Roadway Engineering Mechanical Properties and Roadway Structural Instability Mechanisms in Deep Wells

Xiang-Rui Meng,Rui Peng,Guang-Ming Zhao,Ying-Ming Li 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.5

We proposed a new classification method for stress-bearing structures in very-deep roadways. We conducted tests for roadwayengineeringmechanical properties, including rock mechanical tests and ground stress measurement of two caverns in very-deepwells. We suggested a classification method for stress-bearing structures based on shear stress. Tests revealed that rock strength in theshear direction was the lowest; the stress distributions of acoustic emission and hollow inclusion were highly similar. Based on theroadway-engineering mechanical properties of two caverns and numerical simulation and in-situ tests, the key bearing structureswere classified based on the concentrated shear stress. In deep caverns, shear stress was more concentrated on the softer surroundingrock, the key bearing structure areas, and the more seriously fractured surrounding rocks. Using the loose circle in-situ test, wecompared the classification method of the key bearing structures with other classification methods. The results revealed agreementwith the classification methods used for the key bearing structures. The deformation in-situ test showed that the strata convergence ofconcentrated shear stress areas developed quickly. Therefore, the phenomena of concentrated shear stress and the expanded range ofkey bearing structures are the structural instability mechanisms of deep roadways.

Fancd2os Reduces Testosterone Production by Inhibiting Steroidogenic Enzymes and Promoting Cellular Apoptosis in Murine Testicular Leydig Cells

Xiang Zhai,Xin-yang Li,Yu-jing Wang,Ke-ru Qin,Jin-rui Hu,Mei-ning Li,Hai-long Wang,Rui Guo 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.3

Background: It is well-established that serum testosterone in men decreases with age, yet the underlying mechanism of this changeremains elusive. Methods: The expression patterns of Fancd2 opposite-strand (Fancd2os) in BALB/c male mice and testicular tissue derived celllines (GC-1, GC-2, TM3, and TM4) were assessed using real-time polymerase chain reaction (RT-PCR), Western blot and immunofluorescence. The Fancd2os-overexpressing or knockdown TM3 cells were constructed by infecting them with lentivirus particlesand were used to evaluated the function of Fancd2os. The testosterone production was measured using enzyme linked immunosorbent assay (ELISA) and the steroidogenic enzymes such as steroidogenic acute regulatory protein (StAR), P450 cholesterol sidechain cleavage (P450scc), and 3β-hydroxysteroid dehydrogenase (3β-HSD) were analysed using RT-PCR. The apoptosis of TM3cells induced by ultraviolet light or testicular tissues was detected using flow cytometry, Western blot or dUTP-biotin nick end labeling (TUNEL) assays. Pearson correlation analysis was used to assess the correlation between the Fancd2os expression and TUNELpositive staining in mouse testicular Leydig cells. Results: The Fancd2os protein was predominantly expressed in mouse testicular Leydig cells and its expression increased with age. Fancd2os overexpression inhibited testosterone levels in TM3 Leydig cells, whereas knockdown of Fancd2os elevated testosteroneproduction. Fancd2os overexpression downregulated the levels of StAR, P450scc and 3β-HSD, while Fancd2os knockdown reversed this effect. Fancd2os overexpression promoted ultraviolet light-induced apoptosis of TM3 cells. In contrast, Fancd2os knockdown restrained apoptosis in TM3 cells. In vivo assays revealed that higher Fancd2os levels and mouse age were associated with increased apoptosis in Leydig cells and decreased serum testosterone levels. Pearson correlation analysis exhibited a strong positivecorrelation between the expression of Fancd2os and TUNEL-positive staining in mouse testicular Leydig cells. Conclusion: Our findings suggest that Fancd2os regulates testosterone synthesis via both steroidogenic enzymes and the apoptoticpathway.

비인 모더니즘의 미학적 지각

한루이시앙 ( Rui Xiang Han ) 韓國獨語獨文學會 2009 獨逸文學 Vol.110 No.-

오스트리아 비인 모더니즘은 베를린 자연주의와의 논쟁에서 생긴다. 비인 모더니즘은 외부에서 내부로, 객관성에서 주관성으로의 문학적인 묘사 변화를 수행한다. 그러면서 자아, 영혼, 꿈을 문제시 삼는 새로운 예술양식이 형성되며, `모던`이라는 개념은 당대의 화두가 된다. 헤르만 바의 논문 「모더니즘」(1890)은 새로운 프로그램을 예고하면서 비인 모더니즘을 감수성 이론 내에서 규정짓는 데 일조한다. 이념사적으로 볼 때, 비인 모더니즘의 전통을 뛰어넘는 미학적 의식은 자아를 인식하기 위해 새로운 길을 열었던 마흐의 감수성 철학 및 프로이트의 정신분석과 밀접하게 연관되어 있다. 마흐의 감수성 분석과 자아에 대한 그의 인식은 자연주의를 극복하는 비인 모더니즘을 이해하기 위한 필연적인 미적 토대이다. 프로이트는 언어로 변신한 꿈을 영혼을 규정하는 수단으로 해석한다. 그의 꿈의 언어도 비인 모더니즘의 본질적인 특징이다. 슈니츨러와 호프만스탈은 비인 모더니즘을 대표하는 작가들이다. 그들의 작품은 예를 들면 자아, 영혼, 꿈에 대한 비인식 관점을 묘사하면서 다양한 방식으로 그들만의 특수한 미적 의식을 보여준다. 이처럼 비인 모더니즘의 새로운 미학적 의식과 현대성이 더 이상 전수된 이념상에서가 아니라 참을 수 없는 감수성에서 보여진다는 것은 명백하다. 이런 의미에서 비인 모더니즘은 당대의 경험이자 동시에 당대에 대한 반응이다. 그 위기의 상황에서 비인 모더니즘은 자연주의에 길항하면서 문학적 묘사의 관점 변화를 수행한다. 그때 더 이상 외부의 현실이 아니라 자아, 영혼, 꿈이 미학적 관찰의 중심이 되는 것이다. 비인 모더니즘은 위기에 처한 현실을 필연적으로 경험한 것이며, 동시에 그 위에 바탕을 둔 필연적인 반응이다. 자아, 영혼, 꿈은 당대와 그 시절의 인간들을 인식하기 위한 대상이자 수단이며, 그럼으로써 비인 모더니즘의 미학적인 현대성을 특징짓는다.

Meta-analysis of Gene Expression Data Identifies Causal Genes for Prostate Cancer

Wang, Xiang-Yang,Hao, Jian-Wei,Zhou, Rui-Jin,Zhang, Xiang-Sheng,Yan, Tian-Zhong,Ding, De-Gang,Shan, Lei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Prostate cancer is a leading cause of death in male populations across the globe. With the advent of gene expression arrays, many microarray studies have been conducted in prostate cancer, but the results have varied across different studies. To better understand the genetic and biologic mechanisms of prostate cancer, we conducted a meta-analysis of two studies on prostate cancer. Eight key genes were identified to be differentially expressed with progression. After gene co-expression analysis based on data from the GEO database, we obtained a co-expressed gene list which included 725 genes. Gene Ontology analysis revealed that these genes are involved in actin filament-based processes, locomotion and cell morphogenesis. Further analysis of the gene list should provide important clues for developing new prognostic markers and therapeutic targets.

Detection of Antibodies Against DNA Polymerase of Hepatitis B Virus in HBsAg - Positive Sera Using ELISA

(Li Xiang Rui),(Young Min Park),(Jong Yong Choi),(Boo Sung Kim),(Guhung Jung) 대한내과학회 1998 The Korean Journal of Internal Medicine Vol.13 No.2

N/A Objectives:DNA polymerase (pol) of Hepatitis B virus (HBV) includes 3 different domains such as terminal protein (TP), reverse transcriptase (RT) and RNase H. Humoral immune responses to each of these proteins have not been well documented previously, although antibody to pol was detected in serum of patients with chronic hepatitis B. We have constructed TP (amino acids 1-182), RT (amino acids 346-685) and RNase H (amino acids 690-832). Methods:By ELISA using each protein expressed in E. coli as antigens, the corresponding antibodies were tested in serum from 40 patients with type B viral chronic liver diseases. (20 HBeAg-positive and 20 HBeAg-negative). As negative controls, sera from 3 healthy young men were used. With the mean values of the OD, which were tested 4 times per each test sample and 3 times per each control sample, we considered to be positive if the mean OD of each test sample is 2-fold or higher than that of controls. Results:Five of 40 sera (12.5%) contained one or two different antibodies detectable by this method: 4 of 20 HBeAg-positive sera (20%) and 1 of 20 HBeAg-negative sera (5%). Anti-TP, anti-RT and anti-RNase H antibodies were detected in 2.5% (1/40), 10% (4/40) and 7.5% (3/40), respectively. Among 4/20 HBeAg-positive ELISA-positive sera, anti-TP, anti-RT and anti-RNase H were positive in 5% (1/20), 20% (4/20) and 10% (2/20), respectively, while 1 HBeAg-negative ELISA-positive sera were positive only for anti-RNase H. Conclusions:These results suggest that the corresponding antibody responses to individual recombinant peptides derived from 3 domains of DNA polymerase may tend to be detected more frequently in HBeAg-positive sera than in HBeAg-negative sera from various patients with type B viral chronic liver diseases.

Research of the Interconnection of Workflow System Based on Web Service

Gang Yuan,Rui-zhi Sun,Yong Xiang,Yin-xue Shi 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.2

In order to achieve the interconnection between different workflow management systems, it was proposed that all the distributed workflow systems would be encapsulated as web services to perform the entire business process collaboratively by the way of processes’ composition in this paper. By analyzing the comparison between the composition of processes and ordinary Web service, we studied interactive control, the parameters required to be passed through the distributed workflow systems, the workflow system service’s interfaces and its packaging. Furthermore we put forward a general method of the workflow systems interactive interfaces’ extension and the way of the workflow service’s encapsulating and invoking. By this approach, it can easily combine the processes or process fragments which deployed on different workflow systems without other agents and components. It also provides support for the interconnection of the workflow systems in distributed environment, and ultimately achieves a coordinated operation between different workflow engines.

Structural and Electrical Properties of Epitaxial Nb-Doped SrTiO[sub 3] Film Deposited on Si (100) Substrate

Xiang, Wenfeng,Oh, Seokjoon,Choi, Hyejung,Dong, Rui,Lee, Dongsoo,Seong, Dongjun,Hwang, Hyunsang The Electrochemical Society 2007 Journal of the Electrochemical Society Vol.154 No.6

Practical coherency model suitable for near- and far-field earthquakes based on the effect of source-to-site distance on spatial variations in ground motions

Rui-fang Yu,Abduwahit Abduwaris,Yan-Xiang Yu 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.73 No.6

In this study, the spatial variation mechanisms of large far-field earthquakes at engineering scales are first investigated with data from the 2008 Ms 8.0 Wenchuan earthquake. And a novel ‘coherency cut-off frequency’ is proposed to distinguish the spatial variations in ground motions in the low-frequency and high-frequency ranges. Then, a practical piecewise coherency model is developed to estimate and characterize the spatial variation in earthquake ground motions, including the effects of source-to-site distances, site conditions and neighboring topography on these variations. Four particular earthquake records from dense seismograph arrays are used to investigate values of the coherency cut-off frequency for different source-to-site distances. On the basis of this analysis, the model is established to simulate the spatial variations, whose parameters are suitable for both near- and far-field earthquake conditions. Simulations are conducted to validate the proposed model and method. The results show that compared to the existing models, the proposed model provides an effective method for simulating the spatial correlations of ground motions at local sites with known source-to-site distances.

Studies on Mei Flower (Prunus mume) Breeding, with Special Reference to Produce Hardy Cultivars for Open Gardens in Beijing

Rui-dan Chen,Qi-xiang Zhang,Jun-yu Chen 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Dynamic Response and Long-Term Settlement of a Compacted Loess Embankment under Moving Train Loading

Rui Wang,Zhiping Hu,Jiakuan Ma,Xiang Ren,Fangtao Li,Fei Zhang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.11

There have been many railway construction projects in the loess region of China. Embankment is typically required for rail projects in these regions, since the railway basement is restricted by longitudinal slope requirements. However, there has been little study of the dynamic response of compacted loess embankment under moving train loading. The 2.5D finite element method was adopted to investigate this process and characterize the effects of train speed, height of embankment, and axle weight on the dynamic behavior of subgrade. A rectangular core zone of subgrade was determined, and a prediction model was established to evaluate the long-term settlement of embankment generated by moving train loading. The results showed that embankment height had negligible influence on the variation of dynamic stress. Decays of stress amplitude in both the vertical and horizontal directions slowed with increased train speed. Additionally, the dynamic stress increased linearly with the increase in axle weight due to the linear stress-strain relationship of soil. In the practical speed range (≤ 100 m/s), the dynamic influence depth increased with increasing speed in a range of 3 − 6 m. A core zone depth of 6 m reflects the effects of moving train loading, with a width of 4 m. For practical conditions (v ≤ 100 m/s), only slight settlement of embankment was observed (≤ 6 mm). However, it is difficult to achieve the same physical parameters used in the experiments (moisture content and compaction degree) in engineering practice. Further work should explore long-term dynamic settlement with relation to the degree of compaction of the embankment.