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Wang, Huai,Woo, Wanchuck,Lee, Soo Yeol,An, Gyubaek,Kim, Dong-Kyu Elsevier 2019 International journal of mechanical sciences Vol.160 No.-
<P><B>Abstract</B></P> <P>Localized residual stresses were correlated to ductile fracture toughness quantitatively in steel and aluminium alloys using in situ neutron diffraction method coupled with elastic-plastic finite element modelling. Local out-of-plane compression (LOPC) method generated compressive and tensile residual stresses in the vicinity of the fatigue pre-crack front in two compact tension (CT) specimens, respectively, and the evolution of the stress fields was simultaneously measured using in situ neutron diffraction technique under mode-I fracture loading. The results clearly showed that the localized tensile residual stress apparently accelerated stress transfer at the mid-thickness of the CT specimen compared to the specimen having compressive residual stress. The coupled quasi-static ductile fracture simulations and neutron diffraction results revealed a clear correspondence of fracture initiation toughness with localized residual stresses in both steel and aluminium alloys. In the aluminium case, tensile residual stress of 208 MPa was obviously detrimental to the fracture toughness resulting in a 43% reduction while compression of −220 MPa increases by up to 14%. On the other hand, localized residual stress in steel hardly affected fracture initiation toughness due to high plastic dissipation energy. This experiment-simulation coupled study quantitatively elucidates the distinctive role of plastic deformation and stress triaxiality in ductile fracture initiation between steel and aluminium alloy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Spatially-resolved stress/strain mapping is done inside the material under loading. </LI> <LI> Ductile fracture initiation reveals a clear correlation to localized residual stresses. </LI> <LI> Accumulation of plastic deformation dominates fracture of the EH40 steel. </LI> <LI> Increase of stress triaxiality governs fracture of the Al5083 aluminium. </LI> <LI> Tensile residual stresses reduce 43% of fracture toughness of the Al5083 aluminium. </LI> </UL> </P>
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Huai Wang,Dong-Kyu Kim,우완측,최시훈,Soo Yeol Lee,Sun Kwang Hwang 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.5
This paper presents a new method for contour measurements using a 3D scanner to determine cross-sectional residual stresses in structural components with complex configurations. The proposed method was applied to evaluate the axial residual stress distribution in a dissimilar pipe weld and the obtained results were compared with those obtained using a benchmarked contour measurement machine (CMM) equipped with a confocal laser probe for verification. It reveals a quantitative agreement between the two methods in terms of both the measured contours and the calculated residual stresses. Most importantly, this method allows a significantly reduced measurement time by ~99 % (~20 min, with an effective measurement speed of ~0.2 sec/mm 2 ), compared to the benchmarked method (~48 hr, with an effective measurement speed of ~28.7 sec/mm 2 ). Based on stress uncertainty analysis, this method guarantees a longer range of stable fits due to fewer noisy data points than the benchmarked method.
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The MDM2 SNP309T>G Polymorphism Increases Bladder Cancer Risk among Caucasians: a Meta-analysis
Wang, Huai-Gao,Wu, Qing-Yun,Zhou, Hui,Peng, Xin-Sheng,Shi, Meng-Jie,Li, Jie-Mei,Zhou, Yan-Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Published studies have evaluated associations between the MDM2 SNP309T>G polymorphism and bladder cancer susceptibility. However, these generated inconsistent results. The aim of the present investigation was to quantify the strength of association between MDM2 SNP309T>G polymorphism and bladder cancer risk by conducting a meta-analysis. We searched PubMed and Embase for related studies that had been published in English before April 1, 2014 and associations were assessed by summarizing the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Five case-control studies with a total of 972 cases and 1,012 controls were finally identified to be eligible for the meta-analysis. Overall, the results indicated that there was no significant association between the MDM2 SNP309T>G polymorphism and bladder cancer risk (for the allele model G vs. T: OR=1.08, 95% CI 0.85-1.36, p=0.54; for the co-dominant model GG vs. TT: OR=1.20, 95% CI 0.74-1.93, p=0.46; for the dominant model GG+GT vs. TT: OR=0.98, 95% CI 0.80-1.20, p=0.83; for the recessive model GG vs. GT+TT: OR=1.20, 95% CI 0.83-1.74, p=0.33). However, on subgroup analysis by ethnicity, significant associations were found in Caucasians in three models (for the allele model G vs. T: OR=1.41, 95% CI 1.10-1.81, p=0.006; for the co-dominant model GG vs. TT: OR=2.16, 95% CI 1.28-3.63, p=0.004; for the recessive model GG vs. GT+TT: OR=2.06, 95% CI 1.31-3.22, p=0.002). In summary, the present meta-analysis provides evidence that the genotype for the MDM2 SNP309T>G polymorphism may be associated with genetic susceptibility to bladder cancer among Caucasians.
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Wang, Huai,Woo, Wanchuck,Kim, Dong-Kyu,Em, Vyacheslav,Lee, Soo Yeol Elsevier 2018 Materials & Design Vol.160 No.-
<P><B>Abstract</B></P> <P>Influences of chemical dilution and the number of weld layers on residual stresses in a multi-pass low-transformation-temperature (LTT) weld were investigated by finite element modelling and neutron diffraction. A coupled thermal-metallurgical-mechanical (TMM) model that took into account the chemical dilution effect was developed to simulate the complex LTT welding phenomena. The model was strictly validated by comparing the predictions with experimental measurements and the results found good agreement between them. The results showed that a transformation strain caused by LTT martensitic transformation introduced large compressive residual stresses (−500 MPa) into the weld zone and the quantities were closely related to the chemical dilution between welding layers. Simulation results revealed that the chemical dilution helped mitigate the large localized tensile residual stresses by modulating the phase transformation process and a single LTT layer was sufficient to generate high compression near the weld surface (~2.5 mm), which suggests a great importance for repair welding.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A chemical dilution model was incorporated into thermal-metallurgical-mechanical model for residual stress prediction; </LI> <LI> Chemical dilution reduces inter-layer stress buildup by modulating phase transformation; </LI> <LI> One layer of Low-Transformation-Temperature (LTT) alloy is able to generate high compression around the weld surface; </LI> <LI> The formation mechanism of residual stress in multi-pass LTT welds was clarified. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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가長式領導的結구及其對員工敬업度的影響 -控製點的調節效應-
왕회명 ( Huai Ming Wang ),진정미 ( Chung Mee Chin ) 한중사회과학학회 2014 한중사회과학연구 Vol.12 No.3
The paternalistic leadership style is rooted in the oriental cultural background and is different from the western leadership styles. Currently most researchers believe that the paternalistic leadership consists of three dimensions: authoritarian leadership, benevolent leadership and moral leadership. Existing studies show that the moral and benevolent leadership styles have positive influences on the employees’ work attitudes and behaviors. However, there exists a big difference on behalf of the role of the authoritarian leadership. For example, some researchers believe that the authoritarian leadership has negative effect on the employees’ work attitudes and behaviors; some believe that the effect is not significant; and some even believe the effect is positive. Based on the data analysis of 761 surveyed employees, it is found that the authoritarian leadership consists of two dimensions: zhuan-quan leadership and shang-yan leadership. The zhuan-quan leadership behavior has a negative impact on the employees’ work attitudes and behaviors, while the shang-yan leadership style has a positive impact on them. The four-dimension model can better explain the effectiveness of the paternalistic leadership and the existing academic differences. The benevolent, moral and Shang-Yan leaderships can enhance employees’ job engagement, but the zhuan-quan leadership behavior will reduce the employees’ job engagement. Further analysis shows that the employees’ point of control plays the role as a moderator between the benevolent leadership and the employees’ job engagement. Specifically, compared with the internally controlled employees, the externally controlled employees are more vulnerable to the influence of the benevolent leadership behaviors.
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Zhongxu Wang,Huai Wang,Yi Zhang,Frede Blaabjerg 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
In order to increase the efficiency and to improve the reliability of modular multilevel converters in medium voltage applications, this paper proposes an adaptive control method to choose an optimal carrier frequency dynamically according to power loading conditions of the modular multilevel converter. By evaluating the impact of the carrier frequency on the output current harmonic performance and the capacitor voltage ripple analytically, the proposed adaptive control can reduce the power loss and the thermal stress on the power semiconductors. Meanwhile, the electrical operation requirements can still be fulfilled. One-year mission profile is utilized to assess the energy efficiency and the reliability performance between the proposed and the traditional control scheme. Moreover, theoretical analyses and simulation results are presented to demonstrate the effectiveness of the proposed control.
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왕회명 ( Wang Huai Ming ),진정미 ( Chin Jung Mi ) 한중사회과학학회 2017 한중사회과학연구 Vol.15 No.2
Based on a sample of 310 Chinese and South Korea employees of 70 teams or departments in one Korean transnational corporation in China, this study was designed to examine the influence of benevolent leadership on employee engagement, and investigate the mediating role of perceived organizational support as well as the moderating role of locus of control in the linkages between benevolent leadership and employee engagement under the cross-cultural context by structured questionnaires. Results of hierarchical regression analysis revealed that benevolent leadership existed among South Korean leaders under cross-cultural context. In particular, it had a significant positive influence on employee engagement. And this influence was partly mediated by perceived organizational support. In addition, results of moderated path analysis suggested that employees` locus of control significantly moderated the relationship between benevolent leadership and employee engagement. Meanwhile, the whole indirect effects of benevolent leadership on employee engagement mediated by perceived organizational support and the total effect were also higher when employee was prone to be external locus of control.
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Wei Wang,Dong‑hui Fang,Jia Gan,Yi Shi,Hui Tang,Huai Wang,Mao‑zhong Fu,Jun Yi 한국유전학회 2019 Genes & Genomics Vol.41 No.7
Background In eukaryotic organisms, it has been well acknowledged that 3′ untranslated regions (3′ UTRs) of mRNA are actively involved in post-transcriptional regulations of gene expression. Although both shortening and lengthening of 3′ UTRs of specific candidate genes were explicitly documented to have functional consequences, landscape of 3′ UTR lengths in relation to evolutionary dynamics and biological meanings remains to be elucidated when large-scale data become available. Objectives The primary objective of this study was to revealed different inter- and intra-species patterns on length distribution of 3′ UTRs in comparison with 5′ UTRs and coding regions. Methods In the present study, we investigated 3′ UTR lengths in a highly curated set of 57,135 mRNA sequences among four well-studied and taxonomically diverse metazoan species (fruit fly, zebrafish, mouse and human). Results The average length ratio of 3′–5′ UTRs considerably increased from fruit fly (twofold) to human (fivefold). Moreover, genes can be characterized by the obviously different patterns of evolutionary change on 3′ UTR lengths. By utilizing the Gene Ontology annotations, genes with differential lengths of 3′ UTRs were suggested to have the divergent functional implications. In human, we further revealed that ubiquitously transcribed genes had higher median lengths of 3′ UTRs than the genes of tissue-restricted expressions. Conclusion We conducted a comprehensive analysis and provided an overview regarding 3′ UTRs biology of mRNAs in animals, whereas the mechanistic explanations of 3′ UTRs length variation in correlation to regulation of gene expression still remain to be further studied.
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Genetic structure of six cattle populations revealed by transcriptomewide SNPs and gene expression
Wei Wang,Huai Wang,Hui Tang,Jia Gan,Changgeng Shi,Qing Lu,Donghui Fang,Jun Yi,Maozhong Fu 한국유전학회 2018 Genes & Genomics Vol.40 No.7
There are abundant cattle breeds/populations in China, and the systematic discovery of genomic variants is essential for performing the marker assisted selection and conservation of genetic resources. In the present study, we employed whole transcriptome sequencing (RNA-Seq) technology for revealing genetic structure among six Chinese cattle populations according to transcriptome-wide SNPs and gene expression. A total of 68,094 variants consisting of 61,754 SNPs and 6340 InDels were detected and widely distributed among all chromosomes, by which the clear patterns of population structures were revealed. We also found the significantly differential density of variant distribution among genes. Additionally, we totally assembled 15,992 genes and detected obvious differences on the expression profiles among populations. In contrast to genomic variants, the measure of gene expression levels failed to support the expected population structure. Here, we provided a global landscape on the differential expression genes among these cattle populations.
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