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- 저자 : Y. M. Choi (검색결과 6,167 건)
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Kim, M.C.,Lee, J.S.,Kwon, Y.M.,O, E.,Lee, Y.J.,Choi, J.G.,Wang, B.Z.,Compans, R.W.,Kang, S.M. Elsevier/North-Holland 2013 Antiviral research Vol.99 No.3
The influenza M2 ectodomain (M2e) is poorly immunogenic and has some amino acid changes among isolates from different host species. We expressed a tandem repeat construct of heterologous M2e sequences (M2e5x) derived from human, swine, and avian origin influenza A viruses on virus-like particles (M2e5x VLPs) in a membrane-anchored form. Immunization of mice with M2e5x VLPs induced protective antibodies cross-reactive to antigenically different influenza A viruses and conferred cross protection. Anti-M2e antibodies induced by heterologous M2e5x VLPs showed a wider range of cross reactivity to influenza A viruses at higher levels than those by live virus infection, homologous M2e VLPs, or M2e monoclonal antibody 14C2. Fc receptors were found to be important for mediating protection by immune sera from M2e5x VLP vaccination. The present study provides evidence that heterologous recombinant M2e5x VLPs can be more effective in inducing protective M2e immunity than natural virus infection and further supports an approach for developing an effective universal influenza vaccine.
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Kong, T. Y.,Kim, J. H.,Choi, W. G.,Lee, J. Y.,Kim, H. S.,Kim, J. Y.,In, M. K.,Lee, H. S. Springer Science + Business Media 2017 Analytical and bioanalytical chemistry Vol.409 No.6
<P>MAM-2201 is a synthetic cannabinoid that is increasingly found in recreational drug abusers and cases of severe intoxication. Thus, characterization of the metabolic pathways of MAM-2201 is necessary to predict individual pharmacokinetics and toxicity differences, and to avoid toxic drug-drug interactions. Collectively, 19 phase 1 metabolites of MAM-2201 were identified using liquid chromatography-Orbitrap mass spectrometry following human liver microsomal incubations in the presence of NADPH: 7 hydroxy-MAM-2201 (M1-M7), 4 dihydroxy-MAM-2201 (M8-M11), dihydrodiol-MAM-2201 (M12), N-(5-hydroxypentyl)-MAM-2201 (M13), hydroxy-M13 (M14), N-dealkyl-MAM-2201 (M15), 2 hydroxy-M15 (M16, M17), MAM-2201 N-pentanoic acid (M18), and hydroxy-M18 (M19). On the basis of intrinsic clearance values in human liver microsomes, hydroxy-MAM-2201 (M1), N-(5-hydroxypentyl)-MAM-2201 (M13), and hydroxy-M13 (M14) were the major metabolites. Based on an enzyme kinetics study using human cDNA-expressed cytochrome P450 (CYP) enzymes and an immunoinhibition study using selective CYP antibodies in human liver microsomes, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 enzymes were responsible for MAM-2201 metabolism. The CYP3A4 enzyme played a prominent role in MAM-2201 metabolism, and CYP1A2, CYP2B6, CYP2C8, and CYP2C9 enzymes played major roles in the formation of some metabolites. MAM-2201 is extensively metabolized by multiple CYP enzymes, indicating that MAM-2201 and its metabolites should be used as markers of MAM-2201 abuse and toxicity.</P>
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Choi, Y. -S.,Ho, C. -H.,Ahn, M. -H.,Kim, Y. -M. TaylorFrancis 2007 International journal of remote sensing Vol.28 No.21
<P> The present study documents optimal methods for the retrieval of cloud properties using five channels (0.6, 3.7, 6.7, 10.8 and 12.0 µm) that are used in many geostationary meteorological satellite observations. Those channels are also to be adopted for the Communication, Ocean and Meteorological Satellite (COMS) scheduled to be launched in 2008. The cloud properties focused on are cloud thermodynamic phase, cloud optical thickness, effective particle radius and cloud-top properties with specific uncertainties. Discrete ordinate radiative transfer models are simulated to build up the retrieval algorithm. The cloud observations derived from the Moderate-resolution Imaging Spectroradiometer (MODIS) are compared with the results to assess the validity of the algorithm. The preliminary validation indicates that the additional use of a band at 6.7 µm would be better in discriminating the cloud ice phase. Cloud optical thickness and effective particle radius can also be produced up to, respectively, 64 and 32 µm by functionally eliminating both ground-reflected and cloud- and ground-thermal radiation components at 0.6 and 3.7 µm. Cloud-top temperature (pressure) in ±3 K (±50 hPa) uncertainties can be estimated by a simple 10.8-µm method for opaque clouds, and by an infrared ratioing method using 6.7 and 10.8 µm for semitransparent clouds.</P>
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Amplification of Porcine SRY Gene for Sex Determination
Choi, S.G.,Bae, M.S.,Lee, E.S.,Kim, S.O.,Kim, B.K.,Yang, J.H.,Jeon, C.E.,Kim, H.H.,Hwang, Y.J.,Lee, E.S.,Kim, D.Y. Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.8
The separation of X and Y chromosome-bearing sperm is of use in many aspects of livestock maintenance. In this study, we sought to determine the difference in DNA content between X- and Y-bearing sperm, separate sperm into X- and Y-enriched pools, and assess the efficacy of sorting. Sperm collected from Duroc and miniature pigs were stained with 20.8 $\mu{M}$ Hoechst 33342 and analyzed using a high-speed cell sorter. Measurement of the fluorescence intensity of stained sperm nuclei revealed that the X-bearing sperm of Duroc and miniature pigs respectively contain 2.75% and 2.88% more DNA than Y-bearing sperm. In total, 50.18% of the sperm were assigned to the X-sorted sample and 49.82% was assigned to the Y-sorted sample for Duroc pigs. For miniature pigs, the Xsorted sample represented 50.19% of the population and the Y-sorted represented 49.81% of the population. Duplex PCR was used to evaluate accuracy of sorting. A fast and reliable method for porcine sexing was developed through amplification of the sex-determining region of the Y chromosome gene (SRY). Oligonucleotide primers were designed to amplify the conserved porcine SRY high motility group (HMG) box sequence motif. We found that the primer pair designed in this study was 1.46 times more specific than previously reported primers. Thus, this study shows that the present method can be applied in porcine breeding programs to facilitate manipulation of the sex ratio of offspring and to achieve precise sexing of porcine offspring by amplification of the HMG box of the SRY gene.
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Kim, M.C.,Lee, J.W.,Choi, H.J.,Lee, Y.N.,Hwang, H.S.,Lee, J.,Kim, C.,Lee, J.S.,Montemagno, C.,Prausnitz, M.R.,Kang, S.M. Elsevier Science Publishers 2015 Journal of controlled release Vol.210 No.-
A broadly cross-protective influenza vaccine that can be administrated by a painless self-immunization method would be a value as a potential universal mass vaccination strategy. This study developed a minimally-invasive microneedle (MN) patch for skin vaccination with virus-like particles containing influenza virus heterologous M2 extracellular (M2e) domains (M2e5x VLPs) as a universal vaccine candidate without adjuvants. The stability of M2e5x VLP-coated microneedles was maintained for 8weeks at room temperature without losing M2e antigenicity and immunogenicity. MN skin immunization induced strong humoral and mucosal M2e antibody responses and conferred cross-protection against heterosubtypic H1N1, H3N2, and H5N1 influenza virus challenges. In addition, M2e5x VLP MN skin vaccination induced T-helper type 1 responses such as IgG2a isotype antibodies and IFN-γ producing cells at higher levels than those by conventional intramuscular injection. These potential immunological and logistic advantages for skin delivery of M2e5x VLP MN vaccines could offer a promising approach to develop an easy-to-administer universal influenza vaccine.
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Yu, Y.,Jung, H.J.,Je, M.,Choi, H.C.,Choi, M.Y. Pergamon Press 2016 CHEMOSPHERE - Vol.155 No.-
In this work, the zero valent Fe (ZVI) and graphite-encapsulated Fe (FeΓ) nanoparticles (NPs) were easily and selectively prepared by a pulsed laser ablation (PLA) method in an aqueous sodium borohydride solution and ascorbic acid dissolved in methanol, respectively. Here, the FeΓ NPs were uniquely synthesized by PLA in methanol, where the solvent is used as both a carbon source for the graphitic layers and solvent, which is very unique. Furthermore, Pd NPs were loaded onto the surface of the FeΓ NPs to prepare bimetallic (FeΓ/Pd) NPs for the enhancement of the degradation efficiency of m-dichlorobenzene (m-DCB). The morphology, crystallinity, and surface composition of the prepared NPs were carefully characterized by high-resolution transmission electron microscopy (HRTEM), energy dispersive x-ray spectrometer (EDS), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The degradation rate of m-DCB using single (Fe and Pd) or bimetallic (Fe/Pd and FeΓ/Pd) NPs were compared by using gas chromatography. Among these NPs produced in this work, the FeΓ/Pd NPs with 1.71 wt % of Pd showed an excellent dechlorination efficiency for m-DCB with 100% degradation within 75 min. The graphitic layer on the Fe NPs played as not only an oxidation resistant for the Fe NPs to surroundings, but also a supporter of the Pd NPs for the enhanced degradation efficiency of m-DCB.
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신인구,Y.-H. Ryu,A. Udalski,M. Albrow,S.-M. Cha,J.-Y. Choi,S.-J. Chung,C. Han,K.-H. Hwang,Y. K. Jung,D.-J. Kim,S.-L. Kim,C.-U. Lee,Y. Lee,B.-G. Park,H. Park,R. W. Pogge,J. C. Yee,P. Pietrukowicz,P. Mroz 한국천문학회 2016 Journal of The Korean Astronomical Society Vol.49 No.3
We report the characterization of a massive $(m_p=3.9\pm 1.4 M_{\rm jup})$ microlensing planet (OGLE-2015-BLG-0954Lb) orbiting an M dwarf host ($M=0.33\,\pm 0.12 M_\odot$) at a distance toward the Galactic bulge of $0.6^{+0.4}_{-0.2}\,$kpc, which is extremely nearby by microlensing standards. The planet-host projected separation is $a_\perp \sim 1.2\,\au$. The characterization was made possible by the wide-field ($4\,\rm deg^2$) high cadence ($\Gamma = 6\,\rm hr^{-1}$) monitoring of the Korea Microlensing Telescope Network (KMTNet), which had two of its three telescopes in commissioning operations at the time of the planetary anomaly. The source crossing time $t_*=16\,$min is among the shortest ever published. The high-cadence, wide-field observations that are the hallmark of KMTNet are the only way to routinely capture such short crossings. High-cadence resolution of short caustic crossings will preferentially lead to mass and distance measurements for the lens. This is because the short crossing time typically implies a nearby lens, which enables the measurement of additional effects (bright lens and/or microlens parallax). When combined with the measured crossing time, these effects can yield planet/host masses and distance.
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Yoon, M.Y.,Kim, Y.S.,Ryu, S.Y.,Choi, G.J.,Choi, Y.H.,Jang, K.S.,Cha, B.,Han, S.S.,Kim, J.C. Academic Press 2011 Pesticide biochemistry and physiology Vol.101 No.2
Blast is considered the most important fungal disease of rice due to its wide distribution and destructiveness under favorable conditions. Development of new effective and environmentally benign agents against the causal pathogen, Magnaporthe oryzae, is of great interest. In the course of a search for natural antifungal compounds in medicinal plants, we found that the methanol extract of Angelica gigas roots showed a potent control efficacy against rice blast caused by M. oryzae. We isolated antifungal coumarins from the extract, and they were identified as decursin and decursinol angelate. Antifungal activities of these compounds, along with kasugamycin, were tested on M. oryzae in vivo and in vitro. In an in vivo assay, the three compounds effectively suppressed the development of rice blast at concentrations more than 100μg/mL. Coumarins showed relatively weak inhibitory effect on fungal mycelial growth when compared to kasugamycin. However, they strongly inhibited M. oryzae spore germination, which was not observed in kasugamycin treatments. This is the first report demonstrating that decursinol angelate can provide control against rice blast and that the two coumarins inhibit M. oryzae spore germination. In addition, the wettable powder formulation of the crude extract of A. gigas prohibited the development of blast symptoms on rice plants more effectively than liquid concentrate formulation of kasugamin, a commercial fungicide. Based on our study, we propose that coumarin compounds as well as the A. gigas root crude extract can be used as natural, benign fungicides for controlling rice blast.
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Lee, Y. S.,Kim, S. J.,Kim, B. G.,Lee, S.,Seo, W. S.,Kim, I. H.,Choi, S. M. Springer Science + Business Media 2017 Journal of electronic materials Vol.46 No.5
<P>Metallic glass (MG) can be a candidate for an alternative brazing material of high-temperature thermoelectric modules, since we can expect both a lower brazing temperature and a high operating temperature for the junction from the MG brazers. Another advantage of MG powders is their outstanding oxidation resistance, namely, high-temperature durability in atmosphere. We fabricated three compositions of Al-based MGs-Al-Y-Ni, Al-Y-Ni-Co, and Al-Y-Ni-Co-La-by using the melt spinning process, and their T (g)s were 273A degrees C, 264A degrees C, and 249A degrees C, respectively. The electrical resistivity of the Al-Y-Ni MG ribbon dropped significantly after annealing at 300A degrees C. The electrical resistivity of crystallized Al-Y-Ni reduced down to 0.03 m Omega cm, which is an order of magnitude lower than that of the amorphous one. After the MG ribbons were pulverized to sub-100 mu m, the average particle size was about 400 mu m.</P>
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JEON, B.Y.,LEE, H‐,Y.,PARK, E‐,C.,CHOI, K.S.,JUN, J.K.,KIM, Y.,HAN, M.A.,YOON, N‐,H.,KIM, E.J.,JEON, S.M. Blackwell Publishing Ltd 2011 European journal of cancer care Vol.20 No.6
<P>JEON B.Y., LEE H‐Y., PARK E‐C., CHOI K.S., JUN J.K., KIM Y., HAN M.A., YOON N‐H., KIM E.J. & JEON S.M. (2011) <I>European Journal of Cancer Care</I><B>20</B>, 803–809</P><P><B>Satisfaction with mammography in the National Cancer Screening Programme participants of age 40s in Korea</B></P><P>The aim of this study was to evaluate satisfaction with the National Cancer Screening Programme of mammography in Korea and to examine the association between subscales of satisfaction and general satisfaction. We conducted a cross‐sectional telephone survey for women who had obtained a National Cancer Screening Programme mammographic screening at general hospitals between May and October 2008. The present study included 2005 women in their forties. We performed multivariate linear regression using dependent variable as general satisfaction and independent variables as subscales of satisfaction, such as pre‐screening information transfer, staff interpersonal skills, physical surroundings and results reporting. Participants were stratified according to the result of their mammogram as negative or positive. Mean score of satisfaction was above 2.5 of 4 for all subscales. Women who received positive results were less satisfied with all of subscale factors. Staff interpersonal skills were the most important factor that contributed to general satisfaction. Future efforts such as staff training programme of communication/attitude skills, ensuring privacy and explanation of possible discomfort of the screening would be needed.</P>
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