http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
PE-137: Short Term Life Style Modification Can Improve Fatty Liver in Donor Candidates
( Kyung Chul Yoon ),( Kwang-woong Lee ),( Ok-kyung Kim ),( Sanghee Song ),( Suk Kyun Hong ),( Sung-woo Ahn ),( Hyo-sin Kim ),( Jin Yong Choi ),( Hyeyoung Kim ),( Nam-joon Yi ),( Kyung-suk Suh ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Purpose: It has been known that mild fatty liver grafts (<30%) do not have a significant impact on liver function and liver regeneration. However, NAFLD is related NASH and its general incidence has been reported upto 50% in general population. To reduce both donor and recipient``s risk, we have considered the donor``s liver with even mild fat fraction and inflammatory changes in preoperative liver biopsy. Methods: MRI is used for the decision for undergoing a biopsy and measuring of fat fraction. Even though fat fraction is mild, if it is greater than 5-10%, biopsy is undertaken considering the donor``s age and GRWR, the recipient``s liver function, and emergency status to check for NAFLD, NASH. If the above results are mild and the recipient``s status is not an emergency, we encouraged the donor to exercise. Follow up MRI and biopsy was done to check the changes in fat fraction and once again the recipient``s emergency status was checked to decide whether or not to proceed with the surgery. Moderate or severe degree of fat fraction were determined to be unsuitable for donation. Results: A total of 776 patients underwent donor workup for 588 patients waiting for liver transplantation between July of 2011 and June of 2015. A total of 65 patients had more than 5% fatty liver in CT or MRI, and from the 65 patients 19 patients had moderate to severe fatty liver and were determined to be unsuitable for donation. Out of the 45 patients who had mild fatty liver 13 patients`` biopsy showed more than 10% macrovesicular change and we encouraged life style modification for those 13 patients. Except only one patient, 12 patients were improved their fat fraction and biopsy result. About 45 to 119 days of life style modification by diet and exercise. these patients lost an average of 5.2 kg. Macrovesicular fatty change was reduced from 10-35% to 0-10% of these patients. Weight loss resulted mostly in reduction of macrovesicular change and also in reduction of inflammatory, fibrotic changes. Conclusion: In most of these patients about 2 to 3 months of life style modification resulting in weight loss lowered the fat fraction and changes of inflammation, fibrosis. Thus, it is important to educate and prepare the patients who are preparing for liver donation for liver transplantation.
Life of T Follicular Helper Cells
Suh, Woong-Kyung Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.3
Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases. In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.
서경도,김진웅 한국공업화학회 1998 응용화학 Vol.2 No.2
Seeded dispersion polymerization of monodisperse polystyrene particles crosslinked with the urethane acrylate was carried out to obtain highly crosslinked composite particles. A thermodynamic model of this system was designed and compared with the experimental results. It was found that the effective absorption of the 2^nd monomer (divinylbenzene (DVB)) to the seed particles mainly depended on the sizes of seed particles and the DVB monomer droplets. Therefore, when small DVB emulsions were prepared, the DVB monomer was possibly diffused into the seed particles to about 60 times. Finally highly crosslinked large polymer particles were obtained.