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      • KCI등재

        Young Patients with Hormone Receptor-Positive Breast Cancer Have a Higher Long-Term Risk of Breast Cancer Specific Death

        Jianfei Fu,Chenhan Zhong,Lunpo Wu,Dan Li,Tiantian Xu,Ting Jiang,Jiao Yang,Jinlin Du 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1

        Purpose: Although it is widely accepted that hormone receptor (HR) status is associated with later post-diagnostic periods, a debate exists as to whether the association is independent of age. The aim of our study was to confirm the impact of HR status on later period breast cancer-specific death (LP-BCSD) and later period non-breast cancer-specific death (LP-non-BCSD) in different age subgroups. Methods: Surveillance, Epidemiology, and End Results databases were utilized to identify 181,108 breast cancer patients with > 5 years survival. The cumulative incidence of LP-BCSD and LP-non-BCSD was calculated using the Gray method. The subdistribution hazard ratio (SHR) of variables was estimated via the Fine and Gray proportional hazard regression model. Subgroup analyses for LP-BCSD and LP-non-BCSD were performed according to the HR status. Results: The risk of LP-BCSD was exceeded by that of LP-non-BCSD at > 5 years since the diagnosis, particularly in old women. The competing risk regression model indicated that hormone receptor-positive (HR+) was an independent factor for more LP-BCSD (hazard ratio, 1.54; 95% confidence interval, 1.44–1.54; p < 0.001). However, stratified analysis indicated that HR+ was only associated with more LP-BCSD in the young women subgroup. Although HR+ was associated with more LP-non-BCSD, the predictive value of HR+ for LP-non-BCSD was eliminated after adjusting for age. Conclusions: HR+ was related to LP-BCSD in the premenopausal population. LP-BCSD should be an optimal endpoint in future trials designed to evaluate the role of extended adjuvant endocrine therapy.

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        Comprehensive analysis of acid gases on mercury removal by CuCl2 modified char exposure to oxy-fuel environment: Experiment and XPS perception

        Zeng Qingshan,Wang Hui,Wu Jingmao,Ran Hengyuan,Yang Kang,Wu Jianfei 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.12

        In this work, 0.15 mol/L CuCl2 solution was used to impregnate rice husk char. Experiments were conducted in a laboratory-scale fixed-bed reactor to investigate the oxidation mechanism of Hg0 by acidic gases. The effects of acid gases (SO2, HCl and NO) atmospheres on the mercury removal efficiency of the adsorbent were studied by FTIR, XPS and experiments. The FTIR results showed that the surface of the prepared rice husk char adsorbent contained a large amount of Cu2+ and chlorine-containing functional groups. The XPS results showed that the Cu+ on the surface of the adsorbent increased after mercury adsorption. This work shows that the inhibitory effect of SO2 on Hg removal is reflected in the blockage of the pore structure on the adsorbent surface; the competitive adsorption of O2 needed for the generation of C-O*, the formation of an acid mist by SO2 hinders the contact of Hg0 with the active site. The promotion of HCl is due to the production of active chlorine substances (Cl*) to promote the oxidation of Hg0 to HgCl, HgCl2 and HgO. And introduction of NO will react with O2, while generation of NO2 is beneficial to the oxidation of Hg0 to HgO and Hg(NO3)2. The optimum mercury removal efficiency of the adsorbent is nearly 100% under certain conditions.

      • KCI등재

        Multi‑amplitude voltage vector MPTC for dual three‑phase PMSMs with low torque ripple

        Shuang Wang,Qianru Zhang,Deliang Wu,Jianfei Zhao 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.1

        In model predictive torque control (MPTC), voltage vectors with a fixed amplitude have poor performance in torque tracking. In this paper, a multi-amplitude MPTC (MA-MPTC) method for dual three-phase permanent magnet synchronous motor (PMSM) is proposed, which can effectively reduce torque ripple by combining virtual voltage vectors (VVVs) and actual voltage vectors (AVVs). First, the deadbeat (DB) technique is used to simplify voltage vector selection and to avoid the enumeration of all the possible voltage vectors. After calculating the reference voltage vector (RVV) using this method, four vectors with different amplitudes can be selected as candidate voltage vectors (CVVs) according to the angle of the RVV. Then a new cost function is used to calculate the four candidate vectors, and the vector that minimizes the cost function is the optimal vector. Therefore, the MA-MPTC strategy has the advantages of both the MPTC method and the DB method, which can effectively reduce the torque ripple with a low computational cost. In addition, VVVs are used to reduce the influence of harmonic currents while suppressing torque ripple. Finally, the stability and dynamic response are investigated on the test bench. When compared with a contrast method, the torque ripple is reduced by nearly half and the advantage of fast response is maintained. The experimental results confirm the effectiveness of the proposed method.

      • KCI등재

        Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA

        Chunping Yu,Yi Zhang,Ning Wang,Wensu Wei,Ke Cao,Qun Zhang,Peiying Ma,Dan Xie,Pei Wu,Biao Liu,Jiahao Liu,Wei Xiang,Xing Hu,Xuewen Liu,Jianfei Xie,Jin Tang,Zhi Long,Long Wang,Hongliang Zeng,Jianye Liu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1

        Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-adherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.

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