An Empirical Study on the Public Consciousness and the Willingness to Pay Regarding the Household Waste Charging Systems in Taiwan

( Yu-chi Weng ),( Takeshi Fujiwara ),( Sue-jane Lin ),( Hwong-wen Ma ) 한국폐기물자원순환학회 2011 ISWA Vol.2011 No.0

A Distributed WebGIS Platform based on SaaS Architecture

Weng Yu,Xiaodong Jia,Yuan Jie 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.12

The emergence of cloud computing has changed the software development and deployment, providing users with great convenience. But even in the cloud computing environment, software development efficiency is particularly low. In order to improve the efficiency of software development, and make software release easier, we designed a layered service computing platform. With the help of basic services, the platform makes software development and publishing simple and efficient. To demonstrate our platform, we described the process of building a simple WebGIS system in this paper. This process represents the software development process in our platform. Experiment shows that our work is not only available but also simplifies the process of software development.

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Yu-Hsiang Hsu,Hsing-Hui Li,Junne-Ming Sung,Wei-Yu Chen,Ya-Chin Hou,Yun-Han Weng,Wei-Ting Lai,Chih-Hsing Wu,Ming-Shi Chang 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-β1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-β1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy.

A Customized Web Service Constructing Model Based On Private Cloud

Weng Yu,Peng Guo 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.11

A New Quorum-Sensing Inhibitor Attenuates Virulence and Decreases Antibiotic Resistance in Pseudomonas aeruginosa

Yu-Xiang Yang,Zhen-Hua Xu,Yu-Qian Zhang,Jing Tian,Li-Xing Weng,Lian-Hui Wang 한국미생물학회 2012 The journal of microbiology Vol.50 No.6

Quorum sensing (QS) has been a novel target for the treatment of infectious diseases. Here structural analogs of Pseudomonas aeruginosa autoinducer N-acyl homoserine lactone (AHL) were investigated for QS inhibitor (QSI) activity and a novel QSI was discovered, N-decanoyl-L-homoserine benzyl ester (C2). Virulence assays showed that C2 downregulated total protease and elastase activities, as well as the production of rhamnolipid, that are controlled by QS in P.aeruginosa wild-type strain PAO1 without affecting growth. C2 was also shown to inhibit swarming motility of PAO1. Using a microdilution checkerboard method, we identified synergistic interactions between C2 and several antibiotics, tobramycin, gentamycin, cefepime, and meropenem. Data from real-time RT-PCR suggested that C2 inhibited the expression of lasR (29.67%), lasI (21.57%), rhlR (28.20%), and rhlI (29.03%).

A Multi-Domain Web Text Feature Extraction Model for e-Science Environment

Weng Yu 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.11

The traditional information extraction methods based on specific domain usually depend on the domain dictionaries to discover the text feature. It is inconvenient for reproducing and difficult to transplant in multi-domain environment. The application scope is limited seriously. Oriented to the deficiencies above, a multi-domain web text feature extraction model for e-Science is proposed (named e-FTM). This model adopts the Chinese split words technology without dictionary into the process of multi-domain text feature discovery and avoids the dependency of domain dictionaries effectively. With the help of classification of common and individual features, the model tracks the generation and the development trend of domain events dynamically, and forms a couple of local data centers eventually. Through cooperative scheduling the domain knowledge between different local data centers, the knowledge utilization efficiency of the domain information in the global scope is improved sharply. To validate the performance, the experiments on the multi-domain text feature extraction, topic features dynamical tracking and the domain knowledge cooperative scheduling demonstrate that the model has higher application validity and practicality in e-Science environment.

A Service Pipeline Based On Service Composition Model

Weng Yu,Cheng Wenyi 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.2

With the development of computer science and software engineering, the technology of the service composition has already become the mainstream of the application integration in the Internet environment of distributed interactive technology. Even though, there still be some problems that in some certain occasion. Pipeline technology has been used widely in industry level and micro instruction level, while service pipeline has not draw as much attention as the former. In this paper, the authors combine service composition technology and pipeline technology, and propose a service pipeline based on service composition model. The model can not only reuse variety of hardware and software, but also improve the flexibility of service platform greatly. The model has been validated in the experimental system.

A Service Pipelining Model for Web GIS Based on Distributed Environment

Weng Yu,Cheng WenYi 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.6

Pipeline is one of the classic technologies to enhance efficiency. When the amount of data is becoming more and more big when processing, it becomes a big problem that how to improve the efficiency with existing resources. In the meantime, a large number of older hardware and software feel difficult to deal with new task in new environment with the accumulation of time. In order to ameliorate efficiency of web GIS with low cost, this paper propose a service pipelining model for Web GIS based on distributed environment. The system build a basic service library to reuse plenty of existing resource, and design a segment system to organize pipeline in level of service to improve efficiency. The model can be used in many platforms and occasions, not limited to the application we proposed in this paper. The model we proposed has been proved work well in our experiments and test.

Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.

The feasibility of detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings

Cheng-Chang Chang,Hui-Chen Wang,Yu-Ping Liao,Yu-Chih Chen,Yu-Chun Weng,Mu-Hsien Yu,Hung-Cheng Lai 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1

Objective: We hypothesized that DNA methylation of development-related genes may occur in endometrial cancer (EC)/ovarian cancer (OC) and may be detected in cervical scrapings. Methods: We tested methylation status by quantitative methylation-specific polymerase chain reaction for 14 genes in DNA pools of endometrial and OC tissues. Tissues of EC/normal endometrium, OC/normal ovary, were verified in training set using cervical scrapings of 10 EC/10 OC patients and 10 controls, and further validated in the testing set using independent cervical scrapings in 30 EC/30 OC patients and 30 controls. We generated cutoff values of methylation index (M-index) from cervical scrapings to distinguish between cancer patients and control. Sensitivity/specificity of DNA methylation biomarkers in detecting EC and OC was calculated. Results: Of 14 genes, 4 (PTGDR, HS3ST2, POU4F3, MAGI2) showed hypermethylation in EC and OC tissues, and were verified in training set. POU4F3 and MAGI2 exhibited hypermethylation in training set were validated in independent cases. The mean M-index of POU4F3 is 78.28 in EC and 20.36 in OC, which are higher than that in controls (6.59; p<0.001 and p=0.100, respectively), and that of MAGI2 is 246.0 in EC and 12.2 in OC, which is significantly higher that than in controls (2.85; p<0.001 and p=0.480, respectively). Sensitivity and specificity of POU4F3/MAGI2 were 83%–90% and 69%–75% for detection of EC, and 61% and 62%–69% for the detection of OC. Conclusion: The findings demonstrate the potential of EC/OC detection through testing for DNA methylation in cervical scrapings.