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Surgical Outcomes for Hepatocellular Carcinoma (HCC) with Portal Vein Tumor Thrombosis (PVTT-Vp3,4)
( Xuguang Hu ),( Heejung Wang ),( Bong-wan Kim ),( Ingyu Kim ),( Sung-yeon Hong ),( Xue-yin Shen ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: HCC patients with portal vein tumor thrombosis (PVTT) are classified into Barcelona clinic liver cancer (BCLC) stage C and have an extremely poor prognosis. The aim of the present study: To analyzed the long-term results of our series of patients with Vp3, 4 and try to find out the risk factors which can prognostic overall survival. Methods: From January 2003 to December 2014, a total of 810 cases of HCC were operated in our department. Among them, 52 cases were Vp3, 4 (6.4%). Six cases were excluded: Two cases of salvage liver transplantation, three cases of re-resection and one case of PVTT combined with IVC thrombosis. Finally, 46 cases with PVTT (Vp3, 4) were enrolled in the present study. The cutoff values of continues variables were decided by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate regression analysis were performed to identify prognostic factors of overall survival. Results: The median survival time was 8 months in the present study. Most of the patients preserve the good liver function (child-Pugh stage A, 44/46) The 1-, 3-, and 5-year overall survival rated of all the Vp3, 4 patients in the present study were 52.4%, 32.7% and 26.2%, respectively. There were 16 cases (34.8%) suffered from PVTT recurrence after operation. The tumor size more than 6.5cm and postoperative PVTT recurrence were found to be independent risk factors for overall survival in multivariate regression analysis. Conclusions: In selected patients, surgical treatment can achieve a relatively good outcome with 1-year survival rate of 52.4%. Tumor size was an independent prognostic factor for overall survival for HCC patient with Vp3, 4. Postoperative PVTT is another risk factor for overall survival and the HCC patients with PVTT should be strictly monitored for PVTT recurrence after operation.
Xiaona Huang,Hao Zhang,Xuguang Wang,Xiutian Yang,Rongzhuang Lin,Fan Zhang,Ying Liu,Kun Xu,Chao Zhou,Pixin Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
During cementing construction, H2S gas leak from micro-cracks of cement ring or cementing interface,seriously damaging wellbore integrity and shortening the life of wells. Therefore, microcrack selfhealingcement technology is of great significance for oil wells to maintain the durability of cement ringsand adapt to complex underground environments. Herein, acrylamide (AM), acrylonitrile (AN) and Nvinylformamide(NVF) were used as functional monomers, and laponite was added to prepareLaponite-poly(acrylamide-acrylonitrile-n-vinylformamide) nanocomposite hydrogel (L-PMAN) withexcellent mechanical strength as micro-crack repair agent for gas-triggered cementing cement sheath. Considering the difference of chemical environment in the process of wellbore cement slurry sealingand subsequent micro-fracture plugging, different structural units were selected to design amphotericstructure. The construction of zwitterionic structure makes it exhibit excellent swelling behavior in saltsolution while maintaining 80% of the original mechanical strength. More importantly, after adding LPMANpowder,cement stone (C1) can achieve good repair of microcracks under the trigger of H2S within3 days, and the maximum gas breakthrough pressure can reach 2.5 MPa, indicating the great potentials ofthe L-PMAN for plugging microcracks in cement sheath.
Ion-Imprinted Polymers Modified Sensor for Electrochemical Detection of Cu2+
Zhuolin An,Weifeng Liu,Qi Liang,Guang Yan,Lei Qin,Lin Chen,Meiling Wang,Yongzhen Yang,Xuguang Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.12
An electrochemical sensor (Cu2+-IIPs/GCE) was developed for detection of Cu2+ in water. Cu2+-IIPs/GCE was prepared by dispersing Cu2+ imprinted polymers (Cu2+-IIPs) on a preprocessed glassy carbon electrode. Cu2+-IIPs were synthesized on the surface of modified carbon spheres by ion imprinting technology. The electrochemical performance of Cu2+-IIPs/GCE was evaluated by differential pulse voltammetry method. The response of Cu2+-IIPs/GCE to Cu2+ was linear in 1.0 x 10 -5 mol/L to 1.0 x 10 -3 mol/L. The detection limit was 5.99 x 10 -6 mol/L (S/N = 3). The current response value of Cu2+-IIPs/GCE was 2.14 times that of the nonimprinted electrode. These results suggest that Cu2+-IIPs/GCE can detect the concentration of Cu2+ in water, providing a new way for heavy metal ions adsorption and testing.