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Self-assembled micelles of the natural medicine ginsenosides for cancer metastasis therapy
Xia-Rong Tan,Chao-Li,Ke-Ke Feng,Jing-Qing Le,Jiang-Wen Shen,Jing-Wei Shao 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
The nanocarrier-based drug delivery systems have become an alternative strategy for cancer treatment. Whereas, increasing studies find that the utilization of drug carriers may result in poor biocompatibility,lower drug loading capacity and unpredictable side reactions. Therefore, we herein reported selfassembledmicelles based on herbal product ginsenosides, which are the main active ingredients ofPanax ginseng C.A. The ginsenosides-based micelle system exerts excellent biosafety, better stability, highdrug capacity, and lower cytotoxicity compared to free ginsenosides. Meanwhile, ginsenosides micellesexhibits superior inhibitory effects on cancer cell adhesion activity, especially the expression of intercellularadhesion molecule-1, which is the critical factor of cancer metastasis. Importantly, ginsenosidesmicelles results in remarkably therapeutic efficacy on lung metastasis of liver cancer. All these resultshighlight the potential utilization of ginsenosides micelles in the clinic. Meanwhile, the carrier-freenano-drugs self-delivery system of ginsenosides showed great promise to become an emerging approachfor cancer metastasis therapy.
Direct ethanol production from dextran industrial waste water by Zymomonas mobilis
Ming-xiong He,Han Qin,Xiao-bo Yin,Zhi-yong Ruan,Fu-rong Tan,Bo Wu,Zong-xia Shui,Li-chun Dai,Qi-chun Hu 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.11
The direct production of ethanol from dextran industrial waste water was investigated by using Zymomonasmobilis via batch and semi-continuous fermentation mode. In batch fermentation, pretreated waste water (unsterilizedand sterilized), pH value (3.8 and 6.0), and Mg2+(with and without) was compared with OD600, sugar and ethanol con-centration. After 24 h fermentation, sugar in the dextran waste water was almost exhausted, and the amount of ethanolaccumulated reached 24.33-29.92 g/l, which is nearly 99% of the theoretical yield of ethanol. Kinetic parameters ofZ. mobilis in batch fermentation were also investigated. The raw dextran waste water was also used in semi-continuousfermentation. After 48 h fermentation, the production of ethanol was 28.65 g/l. These results indicated that dextranwaste water may be used as a candidate substrate and Z. mobilis could convert the raw material into ethanol directly.