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Zipeng Gong,Ying Chen,Ruijie Zhang,Qing Yang,Yajie Wang,Yan Guo,Bingbing Zhou,Xiaogang Weng,Xuchen Liu,Yujie Li,Xiaoxin Zhu,Yu Dong 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
Berberine is one of active alkaloids from Rhizomacoptidis in traditional Chinese medicine. The pharmacokineticsof berberine in rat plasma were compared betweennormal and chronic visceral hypersensitivity irritable bowelsyndrome rats (CVH-IBS) established by mechanical colonirritation using angioplasty balloons for 2 weeks after oraladministration of berberine hydrochloride (25 mg/kg) withthe equivalent dose of 22 mg/kg for berberine according tobody weight. Immunohistochemical analysis of c-fos andmyosin light chain kinase (MLCK) and immunofluorescenceanalysis of MLCK in rat colon were conducted. Quantificationof berberine in rat plasma was achieved by using a sensitiveand rapidUPLC-MS/MSmethod. Plasma samples werecollected at 15 different points in time and the pharmacokineticparameters were analyzed by WinNonlin software. Thegreat different pharmacokinetic behavior of berberine wasobserved between normal and CVH-IBS model rats. Compared with normal group, T1/2 and AUC(0–t) of berberinein the model group were significantly increased, respectively(573.21 ± 127.53 vs 948.22 ± 388.57 min; 8,657.19 ±1,562.54 vs 11,415.12 ± 1,670.72 min.ng/ml). Cl/F of berberinein the model group significantly decreased, respectively(13.89 ± 1.69 vs 9.19 ± 2.91 L/h/kg). Additionally,the expressions of c-fos and MLCK in model group werehigher than those in normal group. The pharmacokinetic behaviorof berberine was significantly altered in CVH-IBSpathological conditions, which indicated the dosage modificationof berberine hydrochloride in CVH-IBS were necessary. Especially, improved exposure to berberine in ratplasma inCVH-IBSmodel rats was attributed to increased theexpression of MLCK.
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Xu Chen,Di Gao,Yan Zhang,Jia Xuan Hu,Ye Liu,Feng Xiang 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.1
The effects of Ti on the microstructures, macrohardness and compressive properties of the as-cast Al0.5CrFeNi2.1Mn0.8TixHEAs were investigated. The results showed that the microstructures of as-cast Al0.5CrFeNi2.1Mn0.8Tixalloys was changedfrom FCC phase to a mixture of FCC and BCC phases, then to a mixture of BCC phase and Ti-containing intermetalliccompound as the increasing of Ti content. Chrysanthemum-like eutectic microstructure was obtained in theAl0.5CrFeNi2.1Mn0.8Ti0.5and Al0.5CrFeNi2.1Mn0.8Tialloys. The area of flower core was composed of BCC2 phase, andeutectic microstructure was achieved in the petal area which contained BCC1 phase and BCC2 phase. Moreover, the macrohardnessof the as-cast alloys increased with the increasing of Ti, and the Al0.5CrFeNi2.1Mn0.8Ti0.5alloy showed excellentcomprehensive compressive properties.
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Cu2O Nanoparticles and Multi-Branched Nanowires as Anodes for Lithium-Ion Batteries
Xu Chen,Chunxin Yu,Xiaojiao Guo,Qinsong Bi,Muhammad Sajjad,Yang Ren,Xiaowei Zhou,Zhu Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.09
Novelty Cu2O multi-branched nanowires and nanoparticles with size ranging from ~15 nm to ~60 nm have been synthesized by one-step hydrothermal process. These Cu2O nanostructures when used as anode materials for lithium-ion batteries exhibit the excellent electrochemical cycling stability and reduced polarization during the repeated charge/discharge process. The specific capacity of the Cu2O nanoparticles, multi-branched nanowires and microscale are maintained at 201.2 mAh/g, 259.6mAh/g and 127.4 mAh/g, respectively, under the current density of 0.1 A/g after 50 cycles. The enhanced electrochemical performance of the Cu2O nanostructures compared with microscale counterpart can be attributed to the larger contact area between active Cu2O nanostructures/electrolyte interface, shorter diffusion length of Li+ within nanostructures and the improved stress release upon lithiation/delithiation.
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Evolution of Microstructures and Properties in AlxCrFeMn0.8Ni2.1 HEAs
Xu Chen,Di Gao,Jia Xuan Hu,Ye Liu,Chang Ping Tang 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.5
The microstructures, compression and corrosion behaviors of the as-cast AlxCrFeMn0.8Ni2.1high-entropy alloys (0 ≤ x ≤ 2.3)were investigated in this paper. It was found that the crystal structure changed from initial dual FCC structure to mixed FCCand BCC structure, then to BCC structure as the increasing of Al content. Al0.8CrFeMn0.8Ni2.1alloy exhibited a typicalspinodal structure consisting of alternating two phases microstructure. Moreover, sunflower-like microstructure was obtainedin the as-cast AlxCrFeMn0.8Ni2.1alloys (1.0 ≤ x ≤ 2.0). With the increasing of Al, the macrohardness increased while the plasticitydecreased in the alloys. The addition of an appropriate amount of Al could improve the compressive fracture strengthof the alloys. In addition, the corrosion resistance deteriorated slightly with the increasing of Al in 1 mol/L NaCl solution.
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Corrosion Behavior in Nitric Acid Solution and Tensile Properties of (CuFeNiMn)1−xCrx HEAs
Xu Chen,Jiaxuan Hu,Ye Liu,Feng Xiang 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7
The empirical prediction on the phase formation in as-cast (CuFeMnNi)1−xCrx alloys was consistent with the previousexperimental results, which indicated that the BCC phase formed in the alloys was in the thermodynamically unstable state. The corrosion resistance of the alloys in 2 wt% HNO3 solution was increased with the increased Cr content which wasmainly related to the formation of large anode and small cathode, increasing total volume fraction of Cr-rich FCC1 and BCCphases, the more uniform distribution of Cu and decreasing relative Cu content. The (CuFeMnNi)0.75Cr0.25 alloy exhibitedan excellent corrosion resistance dominated by localized corrosion, while the CuFeMnNi alloy showed the worst corrosionresistance. Moreover, the strength of the investigated alloys increased while the ductility decreased with the increasing of Crcontent, revealing that the extrinsic features played a more important role in the fracture behavior than the intrinsic features.
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Xu Chen,Zhiyi Liu,Peng Xia,Ailin Ning,Sumin Zeng 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.2
The fatigue crack propagation behavior in the overaged Al-Zn-Mg-Cu alloy was characterized by optical microscopy, scanning electron microscopy, transmission electron microscopy and electron backscatter diffraction. The results revealed that a fatigue crack tended to transgranularly propagate in the near-threshold regime, whereas intergranular crack propagation was dominant at the high ΔK regime. The transition of crack propagation from a transgranular to an intergranular path that occurred in the Paris regime was strongly influenced by the misorientation of adjacent grains and precipitate free zones. In addition, a crystallographic model of crack propagation was proposed to interpret the transition. The fatigue short crack propagation on a single slip plane was responsible for the formation of a transgranular propagation path in the near-threshold regime. The fatigue long crack propagation, which was conducted by a duplex slip mechanism in the Paris regime, led to the formation of fatigue striations. The formation of a zigzag crack in the near-threshold regime was ascribed to the high misorientation of adjacent grains.
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