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Park, Subin,Lee, Yeeun,Jun, Jin Yong Elsevier/North Holland Biomedical Press 2017 Psychiatry research Vol.257 No.-
<P><B>Abstract</B></P> <P>North Korean adolescent defectors experience adaptation difficulties along with a wide range of psychosocial problems, but no study has yet examined their Internet addiction symptoms. We compared early traumatic experiences, self-esteem, negative cognition, and Internet addiction symptoms, as well as the relationships between these variables, between North Korean adolescent defectors and South Korean adolescents. Fifty-six North Korean adolescent defectors and 112 age- and sex- matched South Korean adolescents participated. The analyses examined the relationship between traumatic experiences and Internet addiction symptoms, with negative automatic thoughts or low self-esteem as mediators of these relations. North Korean adolescent defectors tended to have higher levels of negative automatic thoughts and more severe Internet addiction symptoms, as well as better self-esteem, than did South Korean adolescents. Furthermore, only among North Korean adolescent defectors, traumatic experiences were positively associated with Internet addition symptoms via increasing negative automatic thoughts. North Korean adolescent defectors are more susceptible to Internet addiction, negative cognitions, and early traumatic experiences compared to South Korean adolescents. However, the cross-sectional design of this study precludes consideration of the causality of these relationships. Interventions aiming to correct negative cognitions and increase self-esteem may be helpful for North Korean adolescent defectors with problematic Internet use.</P> <P><B>Highlights</B></P> <P> <UL> <LI> North Korean adolescent defectors had higher trauma and Internet addiction (IA). </LI> <LI> North Korean defectors also had greater self-esteem and negative automatic thoughts. </LI> <LI> Self-esteem and negative thoughts were mediators in the relation of trauma and IA. </LI> <LI> Country of origin (North vs. South Korea) moderated the mediating effects. </LI> </UL> </P>
Sung, H.C.,Kim, D.W.,Park, J.B.,Joo, Y.H. North-Holland ; Elsevier Science Ltd 2010 FUZZY SETS AND SYSTEMS Vol.161 No.6
This paper presents a new intelligent digital redesign (IDR) method for uncertain nonlinear systems which are represented by a Takagi-Sugeno (T-S) fuzzy model. The term IDR involves converting an analog controller into an equivalent digital one in the sense of state-matching. The IDR problem can be reduced to finding the digital fuzzy gains minimizing the norm distance between the closed-loop states of the analog and digital control systems. The uncertainties in the plant dynamics are considered in the IDR condition that plays an important role in the performance improvement. Also, the robust stability is well guaranteed in the proposed IDR procedure. Its constructive conditions are expressed as linear matrix inequalities (LMIs). Two numerical examples, the chaotic Lorenz system and the Qi system, are demonstrated to visualize the feasibility of the proposed methodology.
Choi, H.,Park, Y.C.,Lee, Y.S.,An, H.,Baeck, K.K. North Holland ; Elsevier Science Ltd 2013 Chemical physics letters Vol.580 No.-
The extremely small (around 0.80kcal/mol) barrier for the -SH rotation of thiophenol is studied by using MP2, CASSCF(12,11), and three DFT (B3LYP, HCTH, and ωB97X-D) methods with various basis sets. The 6-311++G(3df,3pd) turns out to be the proper minimal basis-set for reliable calculations. CCSD(T) and CASPT2//CASSCF calculations confirm that the planar conformation of the -SH is the minimum-energy structure of not only the ground S<SUB>0</SUB> but also the first excited S<SUB>1</SUB> electronic states. The calculated torsional barrier of the S<SUB>1</SUB>, 1.89kcal/mol, is also quite small.
Hong, H.K.,Hoon Lee, B.,Park, M.H.,Ho Lee, S.,Chu, D.,Jin Kim, W.,Choe, H.,Hee Choi, B.,Jo, S.H. North-Holland ; Elsevier Science Ltd 2013 european journal of pharmacology Vol.702 No.1
Fluphenazine is a potent antipsychotic drug that can increase action potential duration and induce QT prolongation in several animal models and in humans. As the block of cardiac human ether-a-go-go-related gene (hERG) channels is one of the leading causes of acquired long QT syndrome, we investigated the acute effects of fluphenazine on hERG channels to determine the electrophysiological basis for its proarrhythmic potential. Fluphenazine at concentrations of 0.1-1.0μM increased the action potential duration at 90% of repolarization (APD<SUB>90</SUB>) and action potential duration at 50% of repolarization (APD<SUB>50</SUB>) in 5min when action potentials were elicited under current-clamp conditions in guinea pig ventricular myocytes. We examined the effects of fluphenazine on hERG channels expressed in Xenopus oocytes and HEK293 cells using two-microelectrode voltage-clamp and patch-clamp techniques. The IC<SUB>50</SUB> for the fluphenazine-induced block of hERG currents in HEK293 cells at 36<SUP>o</SUP>C was 0.102μM at +20mV. Fluphenazine-induced a concentration-dependent decrease of the current amplitude at the end of the voltage steps and hERG tail currents. The fluphenazine-dependent hERG block in Xenopus oocytes increased progressively relative to the degree of depolarization. Fluphenazine affected the channels in the activated and inactivated states but not in the closed states, and the S6 domain mutation from tyrosine to alanine at amino acid 652 (Y652A) attenuated the hERG current block. These results suggest that the antipsychotic drug fluphenazine is a potent blocker of hERG channels, providing a molecular mechanism for the drug-induced arrhythmogenic side effects.
Chae, J.I.,Kim, J.,Son, M.Y.,Jeon, Y.J.,Kim, D.W.,Kim, H.E.,Lee, M.J.,Ryu, J.,Park, B.C.,Lee, D.S.,Seo, K.S.,Lee, H.K.,Choi, N.J.,Kang, Y.K.,Chung, H.M. Elsevier/North-Holland Biomedical Press 2013 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.165 No.2
Background: Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) have attracted attention because of their cardiac regenerative potential in vivo. Differentiated CMs can be distinguished into two different phenotypic populations: beating and non-beating CMs. A thorough understanding of the different molecular conditions of beating and non-beating CMs would provide valuable information for other potential applications and cell therapy. Methods: In this study, we generated a comparative protein profiles using proteomic analysis and western blotting, to compare the specific protein expression patterns of beating and non-beating hESC-CMs. Results: Abundantly 72 upregulated proteins are involved in different biological processes such as stimulus response, cellular catabolism and cell motility. Among these proteins, such as HSPs and other antioxidant molecules, are known to be proteins that potentially play an important role in cardioprotection through the enhancement of cell survival in hypoxic and ischemic conditions present in the injured heart. Conclusion: As a first step toward understanding the different molecular conditions of beating and non-beating hESC-CMs, we sought to study their differential expression patterns and discuss their relevance to in vivo functioning in cardiac injury repair. Thus, the results of this study could provide further evidence supporting a cardiac regenerative approach using an optimized cell source derived from hESCs.
Kang, H.,Jung, S.,Koh, D.Y.,Ahn, Y.H.,Park, S.,Park, J.,Lee, H. North Holland ; Elsevier Science Ltd 2013 Chemical physics letters Vol.587 No.-
The physical properties of semi-clathrate hydrates formed with tetra-n-butylammonium fluoride (TBAF) and tetra-n-butylammonium bromide (TBAB) in the temperature range of 83-263K were studied using terahertz time-domain spectroscopy (THz-TDS). From our measurements, the semi-clathrate hydrate of TBAF shows the general trend of slightly higher refractive indices than the TBAB semi-clathrate hydrate. Furthermore, significant differences in the absorption coefficients and dielectric constants between the TBAF and TBAB semi-clathrate hydrates are discovered. These originate from fundamental structural/compositional differences between the hydrates which are related to their gas storage capacities.
Fluorescence vesicles by self-assembly of oligo(biphenylene vinylene) bolaamphiphiles in n-hexane
Hwang, I.W.,Kim, Y.R. North Holland ; Elsevier Science Ltd 2013 Chemical physics letters Vol.583 No.-
Self-assembly of an oligo(biphenylene vinylene); OBPV bolaamphiphile with two polar coils of significantly long poly(propylene oxide); PPO (n=21) at each end generated a fluorescent vesicle in apolar n-hexane. The vesicle efficiently produced trans-stilbene-like OBPV excimer emissions, as evidenced by an intense, redshifted, structured fluorescence spectrum with a long decay time of 5.0+/-0.1ns. An OBPV chromophore bound at both sides via a polar coil-to-coil interaction in apolar n-hexane was conducive to OBPV excimer emission, as evident from analysis of the spectroscopic data obtained from OBPVs with different PPO coil lengths (n=13, 21, 34).
Kim, S.W.,Lee, J.H.,Kim, H.J.,Cho, J.H. North Holland ; Elsevier Science Ltd 2013 Chemical physics letters Vol.557 No.-
Using van der Waals (vdW) energy-corrected density-functional theory without or with self-consistent screening (SCS) effects, we calculate the adsorption energy of acetylene, ethylene and benzene on Si(100). We find that vdW interactions without SCS effects increase the adsorption energy by 0.23, 0.30, and 0.64eV for adsorbed C<SUB>2</SUB>H<SUB>2</SUB>,C<SUB>2</SUB>H<SUB>4</SUB>, and C<SUB>6</SUB>H<SUB>6</SUB> on Si(100), respectively. However, if SCS effects are included, this increase of the adsorption energy is reduced as 0.19, 0.24, and 0.54eV for the three adsorption systems, respectively. The resulting adsorption energy for each system is between the values computed using the local-density approximation and the generalized-gradient approximation.
Vibronic spectroscopy of dichlorobenzyl radicals: Jet-cooled 3,4-dichlorobenzyl radical
Yoon, Y.W.,Lee, S.K. North Holland ; Elsevier Science Ltd 2013 Chemical physics letters Vol.570 No.-
By means of a technique of corona excited supersonic expansion coupled with a pinhole-type glass nozzle, vibronically excited but jet-cooled 3,4-dichlorobenzyl radical was formed from precursor 3,4-dichlorotoluene in corona discharge. From an analysis of the visible vibronic emission spectrum observed, we determined the electronic energy of the D<SUB>1</SUB>→D<SUB>0</SUB> transition and vibrational mode frequencies in the D<SUB>0</SUB> state of the 3,4-dichlorobenzyl radical by comparing with the known vibrational data of precursor and an ab initio calculation. Also, the substituent effect on the electronic transition energy was explained using Huckel's molecular orbital theory for the first time.
Al-Mamun, M.,Kim, J.Y.,Sung, Y.E.,Lee, J.J.,Kim, S.R. North Holland ; Elsevier Science Ltd 2013 Chemical physics letters Vol.561 No.-
Here we report a novel transparent conductive oxide (TCO) and Pt free silver nanowire and graphene nanoplatelet (AgNW-GNP) based hybrid counter electrode (CE) for dye-sensitized solar cells (DSSCs) having appreciable photovoltaic performances compared to reference Pt-FTO based DSSCs. Simple solution processed bilayer AgNW-GNP hybrid CEs were prepared to investigate its applicability in DSSCs based on their electrocatalytic and charge transport properties. DSSCs prepared with AgNW-GNP hybrid CEs containing the GNP loading of 0.88μg/cm<SUP>2</SUP> showed the photoconversion efficiency of 1.61+/-0.13% which is comparable with that of 1.87+/-0.15% made of standard Pt-FTO CEs.