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이기원,윤춘섭 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)
The purpose of this study is to suggest how juvenile training schools should be planned and designed. Juvenile training schools house young people of over 12 to 20 years who are on the probation of Juvenile Department. The schools are established to give new life to young people who have once committed crime by teaching and training for a limited time. These institutions help such young people to avoid the vicious circle of potential crimes. Nowadays Juvenile training schools are renamed to Specialization schools. Nevertheless, the physical environment which house the young people remains unchanged. This study intends to upgrade the quality of Specialization education by suggesting proper architectural planning of residential and educational space in those institutions.
Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.
Kim, Won,Yoon, Jung-Hwan,Jeong, Jae-Min,Cheon, Gi-Jeong,Lee, Tae-Sup,Yang, Jong-In,Park, Su-Cheol,Lee, Hyo-Suk American Association for Cancer Research 2007 Molecular Cancer Therapeutics Vol.6 No.9
<P>Hypoxia stimulates hepatocellular carcinoma (HCC) cell growth via hexokinase (HK) II induction, and alternatively, HK II inhibition induces apoptosis by activating mitochondrial signaling. This study was to investigate whether the induction of HK II by hypoxia is associated with enhanced mitochondrial stability and to confirm the apoptosis-inducing efficacy of HK II inhibitor in an in vivo model of HCC. Mitochondrial stability was examined by treating isolated mitochondria with deoxycholate, a permeability-enhancing agent. Alteration of permeability transition pore complex composition was analyzed by immunoprecipitation and immunoblotting. An in vivo model of HCC was established in C3H mice i.d. implanted with MH134 cells. The antitumor efficacy of i.p. given 3-bromopyruvate (3-BrPA), a HK II inhibitor, was evaluated by measuring tumor volumes and quantifying apoptosis using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining and (99m)Tc-hydrazinonicotinamide-Annexin V scans. Hypoxia enhanced mitochondrial stability, and this was inhibited by 3-BrPA treatment. In particular, HK II levels in permeability transition pore complex immunoprecipitates were reduced after 3-BrPA treatment. In mice treated with 3-BrPA, mean tumor volumes and tumor volume growth were found to be significantly reduced. Moreover, percentages of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cells were significantly increased in 3-BrPA-treated mice, and this apoptosis-inducing efficacy was reflected in vivo by (99m)Tc-hydrazinonicotinamide-Annexin V imaging. Our results show that hypoxia enhances mitochondrial stability via HK II induction and that HK II inhibitor treatment exhibits an in vivo antitumor effect by inducing apoptosis. Therefore, HK II inhibitors may be therapeutically useful for the treatment of advanced infiltrative hypovascular HCCs, which are growing in a hypoxic environment.</P>
A Resistance Deviation-to-Time Interval Converter Based on Dual-Slope Integration
Chung, Won Sup,Choi, Gi Joo,Choi, Dong Han 청주대학교 산업과학연구소 1990 産業科學硏究 Vol.8 No.-
저항형 센서를 디지탈 시스템에 접속시키기 위한 저항변화-시간간격 변환기를 이중적분에 기초를 두어 개발했다. 이 변환기는 센서의 저항변화를 시간간격으로 선형적으로 변화시켜주며 높은 분해능을 제공한다. 회로의 동작원리 및 실험결과를 제시한다.
전처리 및 포장방법이 냉풍감압건조 복숭아의 품질에 미치는 영향
권기만 ( Gi Man Kwon ),김재원 ( Jae Won Kim ),윤광섭 ( Kwang Sup Youn ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.3
전처리 유무와 포장방법에 따른 건조복숭아를 가속실험(40℃, 50일)하여 품질변화를 조사한 결과 중량 및 PH의 변화는 vitman C 처리가 무처리에 비해 낮았으며, 충진방법에 따라서는 전반적으로 vacuum처리가 passive 및 N₂ 처리방법에 비하여 높은 함량을 나타내었다. 적정산도의 경우는 OPP/AI/PE film이 polyethylene film다 높은 반면 vitamin C 처리 시 포장 재질 간에 유의한 수준의 값을 나타내어 vitamin C 처리가 저장 중에 온도에 의한 산의 손실을 억제 하는 것으로 관찰되었다. 충진 방법에 따라서는 전반적으로 vacuum 및 N₂처리방법이 passive에 비해 높은 적정산도 값을 나타내었고, 식미와 관계가 있는 당산비에서는 vacuum처리방법이 높은 값을 나타내었다. 색도의 변화는 전반적으로 vitamin C 처리가 무처리에 비해 낮은 변화를 보였으며 L값, delta E 값 및 갈변도의 결과 OPP/AI/PE film 포장방법 및 vacuum처리에서 갈변현상이 억제되는 것으로 관찰되었다. 전처리 방법에 따른 폴리페놀 및 플라보노이드 함량은 vitamin C처리가 무처리에 비해 높은 함량을 나타내었으며, 포장재질에 따라서는 polyethylene film에 비하여 OPP/AI/PE film이 유의적으로 높은 함량을 나타내었다. 이상의 결과 무처리군의 passive포장법에서는 갈변 및 품질열화현상이 높은 것으로 관찰되었으나 vitamin C처리군의 vacuum-OPP/AI/PE film 포장은 갈변화 및 품질손상이 적게 관찰되어 품질유지 및 유통기간 연장을 위한 적정포장 방법이 될 것으로 사료된다. This study was conducted to investigate the effects of pretreatment and different packaging methods on the physicochemical properties of cold vacuum-dried peaches. All the dried peach samples were stored such as N₂gas substitution, vacuum and passive packaged with polyethylene (PE) film and oriented polypropylene (OPP)/aluminum (AI)/PE film at 40℃ for 50days. The weight change, pH, soluble solids content, titratable acidity, soluble solid-acid ratio (SS/TA), delta E, browning degree and phenolic compounds were analyzed. The weight change and pH were lower in the 0.1% vitamin C-treated group and were significantly lowest in the vacuum-treated OPP/AL/PE. The soluble solids content and the SS/TA were higher in the non-treated groups than in the vitamin C-treated groups. According to the packaging methods, the L values were higher in the vacuum, N₂ gas and passive package, in that order. In addition, the browning degree and the delta E value were lower in the pretreated groups and significantly lowest in the vacuum-treated OPP/AL/PE with 0.1% vitamin C group. The phenolic compounds were high for the pretreated groups, according to the packaging methods (vacuum > N₂gas> passive), and the OPP/AL/PE was significantly higher than the PE. These results suggest that different packaging materials and pre treatment methods affected the quality of the dried peaches, and the vacuum- OPP/AL/PE film packaging group showed a high quality.
Shin, Hyo-Sup,Okamoto, Akimitsu,Sako, Yasushi,Kim, Sok Won,Kim, Soo Yong,Pack, Chan-Gi American Chemical Society 2013 The journal of physical chemistry. A, Molecules, s Vol.117 No.1
<P>The nonradiative relaxation mechanism of the newly synthesized hybridized-sensitive DNA probe has not been fully understood until now. In this study, the transient dark state of the probe, which is a double fluorescent dye attached to a specific DNA sequence, was investigated using a fluorescence correlation spectroscopy (FCS). The transient dark state was measured in various solvents that are known to affect the intersystem crossing or photoisomerization of the DNA probe. On the basis of the experimental results, a simplified two energy state model of the probe was constructed, and this model provides an insight into the nonradiative relaxation mechanism of the fluorophore and the applications for DNA and RNA detection. The transient dark state that was measured in a time scale of a few microseconds is a triplet state and is related to photoisomerization, viscosity, oxygen concentration, and hybridization, all of which are important parameters for cellular microscopy. The transient dark state in a time scale of a sub-microseconds is sensitively changed after the addition of target DNA. The characterization can improve the probe’s capability to identify target DNA/RNA by using FCS since the triplet state that occurred after hybridization is distinctive in the time scale with that occurred before hybridization.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpcafh/2013/jpcafh.2013.117.issue-1/jp307018k/production/images/medium/jp-2012-07018k_0001.gif'></P>
The magnetization behavior and magnetocaloric effect in amorphous Fe–Nb–B ribbons
Min, Seong-Gi,Kim, Kyeong-Sup,Yu, Seong-Cho,Lee, Kyu-Won Elsevier 2007 Materials science & engineering. properties, micro Vol.449 No.-
<P><B>Abstract</B></P><P>The magnetization behavior and magnetic caloric effect have been analyzed for amorphous Fe<SUB>93−<I>x</I></SUB>Nb<SUB>7</SUB>B<SUB><I>x</I></SUB> (numbers indicate at.%; <I>x</I>=9, 14, 20) alloys. An amorphous phase was formed after quenching by melt spinning with a copper wheel surface speed of 30m/s. The magnetization measurements of the samples were performed by vibrating sample magnetometer. The Curie temperature increased from 299 to 419K with increasing B concentration (<I>x</I>=9–20). Temperature dependence of the entropy change, Δ<I>S</I><SUB>M</SUB> was calculated from the isothermal magnetization. The values of Δ<I>S</I><SUB>M</SUB> are 1.44, 1.07 and 0.97J/kgK at <I>x</I>=9, 14 and 20, respectively. The maximum of Δ<I>S</I><SUB>M</SUB> was found to appear in the vicinity of the Curie temperature in these alloy samples.</P>