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Li Bo,Wang Yeni,Yang Xiaoguang 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
This study assessed the effect of Qianhu (Peucedanum praeruptorum Dunn) on the recovery of movement in mice with D-galactose-induced dyskinesia. The evaluation of the ability of mice to exercise revealed that Qianhu increased the running and swimming time to exhaustion in mice with dyskinesia. In addition, measurement of biochemical indices in mice showed that Qianhu altered the serum levels of blood urea nitrogen (BUN), blood lactic acid (BLA), malonaldehyde (MDA), liver glycogen (HG), muscle glycogen (MG), while the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) remained normal. Additionally, Qianhu regulated the mRNA expression of copper/zinc-superoxide dismutase (Cu/Zn-SOD), manganese-superoxide dismutase (Mn-SOD), catalase (CAT), heme oxygenase 1(HO-1), nuclear factor erythroid2-related factor (Nrf2) and syncytin-1 in mice and also protected mice against D-galactose-induced oxidative stress. The analysis of the chemical composition of Qianhu revealed that it mainly contains isochlorogenic acid B, myricetin, baicalin, luteolin, and kaempferol, which are known excellent antioxidants that protect against tissue damage due to oxidative stress and have anti-aging properties. Thus, these compounds may be the active components in Qianhu that improve the ability of mice to exercise, and may also represent the key compounds for its use as natural medicine or health food.
International Digital Design Invitation Exhibition
Boyang Feng,Chen Song,HanwenXU,He Gao,Kai Huo,Kuifang Li,Niu Wei,Shaopeng Han,Tingting Qu,Ting Li,Wang, di,Xu Yeni,Yanlin Xie,Bertrand Planes,Chi-Wook Nho,Jean-benoit Lallemant,Yeon Gyu-Seok,Bettina W 한국콘텐츠학회 2010 ICCC International Digital Design Invitation Exhib Vol.2010 No.12
Ye, Ni,Wang, Bin,Quan, Zi-Fang,Pan, Hai-Bo,Zhang, Man-Li,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
MicroRNA expression is a research focus in studies of tumors. This article concentrates attention on potential links between tumors caused by mouse mammary tumor virus (MMTV) and human breast cancer, in order to provide theoretical basis for using mouse model to search for miRNA effects mediated by Wnt/beta-catenin signaling in human breast cancer. By analyzing interactions between miRNAs and the Wnt/beta-catenin signaling pathway in breast cancer, we hope to casts light on more biological functions of miRNAs in the process of tumor formation and growth and to explore their potential value in cancer diagnosis, prognosis and treatment. Our endeavor aimed at providing theoretical basis for finding safer, more effective methods for treatment of human breast cancer at the miRNA molecular level.
Functional Roles of Long Non-coding RNA in Human Breast Cancer
Ye, Ni,Wang, Bin,Quan, Zi-Fang,Cao, San-Jie,Wen, Xin-Tian,Huang, Yong,Huang, Xiao-Bo,Wu, Rui,Ma, Xiao-Ping,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.