MCT2 overexpression promotes recovery of cognitive function by increasing mitochondrial biogenesis in a rat model of stroke

Xiaorong Yu,Rui Zhang,Cunsheng Wei,Yuanyuan Gao,Yanhua Yu,Lin Wang,Junying Jiang,Xuemei Zhang,Junrong Li,Xuemei Chen 한국통합생물학회 2021 Animal cells and systems Vol.25 No.2

Monocarboxylate transporter 2 (MCT2) is the predominant monocarboxylate transporter expressed by neurons. MCT2 plays an important role in brain energy metabolism. Stroke survivors are at high risk of cognitive impairment. We reported previously that stroke-induced cognitive impairment was related to impaired energy metabolism. In the present study, we report that cognitive function was impaired after stroke in rats. We found that MCT2 expression, but not that of MCT1 or MCT4, was markedly decreased in the rat hippocampus at 7 and 28 days after transient middle cerebral artery occlusion (tMCAO). Moreover, MCT2 overexpression promoted recovery of cognitive function after stroke. The molecular mechanism underlying these effects may be related to an increase in adenosine monophosphate-activated protein kinase-mediated mitochondrial biogenesis induced by overexpression of MCT2. Our findings suggest that MCT2 activation ameliorates cognitive impairment after stroke.

Enhanced photocatalytic activity of TiO2/graphene by tailoring oxidation degrees of graphene oxide for gaseous mercury removal

Yu Guan,Tao Hu,Jiang Wu,Lili Zhao,Fengguo Tian,Wei-Guo Pan,Ping He,Xuemei Qi,Fangqin Li,Kai Xu 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.1

We used a simple method of graphene oxide (GO) preparation with different oxidation levels, and control the properties of the TiO2 nanocrystals by tuning the content and oxidation degree of GO to enhance the photocatalytic performance. During the hydrothermal reaction, reduction of GO, formation of TiO2 and chemical bonds between TiO2 and reduced graphene oxide (RGO) was achieved simultaneously. Characterization results showed that TiO2 properties such as crystalline grain and particle size could be tailored by the amount of functional groups, and that crystallinity was also controlled by GO degrees of oxidation. TiO2/RGO photocatalysts showed great efficiency of mercury oxidation, which reached 83.7% and 43.6% under UV and LED light irradiation, respectively. The effects of crystalline grain size and surface chemical properties on Hg0 removal under LED and UV light irradiation were analyzed. In addition, the properties of the photocatalysts before and after UV illumination were investigated, finding that part of Ti-OH on TiO2 surface transformed to Ti-O-Ti. In a nutshell, this work could provide a new insight into enhancing activity of photocatalysts and understanding the photocatalytic mechanism.

Host Species as a Strong Determinant of the Intestinal Microbiota of Fish Larvae

Xuemei Li,Yuhe Yu,Weisong Feng,Qingyun Yan,Yingchun Gong 한국미생물학회 2012 The journal of microbiology Vol.50 No.1

We investigated the influence of host species on intestinal microbiota by comparing the gut bacterial community structure of four cohabitating freshwater fish larvae, silver carp, grass carp, bighead carp, and blunt snout bream, using denaturing gradient gel electrophoresis (DGGE) of the amplified 16S and 18S rRNA genes. Similarity clustering indicated that the intestinal microbiota derived from these four fish species could be divided into four groups based on 16S rRNA gene similarity, whereas the eukaryotic 18S rRNA genes showed no distinct groups. The water sample from the shared environment contained microbiota of an independent group as indicated by both 16S and 18S rRNA genes segments. The bacterial community structures were visualized using rank-abundance plots fitted with linear regression models. Results showed that the intestinal bacterial evenness was significantly different between species (P<0.05) and between species and the water sample (P<0.01). Thirty-five relatively dominant bands in DGGE patterns were sequenced and grouped into five major taxa: Proteobacteria (26), Actinobacteria (5), Bacteroidetes (1), Firmicutes (2), and Cyanobacterial (1). Six eukaryotes were detected by sequencing 18S rRNA genes segments. The present study suggests that the intestines of the four fish larvae, although reared in the same environment, contained distinct bacterial populations, while intestinal eukaryotic microorganisms were almost identical.

A first principle study on the magnetic properties of Cu2O surfaces

Xiaohu Yu,Xuemei Zhang,Shengguang Wang,Gang Feng 한국물리학회 2015 Current Applied Physics Vol.15 No.11

Spin-polarized density functional theory calculations were performed to investigate the magnetism of bulk and Cu2O surfaces. It is found that bulk Cu2O, Cu/O-terminated Cu2O(111) and (110) surfaces have no magnetic moment, while, the O-terminated Cu2O(100) and polar O-terminated Cu2O(111) surfaces have magnetism. For low index surfaces with cation and anion vacancy, we only found that the Cu vacancy on the Cu2O(110) Cu/O-terminated surface can induce magnetism. For atomic and molecular oxygen adsorption on the low index surfaces, we found that atomic and molecular oxygen adsorption on the Cuterminated Cu2O(110) surface is much stronger than on the Cu/O-terminated Cu2O(111) and Cuterminated Cu2O(100) surfaces. More interesting, O and O2 adsorption on the surface of Cu/O terminated Cu2O(111) and O2 adsorption on the Cu-terminated Cu2O(110) surface can induce weak ferromagnetism. In addition, we analysis origin of Cu2O surfaces with magnetism from density of state, the surface ferromagnetism possibly due to the increased 2p-3d hybridization of surface Cu and O atoms. This is radically different from other systems previously known to exhibit point defect ferromagnetism, warranting a closer look at the phenomenon.

Dissimilatory Azoreduction of Orange I by a Newly Isolated Moderately Thermophilic Bacterium, Novibacillus thermophilus SG-1

Zhen Yu,Xuemei Zhou,Yueqiang Wang,Guiqin Yang,Shungui Zhou 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.6

Dye wastewater normally is discharged at high temperature, but thermophilic bacteria capable of decolorizing azo dyes have rarely been isolated. Here we report a newly isolated moderately thermophilic bacterium, Novibacillus thermophilus SG-1, which had a remarkable ability to decolorize the azo dye Orange I by utilizing a large variety of organic substrates as electron donors. When Orange I served as the sole electron acceptor, almost complete decolorization occurred at 50ºC and pH 8.0 with acetate as the electron donor after anaerobic incubation of strain SG-1 for 24 h. The decolorization process followed the pseudofirst- order kinetics. The complete reduction of 0.3 mM Orange I was accompanied by a stoichiometric consumption of 0.17 mM acetate over time. The measured molar ratio (1.76) of Orange I reduced to acetate oxidized was close to the theory value of 2.0, suggesting that most of the electrons released by acetate had been transported to Orange I. Simultaneously energy generated from the electron transfer process was used to support cell anaerobic growth, which meant that azoreduction by strain SG-1 is an azorespiration process. To our knowledge, this is the first report of a thermophilic bacterium capable of azorespiration, which increases the limited number of bacteria for treating hightemperature azo dye wastewater.

The Game Model between Government Subsidies Act and Green Supply Chain

Ying Xu,Xuemei Zhang,Yu Hong 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.11

In order to promote the development of green product market, the government will adopt fiscal subsidies to encourage enterprises and consumers. This paper builds the game model of the manufacturers and retailers from the aspect of green supply chain based on the government subsidies. Consider the green supply chain consisting of manufacturers and retailers, the influence of subsidy amount on the decision-making behaviors of the manufacturers, retailers and consumers respectively under the mode of government fiscal subsidies to manufacturers and consumers are studied. Analyze the influence of government subsidy on the decision-making behaviors of manufacturers, retailers and consumers through numerical simulation analysis, and further compare the difference between the manufacturer subsidy mode and consumer subsidy mode. The results indicate that: (1) the manufacturers and retailers will choose consumer subsidy mode; (2) the selection of subsidy mode by consumers is mainly influenced by the relative size of price sensitivity coefficient and subsidy sensitive coefficient.

Optimization Model of Closed Loop Supply Chain Based on System Dynamics and Graph Theory

Ying Xu,Xuemei Zhang,Yu Hong 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.12

In order to assist in the reverse recovery decision of emergency logistics in sudden natural disasters, this paper conducts the system modeling on the reverse recovery of reusable materials in several disaster areas from the perspective of system dynamics under the principle of rescue satisfaction preference. Through the comprehensive analysis of material demand of disaster areas, the occupancy of resources in reverse recovery and other factors, it establishes the function relation between the recovery frequency and rescue satisfaction, and simulates the system model with the system dynamics software Vensim. Finally, the effectiveness and practicability of the model is proved by an example, based on which the impact of transportation resource change on rescue satisfaction is analyzed. Based on the above research conclusion, this paper provides the decision support and countermeasure for the emergency reverse logistics in China.

Influence of Mode of Delivery on Children’s Attention Deficit Hyperactivity Disorder and Childhood Intelligence

Min Xu,Xuemei Yu,Benjie Fan,Guimei Li,Xinxin Ji 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.8

Objective To investigate whether differences exist in attention deficit hyperactivity disorder (ADHD) and intelligence between children born by cesarean delivery and those born by vaginal delivery.Methods This retrospective study included singleton children that were born between January 2013 and December 2014. The Chinese version of the Conners’ Parent Rating Scale–Revised (CPRS-48) was required on the probability of psychological and behavioral problems. The China–Wechsler Intelligence Scale for Children (C-WIRS) was used for evaluation of crystallized intelligence and Raven’s Standard Progressive Matrices for evaluation of fluid intelligence.Results A total of 10,568 valid questionnaires were obtained. CPRS-48 ADHD index and detection rate were higher in cesarean delivery group than those in vaginal delivery group. Cesarean delivery groups had a lower performance intelligence quotient score according to C-WISC.Conclusion Children born by cesarean delivery were more likely to have a risk of ADHD and a lower performance intelligence quotient compared with those born by vaginal delivery.

Abnormal Brain Activity Changes in Patients with Migraine: A Short-Term Longitudinal Study

Ling Zha,Jixin Liu,Xuemei Yan,Wanghuan Dun,Jing Yang,Liyu Huang,Yuan Kai,Dahua Yu,Wei Qin,Tian Jie,Fanrong Liang 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.3

Background and Purpose Whether or not migraine can cause cumulative brain alterationsdue to frequent migraine-related nociceptive input in patients is largely unclear. The aim of thisstudy was to characterize longitudinal changes in brain activity between repeated observationswithin a short time interval in a group of female migraine patients, using resting-state functional magnetic resonance imaging. Methods Nineteen patients and 20 healthy controls (HC) participated in the study. Regionalhomogeneity (ReHo) and functional interregional connectivity were assessed to determine thefocal and global features of brain dysfunction in migraine. The relationship between changes inheadache parameters and longitudinal brain alterations were also investigated. Results All patients reported that their headache activity increased over time. AbnormalReHo changes in the patient group relative to the HC were found in the putamen, orbitofrontalcortex, secondary somatosensory cortex, brainstem, and thalamus. Moreover, these brain regions exhibited longitudinal ReHo changes at the 6-week follow-up examination. These headache activity changes were accompanied by disproportionately dysfunctional connectivity inthe putamen in the migraine patients, as revealed by functional connectivity analysis, suggesting that the putamen plays an important role in integrating diverse information among othermigraine-related brain regions. Conclusions The results obtained in this study suggest that progressive brain aberrations in migraine progress as a result of increased headache attacks.

Study on flexural capacity of simply supported steel-concrete composite beam

Fa-Xing Ding,Jing Liu,Xuemei Liu,Zhi-wu Yu 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.21 No.4

This paper investigates the flexural capacity of simply supported steel-concrete composite I beam and box beam under positive bending moment through combined experimental and finite element (FE) modeling. 24 composite beams are included into the experiments and parameters including shear connection degree, transverse reinforcement ratio, section form of girder, diameter of stud and loading way are also considered and investigated. ABAQUS is employed to establish FE models to simulate the behavior of composite beams. The influences of a few key parameters, such as the shear connection degree, stud arrangement, stud diameter, beam length and loading way, on flexural capacity are discussed. In addition, three methods including GB standard, Eurocode 4, and Nie method are also used to estimate the flexural capacity of composite beams and also for comparison with experimental and numerical results. The results indicate that Nie method may provide a better estimation in comparison to other two standards.