초기성인의 생활습관과 당뇨에 대한 지식

소선이,마지은,고지윤,김은혜,박현화,서유진,서형은,유은미,이하늬,이혜인,정지연,현혜리,이자형,정덕유,강지숙 이화여자대학교 간호과학대학 2009 이화간호학회지 Vol.- No.43

Purposes :The purposes of this study was to investigate the self-managing status according to the life styles and the diabetic knowledge of early adulthood. The subjects in this study were 240people, the early adult aged twenties to thirties living in the metropolitan area. Data were collected by using self-administered questionnaires that measure about the knowledge of diabetes; the dietetic behavior; the knowledge of diet; the exercise behavior; the knowledge of exercise. Descriptive statistics, t-test, ANOVA, and correlation were used for data analysis. Result :1. At the knowledge of diabetes degree based on the general character, the subjects who had experiences of diabetic education have higher degree of the diabetic knowledge. 2. At the knowledge of diabetes degree according to the life style, the subjects who have regular diet are appeared highly. Also the subjects who don't take much food of animal origin have higher degree. 3. At the knowledge of diet based on the life style, the subjects who don't keep three times meals a day are appeared highly. Also the subjects who have regular diet have higher degree. 4. At the knowledge of exercise according to the life style, the subjects who take extra nutritions 3-4 times a week are appeared highly. Although the subjects tend to know about dietary, exercise and health management, it showed that they actually don't perform what they know in their everyday of life. The reason for this could be the lack of perceived seriousness about diabetes mellitus. Thus as nursing professionals, we should provide them proper health education and support. Moreover, advanced research on the empowerment is warranted.

Photo-protection by 3-bromo-4, 5-dihydroxybenzaldehyde against ultraviolet B-induced oxidative stress in human keratinocytes

Hyun, Y.J.,Piao, M.J.,Zhang, R.,Choi, Y.H.,Chae, S.,Hyun, J.W. Academic Press 2012 Ecotoxicology and environmental safety Vol.83 No.-

Exposure of the skin to ultraviolet B (UVB) radiation leads to epidermal damage and the generation of reactive oxygen species (ROS) in skin cells, including keratinocytes. Therefore, the photo-protective effect of 3-bromo-4, 5-dihydroxybenzaldehyde (BDB) against UVB was assessed in human HaCaT keratinocytes exposed to UVB radiation in vitro. BDB restored cell viability, which decreased upon exposure to UVB radiation. BDB exhibited scavenging activity against 1, 1-diphenyl-2-picrylhydrazyl radicals, intracellular ROS induced by hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) or UVB radiation, the superoxide anion generated by the xanthine/xanthine oxidase system, and the hydroxyl radical generated by the Fenton reaction (FeSO<SUB>4</SUB>+H<SUB>2</SUB>O<SUB>2</SUB>). Moreover, BDB absorbed UVB and decreased injury resulting from UVB-induced oxidative stress to lipids, proteins and DNA. Finally, BDB reduced UVB-induced apoptosis, as exemplified by fewer apoptotic bodies and a reduction in DNA fragmentation. Taken together, these results suggest that BDB protects human keratinocytes against UVB-induced oxidative stress by scavenging ROS and absorbing UVB rays, thereby reducing injury to cellular components.

700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery

Hyun, H.,Henary, M.,Gao, T.,Narayana, L.,Owens, E. A.,Lee, J. H.,Park, G.,Wada, H.,Ashitate, Y.,Frangioni, J. V. Elsevier Science B.V., Amsterdam. 2016 Molecular imaging and biology Vol.18 No.1

<P>Purpose: The purpose of this study was to develop a family of 700-nm zwitterionic pentamethine indocyanine near-infrared fluorophores that would permit dual-channel image-guided surgery. Procedures: Three complementary synthetic schemes were used to produce novel zwitterionic chemical structures. Physicochemical, optical, biodistribution, and clearance properties were compared to Cy5.5, a conventional pentamethine indocyanine now used for biomedical imaging. Results: ZW700-1a, ZW700-1b, and ZW700-1c were synthesized, purified, and analyzed extensively in vitro and in vivo. All molecules had extinction coefficients >= 199,000 M-1 cm(-1), emission >= 660 nm, and stability >= 99 % after 24 h in warm serum. In mice, rats, and pigs, >= 80 % of the injected dose was completely eliminated from the body via renal clearance within 4 h. Either alone or conjugated to a tumor targeting ligand, ZW700-1a permitted dual-channel, high SBR, and simultaneous imaging with 800-nm NIR fluorophores using the FLARE (R) imaging system. Conclusions: Novel 700-nm zwitterionic NIR fluorophores enable dual-NIR image-guided surgery.</P>

Guest-driven structural flexibility of 2D coordination polymers: Synthesis, structural characterizations, and gas sorption properties

Hyun, S.m.,Kim, T.K.,Kim, Y.K.,Moon, D.,Moon, H.R. Elsevier 2013 Inorganic chemistry communications Vol.33 No.-

Two coordination polymers, {[(NiL<SUB>allyl</SUB>)<SUB>2</SUB>(BuTC)]@?2DEF@?2H<SUB>2</SUB>O} (1) and {[(NiL<SUB>allyl</SUB>)<SUB>2</SUB>(BuTC)]@?3H<SUB>2</SUB>O} (2), ([NiL<SUB>allyl</SUB>](ClO<SUB>4</SUB>)<SUB>2</SUB>=[Ni(C<SUB>14</SUB>H<SUB>30</SUB>N<SUB>6</SUB>)](ClO<SUB>4</SUB>)<SUB>2</SUB>, H<SUB>4</SUB>BuTC=1,2,3,4-butanetetracarboxylic acid, DEF=N,N'-diethylformamide), were prepared by the self-assembly of [NiL<SUB>allyl</SUB>](ClO<SUB>4</SUB>)<SUB>2</SUB> and H<SUB>4</SUB>BuTC in DEF/H<SUB>2</SUB>O and acetonitrile/H<SUB>2</SUB>O, respectively. Single crystal X-ray diffraction and X-ray powder diffraction (XRPD) results revealed that 1 and 2 have two-dimensional layered structures, and the layers were stacked infinitely. Further, guest molecules were intercalated between the layers. Since both of coordination polymers 1 and 2 were constructed from the same building blocks, the structure of each layer was identical. However, depending on the size and the nature of guest molecules, layer packing and the interlayer distances were different for each coordination polymer. Interestingly, due to the instability of DEF guest molecules intercalated in the coordination polymer 1, these guest molecules could be easily liberated from the host, consequently resulting in the same XRPD pattern as that of 2 with slightly different relative intensities. Dried compounds of 1 and 2 (1' and 2', respectively) also showed the same result as evidenced by the XRPD patterns. The similar but non-identical XRPD patterns were revealed that the dried structure 1' had the same interlayer distance and the same intralayer structure as 2 and 2' did, whereas its layer packing remained the same as that of 1. This subtle structural difference of 1' and 2' resulted in their different CO<SUB>2</SUB> uptake behaviors at 195K.

The catalytic subunit of Arabidopsis DNA polymerase ensures stable maintenance of histone modification

Hyun, Y.,Yun, H.,Park, K.,Ohr, H.,Lee, O.,Kim, D.-H.,Sung, S.,Choi, Y. The Company of Biologists 2013 Development Vol.140 No.1

<P>Mitotic inheritance of identical cellular memory is crucial for development in multicellular organisms. The cell type-specific epigenetic state should be correctly duplicated upon DNA replication to maintain cellular memory during tissue and organ development. Although a role of DNA replication machinery in maintenance of epigenetic memory has been proposed, technical limitations have prevented characterization of the process in detail. Here, we show that INCURVATA2 (ICU2), the catalytic subunit of DNA polymerase α in Arabidopsis, ensures the stable maintenance of repressive histone modifications. The missense mutant allele icu2-1 caused a defect in the mitotic maintenance of vernalization memory. Although neither the recruitment of CURLY LEAF (CLF), a SET-domain component of Polycomb Repressive Complex 2 (PRC2), nor the resultant deposition of the histone mark H3K27me3 required for vernalization-induced FLOWERING LOCUS C (FLC) repression were affected, icu2-1 mutants exhibited unstable maintenance of the H3K27me3 level at the FLC region, which resulted in mosaic FLC de-repression after vernalization. ICU2 maintains the repressive chromatin state at additional PRC2 targets as well as at heterochromatic retroelements. In icu2-1 mutants, the subsequent binding of LIKE-HETEROCHROMATIN PROTEIN 1 (LHP1), a functional homolog of PRC1, at PRC2 targets was also reduced. We demonstrated that ICU2 facilitates histone assembly in dividing cells, suggesting a possible mechanism for ICU2-mediated epigenetic maintenance.</P>

Zn^II coordination polymers constructed with malonate and bipyridyl ligands: Photoluminescence and heterogeneous catalytic reactivity

Hyun, M.Y.,Hwang, I.H.,Lee, M.M.,Kim, H.,Kim, K.B.,Kim, C.,Kim, H.Y.,Kim, Y.,Kim, S.J. Pergamon Press 2013 Polyhedron Vol.53 No.-

Four three-dimensional Zn<SUP>II</SUP> frameworks containing malonates and various bipyridyl pillars (4,4'-bipyridine (1), 1,2-bis(4-pyridyl)ethane (2), 1,2-bis(4-pyridyl)ethylene (3) and 1,3-bis(4-pyridyl)propane (4)) have been prepared, and their structures were determined by X-ray crystallography. In all four frameworks, malonate ligands bridge three Zn ions to form two-dimensional layers, and these layers are connected by bipyridyl pillars to form three-dimensional frameworks with the general formula [{Zn(H<SUB>2</SUB>O)(μ-malonate)}<SUB>2</SUB>(μ-bipyridyl)] and which also contain water or acetonitrile solvates. Reactivity studies of compounds 1-4 showed that they catalyzed a heterogeneous transesterification reaction of phenyl acetate and could be reused without any significant loss of activity through five runs. Emissions were observed at 347-365nm (λ<SUB>ex</SUB>=313nm) for 2 and 363nm (λ<SUB>ex</SUB>=328nm) for 3, while compounds 1 and 4 showed no luminescence properties. The thermal stabilities of these complexes were also examined.

Gold-coated silicon nanowire-graphene core-shell composite film as a polymer binder-free anode for rechargeable lithium-ion batteries

Kim, H.J.,Lee, S.E.,Lee, J.,Jung, J.Y.,Lee, E.S.,Choi, J.H.,Jung, J.H.,Oh, M.,Hyun, S.,Choi, D.G. North-Holland 2014 Physica E, Low-dimensional systems & nanostructure Vol.61 No.-

<P>We designed and fabricated a gold (Au)-coated nanowires/graphene (Au-SiNWs/G) hybrid composite as a polymer binder free anode for rechargeable lithium ion batteries (LIBs). A large amount of SiNWs for LIB anode materials can be prepared by metal assisted chemical etching (MaCE) process. The Au-SiNVVs/G composite film on current collector was obtained by vacuum filtration using an anodic aluminum oxide (AAO) membrane and hot pressing method. Our experimental results show that the Au-SiNVVs/G composite has a stable reversible capacity of about 1520 mA h/g which was maintained for 20 cycles. The Au-SiNWs/G composite anode showed much better cycling performance than SiNWs/ polyvinylidene fluoride (PVDE)/Super-P, SiNWs/G composite, and pure SiNWs anodes. The improved electrochemical properties of the Au-SiNWs/G composite anode material is mainly ascribed to the composite's porous network structure.,(C) 2014 Elsevier B.V. All rights reserved.</P>

Novel Mn^II coordination compounds constructed from benzoate and various bipyridyl ligands: Magnetic property and catalytic activity

Hwang, I.H.,Jo, Y.D.,Kim, H.Y.,Kang, J.,Noh, J.Y.,Hyun, M.Y.,Kim, C.,Kim, Y.,Kim, S.J. Pergamon Press 2012 Polyhedron Vol.42 No.1

Three new Mn<SUP>II</SUP>-benzoates coordination polymers containing various bipyridyl ligands (3,3'-dipicoylamine (3), 3-methylisoquinoline (4), and 4,4'-dithiopyridine (5)) and a [Mn<SUB>6</SUB>(O<SUB>2</SUB>CPh)<SUB>10</SUB>(μ<SUB>4</SUB>-OH)<SUB>2</SUB>(CH<SUB>3</SUB>OH)<SUB>3</SUB>(H<SUB>2</SUB>O)].1.5(C<SUB>4</SUB>H<SUB>4</SUB>N<SUB>2</SUB>) cluster (1) have prepared and their structures were determined. The bipyridyl ligands can act as bridging ligands to produce 1-D or 2-D polymeric compounds. The pyrazine produced a Mn<SUB>6</SUB> cluster molecule, and 3-methylisoquinoline did a benzoate-bridged 1-D Mn<SUP>II</SUP> compound. The Mn<SUB>6</SUB> cluster (1) and 1-D Mn<SUP>II</SUP> compounds (3) and (4) show antiferromagnetic property. The compounds 1, 3, and 4 have catalyzed efficiently the transesterification of a variety of esters, while 5 has displayed a very slow conversion. The thermal stabilities of these complexes were also examined.

Molecular evidence of a teleomorph-anamorph connection between Cordyceps scarabaeicola and Beauveria sungii and its implication for the systematics of Cordyceps sensu stricto

Shrestha, B.,Hyun, M.W.,Oh, J.,Han, J.G.,Lee, T.H.,Cho, J.Y.,Kang, H.,Kim, S.H.,Sung, G.H. Mycological Society of Japan 2014 Mycoscience Vol.55 No.3

A teleomorph of Beauveria sungii S.A. Rehner & Humber is identified as Cordyceps scarabaeicola Y. Kobayasi based on the teleomorphic material of the B. sungii isolate used in the recent phylogenetic study. Cordyceps Fr. 1818 is an older generic name than Beauveria Vuill. 1912 in Cordyceps sensu stricto. Here, C. scarabaeicola is suggested to be adopted for B. sungii on the priority basis of both generic name and species epithet in compliance with the recent revision of Article 59 of the Melbourne Code (recently changed to the 'International Code of Nomenclature for algae, fungi, and plant' or ICN). The pros and cons of a unified nomenclature for pleomorphic fungi are briefly discussed with reference to Beauveria.

Design of the RAON Accelerator Systems

전동오,I. S. Hong,H. J. Kim,J. W. Kim,R. M. Bodenstein,차혁진,S. J. Choi,최숙,O. R. Choi,H. Do,B. H. Choi,C. J. Choi,J. Han,W. K. Han,M. O. Hyun,H. Jang,J. D. Joo,M. J. Joung,H. C. Jung,Y. C. Jung,김도균,E. Kim 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.7

The RAON is the name of the heavy ion accelerator facility under construction in Korea thatincludes the In-flight Fragment (IF) and Isotope Separation On-Line (ISOL) facilities to supportcutting-edge research in various science fields. The superconducting linac is the driver for the IFfacility that can accelerate beams from proton to uranium with 200 MeV/u, 400 kW (for uraniumbeam). A 70-MeV, 1-mA H− cyclotron is the driver for the ISOL facility and is followed by apost-accelerator consisting of s superconducting linac that can accelerate rare-isotope (RI) beamsand deliver them to experimental halls. These facilities provide high-intensity stable ion and rareisotope (RI) beams for domestic and international users. In this paper, design and prototypingefforts for the RAON accelerator systems are presented.