Dynamic Model of the Aqueous Humor Circulation with Application to Simulation of the Treatment for Primary Open Angle Glaucoma

Ying Ju,Boliang Wang,Jiezhen Xie,Liwei Huang,Shaohui Huang,Xiaoyang Huang 대한의료정보학회 2007 Healthcare Informatics Research Vol.13 No.2

Objective: In order to study the mechanism of the aqueous humor circulation and its relationship to the glaucoma macroscopically with engineering methods. Methods: A dynamistic model was presented, which can be used to simulate the situation and the treatment of the primary open angle glaucoma (POAG). The frame of the model was built based on the ophthalmically accepted feedback mechanism between the aqueous humor circulation and the intraocular pressure (IOP). The transfer functions and the parameters were educed from the analysis of physiological theories, the basic elements of hydrodynamics, and the clinical parameters. The relation between the parameters of the system and the episode mechanism of POAG was discussed. A digital method was used to simulate the Challenge test and some medicines' treatment of POAG, and the results were consistent with clinical observations. Results: The results of simulation illuminate that the model can simulate the mechanism of the aqueous humor circulation and the curative mechanism of some medicines under the physiological condition and the pathological condition of the POAG. Conclusion: a few parameters which can hardly be captured with clinical method could be obtained from the model. These parameters can be helpful for the diagnosis and prediction of the curative effect. (Journal of Korean Society of Medical Informatics 13-2, 139-146, 2007)

Adsorption resin/polyethersulfone membrane used for plasma separation and middle molecular toxins adsorption

Xiaoyang Hou,Lilan Huang,Han Zhang,Qingping Xin,Hong Li,Hui Ye,Yuzhong Zhang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

Accumulation of endogenous and exogenous toxins in patients with chronic kidney disease increases thekidney burden. The newly developed plasma separation adsorption membranes provide a new model forthe removal of middle molecular toxins. In this study, the adsorption resin LX-1000H is physically pulverizedand blended into polyethersulfone matrixes to prepare adsorption resin/polyethersulfone (AR/PES) membranes by nonsolvent-induced phase separation for plasma separation and middle moleculartoxins absorption. The results show that the static adsorption capacity of AR/PES membrane for lysozyme(a typical mimic of middle molecular toxins) is up to 108.90 mg/g, which is 4 times that of AR. The maximumdynamic adsorption capacity reaches 102.80 mg/g, which is 93.4% of static adsorption. The adsorptionprocess is more consistent with the Langmuir model and the quasi-first-order kinetic model. Thepermeability of bovine serum albumin in simulated blood surpasses 90% and the cattle blood separatedby AR/PES membrane is colorless and transparent. The AR/PES membrane surface presents electronegativeat pH 7.4 and the water wettability is enhanced with the doping amount. No hemolysis and negligibleleakage indicated favorable hemocompatibility. This paper is devoted to providing a strategy forplasma separation and adsorption membranes.

Adverse effects of subchronic exposure to cooking oil fumes on the gonads and the GPR30‑mediated signaling pathway in female rats

Xiaoyang Zhang,Yonghua He,Quanhui Lin,Lili Huang,Qunwei Zhang,Youqiong Xu 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Cooking oil fumes (COFs) are composed of particulate matter, polycyclic aromatic hydrocarbons, volatile organic compounds, aldehydes, and ketones, and are currently a global health concern. Some agents in COFs are mutagenic and carcinogenic. However, only a few reports have addressed the hazardous effects of COF exposure on the female reproductive system. In this study, we explored the effects of subchronic exposure to COFs on female gonads in vivo and the possible involvement of the G-protein-coupled receptor 30 signaling pathway. Methods COFs were generated by heating commercially available canola oil in an iron pot. Adult female Wistar rats at 2 months of age were exposed to COFs at 32 mg/m3 for 0, 0.5, 1, 2, or 4 h/day for 56 days. The estrous cycle in rats was studied twice at 7:00 a.m. and 7:00 p.m. on the 43rd treatment day until the current estrous cycle was complete. The rat body weight was measured before the experiment and at day 56 post-exposure. At the end of the experiment, rat blood was collected for gonadal hormone assay, and ovaries were collected for histology and mRNA isolation. The mRNA levels of GPR30, EGFR, STAT3, and ERK were determined by quantitative RT-PCR. Results At a concentration of 32.21 ± 5.11 mg/m3, COF exposure extended the estrous cycle in rats, and ovary coefficient decreased. COFs showed various effects on the sex hormone levels and follicles, depending on its exposure level. Exposure to COFs led to the changes in mRNA levels of the G-protein-coupled receptor 30 (GPR30), epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), and extracellular signal-regulated kinase (ERK). Conclusion This study indicated that cooking oil fume exposure disrupted the estrous cycle, sex hormone patterns, and follicle development in female rats in a dose-dependent manner. These adverse effects of cooking oil fumes on female reproductive health were correlated with the G-protein-coupled receptor 30-mediated signaling pathway.

Prediction of dryout-type CHF for rod bundle in natural circulation loop under motion condition

Huang, Siyang,Tian, Wenxi,Wang, Xiaoyang,Chen, Ronghua,Yue, Nina,Xi, Mengmeng,Su, G.H.,Qiu, Suizheng Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.4

In nuclear engineering, the occurrence of critical heat flux (CHF) is complicated for rod bundle, and it is much more difficult to predict the CHF when it is in natural circulation under motion condition. In this paper, the dryout-type CHF is investigated for the rod bundle in a natural circulation loop under rolling motion condition based on the coupled analysis of subchannel method, a one-dimensional system analysis method and a CHF mechanism model, namely the three-fluid model for annular flow. In order to consider the rolling effect of the natural circulation loop, the subchannel model is connected to the one-dimensional system code at the inlet and outlet of the rod bundle. The subchannel analysis provides the local thermal hydraulic parameters as input for the CHF mechanism model to calculate the occurrence of CHF. The rolling motion is modeled by additional motion forces in the momentum equation. First, the calculation methods of the natural circulation and CHF are validated by a published natural circulation experiment data and a CHF empirical correlation, respectively. Then, the CHF of the rod bundle in a natural circulation loop under both the stationary and rolling motion condition is predicted and analyzed. According to the calculation results, CHF under stationary condition is smaller than that under rolling motion condition. Besides, the CHF decreases with the increase of the rolling period and angular acceleration amplitude within the range of inlet subcooling and mass flux adopted in the current research. This paper can provide useful information for the prediction of CHF in natural circulation under motion condition, which is important for the nuclear reactor design improvement and safety analysis.

Comparative Investigation Into Field Performance of Steel Bridge Deck Asphalt Overlay Systems

Xiaoyang Jia,Baoshan Huang,Shangjiang Chen,Dawei Shi 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.7

The steel bridge deck overlay provides a smooth surface for riding and protects the deck from influence of traffic and environment factors. The presence of distress on overlay may compromise the serviceability of a bridge. A better understanding of distress is indispensable for designers to make improvements on asphalt overlay to extend the service life. A field investigation into performance of two bridge deck asphalt overlay systems was conducted. The overlay system included an epoxy asphalt overlay and a composite asphalt overlay consisting of Stone-Matrix-Asphalt (SMA) and Gussasphalt (GA). The field investigation was conducted to evaluate the difference in performance between two systems. Chemical analyses were performed on core samples from each bridge to further investigate the distress mechanism of each system. Results indicated that the two overlay systems generally exhibited similar field performance. Each bridge developed different distress, mainly due to the poor bonding between layers or between overlay and steel deck.

A Maneuver Control Method for Stealthy Engagement in Beyond-visual-range Air Combat Based on Sliding Mode Control

Yue Liu,Zhen Yang,Jichuan Huang,Guang Zhan,Xiaoyang Li,Deyun Zhou 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

A S-type engagement of beyond-visual-range (BVR) air combat tactical method based on sliding mode control is proposed, which is aiming at the problem of Doppler pulse (PD) radar blind zone. By introducing the Electronic Support Measures (ESM), the whole tactical process is divided into two sub-processes: quick engagement and stealthy engagement. This paper designs a stealthy engagement process controller based on the double power sliding mode control, and a quick engagement process controller based on the back-stepping second order sliding mode. The simulation experiment shows that our aircraft can use EMS to judge the enemy radar detection information and switch the strategy. And it can successfully enter the enemy radar blind zone through S-type maneuver, occupy the dominant area, which can effectively complete the stealthy engagement.

Hybrid Gradient Vector Fields Based on Maneuver Space for Path-following Guidance

Yiyang Zhao,Deyun Zhou,Zhen Yang,Xiaoyang Li,Jichuan Huang,Xiaofeng Lv 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

Guidance path-planning and following are two important functionalities of unmanned aerial vehicles (UAVs), but only a few approaches deal with both. In this study, an innovative hybrid gradient vector fields algorithm based on maneuver space (HGVFs-MS) for path-following guidance is proposed to control fixed-wing UAVs to follow a generated guidance path and oriented target curves in three-dimensional space, which can be any combination of straight lines, arcs, and helixes as motion primitives. The strategies designed in earlier studies have flaws that prevent the UAV from following arcs that make its turning angle too large. The switching strategy proposed in this study solves this problem by introducing the concept of the virtual waypoints. Finally, the performance of the HGVFs-MS algorithm is verified by three representative simulation scenarios. The simulation considers the constraints of the aircraft, and its results indicate that the algorithm performs well in following both lateral and longitudinal control, particularly for curved paths.

Study on Cooperative Air-to-Ground Surveillance Planning and Controlling for Unmanned Aerial Vehicles

Shiyuan Chai,Zhen Yang,Jichuan Huang,Xiaoyang Li,Yiyang Zhao,Deyun Zhou 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

The use of unmanned aerial vehicles (UAVs) for air-to-ground mission in complex environments has increased considerably in recent years. The numerous studies on UAVs cooperative air-to-ground mission controlling have been reported, but few have considered the impact of the communication instability due to electromagnetic interference (EMI) which is common in many air-to-ground applications. Under the influence of EMI, the air-to-ground mission stages are represented as a dynamic combination of several communication-available and communication-unavailable stages. Traditional cooperative surveillance algorithms cannot handle such situations well. In this study, we presented a method which based on Voronoi diagrams to solve the impact of communication outages, and an attention mechanism ant-colony optimization (AACO) algorithm was proposed for UAV path-planning control in air-to-ground surveillance missions. The controlling strategy is adaptively updated by introducing an attention mechanism for regular instruction information, a priori information, and emergent information of the mission to satisfy the mission target. Simulation results show that the proposed algorithm achieves better search performance than traditional algorithms in scenarios which include communication-available and communication-unavailable situations.

A Novel Human BTB-kelch Protein KLHL31, Strongly Expressed in Muscle and Heart, Inhibits Transcriptional Activities of TRE and SRE

Weishi Yu,Yuequn Wang,Yongqing Li,Yun Deng,Zequn Wang,Wuzhou Yuan,Dali Li,Chuanbing Zhu,Xueying Zhao,Xiaoyang Mo,Wen Huang,Na Luo,Yan Yan,Karen Ocorr,Rolf Bodmer,Xiushan Wu 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.5

The Bric-a-brac, Tramtrack, Broad-complex (BTB) domain is a protein-protein interaction domain that is found in many zinc finger transcription factors. BTB containing proteins play important roles in a variety of cellular functions including regulation of transcription, regulation of the cytoskeleton, protein ubiquitination, angiogenesis, and apoptosis. Here, we report the cloning and characterization of a novel human gene, KLHL31, from a human embryonic heart cDNA library. The cDNA of KLHL31 is 5743 bp long, encoding a protein product of 634 amino acids containing a BTB domain. The protein is highly conserved across different species. Western blot analysis indicates that the KLHL31 protein is abundantly expressed in both embryonic skeletal and heart tissue. In COS-7 cells, KLHL31 proteins are localized to both the nucleus and the cytoplasm. In primary cultures of nascent mouse cardiomyocytes, the majority of endogenous KLHL31 proteins are localized to the cytoplasm. KLHL31 acts as a transcription repressor when fused to GAL4 DNA-binding domain and deletion analysis indicates that the BTB domain is the main region responsible for this repression. Overexpression of KLHL31 in COS-7 cells inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). KLHL31 also significantly reduces JNK activation leading to decreased phosphorylation and protein levels of the JNK target c-Jun in both COS-7 and Hela cells. These results suggest that KLHL31 protein may act as a new transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions.

Clinical Study on Fluvoxamine Combined with Oxycodone Prolonged-Release Tablets in Treating Patients with Moderate to Severe Cancer Pain

Xiao, Yang,Liu, Jun,Huang, Xin-En,Ca, Li-Hua,Ma, Yi-Min,Wei, Wei,Zhang, Rong-Xia,Huang, Xiao-Hong,Chang, Juan,Wu, Yi-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Objective: To observe treatment effects and safety of fluvoxamine combined with oxycodone prolonged-release tablets in treating patients with moderate to severe cancer pain. Methods: Patients confirmed pathologically with cancer and complicated with moderate to severe pain, were divided into control and experimental groups. Oxycodone prolonged-release tablets, with or without fluvoxamine, were administrated to all study patients until pain relief. Degree of pain relief, dose of oxycodone prolonged-release tablets, side effects and quality of life were compared before and after treatment. Results: In total, 120 patients were recruited. No statistically significant difference was detected regarding age, gender, types of cancer, KPS between two groups of patients (P>0.05). Baseline pain score of patients with moderate pain in treatment and control group was $4.9{\pm}0.8$ and $5.1{\pm}0.8$, respectively; and decreased to $1.8{\pm}1.1$ and $1.2{\pm}1.1$ after treatment, respectively. Pain intensity was significantly reduced in the treatment group (P=0.028). Average daily consumption of oxycodone prolonged-release tablets was ($54.0{\pm}19.6$) mg and ($44.7{\pm}18.7$) mg respectively, which is lower in treatment grpup than in control group, but the difference was not statistically significant (P=0.065). Baseline pain score of patients with severe pain in treatment and control groups were $8.3{\pm}1.1$ and $8.3{\pm}1.1$, respectively; and pain intensity after treatment decreased to $2.9{\pm}1.0$ and $2.3{\pm}1.0$. Pain intensity was significantly reduced in the treatment group, with statistical significance (P=0.026). Average daily consumption of oxycodone prolonged-release tablets was ($132.0{\pm}42.2$) mg and ($110.7{\pm}33.9$) mg, respectively, which is lower in treatment group than in control group, and the difference was statistically significant (P=0.035). In terms of quality of life, patients in treatment group had better performance status, daily activity, mood, and sleep than that in control group (P < 0.05). Patients in two groups had similar side effects, eg., constipation, nausea/vomiting, lethargy, dizziness, itchy skin, dysuria, and ataxia. Lower incidence of nausea/vomiting, lethargy, was obtained from patients in treatment than in control group, while significant low constipation was observed in treatment than in control group (35.0% vs 49.2%, P=0.026). Conclusion: Fluvoxamine combined with oxycodone prolonged-release tablets could be more effective in treating patients with cancer pain, and could reduce the dosage of oxycodone prolonged-release tablets and thus be associated with lower side effects, and improved quality of life.