콩 단백 성분 및 연령이 암컷 흰쥐의 혈장 지질 농도와 인지질 지방산 패턴에 미치는 영향

정은정(Eun-Jung Chung),김수연(Soo-Yeon Kim),김지영(Ji-Young Kim),안지영(Ji-Young Ahn),박정화(Jung-Wha Park),차명화(Myung-Hwa Cha),이양자(Yang-Cha Lee Kim) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.2

혈중 지질농도는 식이단백질 종류보다는 연령의 영향을 많이 받아, young군보다 old군의 총 콜레스테롤, TG, HDL-콜레스테롤, LDL+VLDL-콜레스테롤 및 AI 모두 높았다. 한편 콩 단백질군에서 HDL-콜레스테롤 수준이 증가하고, LDL+VLDL-콜레스테롤와 AI는 감소하여, 심혈관질환에 대한 콩 단백질의 유익한 효과를 확인할 수 있었다. 식이단백질에 의해 유의한 영향을 받은 혈장 인지질의 지방산조성중 22:0, 18:1ω9, ∑MUFA 조성은 카제인군에서 콩 단백질군 보다 높았으며, 반대로 ∑SFA 조성은 카제인군에서 낮았다. 연령에 의해 혈장 인지질 지방산 조성에 있어 유의한 차이를 보인 지방산 중 22:0, 18:1ω9, 22:1, 18:3ω3 및 22:4ω6는 young군에서 높은 반면에, 22:6ω3, ∑ω3, 18:2ω6, 20:4ω6, ∑ω6 및 ∑PUFA의 조성비율은 old군에서 높게 나타났다. 이와 같이 식이 단백질의 종류보다 연령의 영향력이 더 많이 나타난 것은 혈중 콜레스테롤 수준이 식이 단백질보다는 연령의 영향을 더 크게 받았기 때문으로 생각된다. 혈장 인지질 지방산의 대사지표 중 Δ7-desaturation index(16:0⇒16:1ω7)와 Δ9-desaturation index(18:0⇒18:1ω9)가 식이 단백질의 영향을 받아 카제인군에 비해 콩 단백질군에서 유의하게 낮았다. Δ7- 및 Δ9-desaturation index만이 식이 단백질의 영향을 받은 것은 식이 단백질보다 desaturase 활성에 더 큰 영향력을 미치는 콜레스테롤이 식이에 첨가되었기 때문이라 생각된다. Δ-4 desaturation index (22:4ω6⇒22:5ω6)는 young군에 비해 old군에서 높았으며, elongation index(20:4 ω6⇒22:4ω6)는 old군에서 낮았다. 대부분의 elongation과 desaturation 단계는 연령에 따라 유의한 차이를 보이지 못하였으나, ω3계 지방산의 전체적인 elongation-desaturation 단계를 나타내는 ∑products-fatty acid(ω3)/α-LNA(ω3) 비율이 old군에서 young군보다 유의하게 높아, 연령에 따른 PUFA 대사의 변화가 관찰되었다. 이상에서와 같이, 콩 단백질의 섭취로 흰쥐 혈장 인지질의 ∑MUFA 조성은 낮고 ∑SFA 조성은 높아 다른 지질 강화성분의 섭취와 유사한 결과를 나타내었다. 혈중 콜레스테롤 수준이 높은 old군에서 체내 막조직의 유동성을 유지하기 위해 PUFA의 합성 특히 ω3계 지방산의 elongation-desaturation이 증가하여 총 PUFA 조성이 young군보다 높았다. 연구결과로 이소플라본을 포함한 콩 단백질의 혈중 지질저하 기전에 대해 체계적인 설명은할 수 없지만, 콩 단백질이 혈장 지방산의 조성을 변화시킴으로써 간접적으로 심혈관계 질환에 대해 유익한 효과를 미침을 알 수 있었다. 한편, 이러한 혈관의 건강과 관련된 콩의 유익한 효과는 이소플라본과 같은 콩의 특정 성분의 단독효과라기보다는 콩 단백질과의 복합효과에 의한 것이라는 주장은 매우 설득력 있다고 생각된다. Effects of soy protein concentrate (SPC) containing isoflavone and casein diets on plasma phospholipid (PLs)-fatty acid patterns were investigated in 7- & 40- wk old female rats. Diets containing 16% SPC (soy/young: SY, soy/old: SO) and casein (casein/young: CY, casein/ old: CO) supplemented with 0.5% cholesterol were fed for 4 wks. Fatty acid compositions of plasma PLs were determined by TLC and GLC. Compared to the dietary protein effects, age effects on serum lipids were more profound. The levels of total cholesterol (Chol.), triglyceride, HDL-Chol., (LDL+VLDL)-Chol. and atherogenic index (AI) were higher in older groups (OC & OS) than younger groups (YC & YS). Soy groups had higher HDL-Chol. level and lower (LDL+VLDL)-Chol. and AI, compared with casein groups. The compositions of C22:0, C18:1ω9 and sum of MUFA in plasma PLs were significantly higher in casein group (CY & CO) than soy group (SY & SO), but those of sum of SFA were higher in soy group. The compositions of C22:0, C18:1ω9, C22:1, C18:3ω3 and C22:4ω6 were higher and those of C22:6ω3, sum ofω3, C18:2ω6 C20:4ω6, sum ofω6 and sum of PUFA were lower in plasma PLs of younger rats. The average P/S and ω3/ω6 ratio in older group was higher. The Δ-7 desaturation index (16:0⇒16:1ω7) and Δ-9 desaturation index (18:0⇒18 : 1ω9) were lower in soy group than casein group, while Δ-6 and Δ-5 desaturation index were not affected by dietary protein. The Δ-4 desaturation index (22:4ω6⇒22:5ω6) were higher and, elongation index (20:4ω6⇒22:4ω6) were lower in older group. The ratio of the products of ω3 fatty acid series/precursor of ω3 fatty acid series (C18:3) was significantly higher in older group, which in- dicated that age affected the plasma PUFA metabolism. On the other hand, older rats had higher serum cholesterol level compared with younger rats. Taken together, these changes in fatty acid composition might cause minimal changes in the membrane fluidity induced by the increase serum cholesterol level.

젊은 남자 성인의 칼슘과 철의 영양상태에 관한 연구

박영숙,곽주영,권지혜,류화라 순천향대학교 기초과학연구소 2002 순천향자연과학연구 논문집 Vol.8 No.1

A survey was performed to 174 male young men who were living alone(40 persons) and shared living with friends(4143 persons) in Chungnam province. Their average age was 22.6 years old, height 171.8 ㎝, and weight 65.6 ㎏. Their daily calcium intake level was averaged 271.9±169.1 ㎎, which was 38.8 %RDA. Comparing calcium intake of each mealtime, breakfast, lunch, dinner, and snacks were composed of 18.6%, 30.0%, 34.0% and 17.4%, respectively. Their daily iron intake level was averaged 8.9±10.8 ㎎, which was 74.3 %RDA. Comparing iron intake of each mealtime, breakfast, lunch, dinner, and snacks were composed of 15.4%, 33.6%, 36.3% and 14.7%, respectively. These results suggested that deficiency of the two minerals in young male adults were severe and the nutrient qualities were also poor, no matter of their living alone or with accompanies. The deficiency was more profound in calcium than iron. And we observed iron nutriture differed significantly according to their living status, such as iron intake and its %RDA were significantly worse in single living subjects than the others. However calcium did not show significant difference. We concluded that shared living environment in young male adults could possibly improve their dietary mineral intake levels.

어린이의 이야기에 대한 理解의 발달

權英花,金娜英 대구산업정보대학 1987 논문집 Vol.1 No.-

It is assumed that comprehending and remembering a story depeends not only on what the children hear or read, but also on their general knowledge. Some factors for children's story comprehension were considered under the following eading: 1) Mechanisms of understanding contained in story-comprehension, 2) The development of interesting of children for picture-books, 3) The role of repeating structure on the formation of "story schema", 4) The relation between levels of story-understanding and those of story-schema. From these consideration, the following suggestions were derived: 1) A large number of stories for children have some kind of repeating structure and children enjoy them very much, 2) Repeating structure play an important role on the formation of "story schema", 3) "story schema" is constructed in children's mind by their experience mainly about listening the story telling, 4) The developmental features of understanding depends upon the levels of children's schema or the degree of awareness for the goal or structure of task.

도시지역 건축물의 석면슬레이트 지붕재료 분포특성 연구

김영찬(Kim Young-Chan),손병훈(Son Byeung-Hun),박화미(Park Wha-Me),홍원화(Hong Won-Hwa) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.1

Asbestos hazards have been studied by many people. Approximately 10% of slate containing asbestos, and asbestos which was imported in the 1970s was used to construct as building materials. The slate company, Asano which is located in Young-san in 1930's becomes the beginning and the slate is coming to be used until recently. Since 1960 in the aftermath of the Korea Saemaul Movement it was greatly expanded slate industry. Slate containing Asbestos and the surface is likely to drift over time, the government managed the comprehensive plan of 2010 Asbestos slate farmhouse in the National Survey on the usage of the progress and improve farmers slate roof construction. Non-conventional evaluation of the slate there is no index, especially in the concentration of urban population exposure to asbestos is a wide but a range of survey data on an unprecedented situation is urgent so long-term management measures are urgently needed. In this study, slate intergovernmental basic data for comprehensive measures proposed.

췌장 가성낭종의 CT진단 후 치료경과 관찰

조원수,김영통,김영화,김일영,이문호 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

Purpose: To evaluate clinical outcome after documentation of pancreatic pseudocyst by computed tomography (CT). Methods: The clinical course of 18 patients with pancreatic pseudocysts documented by computed tomography (CT) were retrospectively reviewed. History, physical examination, laboratory findings and CT finding were analyzed between operated and non -operated group of pancreatic pseudocysts. Result: There are 20 pancreatic pseudocysts in 18 patients with 16 males and two females (mean age: 45). There is no significant difference between operated and non- operated group in clinical symptoms and laboratory findings. On CT study, there are six cases of intrapancreatic pseudocysts and four cases of extrapancreatic pseudocysts in operated group. The mean diameter of pancreatic pseudocyst is 10.4 cm. In 10 pseudocysts of non-operated group, there are four case of intrapancreatic pseudocysts and six cases of extrapancreatic pseudocysts. The mean diameter of pancreatic pseudocyst is 5.4cm. There are approximately twice in diameter of the pseudocysts between operated and non-operated group (p < 0.05). Conclusion: CT is useful in the guiding of pancreatic pseudocyst management.

송사리 상피의 미세구조적 연구

김한화,지영득,문영호,강화선 최신의학사 1988 最新醫學 Vol.31 No.12

해수에 적응시킨 Guppy(Lebistes reticulatus) 신장의 proximal tubule의 미세구조의 변화

김한화,지영득,문영화,강화선,한지원 최신의학사 1991 最新醫學 Vol.34 No.12

1,4-Butanediamines를 carrier ligand로 하는 7원환 백금착체의 설계 및 합성

황규자,이근임,권영이 숙명여자대학교 약학연구소 1995 약학논문집-숙명여자대학교 Vol.11 No.-

Platinum complexes having 7-membered ring structure with N,N'-bis(2-hy-droxyethyl)butylenediamine(HeBn) and N,N'-bis(2-chloroethyl)butyelenediamine(CeBn) as carrier ligands were synthesized to enhance antitumor activity and to decrease the toxicity. Platinum complexes were prepared by reacting K_2PtI_4 with HeBn or CeBn. IR, NMR, elementary analysis, ICP-AES and titration method were applied for identification and analysis of the synthesized platinum complexes.

하악골에서 발생한 원발성 Ewing씨 육종 1례

고중화,전상훈,오영택,최진혁 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

수평하중을 받는 단층 라멘구조물의 변위에 관한 연구

최영화 대구대학교 산업기술연구소 2013 産業技術硏究 Vol.24 No.1

The purpose of this study is to analyze the displacement of one-story rahmen structure under lateral load according to the support condition, the bracing shape, the relative stiffness ratio, the bay number and the bracing section ratio by the MIDAS/GENw programs and the theory of slope deflection method. As results, it has been more effective to choose not pin end but fixed end in the support condition and K-bracing in the bracing shape to reduce the displacement. For the same purpose, increment of culumn has been better than that of beam in the relative stiffness ratio and it needs to increase the bay naumber and the bracing section ratio. Additionally, the difference of value by the slope deflecction method and the program has been by 5.6%