease the failure rate of microvascular anastomosis and to prevent the need of reoperation. Heparin, which has been known to be effective in preventing thrombosis and in improving patency after microvascular anastomosis, is used locally or systematically. However, their effects is controversial. This study was performed to evaluate the effect of topical and intravenous heparin on thrombosis and patency in the microvascular anastomosis of the traumatized veins. Nine white rabbits wishing about 2 kg were used. After exposure of both femoral veins, the veins were crushed by the jaws of smooth needle holder in order to create a thrombosis model. Transectional incision was made in the vein. The animals were then divided into 3 groups based on the administration method of heparin: 1) Experimental Group 1, topical irrigation of lumen with heparin saline solution (n=6); 2) Experimental Group 2, topical irrigation of lumen with heparin saline solution and intravenous injection of heparin (0.75 mg/kg) via the marginal ear vein for 3 days; 3) Control Group. topical irrigation of lumen with saline solution (n=6). The veins were anastomosed utilizing microvascular technique with 10-0 Ethilon. The vascular patency was evaluated with empty-and-refill test 30 minutes and 3 days after microvascular anastomosis. The amount of thrombus was evaulated by surgery microscope 3 days after microvascular anastomosis and histologic findings were observed. The results are as follows: 1. Thirty minutes after microvascular anastomosis, the patency of all Experimental Groups was better than Control group. However, there was no significant difference among groups. 2. Three days after anastomosis, the patency of all Experimental Groups was much more improved than that of Control Group (p<0.05). There was no significant difference between Experimental Group 1 and 2. 3. Three days after anastomosis, the amount of thrombus in all Experimental Groups was much less than that of Control Group (p<0.05). 4. In histologic findings a lot of luminal thrombus were observed around sutured area in Control Groups. Few luminal thrombus was observed in all Experimental Groups. Mild necrosis in the vessel wall was observed around sutured area in all specimens. These results indicate that topical irrigation of heparin may improve the patency and inhibit the formation thrombus in the microvascular anastomosis of the traumatized veins.

외과적 보조의 급속상악확장술 : 치험 5예 REPORT OF 5 CASES

박충열,이용욱,송종운,김영운,박홍주,오희균,유선열,이기현,황현식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Five adults (3 cases of bilateral posterior crossbite, 2 cases of unilateral posterior crossbite) with intermaxillary discrepancy of over 5㎜ due to maxillary transverse deficiency were treated by surgically assisted rapid maxillary expansion (SARME). Bilateral maxillary horizontal osteotomies, osteotomies of pterygomaxillary junction and anterior lateral nasal wall, ans anterior palatal osteotomy were performed in 4 cases, and unilateral osteotomies in 1case, followed by palatal expansion with tooth-borne orthopedic applicance. No significant complication was observed. The mean palatal expansion was 7.2㎜ (5.8∼10.0㎜) in the maxillary first molar region. During the mean follow-up period of 4 years (5 months∼8 years 7 months), no recurrence of crossbite was observed in all cases. The SARME seemed to be a simple, stable, and reliable procedure for achieving a permanent increase of over 5㎜ in skeletal maxillary transverse width of adults.

케토프로펜-폴리에틸렌글리콜 전구약물의 합성 및 가수분해

이세희,김희두,오승열 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.1

The objective of this study is to prepare ketoprofen (KP) - poly(ethylene glycol) (PEG) conjugates and to investigate their degradation kinetics. KP-PEG conjugates were synthesized from KP and PEG methylester by esterification in the presence of DCC. The KP-PEG conjugates (KPEG) were characterized by IR and ^1H-NMR spectroscopy. The hydrolysis of KPEG with time was studied using HPLC by simultaneous quantification of KP and KPEG. The hydrolysis rate constant was high at low and high pHs, and showed minimum at pH 4 and 5. As the size of KPEG increase, hydrolysis rate increased. The slope of degradation rate profile suggests that catalytic reaction seems to occur by specific acid/base catalysis. These results suggest that KPEG could be used as a prodrug for KP, which releases KP slowly in the body.

밭토양에 처리된 규산질 비료의 유효화와 토양반응 교정효과

조현종,최희열,이용우,이윤정,정종배 한국환경농학회 2004 한국환경농학회지 Vol.23 No.2

이화학적 특성이 다른 4가지의 밭토양에 대한 규산질 비료를 처리하여 토양의 유효규산 함량과 pH 변화에 미치는 효과를 조사하였다. 토양의 이화학적 특성과 기존 유효규산 함량에 상관없이 토양 유효규산 함량은 규산질 비료 시용량에 비례하여 증가 하였다. 규산질 비료의 유효화 정도는 토양마다 차이가 있었으며 최저 9.1%에서 최고 19.2% 정도의 비율을 나타냈다. 규산질 비료 100 kg/10a 수준의 처리는 용탈 등으로 제거되지 않는 한 10 cm 깊이 표토에 평균적으로 100 mg/kg 정도 의 유효규산을 공급할 수 있는 것으로 나타났다. 퇴비 혼합처리는 토양 유효규산 함량 증가에 큰 영향을 미치지 못했으며, 석회 처리는 유효규산 함량을 다소 증가시켰다. 토양 pH 변화는 모든 토양에서 규산질 비료 시비량에 비례하여 증가하였으며, 규산질 비교 100 kg/10a 처리로 토양 pH를 0.1~0.2 단위 증가시킬 수 있는 것으로 나타났다. 따라서 산성 토양의 경우에는 규산질 비료의 시용과는 별도로 pH 교정을 위해 석회비료를 시용해야 할 것이다. Although silicon (Si) has been known to be an essential element for rice growth, the optimum soil level of Si for upland crops remains unestablished. This study was conducted to estimate the availability of Si fertilizer in upland soils, and also effect of the Si fertilizer on soil pH was examined. Different application rates of Si fertilizer were tested using four soils of different available Si levels and pHs in a series of laboratory incubation study. The treatments included Si fertilizer levels of 100, 200, and 300 kg/10a. Also to examine the effects of compost and lime on the availability of Si fertilizer in upland soil, treatment of silicate fertilizer 200 kg/10a + compost 1,000 kg/10a and lime alone treatment were included. Changes of Si availability in the soils during the incubation period were measured by 1 N NaOAc extraction procedure. Availability of Si fertilizer was different among the tested soils, and about 9.1~19.2% of the applied Si fertilizer was extracted after 60 days laboratory incubation. Application rate could not influence the availability of Si fertilizer. Application of compost with Si fertilizer could not increase Si availability in upland soils, but lime treatment could increase Si availability. Soil pH increased by application of Si fertilizer, but the effect of Si fertilizer on soil pH was minimal. When Si fertilizer is applied on the purpose of Si nutrition in acid upland soils, lime treatment should be coupled with the Si fertilizer for remediation of soil acidity.

새로운 Celecoxib 전구체 약물의 가수분해와 체내동태 연구

민혜란,김희두,오승열 숙명여자대학교 약학연구소 2006 약학논문집-숙명여자대학교 Vol.23 No.-

난용성 약물인 세례콕시보의 용해도를 개선하고 서방성을 중진하기 위해 세레콕시브의 benzenesulfonamide ring을 수식한 전구체 약물(PCX)을 합성하여 그 가능성을 알아보고자 하였다. 우선 이들의 용해도를 알아보기 위하여 PEG 400을 보조 용매로 하여,생리 식염수와 인공 위액,인공장액에서의 용해도를 확인하였다. 또 한 쥐의 혈장,간 그리고 장에서의 in vitro 가수분해 실험을 통하여 각 약물이 모약물인 세레콕시보로 분해되는 것을 확인할 수 있었다. 용해도와 가수분해 결과를 바탕으로 하여 세례콕시브와 PCX의 약동학 실험을 실시하였다. 세례콕시브와 PCX(세레콕시브로서 50 ㎎/㎏ 용량)를 쥐의 경구와 정맥으로 투여하여 혈중 농도변화를 알아보았다. 경구투여 결과, PCX은 세례콕시브보다 혈중 농도는 낮으나 소실속도가 현저히 저하되었다. 세례콕시브의 경우, C_(max)는 1.89 ± 0.79 ㎍/㎖였으며,이에 비하여 PCX은 0.41 ± 0.14 ㎍/㎖을 나타내었다. k_(el)의 경우, PCX은 0.05 ± 0.01 hr^(-1)로 세례콕시브 (0.15 ± 0.06 hr^(-1))보다 약물소실속도가 저하되었다. 이상의 실험결과는 향후 세레콕시브 전구체 약물의 체내동태 연구와 개발에 도움이 될 것으로 기대된다.

곰팡이 독소인 Fumonisin B₁의 Polyclonal Antibody 제조

김동수,이은열,김희숙 경성대학교 2001 論文集 Vol.22 No.1

Specific antibodies were produced to develope the enzyme-linked immunosorbent assay for analysis of fumonisin Bl, a toxin which Fusaium sp. produced in com, soghum, and rice. Fumionisin Bl-keyhole impact hemocyanin conjugate were immunized to produce polyclonal antibodies. By using indirect competitive ELISA, the reactivity of the antibodies against fumonisin Bl were investigated and the problems on developing the ELISA were detected. And, contamination level of fumonisin Bl in imported corns and animal feeds was also investigated.