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RISS 인기검색어
- 검색키워드
- 저자 : Jing-Qing Le (검색결과 2 건)
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Jing-Qing Le,Fang Yang,Xun-Huan Song,Ke-Ke Feng,Ling-Wu Tong,Meng-Die Yin,Wen-Zhong Zhang,Ying-Qi Lin,Hui Wu,Jing-Wei Shao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, whichprovides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesisand metastasis, but also is responsible for the development of treatment resistance, which graduallybecomes a significant impediment for cancer therapy. Therefore, we developed a biomimetic nanosystemcontaining hemoglobin extracted from red blood cells, chemotherapy drug sorafenib, sensitizer ursolicacid and photosensitizer indocyanine green for enhanced chemo-photo combination therapy of hepatocellularcarcinoma, which could not only enhance the chemotherapy effect of sorafenib bowing to thesensitizing effect of ursolic acid, but also achieved synergetic phototherapy in virtue of indocyaninegreen. Besides, the nanoparticles could effectively delivery exogenous oxygen to tumor site and amelioratethe tumor hypoxic environment with the assistance of hemoglobin. The dual-sensitization drugdelivery system was expected to effectively reduce the resistance of traditional treatment methodsagainst tumor hypoxia, providing a novel prospect for the synergistic hepatocellular carcinomatreatment.
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Self-assembled micelles of the natural medicine ginsenosides for cancer metastasis therapy
Xia-Rong Tan,Chao-Li,Ke-Ke Feng,Jing-Qing Le,Jiang-Wen Shen,Jing-Wei Shao 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
The nanocarrier-based drug delivery systems have become an alternative strategy for cancer treatment. Whereas, increasing studies find that the utilization of drug carriers may result in poor biocompatibility,lower drug loading capacity and unpredictable side reactions. Therefore, we herein reported selfassembledmicelles based on herbal product ginsenosides, which are the main active ingredients ofPanax ginseng C.A. The ginsenosides-based micelle system exerts excellent biosafety, better stability, highdrug capacity, and lower cytotoxicity compared to free ginsenosides. Meanwhile, ginsenosides micellesexhibits superior inhibitory effects on cancer cell adhesion activity, especially the expression of intercellularadhesion molecule-1, which is the critical factor of cancer metastasis. Importantly, ginsenosidesmicelles results in remarkably therapeutic efficacy on lung metastasis of liver cancer. All these resultshighlight the potential utilization of ginsenosides micelles in the clinic. Meanwhile, the carrier-freenano-drugs self-delivery system of ginsenosides showed great promise to become an emerging approachfor cancer metastasis therapy.
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