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Wang Pengzhen,Deng Zhanyu,Li Aiguo,Li Rongsen,Huang Weiguang,Huang Weiguang,Chen Songsheng,Li Biao,Li Biao 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Stem cell therapy has been extensively studied to improve heart function following myocardial infarction; however, its therapeutic potency is limited by low rates of engraftment, survival, and differentiation. Here, we aimed to determine the roles of the β-catenin/Oct4 signaling axis in the regulation of long-term survival and angiogenesis of peripheral blood mesenchymal stem cells (PBMSCs). These cells were obtained from rat abdominal aortic blood. We showed that β-catenin promotes the self-renewal, antiapoptotic effects, and long-term survival of PBMSCs by activating the Oct4 pathway through upregulation of the expression of the antiapoptotic factors Bcl2 and survivin and the proangiogenic cytokine bFGF and suppression of the levels of the proapoptotic factors Bax and cleaved caspase-3. β-Catenin overexpression increased Oct4 expression. β-Catenin knockdown suppressed Oct4 expression in PBMSCs. However, β-catenin levels were not affected by Oct4 overexpression or knockdown. Chromatin immunoprecipitation assays proved that β-catenin directly regulates Oct4 transcription in PBMSCs. In vivo, PBMSCs overexpressing β-catenin showed high survival in infarcted hearts and resulted in better myocardial repair. Further functional analysis identified Oct4 as the direct upstream regulator of Ang1, bFGF, HGF, VEGF, Bcl2, and survivin, which cooperatively drive antiapoptosis and angiogenesis of engrafted PBMSCs. These findings revealed the regulation of β-catenin in PBMSCs by the Oct4-mediated antiapoptotic/proangiogenic signaling axis and provide a breakthrough point for improving the long-term survival and therapeutic effects of PBMSCs.
Single-Crystalline Self-Branched Anatase Titania Nanowires for Dye-Sensitized Solar Cells
Zhenquan Li,Huang Yang,Fei Wu,Jianxun Fu,Linjun Wang,Weiguang Yang 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.2
The morphology of the anatase titania plays an important role in improving thephotovoltaic performance in dye-sensitized solar cells. In this work, singlecrystallineself-branched anatase TiO2 nanowires have been synthesized byhydrothermal method using TBAH and CTAB as morphology controlling agents. The obtained self-branched TiO2 nanowires dominated by a large percentage of(010) facets. The photovoltaic conversion efficiency (6.37%) of dye-sensitizedsolar cell (DSSC) based on the self-branched TiO2 nanowires shows a significantimprovement (26.6%) compared to that of P25 TiO2 (5.03%). The enhancedperformance of the self-branched TiO2 nanowires-based DSSC is due to heir largepercent of exposed (010) facets which have strong dye adsorption capacity andeffective charge transport of the self-branched 1D nanostructures.
Mengzi Zheng,Fuxian Wu,Weiguang Huang,Chuang Gao,Suoli Liu 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.12
Superfine grinding technology is widely used in various industries, such as food, medicine and chemistry. Traditional superfine grinding methods have some problems in temperature rise, material pollution and environmental pollution. Therefore, a new type of superfine grinding technology, impeller-type turbulence mill (ITTM) driven by a high-speed permanent magnet machine (HSPMM), is studied in this paper to overcome these problems. Firstly, the design processes of the HSPMM and ITTM are proposed. On this basis, the mechanical and electromagnetic losses of the HSPMM are calculated using analytical method and finite element method (FEM), respectively. The power losses are used as the heat source to calculate the temperature field of the HSPMM. Considering the axial and radial temperature gradient, the ITTM rotor thermal stress is investigated by the thermal-stress coupling method. In addition, the computational fluid dynamics (CFD) method is utilized to analyze the superfine grinding mechanism of the ITTM. The HSPMM and ITTM are fabricated and tested to verify the design and analysis. The experimental results show that the ground materials reach the submicron level, and the temperature rise of the ground materials is only 30 °C. Compared with other superfine grinding technologies, the developed ITTM has a superior comprehensive performance.
JIAHUI ZHANG,Lili Zhang,JIN HUANG,Shouyong Zhou,Haiqun Chen,WEIGUANG ZHANG,Xin Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.6
Palygorskite (denoted as Pal) was used as an economical carrier of hybrid photocatalystTiO 2 – FexOy via an in situ depositing technique (marked as Pal – TiO 2 – FexOy). The samples werecharacterized by X-ray di®raction (XRD), transmission electron microscopy (TEM), brunner-emmet-teller (BET) measurements, X-ray photoelectron spectroscopy (XPS) and UV-Vis di®usere°ectance spectra measurements. Results showed that TiO 2 – FexOy composite particles withaverage size of about 10 nm were loaded onto the Pal ¯bers' surface. FexOy acted not only asmagnetic source but also took part in the formation of TiO 2 – FexOy heterojunction structure, which resulted in the obvious absorption in visible light region for the obtained Pal – TiO 2 – FexOy com-posite photocatalyst. The obtained Pal – TiO 2 – FexOy shows excellent photocatalytic activity to-ward photodegradation of Methyl orange (MO) under visible light irradiation and the degradationratio reached 94% within 180 min. Moreover, Pal – TiO 2 – FexOy could be readily recovered from thereaction solution by the magnet. Possible mechanism for the enhancement was also proposed.