Analysis on Response Prediction of a Single Pile and Pile Groups Based on the Runge-Kutta Method

Dong-dong Pan,Qian-qing Zhang,Shan-wei Liu,Shi-min Zhang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.1

The conventional load-transfer approach can not consider the interaction of piles, and can not be directly used in the analysis of the response of pile groups. The interactive effects among piles can be taken into account in the shear displacement method based on the principle of superposition. In the present analysis, the shaft displacement of a single pile at a given depth is assumed to be composed of the pile-soil relative displacement developed at the disturbed soil around pile and the elastic vertical soil displacement developed in the soil mass. A new load-transfer function which is very similar to a hyperbolic model is then established to describe the relationship between unit skin friction and shaft displacement at a given depth. Furthermore, a hyperbolic model is used to simulate the relationship between unit end resistance and pile end displacement. As to the analysis of the response of pile groups, the interactive effects among piles are considered by using the shear displacement method. For an individual pile in pile groups, new load-transfer functions are established to capture the relationship between unit skin friction and shaft displacement and the relationship between end resistance and pile end displacement. Based on the fourth order Runge-Kutta method, a modified loadtransfer method is proposed to analyze the response of pile groups considering the interactive effects among piles. The reliability of the present method is checked by using comparisons of the present calculated results, the measured results and the computed values derived from other methods.

Homoisoflavanones from Polygonatum odoratum Rhizomes Inhibit Advanced Glycation End Product Formation

Wei Dong,Hai Bo Shi,Heng Ma,Yan Bo Miao,Tong Jun Liu,Wei Wang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.5

Protein glycation inhibitors from Polygonatum odoratum rhizomes were investigated using a bioassay-guided procedure to characterize active compounds for preventing and treating diabetic complications. The EtOH extract and soluble fractions were evaluated using an in vivo model of renal advanced glycation end-product (AGE) accumulation in streptozotocin-induced diabetic rats and an in vitro bovine serum albumin-glucose assay. Three homoisoflavanones 3-(4’-hydroxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (1), 3-(4’-hydroxybenzyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one (2), and 3-(4’-methoxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (3), isolated from the active CHCl3-soluble fraction of the EtOH extract, were subjected to in vitro bioassays to evaluate their inhibitory activities against AGE formation. All the isolates inhibited AGE formation more effectively than the positive control, aminoguanidine. These results indicate that pending further study these compounds could be used as novel natural product drug for mitigating diabetic complications.

Key Point Detection in 3D Reconstruction Based On Human-Computer Interaction

Zhu Shi Wei,Zhang Xiao Guo,Lv Jia Dong,Wang Qing 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1

Aiming at solving problem of points’ redundancy caused by full automatically detecting points and the problem of large workload caused by picking all points manually, I advanced a new method of picking points which is based on Human-Computer Interaction in our 3D reconstruction platform after automatically detecting points. We first detected and matched points automatically and got the homograph matrix between two images, then projected points which were picked by hand on the one image to the other image, at last we would search the interesting feature points in the neighborhood of corresponding points in the two images. Experiments have shown that this method decreases the redundancy brought by large number of points and successfully finds the important feature points, so it lays a good foundation for 3D reconstruction.

Evolutionary and functional implications of 3′ untranslated region length of mRNAs by comprehensive investigation among four taxonomically diverse metazoan species

Wei Wang,Dong‑hui Fang,Jia Gan,Yi Shi,Hui Tang,Huai Wang,Mao‑zhong Fu,Jun Yi 한국유전학회 2019 Genes & Genomics Vol.41 No.7

Background In eukaryotic organisms, it has been well acknowledged that 3′ untranslated regions (3′ UTRs) of mRNA are actively involved in post-transcriptional regulations of gene expression. Although both shortening and lengthening of 3′ UTRs of specific candidate genes were explicitly documented to have functional consequences, landscape of 3′ UTR lengths in relation to evolutionary dynamics and biological meanings remains to be elucidated when large-scale data become available. Objectives The primary objective of this study was to revealed different inter- and intra-species patterns on length distribution of 3′ UTRs in comparison with 5′ UTRs and coding regions. Methods In the present study, we investigated 3′ UTR lengths in a highly curated set of 57,135 mRNA sequences among four well-studied and taxonomically diverse metazoan species (fruit fly, zebrafish, mouse and human). Results The average length ratio of 3′–5′ UTRs considerably increased from fruit fly (twofold) to human (fivefold). Moreover, genes can be characterized by the obviously different patterns of evolutionary change on 3′ UTR lengths. By utilizing the Gene Ontology annotations, genes with differential lengths of 3′ UTRs were suggested to have the divergent functional implications. In human, we further revealed that ubiquitously transcribed genes had higher median lengths of 3′ UTRs than the genes of tissue-restricted expressions. Conclusion We conducted a comprehensive analysis and provided an overview regarding 3′ UTRs biology of mRNAs in animals, whereas the mechanistic explanations of 3′ UTRs length variation in correlation to regulation of gene expression still remain to be further studied.

Effects of hydrothermal parameters on the physicochemical property and photocatalytic degradation of bisphenol A of Ti-based TiO2 nanomaterials

Dong Li,Yunzhou Chen,Jialin Jia,Haiyang He,Wei Shi,Jianghua Yu,Jun Ma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-

Effects of hydrothermal parameters on morphology, crystal structure, light absorption, separation efficiencyof photo-generated charge carriers, and photocatalytic removal of Bisphenol A (BPA) of Ti-basedTiO2 nanomaterials were systematically investigated. Through changing hydrothermal parameters,TiO2 nanobelts, TiO2 nanosheets and TiO2 nanowires were prepared. With increasing NaOH concentration,hydrothermal temperature, and hydrothermal time, more TiO2 with (101) crystal plane grew onTi substrate, resulting in higher crystallinity. The UV-light absorption enhanced with increasing NaOHconcentration, but decreased with improving hydrothermal temperature, hydrothermal time, and HClconcentration. Variation of UV-light absorption was mainly affected by morphology, and UV-light absorptionof TiO2 nanomaterials with different morphologies was arranged in order ofnanobelts > nanosheets > nanowires. The hydrothermal growth of TiO2 nanomaterials on Ti plate conformedto Ostwald ripening mechanism. Variation trend of photo-generated current was consistent withthat of BPA degradation, they both first increased and then decreased within investigated range. The optimalNaOH concentration, hydrothermal temperature, hydrothermal time, and HCl washing concentrationwere 1 M, 170℃, 28 h, and 0.1 M, respectively. Under this condition, Ti-based TiO2 nanosheets exhibitedthe highest BPA removal efficiency (92.7%), which was due to highly ordered nanosheet structure, goodcrystallinity, appropriate UV-light absorption and high separation efficiency of electron-hole pairs.

A Cluster-Based Countermeasure against MAC Layer Attacks in IEEE 802.11 MANETs

Shi, Fei,Liu, Wei Jie,Jin, Dong Xu,Song, Joo Seok Trans Tech Publications, Ltd. 2013 Applied mechanics and materials Vol.284 No.-

<P>MANETs become a considerable interest nowadays. However, these types of networks are vulnerable to a large group of attacks, e.g., MAC layer attacks. Most of the previous researches related to security issues focus on detection of misbehaviors after it occurred. We propose a new way of thinking to evade occurrence of misbehaviors. A novel clustering algorithm is presented using analytic hierarchy process to elect clusterhead. Afterwards, the clusterhead is required to assign backoff values to originators in its transmission range, which are also the members in the corresponding cluster, rather than permitting the originators to choose backoff values. Meanwhile, the elected clusterhead also monitors whether originators obey the backoff values. With the proposed scheme, the misuse of the backoff in MAC layer in 802.11 DCF can be prevented.</P>

CIC-3 chloride channel blockade protects mouse photoreceptorderived 661W cells against ischemia-reperfusion-induced injury in vitro

Shi Wei Huang,Yuan Yin,Ya Juan Zheng,Ya Ru Dong 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1

Exposure to ischemia/reperfusion leads to the development and progression of retinal degenerative diseases. However, the exact mechanisms are not fully understood. In this article, the role of CIC-3 chloride channel in OGD-R (oxygen-glucose deprivation followed by reperfusion)-induced retinal damage was examined. Mouse photoreceptor-derived 661W cells were treated with the CIC-3 antisense oligonucleotide before exposure to OGD-R. Cell viability, mitochondrial membrane potential, cytochrome-c level, DNA fragmentation, caspase activity and protein expression were detected. Pretreatment of 661W cells with CIC- 3 antisense oligonucleotide significantly decreased OGD-R-mediated toxicity. In addition, apoptosis-related biochemical indicators showed that pre-incubation of CIC-3 antisense oligonucleotide would elevate the mitochondrial membrane potential, decrease the release of cytochrome-c as well as formation of DNA fragmentation, and inhibit activities of caspase-3 and caspase- 9 in exogenous OGD-R-treated 661W cells. Moreover, treatment with CIC-3 antisense oligonucleotide changed the expression of apoptosis-related protein. These results suggest that CIC-3 chloride channel mediates OGD-R-induced apoptosis, at least partially through mitochondrial membrane potential pathway and increasing the levels of proapoptotic molecules in 661W cells. CIC-3 chloride channel blockade may provide a new therapeutic approach for preventing ischemia/reperfusion- induced retinal neural damage.

Construction of an Oscillator Gene Circuit by Negative and Positive Feedbacks

( Shi Hui Shen ),( Yu Shu Ma ),( Yu Hong Ren ),( Dong Zhi Wei ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1

Synthetic oscillators are gene circuits in which the protein expression will change over time. The delay of transcription, translation, and protein folding is used to form this kind of behavior. Here, we tried to design a synthetic oscillator by a negative feedback combined witha positive feedback. With the mutant promoter PLacC repressed by LacIq and PLux activated by AHL-bound LuxR, two gene circuits, Os-LAA and Os-ASV, were constructed and introduced into LacI-deleted E. coli DH5α cells. When glucose was used as the carbon source, a low level of fluorescence was detected in the culture, and the bacteria with Os-ASV showed no oscillation, whereas a small portion of those carrying Os-LAA demonstrated oscillation behavior with a period of about 68.3 ± 20 min. When glycerol was used as the carbon source, bacteria with Os-ASV demonstrated high fluorescence value and oscillation behavior with the period of about 121 ± 21 min.

Enhancement of the electro-Fenton degradation of organic contaminant by accelerating Fe3+/Fe2+ cycle using hydroxylamine

Dong Li,Tong Zheng,Jianghua Yu,Haiyang He,Wei Shi,Jun Ma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

The Electro-Fenton process can generate reactive oxygen species capable of oxidizing refractory organiccontaminants. However, low regeneration efficiency of Fe2+ restricts its application. Herein, hydroxylamine(HA) was added into the Electro-Fenton (HA/Electro-Fenton) process to accelerate the transformationof Fe3+ to Fe2+. Using dimethyl phthalate (DMP) as target contaminant, the HA/Electro-Fenton systemalleviated the two-stage reaction process and accelerated the removal of DMP in the pH range of 2.0–6.0. With improving DMP concentration from 5 mg L-1 to 50 mg L-1, their degradation rate increased in theHA/Electro-Fenton system, while decreased in the Electro-Fenton system. The addition of HA had negligibleeffect on electro-generation of H2O2, but facilitate the redox cycle of Fe3+/Fe2+ and the generation ofhydroxyl radicals, thus improving the degradation of DMP. The final transformation products of HA wereN2, N2O, and NO3. The presence of PO4 3 improved DMP degradation, while Cl and organic matters inhibitedDMP removal in varying degrees. This study provided useful reference to solve the low efficiency ofFe3+/Fe2+ cycle and expand the pH application range in the Electro-Fenton process.

Observation of multi-channel non-local transport in J-TEXT plasmas

Shi, Yuejiang,Chen, Zhongyong,Yang, Zhoujun,Shi, Peng,Zhao, Kaijun,Diamond, Patrick H.,Kwon, JaeMin,Yan, Wei,Zhou, Hao,Pan, Xiaoming,Cheng, Zhifeng,Chen, Zhiping,Yang, SeongMoo,Zhang, Chi,Li, Da,Dong, IOP 2018 Nuclear fusion. Fusion nucléaire. &n.Illiga Vol.58 No.4

<P>In cold pulse experiments in J-TEXT, not only are rapid electron temperature increases in the core observed, but also steep rises in the inner density are found. Moreover, some evidence of acceleration of the core toroidal rotation is also observed during the non-local transport process of electron temperature. These new findings of cold pulse experiments in J-TEXT suggest that turbulence spreading is a possible mechanism for the non-local transport dynamics.</P>