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Surface Plasmon Resonance Immunosensor for Detection of Legionella pneumophila
Oh, Byung-Keun,Lee, Woochang,Bae, Young-Min,Lee, Won-Hong,Park, Jeong-Woo The Korean Society for Biotechnology and Bioengine 2003 Biotechnology and Bioprocess Engineering Vol.8 No.2
An immunosensor based on surface plasmon resonance (SPR) onto a protein G layer by Self-assembly technique was developed for detection of Legionella pneumophila. The protein G layer by self-assembly technique was fabricated on a gold (Au) surface by adsorbing the 11-mercaptoundecanoic acid (MUA) and an activation process for the chemical binding of the free amino (-NH$_2$) of protein G and 11-(MUA) using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDAC) in series. The formation of the protein G layer by self-assembly technique on the Au Substrate and the binding of the antibody and antigen in series were confirmed by SPR spectroscopy. The Surface topographies of the fabricated thin films on an Au substrate were also analyzed by using an atomic force microscope (AFM). Consequently, an immunosensor for the detection of L. pneumophila using SPR was developed with a detection limit of up to 10$^2$CFU per mL.
Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms
Oh Young Bang,Jong-Won Chung,Mi Ji Lee,Woo-Keun Seo,Gyeong-Moon Kim,Myung-Ju Ahn,OASIS-Cancer Study Investigators 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1
Systemic cancer and ischemic stroke are common conditions and two of the most frequent causes of death among the elderly. The association between cancer and stroke has been reported worldwide. Stroke causes severe disability for cancer patients, while cancer increases the risk of stroke. Moreover, cancer-related stroke is expected to increase due to advances in cancer treatment and an aging population worldwide. Because cancer and stroke share risk factors (such as smoking and obesity) and treatment of cancer can increase the risk of stroke (e.g., accelerated atherosclerosis after radiation therapy), cancer may accelerate conventional stroke mechanisms (i.e., atherosclerosis, small vessel disease, and cardiac thrombus). In addition, active cancer and chemotherapy may enhance thrombin generation causing stroke related to coagulopathy. Patients with stroke due to cancer-related coagulopathy showed the characteristics findings of etiologic work ups, D-dimer levels, and infarct patterns. In this review, we summarized the frequency of cancer-related stroke among patients with ischemic stroke, mechanisms of stroke with in cancer patients, and evaluation and treatment of cancer-related stroke. We discussed the possibility of cancer-related stroke as a stroke subtype, and presented the most recent discoveries in the pathomechanisms and treatment of stroke due to cancerrelated coagulopathy.
Achieving tolerant CO<sub>2</sub> electro-reduction catalyst in real water matrix
Won, Da Hye,Shin, Hyeyoung,Chung, Min Wook,Jung, Hyejin,Chae, Keun Hwa,Oh, Hyung-Suk,Hwang, Yun Jeong,Min, Byoung Koun Elsevier 2019 Applied Catalysis B Vol.258 No.-
<P><B>Abstract</B></P> <P>In order to achieve practical application of electrochemical CO<SUB>2</SUB> conversion technologies, the development of durable catalyst in real water matrix is essential because the use of catalysts only showing high performance within a well-refined environment cannot guarantee their feasibility in realistic conditions. Here, we report a design strategy for a catalyst, which shows excellent tolerance to deactivation factors, using a carbon-based material under more practical condition implemented by real tap water. Screening analyses on various components in tap water elucidated that the impurity group, which can be deposited on the catalyst surface and impede the active sites, such as copper, zinc, and especially iron are the main factors responsible for deactivation. Based on these findings, the structural modified nitrogen-doped carbon nanotube (denoted as ball mill N-CNT) was adopted as a catalyst design to secure durability. Consequently, the ball mill N-CNT revealed tolerance to the disclosed deactivation factors and showed stable performance during unprecedented long-time of 120 h in tap water media.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Electro-reduction of CO<SUB>2</SUB> was performed in real water matrix (tap water) conditions. </LI> <LI> Iron was found to be the most detrimental element in silver catalyzed CO<SUB>2</SUB> electro-reduction. </LI> <LI> Nitrogen doped carbon based material was designed to be a stable model catalyst in real water. </LI> <LI> Stable performance was tested for an unprecedented long-time of 120 h in tap water media. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Influence of Obesity on the Severity and Clinical Outcome of Acute Pancreatitis
( Keun Young Shin ),( Wan Suk Lee ),( Duk Won Chung ),( Jun Heo ),( Min Kyu Jung ),( Won Young Tak ),( Young Oh Kweon ),( Chang Min Cho ) 대한소화기기능성질환·운동학회 2011 Gut and Liver Vol.5 No.3
Background/Aims: Obesity tends to be associated with increased mortality and morbidity in acute pancreatitis. However, in Asian populations, higher morbidity and mortality have been reported in patients with low body mass indexes (BMIs). This study was undertaken to evaluate the relation between obesity and outcome, and to investigate the occurrence of complications by overweightedness in acute pancreatitis. Methods: The medical records of 403 patients with acute pancreatitis were reviewed retrospectively, and Ranson`s scores, modified Glasgow scores, Acute Physiology and Chronic Health Evaluation (APACHE) II scores and computed tomography severity indexes were calculated. Patients were categorized by BMI for the analysis. Results: When compared with normal patients (BMI 18.5 to 22.9), all categories with a BMI ≥23 had an increased risk of developing a severe form of acute pancreatitis (p=0.003) and all categories with a BMI ≥25 significantly predicted severity (p<0.001). Patients with class 1 obesity (BMI 25 to 29.9) developed significantly more systemic and metabolic complications. Conclusions: Overweightedness and obesity were found to be associated with a higher risk of developing severe pancreatitis. Further studies are needed to establish the precise prognostic value of obesity in members of the population with low BMIs. (Gut Liver 2011;5:335-339)
Geometric Transformation Invariant Fast Image Identifier
Won-Keun Yang,Ayoung Cho,In-su Won,Sang-Il Na,Weon-Geun Oh,Dong-Seok Jeong 한국멀티미디어학회 2008 한국멀티미디어학회 학술발표논문집 Vol.2008 No.2
Image identifier can be used in finding original images from the large database of geometrically transformed images. In this paper, geometric transformation invariant fast image identifier is introduced. Proposed identifier consists of three different features. Used features are color feature, texture feature by Modified Generalized Symmetry Transform and angular partitioning feature. Each feature is quantized adaptively to compose three-dimensional histogram. For fast matching, pre-screening with bit-stream is used. Experimental results show that the proposed image identifier has good performance under various geometric transformations. And because of its fast matching, the proposed image identifier is very useful in real environment.
Oh, Hyung-Keun,Kim, Won-Kee,Kang, Ah-Rang,Kim, In-Seon,Lee, Hyang-Burm,Kim, Ik-Soo Korean Society of Sericultural Science 2010 International Journal of Industrial Entomology Vol.21 No.1
The perilla leaf pyralid moth, Pyrausta panopealis Walker (Lepidoptera: Pyralidae), is a serious pest damaging to leaf perilla. In order to establish the life parameters of P. panopealis for eventual purpose of control, the developmental span of each stage was investigated under five temperature regimes ($20^{\circ}C{\sim}30^{\circ}C$). The larval period of P. panopealis was longest as 26.8 days at $20^{\circ}C$ and shortened as temperature goes up to $30^{\circ}C$ as 11.3 days. Survivorship of the larval P. panopealis was the highest at $27.5^{\circ}C$ as 82.5%, whereas that of other temperatures ranged from 40% ($20^{\circ}C$) to 60.0% ($30^{\circ}C$), indicating that the P. panopealis appears to favor somewhat higher temperature. In addition to larval period, the duration of egg, prepupal, and pupal period also were shortened sharply as temperature goes up, whereas the duration of adult stage shortened a maximum of only two days as temperature goes up. After the perilla leaf pyralid moths were successfully stabilized in indoor environment the larvicidal efficacy of ten on-the-market environmentfriendly agricultural materials (EFAMs) that were previously selected from the result of other moth species was tested. Seven of the ten tested showed more than 90% of mortality within 12 hrs and reached nearly up to 100% within 24 hrs, but the remaining three showed less than ~70%.
Auricular Cartilage Regeneration with Adipose-Derived Stem Cells in Rabbits
Oh, Se-Joon,Park, Hee-Young,Choi, Kyung-Un,Choi, Sung-Won,Kim, Sung-Dong,Kong, Soo-Keun,Cho, Kyu-Sup Hindawi 2018 MEDIATORS OF INFLAMMATION Vol.2018 No.-
<P>Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investigate whether ASCs can promote the auricular cartilage regeneration in the rabbit. In order to assess their differentiation ability, ASCs were injected into the midportion of a surgically created auricular cartilage defect in the rabbit. Control group was injected with normal saline. After 1 month, the resected auricles were examined histopathologically and immunohistochemically. The expression of collagen type II and transforming growth factor-<I>β</I>1 (TGF-<I>β</I>1) were analyzed by quantitative polymerase chain reaction. Histopathology showed islands of new cartilage formation at the site of the surgically induced defect in the ASC group. Furthermore, Masson's trichrome staining and immunohistochemistry for S-100 showed numerous positive chondroblasts. The expression of collagen type II and TGF-<I>β</I>1 were significantly higher in the ASCs than in the control group. In conclusion, ASCs have regenerative effects on the auricular cartilage defect of the rabbit. These effects would be expected to contribute significantly to the regeneration of damaged cartilage tissue <I>in vivo</I>.</P>