Comparison of Clinical and Radiographic Outcomes Between Transforaminal Endoscopic Lumbar Discectomy and Microdiscectomy: A Follow-up Exceeding 5 Years

Xinyu Yang,Shijun Zhang,Junxiao Su,Sai Guo,Yakubu Ibrahim,Kai Zhang,Yonghao Tian,Lianlei Wang,Suomao Yuan,Xinyu Liu 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: To compare the long-term clinical and radiographic outcomes of transforaminal endoscopic lumbar discectomy (TELD) versus microdiscectomy (MD). Methods: The data of 154 patients with lumbar disc herniation (LDH) who underwent TELD (n = 89) or MD (n = 65) were retrospectively analyzed. The patients’ clinical outcomes were evaluated using visual analogue scales for leg and low back pain, the Japanese Orthopaedic Association (JOA) score, and the Oswestry Disability Index (ODI). The evolution of radiographic manifestations was observed during follow-up. Potential risk factors for a poor clinical outcome were investigated. Results: During a mean follow-up of 5.5 years (range, 5–7 years), the recurrence rate was 4.49% in the TELD group and 1.54% in the MD group. All scores significantly improved from preoperatively to postoperatively in both groups (p < 0.01). The improvement in the ODI and JOA scores was significantly greater in the TELD than MD group (p < 0.05). Forty-seven patients (52.8%) in the TELD group and 32 (49.2%) in the MD group had Modic changes before surgery, most of which showed no changes at the last follow-up. The degeneration grades of 292 discs (71.0%) were unchanged at the last follow-up, while 86 (20.9%) showed improvement, mostly at the upper adjacent segment. No significant difference was observed in the intervertebral height index or paraspinal muscle-disc ratio. Conclusion: Both TELD and MD provide generally satisfactory long-term clinical outcomes for patients with LDH. TELD can be used as a reliable alternative to MD with less surgical trauma. Modic type II changes, decreased preoperative intervertebral height, and a high body mass index are predictors of a poor prognosis. Objective: To compare the long-term clinical and radiographic outcomes of transforaminal endoscopic lumbar discectomy (TELD) versus microdiscectomy (MD). Methods: The data of 154 patients with lumbar disc herniation (LDH) who underwent TELD (n = 89) or MD (n = 65) were retrospectively analyzed. The patients’ clinical outcomes were evaluated using visual analogue scales for leg and low back pain, the Japanese Orthopaedic Association (JOA) score, and the Oswestry Disability Index (ODI). The evolution of radiographic manifestations was observed during follow-up. Potential risk factors for a poor clinical outcome were investigated. Results: During a mean follow-up of 5.5 years (range, 5–7 years), the recurrence rate was 4.49% in the TELD group and 1.54% in the MD group. All scores significantly improved from preoperatively to postoperatively in both groups (p < 0.01). The improvement in the ODI and JOA scores was significantly greater in the TELD than MD group (p < 0.05). Forty-seven patients (52.8%) in the TELD group and 32 (49.2%) in the MD group had Modic changes before surgery, most of which showed no changes at the last follow-up. The degeneration grades of 292 discs (71.0%) were unchanged at the last follow-up, while 86 (20.9%) showed improvement, mostly at the upper adjacent segment. No significant difference was observed in the intervertebral height index or paraspinal muscle-disc ratio.

Extinction and permanence of a kind of pest-predator models with impulsive effect and infinite delay

Xinyu Song,Hongjian Guo 대한수학회 2007 대한수학회지 Vol.44 No.2

Gut Microbiome Alterations and Functional Prediction in Chronic Spontaneous Urticaria Patients

( Xinyue Zhang ),( Jun Zhang ),( Zhaowei Chu ),( Linjing Shi ),( Songmei Geng ),( Kun Guo ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.5

The effects of the gut microbiome on both allergy and autoimmunity in dermatological diseases have been indicated in several recent studies. Chronic spontaneous urticaria (CSU) is a disease involving allergy and autoimmunity, and there is no report detailing the role of microbiota alterations in its development. This study was performed to identify the fecal microbial composition of CSU patients and investigate the different compositions and potential genetic functions on the fecal microbiota between CSU patients and normal controls. The gut microbiota of CSU patients and healthy individuals were obtained by 16s rRNA massive sequencing. Gut microbiota diversity and composition were compared, and bioinformatics analysis of the differences was performed. The gut microbiota composition results showed that Firmicutes, Bacteroidetes, Proteobacteria, and Verrucomicrobia were dominant microbiota in CSU patients. The differential analysis showed that relative abundance of the Proteobacteria (p = 0.03), Bacilli (p = 0.04), Enterobacterales (p = 0.03), Enterobacteriaceae (p = 0.03) was significantly increased in CSU patients. In contrast, the relative abundance of Megamonas, Megasphaera, and Dialister (all p < 0.05) in these patients significantly decreased compared with healthy controls. The different microbiological compositions impacted normal gastrointestinal functions based on function prediction, resulting in abnormal pathways, including transport and metabolism. We found CSU patients exhibited gut microbiota dysbiosis compared with healthy controls. Our results indicated CSU is associated with gut microbiota dysbiosis and pointed out that the bacterial taxa increased in CSU patients, which might be involved in the pathogenesis of CSU. These results provided clues for future microbial-based therapies on CSU.

Generation of U and P Singularities in Partially Coherent Beams Using Intensity Control Holographic Modal Wavefront Sensor

Xinyu Peng,Dong Ye,Guo Zheng Zhao,Qi Zhao,Minmin Song 한국광학회 2017 Current Optics and Photonics Vol.1 No.2

It is shown that polarization singularities of a new type, namely U and P singularities, arise at thetransverse cross section of a partially coherent beam, instead of the common singularities such as C pointsand L lines in a completely coherent vector field. A relationship between the two kind of singularitieswith respect to intensity is proposed. We also present a setup that can generate the new singularities, andany desired distribution of degree of polarization, using intensity control.

Intraoperative frozen pathology exam of Common iliac lymph nodes and Para-Aortic lymphadenectomy on the prognosis and quality of life for patients with IB2-IIA2 Cervical Cancer: trial protocol for a randomized controlled trial (C-PACC trial)

Xinyu Qu,Junjun Qiu,Lili Jiang,Xiaorong Qi,Guonan Zhang,Weiwei Feng,Yudong Wang,Yincheng Teng,Xipeng Wang,Xiaoqing Guo,Keqin Hua 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.2

Background: The impact of para-aortic lymphadenectomy (PALD) on prognosis and quality of life (QoL) for IB2-IIA2 cervical cancer patients remain controversial. And whether intraoperative frozen pathology exam on common iliac lymph nodes could help predict para-aortic lymph node (PALN) metastasis was unanswered with high-level evidence. Methods: A multi-center, randomized controlled study is intended to investigate the effect of PALD on the prognosis and QoL in cervical cancer patients and to assess the value of intraoperative frozen pathological evaluation of common iliac nodes metastasis for the prediction of PALN metastasis. After choosing whether to receive intraoperative frozen pathological examination of bilateral common iliac lymph nodes, eligible patients will be randomly assigned (1:1) to receive PALD or not. The primary end point is 2-year progression-free survival (PFS). The secondary end points include 5-year PFS, 2-year overall survival (OS), 5-year OS, adverse events (AEs) caused by PALD, AEs caused by radiotherapy and QoL. A total of 728 patients will be enrolled from 8 hospitals in China within 3-year period and followed up for 5 years.

EXTINCTION AND PERMANENCE OF A KIND OF PEST-PREDATOR MODELS WITH IMPULSIVE EFFECT AND INFINITE DELAY

Song, Xinyu,Guo, Hongjian Korean Mathematical Society 2007 대한수학회지 Vol.44 No.2

In this paper, a kind of pest-predator model with impulsive effect and infinite delay is considered by the method of chain transform. By using Floquet's theorem, it is shown that there exists a globally asymptotically stable periodic pest eradication solution when the impulsive period is less than or equal to some critical value which is a directly proportional function with respect to the population of release. Furthermore, it is proved that the system is permanent if the impulsive period is larger than some critical value. Finally, the results of the corresponding systems are compared, those results obtained in this paper are confirmed by numerical simulation.

Surface Micro-Structuring of Coarse-Grained Diamond Wheels by Nanosecond Pulsed Laser for Improving Grinding Performance

Bing Guo,Qingliang Zhao,Xinyu Zhao 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

The conditioned coarse-grained diamond wheels are able to achieve the identical surface roughness, higher form accuracy and largergrinding rate when compared to the traditional fine-grained diamond wheels. However, deeper subsurface damage could be inevitablyintroduced due to the flat tops of the coarse diamond grains. This work presents a micro-structuring method for coarse-graineddiamond wheels by means of nanosecond pulsed laser, which allows the generation of micro grooves arrays on the coarse diamondgrains distributed on the whole grinding wheel cylindrical surface. The influence of laser parameters such as focal point shift, laserpower, scanning speed and scanning passes on micro-structured surface was investigated, and then the laser machining process wasoptimized in fabricating uniform and continuous micro-structures. The grinding experiments indicate that, when compared to the nonmicro-structured grinding wheels, the subsurface cracks depth of ground optical glass was reduced effectually by using the microstructuredcoarse-grained diamond wheels.

Theoretical study of UHPCC composite column behaviors under axial compression

Xiang-Guo Wu,Ruofei Zou,Xinyu Zhao,Qun Yu 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.55 No.5

To improve the durability and service life of reinforced concrete column such as bridge piers, an advanced composite column made of Ultra High Performance Cementitious Composites (UHPCC) permanent form is proposed. Based on elasticity plasticity theory, axial compression behavior of the composite column was studied theoretically. The first circumferential cracking load and ultimate limit loading capacity are derived for the composite column. Short composite column compression tests and numerical simulations using FEM method were carried out to justify the theoretical formula. The effects of UHPCC tube thickness on the axial compression behavior were studied. Using the established theoretical model and numerical simulation, the large dimension composite columns are calculated and analyzed with different UHPCC tube thickness. These studies may provide a reference for advanced composite column design and application.

Cloning and expression of a Chk1 gene in Daphnia pulex during different modes of reproduction

Xiaoge Guo,Shanliang Xu,Xuemei Yan,Wei Zhou,Xinyu Dai,Xiu Zou,Chunlin Wang,Danli Wang,Yunlong Zhao 한국유전학회 2015 Genes & Genomics Vol.37 No.9

The full-length cDNA of a Chk1 gene (DpChk1) was cloned from Daphnia pulex using RACE method. This cDNA is 1767 bp in length, consisting of a 1497 bp open reading frame encoding 498 amino acid protein. The deduced DpChk1 protein sequence contains phosphorylation sites, three conserved Ser-Gln and Thr- Gln motifs and shares 51–55 % similarity with A. pisum, M. rotundata, D. melanogaster, A. echinatior, B. terrestris, R. pulchellus and M. occidentalis, respectively. Gene expression analysis showed that Chk1 is differentially expressed in D. pulex during different reproductive modes. DpChk1 expression in sexually-reproducing females and males is significantly higher than in parthenogenetic Daphnia. Whole-mount in situ hybridization revealed that DpChk1 was expressed during two kinds of reproductive modes. In parthenogenetic females, hybridization signals were found in the antennae and thoracic limb, whereas expression levels in the corresponding sites of sexuallyreproducing females were relatively strong, DpChk1 could not be detected in the gonads of ephippial and parthenogenetic females. Taken together, these different reproductive stages and sex specific expression patterns are regulated temporally and spatially. We speculate that DpChk1 may be involved in conversion between different stages of reproduction and in sexual differentiation in D. pulex.

A data corruption detection scheme based on ciphertexts in cloud environment

( Sixu Guo ),( Shen He ),( Li Su ),( Xinyue Zhang ),( Huizheng Geng ),( Yang Sun ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.9

With the advent of the data era, people pay much more attention to data corruption. Aiming at the problem that the majority of existing schemes do not support corruption detection of ciphertext data stored in cloud environment, this paper proposes a data corruption detection scheme based on ciphertexts in cloud environment (DCDC). The scheme is based on the anomaly detection method of Gaussian model. Combined with related statistics knowledge and cryptography knowledge, the encrypted detection index for data corruption and corruption detection threshold for each type of data are constructed in the scheme according to the data labels; moreover, the detection token for data corruption is generated for the data to be detected according to the data labels, and the corruption detection of ciphertext data in cloud storage is realized through corresponding tokens. Security analysis shows that the algorithms in the scheme are semantically secure. Efficiency analysis and simulation results reveal that the scheme shows low computational cost and good application prospect.