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( Tae Jun Park ),( Keun Soo Ahn ),( Yong Hoon Kim ),( Hyungseop Kim ),( Ui Jun Park ),( Hyoung Tae Kim ),( Won Hyun Cho1 ),( Woo Hyun Park ),( Koo Jeong Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.1
Hepatopulmonary syndrome (HPS) is a serious complication of end-stage liver disease, which is characterized by hypoxia, intrapulmonary vascular dilatation, and liver cirrhosis. Liver transplantation (LT) is the only curative treatment modality for patients with HPS. However, morbidity and mortality after LT, especially in cases of severe HPS, remain high. This case report describes a patient with typical findings of an extracardiac pulmonary arteriovenous shunt on contrast-enhanced transesophageal echocardiography (TEE), and clubbing fingers, who had complete correction of HPS by deceased donor LT. The patient was a 16-year-old female who was born with biliary atresia and underwent porto-enterostomy on the 55th day after birth. She had been suffered from progressive liver failure with dyspnea, clubbing fingers, and cyanosis. Preoperative arterial blood gas analysis revealed severe hypoxia (arterial O2 tension of 54.5 mmHg and O2 saturation of 84.2%). Contrast-enhanced TEE revealed an extracardiac right-to-left shunt, which suggested an intrapulmonary arteriovenous shunt. The patient recovered successfully after LT, not only with respect to physical parameters but also for pychosocial activity, including school performance, during the 30-month follow-up period. (Clin Mol Hepatol 2014;20:76-80)
석탄 가스화를 통한 전력 생산과 DME 병산 공정에 대한 기초 경제성 분석
유영돈 ( Young Don Yoo ),김수현 ( Su Hyun Kim ),조원준 ( Won Jun Cho ),모용기 ( Yong Gi Mo ),송용택 ( Tae Kyong Song ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.6
석탄가스화를 기반으로 한 발전(IGCC 발전) 및 화학원료 제조공정의 상업화 관건은 화석연료인 원유 또는 천연가스를 기반으로 생산되는 경우와 비교하여 경제성을 확보할 수 있는지 여부이다. 경제성 확보를 위한 가장 현실적인 방법으로는 석탄 가스화를 통해 얻어진 합성가스로부터 2개 이상의 생산물(예: 발전과 화학원료를 동시 생산)을 병산(coproduction또는 poly-generation)하는 것이다. 본 연구에서는 석탄 가스화를 기반으로 하여 발전과 수송용, 발전용 및 가정용 연료로 사용이 가능한 DME(dimethyl ether)를 병산하는 공정에 대한 경제성 분석을 실시하였다. 경제성 분석을 위한 병산 공정에서는 250 MW 전력생산 연간 30만 톤의 DMZ 생산을 기준으로 하였다. 병산 공정에서 DME 판매가격이 50만원/ton인 경우, 전기 생산원가는 34.8~58.4원/kWh으로 SMP(계통한계가격) 가중평균인 150.69원/kwh(2013년 1월~12월까지의 평균값)의 33~58% 수준으로 산정되었다. 따라서, DME 판매가격이 적정하게 유지될 경우 석탄IGCC+DME 병산공정은 IGCC 단독 발전과 비교하여 경제성을 확보할 수 있을 것으로 판단된다. 현재 중국에서 DME판매가격이 900,000원/톤 내외이므로, 전력과 DME를 병산할 경우, IGCC 단독으로 전력을 생산할 경우와 비교하여 전력 생산 원가를 월등하게 낮출 수 있음을 알 수 있다. 이와 같이 석탄 가스화를 기반으로 한 병산 공정을 통해 전력과 DME를 병산하는 시스템에서, 시장 여건에 따라 전력과 DME 생산비율 제어가 가능하고, 석탄 가스화기 및 정제 시스템을 공통 설비로 활용함으로써, 개별적으로 생산하는 것보다 생산 원가를 낮출 수 있다는 결과를 얻었다. The key for the commercial deployment of IGCC power plants or chemical (methanol, dimethyl ether, etc.) production plants based on coal gasification is their economic advantage over plants producing electricity or chemicals from crude oil or natural gas. The better economy of coal gasification based plants can be obtained by co-production of electricity and chemicals. In this study, we carried out the economic feasibility analysis on the process of co-producing electricity and DME (dimethyl ether) using coal gasification. The plant’s capacity was 250 MW electric and DME production of 300,000 ton per year. Assuming that the sales price of DME is 500,000 won/ton, the production cost of electricity is in the range of 33~58% of 150.69 won/kwh which is the average of SMP (system marginal price) in 2013, Korea. At present, the sales price of DME in China is approximately 900,000 won/ton. Therefore, there are more potential for lowering the price of co-produced electricity when comparing that from IGCC only. Since the co-production system can not only use the coal gasifier and the gas purification process as a common facility but also can control production rates of electricity and DME depending on the market demand, the production cost of electricity and DME can be significantly reduced compared to the process of producing electricity or DME separately.
( Won Jong Oh ),( In Young Oh ),( Kapsok Li ),( Eun Joo Kim ),( Dae Yeon Cho ),( Kyu Han Kim ),( Seong Jun Seo ),( Chang Kwon Hong ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Since the report on the association of FLG mutations with atopic dermatitis(AD), genetic diversity of FLG mutation was intensively investigated for European and other ethnic populations. However, detailed analysis on the genetic diversity and its clinical implication of FLG mutation for East Asian ancestry was not performed, yet. Objectives: We study geographic distribution of FLG mutations in East Asia and evaluate clinical significance of FLG mutations in East Asian AD patients. Methods: We summarized data related to FLG mutations across East Asian countries, and then analyzed geographic distribution of FLG mutations in the light of human migration history in East Asia, and we investigated the association of FLG mutations with various clinical features of AD. Results: The distribution of FLG mutations among East Asian populations was consistent with hypothetical waves of human migrations along the southeastern coast of Asia.Similar to Europeans, FLG mutations were significant risk factor of AD for East Asian and palmar hyperlinearity was a useful clinical marker in screening carriers of FLG mutation, however, in contrast to European, FLG mutations do not increase the risk of concomitant asthma for East Asian. Conclusion: Genetic diversity of FLG mutation across EastAsia is consistent with hypothetical waves of human migration along the costal border of East Asia. And European and Asian of FLG mutation have similarity and differences.
Cho Eunae,Kim Seong-Hun,Choi Seong Ji,Jung Min Kyu,Song Byeong Jun,Park Jin Myung,Kang Jingu,Park Won Suk,Park Joo Kyung,Woo Sang Myung,Kim Hyo Jung 거트앤리버 소화기연관학회협의회 2024 Gut and Liver Vol.18 No.1
Background/Aims: Based on their anatomy, cholangiocarcinomas (CCAs) are classified into intrahepatic, hilar, and distal CCAs. Although the diagnosis and treatment of each type of CCA are thought to be different, real-world data studies on the current practice are limited. Therefore, this study was designed to capture the current practice of diagnosing and treating perihilar CCA in Korea. Methods: We conducted a survey using an online platform. The questionnaire consisted of 18 questions designed to evaluate the current practice of diagnosing and treating perihilar CCA in Korea. The targets of this survey were biliary endoscopists who are members of the Korean Pancreatobiliary Association. Results: In total, 119 biliary endoscopists completed the survey. Of the respondents, 89.9% thought that the use of the International Classification of Diseases, 11th Revision (ICD-11) system is necessary to classify CCA. Approximately half of the respondents would recommend surgery or chemotherapy until patients were 80 years of age. For the pathological diagnosis of CCA, endoscopic retrograde cholangiopancreatography with biopsy was the most preferred modality. Routine preoperative biliary drainage was performed by 44.5% of the respondents. For operable CCAs, 64.7% of the respondents preferred endoscopic biliary drainage using plastic stents. For palliative biliary drainage, 69.7% of the respondents used plastic stents. For palliative endoscopic biliary drainage using metal stents, 63% of the respondents preferred the stent-in-stent method. Conclusions: A new coding system using the ICD-11 is needed for classifying CCAs. Guidelines for diagnosing and treating CCA based on the clinical situation in Korea are needed.
( Won-tae Cho ),( Jae-woo Cho ),( Jinil Kim ),( Jin-kak Kim ),( Jong-keon Oh ),( Hak Jun Kim ),( Namryeol Kim ),( Jun-min Cho ) 대한외상학회 2016 大韓外傷學會誌 Vol.29 No.4
Purpose: The major pelvic trauma results in high mortality with associated fatal other injuries. During early stage of resuscitation, multidisciplinary approach is essential to improve the survival and outcomes. This study aims to report the effect and positive outcome of the trauma team approach on the management of hemodynamically unstable pelvic bone fracture. Methods: This retrospective review included all patients with hemodynamically unstable pelvic bone fracture admitted between March 2007 and December 2015. Patients were divided into group A, which comprised those admitted before the trauma team approach was started, and group B, which comprised those admitted after the approach was started. The advanced trauma life support protocol was followed for all patient. The comparisons between the two groups were based on medical records. Study variables included demographics, initial vital sign, injury severity score, fracture type, and injury mechanism. We analyzed the outcomes in each group with respect to the time interval for doctors` arrival, total length of stay in the emergency department (ED), time interval for computed tomography evaluation, 24-hour mortality, time interval for definitive fixation, and definitive fixation in the time-window of opportunity. Results: Fifty-three patients met the inclusion criteria. No statistically significant differences in demographic data existed between the two groups. The time interval for doctors` arrival (min, 63.09±50.48 vs 21.48±17.75; p=0.038) and total length of stay in the ED (min, 269.33±105.96 vs 115.49±56.24; p=0.023) were significantly improved. The 24-hour mortality was not significantly different between the two groups.(%, 14.3 vs 12.0; p=1.000) However, the time interval for definitive fixation and definitive fixation in the time-window of opportunity showed better results. Conclusion: The trauma team approach has positive effects, which include initial resuscitation through multidisciplinary approach and shortening the time interval to definitive fixation, on the management of hemodynamically unstable pelvic bone fracture. [ J Trauma Inj 2016; 29: 139-145 ]
Cho, Hee Jun,Baek, Kyoung Eun,Kim, In-Kyu,Park, Sun-Mi,Choi, Yeong-Lim,Nam, In-Koo,Park, Seung-Ho,Im, Min-Ju,Yoo, Jong-Min,Ryu, Ki-Jun,Oh, YoungTaek,Hong, Soon-Chan,Kwon, Oh-Hyung,Kim, Jae Won,Lee, Ch American ChemicalSociety 2012 JOURNAL OF PROTEOME RESEARCH Vol.11 No.4
<P>Rho GDP dissociation inhibitor 2 (RhoGDI2) was initiallyidentifiedas a regulator of the Rho family of GTPases. Our recent works suggestthat RhoGDI2 promotes tumor growth and malignant progression, as wellas enhances chemoresistance in gastric cancer. Here, we delineatethe mechanism by which RhoGDI2 promotes gastric cancer cell invasionand chemoresistance using two-dimensional gel electrophoresis (2-DE)on proteins derived from a RhoGDI2-overexpressing SNU-484 human gastriccancer cell line and control cells. Differentially expressed proteinswere identified using matrix-assisted laser desorption ionization-time-of-flightmass spectrometry (MALDI-TOF-MS). In total, 47 differential proteinspots were identified; 33 were upregulated, and 14 were downregulatedby RhoGDI2 overexpression. Upregulation of SAE1, Cathepsin D, Cofilin1,CIAPIN1, and PAK2 proteins was validated by Western blot analysis.Loss-of-function analysis using small interference RNA (siRNA) directedagainst candidate genes reveals the need for CIAPIN1 and PAK2 in RhoGDI2-inducedcancer cell invasion and Cathepsin D and PAK2 in RhoGDI2-mediatedchemoresistance in gastric cancer cells. These data extend our understandingof the genes that act downstream of RhoGDI2 during the progressionof gastric cancer and the acquisition of chemoresistance.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2012/jprobs.2012.11.issue-4/pr2011186/production/images/medium/pr-2011-011186_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr2011186'>ACS Electronic Supporting Info</A></P>
Cho, Chi‐,Hyun,Nam, Myoung Hyun,Kim, Jang Su,Han, Eun Taek,Lee, Won Ja,Oh, Jun Seo,An, Seong Soo A.,Lim, Chae Seung Blackwell Publishing Ltd 2011 Tropical medicine & international health Vol.16 No.2
<P><B>Summary</B></P><P>Introduction of rapid malaria diagnostic tests (RDT) initiated numerous field evaluations in various epidemiologic settings. But the efficiency of some RTD kits based on aldolase raised reservations for direct implementation of RDT into clinical settings. We performed Binax Now malaria test in 84 Korean <I>Plasmodium vivax</I> isolates and compared it with the traditional Giemsa stain microscopy test as the reference standard. The sensitivity of Binax Now was 62.0% for <I>P.?vivax</I> cases (52/84, 95% CI 51.2–71.6%) with 100.0% specificity (50/50, 95% confidence interval 92.9–100%). After the aldolase gene sequence analysis of 84 isolates, two synonymous mutations in aldolase gene were identified in both Binax Now positive and negative samples. No significant association between the mutations and Binax Now malaria tests was found. Thus, the genetic variability would not explain the poor performance of <I>P.?vivax</I> RDTs by detecting aldolase in ROK isolates.</P>