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Xiao, Juan,Zhang, Tao,Xu, Daichao,Wang, Huibing,Cai, Yu,Jin, Taijie,Liu, Min,Jin, Mingzhi,Wu, Kejia,Yuan, Junying Cold Spring Harbor Laboratory Press 2015 Genes & development Vol.29 No.2
<P>Vps34, the catalytic subunit in the class III phosphatidylinositol 3 kinase complexes, mediates the production of PtdIns3P, a key intracellular lipid involved in regulating autophagy and receptor degradation. Xiao et al. show that DNA damage-activated mitotic arrest and CDK activation lead to the phosphorylation of Vps34. This provides a signal to promote Vps34 ubiquitination and proteasomal degradation mediated by FBXL20, leading to inhibition of autophagy and receptor endocytosis. Importantly, they also find that expression of FBXL20 is regulated by p53-dependent transcription.</P><P>Vacuolar protein-sorting 34 (Vps34), the catalytic subunit in the class III PtdIns3 (phosphatidylinositol 3) kinase complexes, mediates the production of PtdIns3P, a key intracellular lipid involved in regulating autophagy and receptor degradation. However, the signal transduction pathways by which extracellular signals regulate Vps34 complexes and the downstream cellular mechanisms are not well understood. Here we show that DNA damage-activated mitotic arrest and CDK activation lead to the phosphorylation of Vps34, which provides a signal to promote its ubiquitination and proteasomal degradation mediated by FBXL20 (an F-box protein) and the associated Skp1 (S-phase kinase-associated protein-1)–Cullin1 complex, leading to inhibition of autophagy and receptor endocytosis. Furthermore, we show that the expression of FBXL20 is regulated by p53-dependent transcription. Our study provides a molecular pathway by which DNA damage regulates Vps34 complexes and its downstream mechanisms, including autophagy and receptor endocytosis, through SCF (Skp1–Cul1–F-box)-mediated ubiquitination and degradation. Since the expression of FBXL20 is regulated by p53-dependent transcription, the control of Vps34 ubiquitination and proteasomal degradation by FBXL20 and the associated SCF complex expression provides a novel checkpoint for p53 to regulate autophagy and receptor degradation in DNA damage response.</P>
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Xiao, Juan,Deng, Lei,Yang, Ming-Ge Korean Mathematical Society 2014 대한수학회논문집 Vol.29 No.1
In a uniformly convex Banach space, we introduce a iterative scheme for a finite family of asymptotically quasi-nonexpansive mappings and utilize a new inequality to prove several convergence results for the iterative sequence. The results generalize and unify many important known results of relevant scholars.
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Pretreatment of Switchgrass with Electrolyzed Water and a Two-stage Method for Bioethanol Production
Xiaojuan Wang,Hao Feng,Zhiyi Li 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.3
In this study, switchgrass, which is a promising energy crop, was treated with two new pretreatment methods for the production of bioethanol. Acidic electrolyzed water (AEW) and alkaline electrolyzed water (ALEW) were first used as pretreatment catalysts at three temperatures (170,185, and 200oC) and 3 treatment times (5, 15, and 25 min). In the two-stage pretreatment, 1.0, 2.0 and 3.0% H2O2solutions were used to partially remove hemicellulose and lignin during the 1st stage at 50oC for 16, 24, or 32 h at a solid concentration of 5%. The supernatant of the 1st stage was used for hemicellulose precipitation. The remaining solids were subjected to a 2nd stage treatment with hot water at 121oC for 30 min in an autoclave at a solid concentration of 12.5%. In the electrolyzed water pretreatment,the highest glucose yield was achieved by pretreatment with ALEW at 200oC and 25 min, which resulted in the release of 23.8 g glucose from 100 g dry switchgrass. The hydrolyzate obtained from switchgrass pretreated with 3% H2O2 for 16 h followed by enzymatic hydrolysis was fermented using S. cerevisiae at 30oC for 96h without any concentration or detoxification steps. The final ethanol concentration was 11.8 g/L and the productive yield was 74% of the theoretical yield. A mass balance for the two-stage process showed that 12 g of ethanol was produced from 100 g dry switchgrass. In this study, switchgrass, which is a promising energy crop, was treated with two new pretreatment methods for the production of bioethanol. Acidic electrolyzed water (AEW) and alkaline electrolyzed water (ALEW) were first used as pretreatment catalysts at three temperatures (170,185, and 200oC) and 3 treatment times (5, 15, and 25 min). In the two-stage pretreatment, 1.0, 2.0 and 3.0% H2O2solutions were used to partially remove hemicellulose and lignin during the 1st stage at 50oC for 16, 24, or 32 h at a solid concentration of 5%. The supernatant of the 1st stage was used for hemicellulose precipitation. The remaining solids were subjected to a 2nd stage treatment with hot water at 121oC for 30 min in an autoclave at a solid concentration of 12.5%. In the electrolyzed water pretreatment,the highest glucose yield was achieved by pretreatment with ALEW at 200oC and 25 min, which resulted in the release of 23.8 g glucose from 100 g dry switchgrass. The hydrolyzate obtained from switchgrass pretreated with 3% H2O2 for 16 h followed by enzymatic hydrolysis was fermented using S. cerevisiae at 30oC for 96h without any concentration or detoxification steps. The final ethanol concentration was 11.8 g/L and the productive yield was 74% of the theoretical yield. A mass balance for the two-stage process showed that 12 g of ethanol was produced from 100 g dry switchgrass.
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Xiaojuan Yang,Qing-Ping Wu,Ju-Mei Zhang,Weipeng Guo,Shuping Mo,Sheng-Rong Liu 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4
This study aimed to classify a collection of Enterobacter sakazakii (E. sakazakii) strainspreviously identified from powdered infant formula (PIF) to species level by recN gene sequencing andbiochemical testing to determine the distribution of Cronobacter species in China and investigate thestrain diversity by cellular fatty acid (CFA) analysis. Of 24 E. sakazakii isolates, 23 were identified as C. sakazakii and one was C. malonaticus. The 23 C. sakazakii isolates showed the same CFA profiles. TheC. malonaticus isolate was discriminated from the C. sakazakii isolates by the significant difference inthe amounts of C12:0, C14:0, and C17:0 cyclo acids. These results showed that C. sakazakii and C. malonaticuswere the common Cronobacter species distributed in PIF in China and that the isolates of the twospecies exhibited different CFA profiles. These findings are of value for epidemiological investigationsand provide an alternative method for confirming various Cronobacter spp.
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High Power Switchable Dual-Wavelength Linear Polarized Yb-Dozped Fiber Laser around 1120 nm
Xiaojuan Liu,Bangcai Huang,Gongxiang Wei,Kezhen Han,Yan Huang,Fangfang Liu 한국광학회 2016 Current Optics and Photonics Vol.20 No.6
A single-and dual-wavelength switchable polarized Yb-doped double-clad fiber laser around 1120 nmbased on a pair of fiber Bragg gratings (FBGs) is demonstrated. The polarization-maintaining (PM) linearcavity is composed of a double clad PM Yb-doped fiber (YDF) and a pair of PM FBGs. The laser canoperate in stable dual-wavelength or wavelength-switching modes due to the polarization hole burning(PHB) and the spatial hole burning (SHB) enhanced by the PM linear cavity. In dual-wavelength operation,the two orthogonally polarized wavelengths are centered at 1118.912 nm and 1119.152 nm, with an intervalof 0.24 nm and a signal to noise ratio (SNR) of 35 dB. The maximum output power is 14.67 W whenthe launched LD pump is 24 W corresponding to an optical efficiency of 61.1%. The lasing lines switchovermay be realized by adjusting the polarization controller (PC) fitted in the cavity. The two single-wavelengthsare 1118.912 nm and 1119.152 nm. When the injected LD pump is 24 W, the highest output powersare 7.68 W and 8.64 W corresponding to optical efficiencies of 32% and 36% respectively. The spectrallinewidth of the lasing lines are 0.075 nm and 0.07 nm, and the average numerical values of PER are20.3 dB and 19.9 dB, respectively.
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Xiaojuan Feng,Yanlong Shi,yuanyuan Chen,Zhirong Xu,Haiyu Guan 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.113 No.-
Exploring high-efficient and stable low-cost electrocatalysts is of significant importance for boosting theefficiency of water splitting and purifying urea-enriched wastewater. Herein, bimetallic doping strategywas adopted to obtain jasminum nudiflorum-like Fe, V doped NiS arrays (Fe, V-NiS/NF) via typicalhydrothermal process and subsequent anion exchange reaction. The as-obtained Fe, V-NiS/NF array displayshigh catalytic activity and stability toward oxygen evolution reaction (OER) and urea oxidationreaction (UOR) in alkaline media, with reduced overpotentials of 273 and 214 mV to deliver the currentdensity of 50 mA cm2 for OER and UOR, respectively. More notably, when employing Fe, V-NiS/NF assymmetric electrolytic cell for urea electrolysis, a low cell voltage of 1.45 V is needed at 10 mA cm2,which is about 110 mV lower than the conventional water electrolysis. Meanwhile, the catalyst also displayssuperior stability for over 72 h. Such outstanding performance is attributed to the following points:(i) 3D porous flower-like structure facilitates the mass transfer and abundant exposure of active sites; (ii)in situ growth of catalysts on conductive substrate and the effective interface engineering of differentcomposition shorten the charge transport pathways and expedite electron transfer. Density functionaltheory calculations demonstrate that the Fe and V dopants regulate the electronic environment of Ni sitesand optimize the adsorption free energy of urea. This work provides a universal pathway to design highefficientand non-noble electrocatalysts for H2 production in an energy-saving way via urea electrolysis.
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Xiaojuan Pei,최원준,김유민,Long Xuan Zhao,정낙신 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'- C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.
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