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Microstructure and Mechanical Properties of Mg–2.0Gd–1.2Y–1.0Zn–0.2Zr Alloy
Jianan Liu,Xiaoru Zhang,Wenxue Lv,Yumei Zhou,Daqing Fang,Xiangdong Ding,Jun Sun 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7
The microstructural evolution of Mg–2.0Gd–1.2Y–1.0Zn–0.2Zr (GWZK) alloy during homogenization and subsequentaging heat-treatment and the tensile properties of the peak-aged sample at various temperatures have been investigated. Thephase transformation during homogenization, static precipitation during aging, and deformation mechanisms at 250 °C aresystematically analyzed through XRD, TEM and EBSD measurements. The peak-aged GWZK alloy has good combinationof strength and ductility at elevated temperatures owing to its high thermal stability by the LPSO phases distributed alongthe grain boundaries. The change (19 MPa) in the yield strength of peak-aged samples between RT and 250 °C is mainlyrelated to easy gliding of dislocations on the non-basal planes due to the decrease in critical resolved shear stress of slip. Two strengthening models are applied to quantitatively describe the efect of {11 −2 0}훼precipitate plates on Orowanstrengthening corresponding to RT and 250 °C. Ignoring changes in solid solution strengthening and grain boundary strengthening of the peak-aged sample caused by increasing temperature, the calculated reduction value (16.5 MPa) in macroscopicyield strength from RT (based on the basal<a>slip mode) to 250 °C (based on the pyramidal<c+a>slip mode) is in goodagreement with the measured reduction value (19 MPa).
Dan Wang,Xin Wen,Xinyu Zhang,Yadong Hu,Xinru Li,Wenxu Zhu,Tao Wang,Shaowu Yin 한국유전학회 2018 Genes & Genomics Vol.40 No.11
Hypoxia seriously affects the innate immune system of fish. However, the roles of suppressor of cytokine signaling (SOCS), pivotal anti-inflammatory genes, in response to hypoxia/reoxygenation remain largely unexplored. The primary objective of this study was to elucidate the function of SOCS genes under acute hypoxia and reoxygenation in pufferfish (Takifugu fasciatus). In the present study, SOCS1, 2 and 3 were identified in T. fasciatus referred to as TfSOCS1, 2 and 3. Then, qRTPCR and western blot analysis were employed to assess their expressions at both the mRNA and protein levels. Tissue distribution demonstrated that the three SOCS genes were predominantly distributed in gill, brain and liver. Under hypoxia challenge (1.63 ± 0.2 mg/L DO for 2, 4, 6 and 8 h), the expressions of TfSOCS1 and 3 in brain and liver at the mRNA and protein levels were significantly decreased, while their expressions showed an opposite trend in gill. Different from the expressions of TfSOCS1 and 3, the expression of TfSOCS2 was inhibited in gill, along with its increased expression in brain and liver. After normoxic recovery (7.0 ± 0.3 mg/L of DO for 4 and 12 h), most of TfSOCS genes were significantly altered at R4 (reoxygenation for 4 h) and returned to the normal level at R12 (reoxygenation for 12 h). SOCS genes played vital roles in response to hypoxia/reoxygenation challenge. Our findings greatly strengthened the relation between innate immune and hypoxia stress in T. fasciatus.
Qin Lu,Yue Junqing,Guo Mingzhou,Zhang Cong,Fang Xiaoyu,Zhang Shengding,Bai Wenxue,Liu Xiansheng,Xie Min 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.5
Purpose: Although estrogen receptors (ERs) signal pathways are involved in the pathogenesis and development of asthma, their expressions and effects remain controversial. This study aimed to investigate the expressions of ERα and ERβ as well as their mechanisms in airway remodeling and mucus production in asthma. Methods: The expressions of ERα and ERβ in the airway epithelial cells of bronchial biopsies and induced sputum cells were examined by immunohistochemistry. The associations of ERs expressions with airway inflammation and remodeling were evaluated in asthmatic patients. In vitro, the regulations of ERs expressions in human bronchial epithelial cell lines were examined using western blot analysis. The epidermal growth factor (EGF)-mediated ligand-independent activation of ERα and its effect on epithelial-mesenchymal transitions (EMTs) were investigated in asthmatic epithelial cells by western blot, immunofluorescent staining, and quantitative real-time polymerase chain reaction. Results: ERα and ERβ were expressed on both bronchial epithelial cells and induced sputum cells, and the expressions showed no sex difference. Compared to controls, male asthmatic patients had higher levels of ERα on the bronchial epithelium, and there were cell-specific expressions of ERα and ERβ in induced sputum. The expression of ERα in the airway epithelium was inversely correlated to forced expiratory volume in 1 second (FEV1) % and FEV1/forced vital capacity. Severe asthmatic patients had significantly greater levels of ERα in the airway epithelium than mild-moderate patients. ERα level was positively correlated with the thickness of the subepithelial basement membrane and airway epithelium. In vitro, co-stimulation of interleukin (IL)-4 and EGF increased the expression of ERα and promoted its nuclear translocation. EGF activated the phosphorylation of ERα via extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways. ERα knockdown alleviated EGF-mediated EMTs and mucus production in airway epithelial cells of asthma. Conclusions: ERα contributes to asthmatic airway remodeling and mucus production through the EGF-mediated ligand-independent pathway.
Low Cost Fabrication of UV Photodetector Based on Hexagonal Nanocrystal ZnO:Al/p-Si Heterojunction
Li Duan,Feng Wei,Jibin Fan,Xiaochen Yu,Wenxue Zhang,Yan Zhang,Fengni He,Xiaojiao Cheng,Ye Tian 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.2
ZnO:Al/p-Si heterojunction was fabricated by depositing a hexagonal nanocrystal ZnO:Al film on p-type Si substrate using a simple chemical bath deposition (CBD) method. The vertically aligned hexagonal ZnO:Al nanocrystals reduce the grain boundary scattering and provide good conductivity. The ZnO:Al/Si heterojunction shows obvious photocurrent under ultraviolet (UV) illumination. A high UV-to-visible rejection ratio of the ZnO:Al/Si heterojunction indicates that the hexagonal nanocrystal ZnO:Al film is a good material for fabricating UV photodetectors. Furthermore, the response speed of the photodetector based on ZnO:Al hexagonal nanocrystal film is faster than that of most previously reported photodetectors based on ZnO:Al nanorods. We infer it is because the ZnO:Al nanocrystals film has a smaller surface to volume ratio than the ZnO:Al nanorod array.
Wu Dun,Li Bo,Jia Cheng,Dong Min,Liang Wenxu,Gao Xia,Zhang Hui 한국탄소학회 2024 Carbon Letters Vol.34 No.3
In recent years, the efficient and clean utilization of coal has been widely concerned by scholars at home and abroad. Despite the abundance of global coal resources, the deep utilization rate of coal is still insufficient. To address this challenge, it has been explored the development and preparation of coal-based high value-added carbonaceous materials. In the present study, a novel process was developed for the preparation of graphene using biphenyl sourced from low-rank coal. Using chemical vapor deposition (CVD) technology, it was successfully implemented for us to grow high-quality graphene on copper foils. The prepared graphene products were observed and characterized using Raman spectroscopy, optical microscopy and scanning electron microscopy techniques. The results of this research provide a new perspective for the utilization of low-rank coal resources.
Ultra Low Sheet Resistance on Poly Silicon Film by Excimer Laser Activation
다까시노구찌,Hyuck Lim,Do Young Kim,Hans S. Cho,Huaxiang Yin,권장연,Ji-Sim Jung,Jong-Man Kim,Kyung-Bae Park,Wenxu Xianyu,Xiaoxin Zhang 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I
We found that the sheet resistance (Rs) value of phosphorus-doped poly-Si film activated by excimer laser annealing (ELA) has a strong correlation with the crystallinity in the film. At the optimum ELA condition of 10 shots and 450 mJ/cm2, we achieved a very low Rs value of 60 ohm/sq. in poly-Si films. With laser activation, we could get much lower Rs than with conventional rapid thermal annealing (RTA), for silicon layers of the same crystallinity level. The active dopant diffusion is observed from the energy which is speculated to correspond to the near-complete-melting energy regime during laser irradiation.