Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer

Shin, S.J.,Kim, N.K.,Keum, K.C.,Kim, H.G.,Im, J.S.,Choi, H.J.,Baik, S.H.,Choen, J.H.,Jeung, H.C.,Rha, S.Y.,Roh, J.K.,Chung, H.C.,Ahn, J.B. Elsevier Science Publishers 2010 Radiotherapy and oncology Vol.95 No.3

Background and purpose: The aim of this study is to evaluate the efficacy and safety of preoperative radiation therapy combined with S-1 and irinotecan (SI) in LARC. Materials and methods: Patients were considered LARC if they had a T3/T4 lesion or node positive. Weekly doses of 40mg/m<SUP>2</SUP> irinotecan were intravenously administered once per week during weeks 1-5 of radiotherapy. S-1 (70mg/m<SUP>2</SUP>) was given from Monday to Friday in all weeks of radiotherapy. 3-D conformal radiotherapy was given at daily fractions of 1.8Gy for 5days for a total dose of 50.4 (45+5.4)Gy. Surgery was performed 4-6weeks following the completion of chemoradiation. Results: Between June 2006 and November 2007, 43 pts were enrolled. The stage was: cT3 24 patients, cT4 6 patients; 28 patients were cN+. Forty-one patients completed the chemoradiation and 42 patients underwent operation: a low anterior resection was performed in 36 patients, a total colectomy in 1 patient, and an abdominal perineal resection in 5 patients. T downstaging was observed in 50%; 23 N+ patients became N- (55%). The complete pathological response was observed in 9 patients (21%). The 3-year locoregional failure rate, distant failure rate, disease-free survival, and overall survival were 9.5%, 18.6%, 72.1%, and 94.3%, respectively. Only three patients experienced G3 diarrhea; one had G3 sepsis and two had septic shock. Hematological toxicity (G3-G4) was observed in five patients. Conclusions: This study demonstrated the efficacy of preoperative CRT with S-1 and irinotecan with 21% of complete response. However, prompt recognition and management of infection is needed to use it in patients with locally advanced rectal cancer.

Site-specific mutagenesis of yeast 2-Cys peroxiredoxin improves heat or oxidative stress tolerance by enhancing its chaperone or peroxidase function

Hong, S. H.,Lee, S. S.,Chung, J. M.,Jung, H. s.,Singh, S.,Mondal, S.,Jang, H. H.,Cho, J. Y.,Bae, H. J.,Chung, B. Y. Springer Science + Business Media 2017 Protoplasma Vol.254 No.1

<P>Yeast peroxiredoxin II (yPrxII) is an antioxidant enzyme that plays a protective role against the damage caused by reactive oxygen species (ROS) in Saccharomyces cerevisiae. This enzyme consists of 196 amino acids containing 2-Cys Prx with highly conserved two active cysteine residues at positions 48 and 171. The yPrxII has dual enzymatic functions as a peroxidase and molecular chaperone. To understand the effect of additional cysteine residues on dual functions of yPrxII, S79C-yPrxII and S109C-yPrxII, the substitution of Ser with Cys residue at 79 and 109 positions, respectively, was generated. S109C-yPrxII and S79C-yPrxII showed 3.7- and 2.7-fold higher chaperone and peroxidase activity, respectively, than the wild type (WT). The improvement in enzyme activity was found to be closely associated with structural changes in proteins. S109C-yPrxII had increased beta-sheet in its secondary structure and formed high-molecular-weight (HMW) as well as low-molecular-weight (LMW) complexes, but S79C-yPrxII formed only LMW complexes. HMW complexes predominantly exhibited a chaperone function, and LMW complexes showed a peroxidase function. In addition, transgenic yeast cells over-expressing Cys-substituted yPrxII showed greater tolerance against heat and oxidative stress compared to WT-yPrxII.</P>

한국잔디 수집계통들 중에서 우수계통들의 생육특성 비교

임용우(Y. W. Rim),김기용(K. Y. Kim),김맹중(M. J. Kim),성병렬(B. R. Sung),임영철(Y. C. Lim),정의수(E. S. Chung),신홍균(H. K. Shin),김용선(Y. S. Kim) 한국잡초학회·한국잔디학회 2003 Weed & Turfgrass Science Vol.17 No.2,3

2001년 수집된 한국잔디 133계통들 중에서 우수한 계통들을 선발하기위하여 밀도(품질),<br/> 피복성, 녹색기간, 내병성, 출수유무(종자수) 등의 주요특성과 그 외 생육특성들이 조사되었다. 생육특성이 우수한 6계통이 선발되었으며 그 결과를 요약하면 다음과 같다.<br/> 수집된 133계통들 중에서 가장 녹색기간이긴 계통은 J01067으로 11월초까지 녹색도를 유지하였다. J01106 및 J01129 계통들은 엽폭이 각각 1.5mm 및 2mm 정도로 매우 좁으며, 밀도가 높고, 피복성도 좋은 것으로 나타났으며, 내병성도 강하였다. J01122 계통은 들잔디 계통들 중에서 유일하게 내병성이 강한 계통으로 선발되었다. J01128 계통은 엽폭이 3.2mm로 중엽에 속하였으며, 대비품종인 Sunburst 와 비슷하였다. 이 계통의 경우도J01106, J01129 계통들과 마찬가지로 밀도가 높고 내병성이 강한 것으로 나타났다.<br/> 수집된 133계통들의 형태적 분류를 위하여 5가지의 생육특성을 사용하여 크게 세가지 군집<br/> 으로 분류하였으며, 그 중에서 대비품종으로 사용된 6품종들과 선발된 우수 6계통의 분류는<br/> 다음과 같다. 제 1군집에 속하는 품종 및 계통은 Belare, Meyer, 안양중지(Anyang-jungji), J01067, J01112 등이 포함되었으며, 제 2군집으로는 S-94, J01105가 포함되었고, 제 3군집에는 Sunburst, 건희(Konhee), J01106, J01128, J01129 등이 포함되었다. Growth characteristics such as density(quality), covering speed, green period, disease resistance, heading existence(number of seeds) and other characteristics were examined for selection of superior lines among the 133 zoysiagrass lines collected in 2001. Six superior lines were selected and the results were summarized as follows.<br/> Superior line, J01067 was longest for green period among the 133 zoysiagrasses and stayed green until the beginning of November. Leaf width of J01106 and J01129 lines was very narrow as 1.5㎜ and 2㎜, respectively and superior for density(quality), covering speed and disease resistance. J01122 line was selected for strongest disease resistance among the lines of Zoysia japonica. Leaf width of J01128 was 3.2㎜ showing midium type and similar to standard cultivar, Sunburst. This line also showed higher density and strong disease resistance like J01106 and J01129.<br/> Five growth characteristics for morphological classification of 133 zoysiagrass lines<br/> was used and divided into 3 cluster groups. Of 133 lines, 6 standard cultivars and 6 superior lines were classified as follows. First cluster group contained Belare, Meyer, Anyang-jungji, J01067, J01122, and second group contained S-94 and J01105, and third group contained Sunburst, Konhee, J01106, J01128 and J01129.<br/> <br/>

세관 양광주 방전에서 플라즈마 확산의 완전 해

김동준,정종문,김정현,황하청,정재윤,조윤희,임현교,구제환,최은하,조광섭,Jin, D.J.,Jeong, J.M.,Kim, J.H.,Hwang, H.C.,Chung, J.Y.,Cho, Y.H.,Lim, H.K.,Koo, J.H.,Choi, E.H.,Cho, G.S. 한국진공학회 2010 Applied Science and Convergence Technology Vol.19 No.1

관경이 수 mm인 세관 램프 내부에서 플라즈마의 확산을 조사하기 위하여 이극성(ambipolar) 확산방정식을 해하였다. 반경 방향의 확산에 의한 유리관 벽에서의 플라즈마 소멸 특성시간은 $\tau_r\;=\;(r_0/2.4)^2/D_a$로 주어진다. 반경 $r_0{\sim}1\;mm$이고 이극성 확산계수 $D_a{\sim}0.01\;m^2/s$ 이면, $\tau_r{\sim}17\;{\mu}s$이다. 이는 램프의 교류전원 구동에서 플라즈마를 유지하기 위한 구동 최소 주파수 ~30 kHz에 해당한다. 고전압이 인가되는 전극부에 발생한 고밀도의 플라즈마가 양광주로 확산되는 특성시간은 $\tau_z{\sim}0.1\;s$이다. 고밀도 플라즈마 경계에서의 시간에 대한 확산속도는 $t{\sim}10^{-6}\;s$일 때 $u_D{\sim}10^2\;m/s$이고, $t{\sim}10^{-3}\;s$이면 그 속도는 $u_D{\sim}1\;m/s$로 느려진다. 따라서 램프 길이 ~1 m에 대하여 전극부에서 생성된 고밀도 플라즈마가 양광주 전체로 확산되는 시간은 수 초가 걸린다. The ambipolar diffusion equation has been solved in a fine-tube lamp of a few mm in diameter. In the diffusion of radial direction, the plasma diffuses and vanishes away at the glass wall by recombination with the characteristic time of plasma loss is given by $\tau_r\;=\;(r_0/2.4)^2/D_a$. With the radius $r_0{\sim}1\;mm$ and the ambipolar diffusion coefficient $D_a{\sim}0.01\;m^2/s$, the vanishing time is calculated $\tau_r{\sim}10\;{\mu}s$ which corresponds to the least value of frequency 30 kHz for the sustaining the plasma in the operation of high voltage AC-power. In the diffusion of longitudinal z-direction, a high density plasma generated at the area of a high voltage electrode, diffuses into the positive column with the characteristic time $\tau_z{\sim}0.1\;s$. The plasma diffusion velocity at the boundary of high density plasma is $u_D{\sim}10^2\;m/s$ at the time $t{\sim}10^{-6}$ s and the diffusion velocity becomes slow as $u_D{\sim}1\;m/s$ at $t{\sim}10^{-3}\;s$. Therefore, for the long lamp of 1 m, it takes about several seconds for the high density plasma at the area of electrode to diffuse through the whole positive column space.

급성 D. D. S. 중독증의 임상적 고찰

정시전 ( S. J. Chung ),최등영 ( D. Y. Choi ),이천각 ( C. K. Lee ),김형순 ( H. S. Kim ),태철현 ( T. H. Jeen ) 대한내과학회 1968 대한내과학회지 Vol.11 No.4

D.D.S. is well known as the drug of choice for Leprosy. Chronic D.D.S. intoxication has been reported in the many countries. It includes hematological changes, skin manifestations, abnormal liver function test and psychosis, There are few acute intoxicatio

Sexuality and the management of BPH with alfuzosin (SAMBA) trial

Chung, B-H,Lee, J-Y,Kim, C-I,Kim, C-S,Oh, C-Y,Lee, S-W,Lee, J-S,Yoo, S-J Nature Publishing Group 2009 International journal of impotence research Vol.21 No.1

The sexuality and the management of benign prostatic hyperplasia (BPH) with alfuzosin (SAMBA) trial evaluated the effect of alfuzosin on sexual function in men treated for BPH using two sexual function scales: male sexual health questionnaire (MSHQ) and international index of erectile function (IIEF-15). A total of 148 patients with BPH were treated with alfuzosin for 24 weeks. The patients were followed at baseline, 4, 12 and 24 weeks after medication with alfuzosin. MSHQ was collected at every visit, whereas Q<SUB>max</SUB>, IPSS and IIEF-15 were checked at baseline and end point. At the end point, Q<SUB>max</SUB> (+4.7 ml s<SUP>−1</SUP>, P<0.01) and IPSS (−5.3, P<0.01) had improved significantly. Alfuzosin also significantly improved the total MSHQ (19.2%, 79.1–94.3, P<0.01) and the MSHQ ejaculatory scores (26.0%, 22.3–28.1, P=<0.01) versus baseline. Alfuzosin for the treatment of patients with BPH is effective in improving sexual function, as well as lower urinary tract symptoms (LUTSs) and quality of life, and is well tolerated.International Journal of Impotence Research (2009) 21, 68–73; doi:10.1038/ijir.2008.62; published online 11 December 2008

COMPARISON OF THE COMBUSTION CHARACTERISTICS BETWEEN S.I. ENGINE AND R.I. ENGINE

Chung, S.S.,Ha, J.Y.,Park, J.S.,Kim, K.J.,Yeom, J.K. The Korean Society of Automotive Engineers 2007 International journal of automotive technology Vol.8 No.1

This experimental study was carried out to obtain both low emissions and high thermal efficiency by rapid bulk combustion. Two kinds of experiments were conducted to obtain fundamental data on the operation of a RI engine by a radical ignition method. First, the basic experiments were conducted to confirm rapid bulk combustion by using a radical ignition method in a constant volume chamber (CVC). In this experiment, the combustion velocity was much higher than that of a conventional method. Next, to investigate the desirable condition of engine operation using radical ignition, an applied experiment was conducted in an actual engine based on the basic experiment results obtained from CVC condition. A sub-chamber-type diesel engine was reconstructed using a SPI type engine with controlled injection duration and spark timing, and finally, converted to a RI engine. In this study, the operation characteristics of the RI engine were examined according to the sub-chamber's specifications such as the sub-chamber volume and the diameter and number of passage holes. These experimental results showed that the RI engine operated successfully and was affected by the ratio of the passage hole area to the sub-chamber volume.

[S9-1] Anti-diabetic Effects of Two Variants of Korean Arlemisia princeps Pampanini Cultivated in Ganghwa Island

U.J. Jung,N-I. Bae,H-G. Chung,M-H. Bang,J-S. Yoo,T-S. Jeong,K-T. Lee,Y-J. Kang,M-K. Lee,S-N. Ryu,M-S. Choi 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10

Geological and Geotechnical Characteristics of Marine Clay in Busan New Port

Chung, S.G,E. Ninjgarav,M. Suneel,K.Ganapathi Rao,Kim, G.J. 東亞大學校 建設技術硏究所 2005 硏究論文集 Vol.28 No.2

Since early 1990s reclamation projects for Busan and its vicinity in Nakdong River plain have been performed for industrial and residential complexes. As well it has started to build a new port (Busan Newport) with increase in overloads of Busan port since late 1990s. In the area the sedimentary deposit is composed of soft clay of about 30m thick, thin sand layer of 3-4m thick, hard clayey soil, and then basal conglomerates and sandy sediments, total thickness of which is about 70m at maximum under seawater. For the huge project many contract companies have simultaneously performed geotechnical investigations to get design parameters. Based on the harmful experiences gained by the previous projects, it was also required to pay careful attention to sampling and laboratory and field tests for theproject. Nevertheless the results of laboratory tests were so scattered and then resulted in difficulty to evaluate the design parameters. Existing data has been reviewed to evaluate the validity or cause of their variation. In addition geological study, sampling and soil tests have been carefully carried out at a few locations. Using the results the clay would be effectively characterized for depositional environment and its relation to soil properties.

COMPARISON OF THE COMBUSTION CHARACTERISTICS BETWEEN S.I. ENGINE AND R.I. ENGINE

S. S. CHUNG,J. Y. HA,J. S. PARK,K. J. KIM,J. K. YEOM 한국자동차공학회 2007 International journal of automotive technology Vol.8 No.1

This experimental study was carried out to obtain both low emissions and high thermal efficiency by rapid bulk combustion. Two kinds of experiments were conducted to obtain fundamental data on the operation of a RI engine by a radical ignition method. First, the basic experiments were conducted to confirm rapid bulk combustion by using a radical ignition method in a constant volume chamber (CVC). In this experiment, the combustion velocity was much higher than that of a conventional method. Next, to investigate the desirable condition of engine operation using radical ignition, an applied experiment was conducted in an actual engine based on the basic experiment results obtained from CVC condition. A sub-chamber-type diesel engine was reconstructed using a SPI type engine with controlled injection duration and spark timing, and finally, converted to a RI engine. In this study, the operation characteristics of the RI engine were examined according to the sub-chamber’s specifications such as the sub-chamber olume and the diameter and number of passage holes. These experimental results showed that the RI engine operated successfully and was affected by the ratio of the passage hole area to the sub-chamber volume.