금호강수계 수질과 하천유역의 토양 및 농작물의 중금속루 오염에 관한 연구(II)

金相烈,李萬正,趙康烈,崔閏壽,石敬順,禹美姬,李蘭姬 대구효성 가톨릭 대학교 1984 연구논문집 Vol.29 No.2

Soil are mostly sandy and it has a little clay below 10%. In the fine sand fraction, quartz, plagioclase and alkali-feldspar are dominant in almost all samples. Small amounts of altered-feldspar, muscovite, biotite, hornblende and plant opal are present in some samples. They are mainly derived from weathering prodructs df granite, granodiorite and arkose or is mixture. The clay minerals are mainly expanding or nonexpanding 14A˚minerals, illite and kaolin minerals. Nonexpanding 14A˚minerals seems to be dioctahedral vermicurite which sandwiches gibbsite or chlorite.

스킨 큐레이션을 위한 인공지능 학습 데이터베이스 구축 방안 연구

남현우(Nam, Hyun Woo) 한국전시산업융합연구원 2020 한국과학예술융합학회 Vol.38 No.4

본 연구는 뷰티테크 산업중에서 스킨과 관련된 인공지능 학습 데이터베이스 설계에 따른 방향성을 도출하는데 목표가 있다. 본 논문의 방법은 문헌분석과 집단심층면접(FGI) 방법을 이용하였다. 본 연구의 범위는 인공지능 학습데이터 중에서 스킨 큐레이션에 사용되는 인공지능 학습 DB 구축에 필요한 접근 방법과 프로세스를 연구의 범위로 한정하였다. 연구 결과 및 내용은 다음과 같이 진행되었다. 스킨인공지능 학습 DB 구축을 수립하기 위해 3가지 방안을 제안하였다. 첫째, 국내외 인공지능 학습 DB의 현황과 뷰티 산업의 인공지능 개발 현황을 분석하여, 향후 연구 개발의 방향성을 구축하였다. 둘째, 뷰티 산업에서 스킨 인공지능 학습 DB를 구축하기 위해서는 머신러닝의 확장된 CNN+RNN 알고리즘을 통해 접근을 제안하는 방법을 제안하였다. 셋째, 스킨 인공지능학습 DB 구축을 위한 VQA 데이터셋의 형태, 규모, 획득, 가공, 활용, 검증 등을 방향성을 제안하였다. 본 연구의 결과에서 도출된 스킨 인공지능 학습 DB구축에 대한 방향성은 스킨 인공지능 딥러닝 개발에 활용 가능하며, 인공지능 산업적, 경제적, 기술적 측면에서 융합적 기여를 할 것이다. This study aims to draw directionality in accordance with the construction of artificial intelligence(AI) learning database related to skin in beauty tech industry. This study used literature review and focus group interview(FGI) methods. Scope of study was limited to the approach methods and processes necessary to construct AI learning DB used in skin curation. Result and contents of the study are as follows. 3 plans were suggested to construct AI learning DB for skin curation. First, current status of AI learning DB in Korea and abroad and AI development status in beauty industry were analyzed to establish the directionality of future research and development. Second, in order to construct skin AI learning DB in beauty industry, an approach through extended CNN+RNN algorithm of machine learning was suggested. Third, directionality for form, size, acquisition, processing, utilization, and verification of VQA data set to construct skin AI learning DB was suggested. Directionality of skin AI learning DB drawn in the result of this study may be utilized in the development of skin AI deep learning, and will make convergent contribution in terms of AI industry, economy, and technology.

Correlation Between Response to Induction chemotherapy and Subsequent Radiotherapy in Previously Untreated Patients with Squamous Cell Carcinomas of the Head and Neck

Woo Yoon Park(박우윤),Seong Yul Yoo(류성렬),Kyong Hwan Koh(고경환),Chul Koo Cho(조철구),Young Hwan Park(박영환),Youn Sang shim(심윤상),Kyung Kyoon Oh(오경균),Yong Sik Lee(이용식) 대한방사선종양학회 1990 Radiation Oncology Journal Vol.8 No.2

유도화학요법과 방사선치료후 종양 관해의 상호 관련성을 파악하고자 1986년부터 1989년까지 원자력병원에서 소정의 충분한 유도화학요법과 근치적 방사선치료를 받은 국소적으로 진행된 두경부 악성종양 환자 60예에 대한 후향적 분석을 시도하였다. 유도화학요법은 CDDP를 기본으로한 복합요법을 2내지 3회 시행한바, 20에에서 Bleomycin + CDDP(BP), 37예에서 5-FU+CDDP(FP), 그리고 3예에서 BP/FP의 교대요법을 시행하였으며, 방사선은 병소에 따라서 65Gy 내지 75GY 또는 그 이상을 조사하였다. 유도화학요법에 의한 종양의 관해율은 원발병소에서는 80%(48/60), 경부임파절에서는 79%(31/39)였으며, 약제, T-병기, 그리고 N-병기에 의한 통계적 유의성은 관찰되지 않았다. 방사선조사 6개월후 원발부위에서는 67%(40/60)의 완전관해를, 경부임파절에서는 77%(30/39)의 완전관해를 보인바, 이를 유도화학요법에 의한 관해 유무에 따른 차이를 분석한 결과 원발부위에서는 유도화학요법에 의한 관해(완전관해 또는 부분관해)를 얻었던 48예중 39예에서 완전관해를 얻었으나(81%), 관해를 얻지 못한 12예에서는 1예에서만이 방사선 치료에 의해 완전관해를 얻을 수 잇었으며(8%)(p<0.0005), 경부임파절에서는 유도화학요법에 의해 관해를 얻었던 32예중 28예에서 완전관해를 얻은 반면(90%), 관해를 얻지 못한 8예에서는 2예에서만이 방사선 치료에 의해 완전관해를 얻을 수 있었던바 (25%)(p<0.001), 모두 통계적으로 유의한 차이를 보였다. 한편 이를 원발부위, T-병기 그리고 N-병기에 따라 분석해본 결과, 특히 T-병기중 T3,4에서는 유의한 차이가 관찰되었으나 (p<0.0005), T1,2에서는 유의한 차이가 관찰되지 않았다(0.3<p). 따라서 유도화학요법과 방사선치료에 의한 종양의 관해정도는 대체적으로 상호연관성이 관찰되고 있으나, 초기 병변에서는 이러한 현상이 관찰되지 않는바 유도화학요법에 의해 관해가 없더라도 방사선 치료에 의해 완전관해를 얻을 수 있을 것이다. To determine the correlation between the response to induction chemotherapy and subsequent radiotherapy we analyzed the clinical records of 60 patients with locally advanced carcinoma of the head and neck retrospectively who had completed a full course(2~3 cycle) of induction chemotherapy and curative radiotherapy in Korea Cancer Center Hospital between 1986 and 1989. Chemotherapy was administered with CDDP+Bleomycin (BP)in 20, CDDP+5-FU(FP) in 37, and hybrid of BP and FP in three patients. Radiotherapy was given conventionally with a dose of 65 to 75 Gy or more over seven to eight weeks according to the size of lesion. Response rates following induction chemotherapy were 80% for the tumors and 79% for the nodes whereas complete response rates were 12% and 13%, respectively. Six months after radiotherapy 67% of the the tumors and 77% of the nodes achieved a complete response. Among the 48 tumor responders and the 31 nodal responders to chemotherapy. 39(81%) and 28(90%), respectively, achieves complete response ofter radiotherapy. Thus, whether or not the tumor and node respond to induction chemotherapy was predictive of the response to subsequent radiotherapy (p<0.0005 in tumor, p<0.0001 in node). By reanalyzing according to disease (p>0.3). Therefore the tumor of node's response to induction chemotherapy is a predictor for subsequent radiotherapy except in T1-t2 tumors, and complete response to radiotherapy can be expected despite the failure of induction chemotherapy in T1-T2 tumors.

자살 기도자와 우울환자의 스트레스 비교에 관한 연구

윤방부,이혜리,곽기우,오미경,이장희,박계열,이선권 대한가정의학회 1991 Korean Journal of Family Medicine Vol.12 No.1

A variant block-based comparative genomics method for the detection of functional loci in soybeans

Yul Ho Kim,Tae-Young Hwang,Hyang Mi Park,Seuk Ki Lee,Man Soo Choi,Seung woo Hwang,Kwang Ho Jeong,Min Jung Seo,Hong Tai Yun,Sun Lim Kim,Young-Up Kwon,Ho-Sung Yoon,Suk-Ha Lee,JongBhak,Sunghoon Lee 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Although much effort has been made to find agronomically important loci in the soybean plant, extensive linkage disequilibrium and genome duplication have limited efficient genome-wide linkage analyses that can identify important regulatory genes. In this respect, recombination block-based analysis of cultivated plant genomes is a potential critical step for molecular breeding and target locus screening. We propose a new three-step method of detecting recombination blocks and comparative genomics of bred cultivars. It utilizes typical reshuffling features of their genomes, which have been generated by the recombination processes of breeding ancestral genomes. To begin with, mutations were detected by comparing genomes to a reference genome. Next, sequence blocks were examined for likenesses and difference with respect to the reference genome. The boundaries between the blocks were taken as recombination sites. All recombination sites found in the cultivar set were used to split the genomes, and the resulting sequence fragments were named as core recombination blocks (CRBs). Finally, the genomes were compared at the CRB level, instead of at the sequence level. In the genomes of the five Korean soybean cultivars used, the CRB-based comparative genomics method produced long and distinct CRBs that are as large as 22.9 Mb. We also demonstrated efficiency in detecting functionally useful target loci by using indel markers, each of which represents a CRB. We further showed that the CRB method is generally applicable to both monocot and dicot crops, by analyzing publicly available genomes of 31 soybeans and 23 rice accessions.

Comparison of Several Leaf Morphological Traits between the Two DH Populations in Chinese Cabbage

Yul-Kyun Ahn,Moo-Kyoung Yoon,Jong-Gyu Woo,Myeong-Cheoul Cho,Hye-Eun Lee,Young-Il Cho 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.10

Both endurance- and resistance-type exercise prevents neurodegeneration and cognitive decline in mice with impaired glucose tolerance

Woo, Jinhee,Shin, Ki-Ok,Park, Chan-Ho,Yoon, Byung-Kon,Kim, Do-Yeon,Bae, Ju-Yong,Lee, Yul-Hyo,Ko, Kangeun,Roh, Hee-Tae The Korean Society of Applied Science and Technolo 2019 한국응용과학기술학회지 Vol.36 No.3

The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). HOMA-IR was significantly higher in IGT group than CO group (p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group (p < 0.05), while beta-amyloid ($A{\beta}$) was significantly higher in IGT group than in CO group (p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups (p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.

Both endurance- and resistance-type exercise prevents neurodegeneration and cognitive decline in mice with impaired glucose tolerance

Jinhee,Woo,Ki-Ok,Shin,Chan-Ho,Park,Byung-Kon,Yoon,Do-Yeon,Kim,Ju-Yong,Bae,Yul-Hyo,Lee,Kangeun,Ko,Hee-Tae,Roh 한국응용과학기술학회 (구.한국유화학회) 2019 한국응용과학기술학회지 Vol.36 No.3

The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). HOMA-IR was significantly higher in IGT group than CO group ( p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group ( p < 0.05), while beta-amyloid (Aβ) was significantly higher in IGT group than in CO group ( p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups ( p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.

Consoramides A-C, New Zwitterionic Alkaloids from the Fungus Irpex consors

( Ji-yul Kim ),( Dae-won Ki ),( Yoon-ju Lee ),( Lee Su Ha ),( E-eum Woo ),( In-kyoung Lee ),( Bong-sik Yun ) 한국균학회 2021 Mycobiology Vol.49 No.4

In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C₁₈ cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A-C (1-3).

제초제저항성 유전자가 도입된 유전자 변형 ‘삼척마늘’의 형태적 특성

안율균(Yul Kyun Ahn),박미희(Me Hae Park),우종규(Jong Gyu Woo),이혜은(Hye Eun Lee),김정호(Jeong Ho Kim),윤무경(Moo Kyoung Yoon) 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.10