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Woo Bin Yun,Hye Ryeong Kim,Ji Eun Kim,Jun Young Choi,Mi Rim Lee,Jin Ju Park,Bo Ram Song,Young Suk Jung,Hyun Keun Song,Joon Young Cho,Kil Soo Kim,Dae Youn Hwang 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.2
C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. To compare the fertilization rates of C57BL/6NKorl mice with two commercial C57BL/6N stocks, differences in reproductive organ structures, sperm and egg numbers, fertilization rates, and embryo development rates among C57BL/6NKorl (Korea FDA source), C57BL/6NA (USA source), and C57BL/6NB (Japan source) mice were determined. Among the stocks, no significant differences were detected in organ weight and histological structure of male and female reproductive organs, although body weight was higher in C57BL/6NKorl mice than that in the other groups. The concentration and morphology of sperm and eggs in C57BL/6NKorl mice were similar to those of C57BL/6NA and C57BL/6NB mice. Furthermore, the three stocks had similar in vitro fertilization and embryo development rates, although these rates tended to be higher in C57BL/6NB mice. Pup body weight was higher in C57BL/6NKorl and C57BL/6NB mice than that in C57BL/6NA mice. The results of the present study suggest that C57BL/6NKorl, C57BL/6NA, and C57BL/6NB mice obtained from three different sources have similar fertilization and embryo development rates, although there were slight differences in the magnitude of their responses rates.
Seung-Woo Son,Jung Ho Park,Ji-Min Baek,Do-Kwyn Kim,Seung Ryul Lee,Sang-Moon Lee,Jieon Yoon,Jungtaek Kim,Woo-Bin Song,Sunjung Kim,Dong Suk Shin,Yihwan Kim,Seung Heon Shin,Tae-Woo Kim,Jung-Hee Lee,Dae-H IEEE 2017 IEEE electron device letters Vol.38 No.6
<P>In this letter, we have investigated the properties of In0.53Ga0.47As quantum-well (QW) metal-oxide-semiconductor field-effect-transistors (MOSFETs) on a 300-mm(100) Si wafer. We have explored the impact of scaling down In0.53Ga0.47As channel thickness (t(ch)) from 15 to 5 nm. The fabricated devices show excellent electrostatic integrity, such as subthreshold-swing (SS) < 80 mV/decade and drain-induced barrier-lower (DIBL) < 20 mV/V. Furthermore, we have extracted the effective mobility (mu(n_eff)) of the fabricated devices to investigate the carrier transport properties of the InGaAs MOSFETs with different values of t(ch). The device with t(ch) = 15 nm displayed a value of mu(n_eff) = 2, 190 cm(2)/V-s at room temperature. This value was found to decrease as tch was scaled down.</P>
공공 흡연장에서의 흡연 중 침 뱉기가 흡연장 주변 바닥의 미생물 오염도 변화와 미생물 확산에 미치는 영향
양성우(Sung Woo Yang),여승현(Seung Hyeon Reo),김승준(Seung Jun Kim),조정욱(Jeong Wook Jo),최용근(Yong-Keun Choi),송학진(Hak Jin Song),오경빈(Kyung Bin Oh),이주연(Ju Yeon Lee),정윤석(Yunseok Jung),김형주(Hyung Joo Kim) 대한환경공학회 2021 대한환경공학회지 Vol.43 No.11
목적 : 본 연구의 목적은 공공 흡연장에서 흡연 중 바닥에 직접 침을 뱉는 행위가 공중위생에 미치는 영향을 조사하는 것이다. 이 연구를 통하여 향후의 공중위생과 환경을 위해 흡연장에서의 세균 농도와 세균의 확산을 평가하였다. 방법 : 흡연 구역에서 침 뱉는 횟수와 침 뱉는 위치를 관찰자들이 시각적으로 측정하였다. 미생물 분석을 위해 거름종이(5 × 5 cm)를 일정한 시간 동안 흡연 구역의 바닥 표면에 부착하여 샘플을 채취하였다. 샘플을 채취한 거름종이를 이용하여 ATP bioluminescence (RLU), Colony forming unit (CFU)를 측정하였다. 흡연장에서 침 뱉는 행위를 통한 미생물의 확산을 확인하기 위해 흡연장에서 침이 존재하는 거름종이를 선정하여 형광분말(0.01 g/㎠)을 거름종이에 도포하였다. 4시간 후에 흡연장 주변의 거름종이를 수거하여 거름종이의 형광량(RFU, Relative Fluorescence Unit)을 측정하였다. 결과 및 토의 : 흡연장 바닥의 침 뱉는 행위와 그에 따른 흡연장 바닥의 미생물 활성이 명확한 관계가 있다는 결과를 보여주었다. 시료를 채취한 A 구역의 경우, 점심시간에 가장 많은 침 뱉는 횟수(102 ± 16회)가 흡연통 주변에서 관찰되었다. 이때 흡연을 하면서 침을 뱉는 흡연통 근처의 15개 구역에서 채취한 시료의 평균 RLU는 5,139 ± 1,267로 측정되었다. 또한 흡연장 주변 RLU 측정 시, 흡연통으로부터 11 m, 17 m 떨어진 곳에서 가장 낮은 값이 확인되었으며(1,329 ± 148 RLU, 1,204 ± 203 RLU), 이 장소는 흡연 및 침 뱉기가 발생하지 않은 곳으로 확인되었다. 시료를 채취한 B 구역의 경우는 저녁 시간에 가장 많은 침 뱉는 횟수(45 ± 6회)가 관찰되었다. B 구역의 흡연을 하면서 침을 뱉는 흡연통 근처 15개의 장소 RLU는 5,274 ± 1,297 RLU로 측정되었으며, 흡연통에서 11 m, 18 m 떨어진 곳에서 가장 낮은 RLU (1,181 ± 243 RLU, 1,148 ± 168 RLU)가 측정되었다. 이 구역 또한 흡연 및 침 또한 뱉지 않은 구역으로 확인되었다. 이상의 결과는 침 뱉는 행위 및 바닥의 침이 흡연장 바닥의 미생물 오염도에 영향을 준다는 것을 보여주고 있다. 형광분말 확산 분석 결과는 흡연장 표면에서 침의 존재가 흡연장으로부터 다른 지역으로 미생물의 확산을 유발할 수 있다는 것을 나타내고 있다. 결론 : 침을 뱉는 행위는 흡연장에 있는 흡연자들과 비흡연자들이 미생물에 감염될 수 있는 위험을 유발할 수 있다. 따라서 공중위생을 안전하게 유지하기 위해서는, 흡연 중 침 뱉기의 위험성에 대한 설명과 주의가 필요하다고 판단된다. Objectives : The purpose of this study was to investigate the effect of spitting behavior on microbial public health in smoking areas. Through this investigation, bacterial concentration and spread of bacteria from the smoking areas were evaluated for the prospective public health and environment. Methods : The number of spitting and the spitting location in the smoking areas were measured visually by observers. For the microbial analysis, filter papers (5 × 5 cm) as sample collectors had been attached to the surface of the smoking areas for a given time. Using the collected filter paper, ATP bioluminescence measurement (RLU), colony forming unit (CFU) were measured. For the estimation of spitting behaviors in the smoking area on the spread microorganisms, saliva containing filters were selected from the areas, and fluorescent powder (0.01 g/㎠) was added to the papers. After 4 hours, the papers around the smoking areas were collected and the fluorescence activity was measured. Results and Discussion : The results showed that there was a clear relationship between the spitting behavior and the microbial activity in the smoking areas. In the case of sampling area A, the highest number of spitting was observed at the lunch hour (102 ± 16 times), and the RLU from the sample collected near the smoking area showed about 5,139 ± 1,267 RLU. When the RLU around the smoking area was measured, the lowest values were found at distance of 11 and 17 m from the cigarette bin (1,329 ± 148 and 1,204 ± 203 RLU), and it was confirmed that smoking and spitting did not occur at this sampling points. In the case of sampling area B, the highest number of spitting (45 ± 6 times) was observed at evening hour, and the RLU from the sample collected near the smoking area showed about 5,274 ± 1,297 RLU. The lowest value was in the sampling area B shown at 11 and 18 m (1,181 ± 243 RLU and 1,148 ± 168 RLU) from the cigarette bin, and it was also confirmed that smoking and spitting did not occur at this sampling points. The results indicate that the spitting during the smoking induced the increases of the microbial contamination of the public environment. The fluorescence powder diffusion analysis indicated that the saliva on the ground surface would enhance the spread of the microorganisms from the smoking area. Conclusions : Spitting in smoking areas can pose a high risk of microbial infection for smokers and non-smokers in smoking areas. Thus extensive and systematic attention related to the smoking manner must be paid to protect our public health.
Song, Joon Young,Cheong, Hee Jin,Seo, Yu Bin,Kim, In Seon,Heo, Jung Yeon,Noh, Ji Yun,Choi, Won Suk,Kim, Woo Joo National Institute of Infectious Diseases 2013 Japanese journal of infectious diseases Vol.66 No.1
<P>Vancomycin-resistant enterococci (VRE) strains with the VanD phenotype and vanA genotype (VanD-vanA) have been reported in Asian countries. The VanD phenotype is characterized by low-level resistance to vancomycin and susceptibility or intermediate resistance to teicoplanin. We retrospectively determined the risk factors, clinical outcomes, and virulence factors for VanD-vanA VRE (20 patients colonized with Enterococcus faecium) compared to VanA-vanA VRE (20 patients colonized with E. faecium). Multiple VRE colonizations and recent glycopeptide use were related to the presence of the VanA phenotype. There were no significant differences between patients colonized with VanD-vanA VRE and VanA-vanA VRE for duration of hospital stay, duration of intensive care unit stay, or hospital mortality. The esp gene was identified from all enterococci, while 90% of VanD-vanA VRE isolates and 95% of VanA-vanA VRE isolates were positive for the hyl gene. VanA-vanA VRE was subsequently isolated from sequential samples in 8 of 20 patients (40%) with VanD-vanA VRE. All of these patients had received glycopeptides during the interval between sample collection, and 2 of 8 paired isolates (VanD-vanA VRE and VanA-vanA VRE) were closely related subtypes according to pulsed-field gel electrophoresis analysis. In conclusion, VanD-vanA VRE isolates might represent an unstable, heterogeneous population that can convert to the VanA phenotype after exposure to glycopeptides.</P>
Song, Young Hyun,Kwon, Seok Bin,Jung, Mong Kwon,Park, Won Kyu,Yoo, Jung Hyeon,Lee, Chul Woo,Kang, Bong Kyun,Yang, Woo Seok,Yoon, Dae Ho Elsevier 2018 Ceramics international Vol.44 No.1
<P><B>Abstract</B></P> <P>We report on the fabrication of a YAG: Ce<SUP>3+</SUP>/Al<SUB>2</SUB>O<SUB>3</SUB> ceramic converter (YAGC) under various conditions for use in laser diode (LD)-based automotive lighting applications. The prepared YAGC shows improved luminous characteristics regarding the use of a pore forming agent and a change in the fabrication method. In particular, when the fabrication method of the YAGC changes, an area with a yellow ring is reduced to 37.4% compared to previous fabrication methods. The results of the study indicate that the change in the YAGC fabrication method can result in an alternative for high-quality YAGC fabrication for automotive lighting applications.</P>
Song, Joon Young,Cheong, Hee Jin,Hyun, Hak Jun,Seo, Yu Bin,Lee, Jacob,Wie, Seong-Heon,Choi, Min Joo,Choi, Won Suk,Noh, Ji Yun,Yun, Jae Won,Yun, Jin Gu,Kim, Woo Joo Elsevier Ltd. 2017 Vaccine Vol. No.
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Concomitant administration of influenza and pneumococcal vaccines could be an efficient strategy to increase vaccine uptake among older adults. Nevertheless, immune interference and safety issues have been a concern when more than one vaccines are administered at the same time.</P> <P><B>Methods</B></P> <P>Subjects aged ⩾60years were randomized in a 1:1:1 ratio to receive MF59-adjuvanted trivalent inactivated influenza vaccine (MF59-aTIV)+13-valent pneumococcal conjugate vaccine (PCV13) (Group 1), PCV13 alone (Group 2), or MF59-aTIV alone (Group 3). Hemagglutination inhibition (HI) and opsonophagocytic activity (OPA) assays were used to compare immunogenicity after single or concomitant vaccination.</P> <P><B>Results</B></P> <P>A total of 1149 subjects (Group 1, N=373; Group 2, N=394; Group 3, N=382) were available for the assessment of immunogenicity and safety. All groups met immunogenicity criteria for the influenza vaccine in older adults with similar seroprotection rates, seroconversion rates, and geometric mean titer (GMT) fold-increases, irrespective of concomitant vaccination. For each pneumococcal serotype, OPA titers increased markedly after the PCV13 vaccination, irrespective of the concomitant influenza vaccination. After concomitant administration, the non-inferiority criteria of GMT ratios were met for all three influenza subtypes and 13 pneumococcal serotypes. No vaccine-related serious adverse events occurred.</P> <P><B>Conclusions</B></P> <P>Concomitant MF59-aTIV and PCV13 administration showed no interference with antibody response and showed good safety profiles.</P> <P>(Clinical Trial Number – NCT02215863).</P> <P><B>Highlights</B></P> <P> <UL> <LI> No immune interference was observed when PCV13 and MF59-aTIV were given together. </LI> <LI> The immunogenicity criteria of influenza vaccine was met irrespective of concomitant vaccination. </LI> <LI> Concomitant vaccination showed good safety profiles. </LI> </UL> </P>
Study on Application of Piezoelectricity to Korea Train eXpress (KTX)
SONG, DANIEL,YANG, CHAN HO,HONG, SEONG KWANG,KIM, SE BIN,WOO, MIN SIK,SUNG, TAE HYUN Gordon and Breach 2013 Ferroelectrics Vol.449 No.-
<P> In this study, we have investigated application of piezoelectricity to actual commercially operating high-speed Korean train. We recorded and analyzed the vibrations of commercial Korea Train eXpress (KTX). We experimented with different cantilever beam thicknesses (0.25 mm, 0.6 mm, and 1.0 mm) and different piezoelectric material dimensions (length × width × thickness, 10.0 mm × 10.0 mm × 0.5 mm, 20.0 mm × 10.0 mm × 0.5 mm, and 30.0 mm × 10.0 mm × 0.5 mm) on real data from recorded random frequencies and train vibration amplitudes. The addition of tip masses on the cantilever beam decreased the resonance frequency range when the vibrations were constant but not when they were random. The optimal condition was experimentally found, to involve decreasing the piezoelectric substrate beam thickness and increasing the piezoelectric substrate beam area rather than merely increasing the tip mass. The most effective method to improve the operational sensitivity was combination of decreasing the resonance frequency by adding tip masses, decreasing beam thicknesses, and increasing beam areas. </P>