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Wang, Xian-Yu,Wang, Songhu,Hinse, Tobias C.,Li, Kai,Wang, Yong-Hao,Laughlin, Gregory,Liu, Hui-Gen,Zhang, Hui,Wu, Zhen-Yu,Zhou, Xu,Zhou, Ji-Lin,Hu, Shao-Ming,Wu, Dong-Hong,Peng, Xi-Yan,Chen, Yuan-Yuan Astronomical Society of the Pacific 2018 Publications of the Astronomical Society of the Pa Vol.130 No.988
Xu-Dong TANG,Nan LIU,Wei Wang,Jieyun Yan,Li Xu,Zhongyuan Shen 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.1
The silkworm (Bombyx mori) is an important insect for various industrial applications and is also a model insect for the order Lepidoptera. The silkworm is more resistant to deltamethrin at high temperatures than at low temperatures. To elucidate the role of the negative temperature coefficient of deltamethrin in the silkworm, digital gene expression (DGE) analysis was performed for the identification of differentially expressed genes in silkworms challenged with deltamethrin at different temperatures. Compared with deltamethrin exposure at 30 °C, silkworms treated at 20 °C exhibited more severe stress responses, and gene sets associated with peptidoglycan recognition protein (PGRP),mucin, and antimicrobial peptides (AMPs)were downregulated dramatically. Similarly, a decrease in genes related to reactive oxygen species scavenging was also detected, which may have resulted in an imbalance between radical-generating and radical-scavenging systems. These results indicated that the lower mortality rate after deltamethrin treatment at high temperature was caused by a series of gene alterations (quantitative increases) rather than qualitative changes.
Advances of Cancer Therapy by Nanotechnology
Xu Wang,Yiqing Wang,Zhuo (Georgia) Chen,Dong M. Shin 대한암학회 2009 Cancer Research and Treatment Vol.41 No.1
Recent developments in nanotechnology offer researchers opportunities to significantly transform cancer therapeutics. This technology has enabled the manipulation of the biological and physicochemical properties of nanomaterials to facilitate more efficient drug targeting and delivery. Clinical investigations suggest that therapeutic nanoparticles can enhance efficacy and reduced side effects compared with conventional cancer therapeutic drugs. Encouraged by rapid and promising progress in cancer nanotechnology, researchers continue to develop novel and efficacious nanoparticles for drug delivery. The use of therapeutic nanoparticles as unique drug delivery systems will be a significant addition to current cancer therapeutics.
A New Full-Aperture Reflective Null Measuring Method for Conformal Dome
Xu Dong Yang,Junhua Wang,Min Xu 한국광학회 2016 Current Optics and Photonics Vol.20 No.1
In this paper, a novel full-aperture reflective null measuring method is proposed to detect the transmissionwavefront of a conformal dome surface. An aspheric compensator is designed and placed behind the dometo reflect the aspheric testing wave back to the same path. To ensure the feasibility of this method, toleranceanalysis is conducted, and guidance to assembly is given accordingly. The accuracy of this method isverified to be λ/30 (λ =3.39 μm) by Monte Carlo algorithm. In addition, the influence of different error factors,including the thickness error and decenter error of the dome, on the testing wavefront is analyzed. Simulationand experiment indicate that this method is practical and simple, and can measure the conformal domesprecisely and comprehensively.
Autophagy in Tumorigenesis and Cancer Treatment
Xu, Dong-Wei,Zhang, Guan-Qing,Wang, Zong-Wei,Xu, Xiao-Yin,Liu, Tong-Xiang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Autophagy is a self-digestion process, wrapping cytoplasmic proteins or organelles to form vesicles for degradation in lysosomes. The process plays an important role in the maintenance of intracellular homostasis. Here we overview articles on autophagy and cancer/tumors in Pubmed and found 327 articles. Autophagy exists in many tumors and is involved in cell malignant transformation and tumor cell growth. In early phases of tumorigenesis, autophagy clears the abnormally folded proteins and dysfunctional organelles such as mitochondria. Autophagy can also inhibit cell stress responses and prevent genetic damage. When a tumor develops, autophagy helps tumor cells survive nutritional deficiencies and hypoxic conditions. Studies of autophagy in the occurrence and progression of tumors should provide new therapeutic strategies for tumors.
Preparation of porous cordierite ceramic with acid-leached coal gangue
Wang Xu-Dong,Xu Hai-Yan,Zhang Feng-Jun,Li Dong-Cai,Wang Ai-Guo,Sun Dao-Sheng,오원춘 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.4
The eff ect of impurities in coal gangue on the sintering and properties (porosity and compressive strength) of porous cordierite ceramics has been investigated by adjusting the amount of impurities by controlling the acid–gangue ratio during acid leaching. The sintering behavior and microstructure of the porous ceramics have been characterized via X-ray diff ractometry and scanning electron microscopy. The eff ects of both the acid–gangue ratio and sintering temperature on the porosity and compressive strength have been also investigated. The results indicated that both porosity and compressive strength of the porous cordierite ceramics prepared using acid-leached coal gangue were evidently improved. The content of the impurities in coal gangue was adjusted via acid leaching by controlling the acid–gangue ratio. The appropriate content of impurities in coal gangue facilitated the sintering process and improved the porosity and compressive strength of the obtained porous cordierite ceramics.
Xu, Xu,Wang, Lin,Xu, Huan-Qin,Huang, Xin-En,Qian, Ya-Dong,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Aim: To compare the efficacy and safety of paclitaxel liposome (Lipusu$^{(R)}$) with paclitaxel in combination with tegafur and oxaliplatin in treating patients with advanced gastric cancer. Materials and Methods: Patients with advanced gastric cancer receiving chemotherapy were retrospectively collected, and divided into two groups. Patients in group A received paclitaxel liposomes at a dose of 135 $mg/m^2$ on day 1 of each cycle, and patients in group B were given paclitaxel at the same dose with the same timing. All patients received tegafur at a dose of 500 $mg/m^2$ on days 1-5, and oxaliplatin at a dose of 80-100 $mg/m^2$ on day 1 for 2 cycles (each cycle was 21 d in total). Results: Fifty-eight patients could be evaluated for efficacy. The overall response rate was 47% in group A (14/30), and 46% in group B (13/28). Disease control rate was 73% in group A (22/30), and 71% in group B (20/28) (P>0.05). No significant differences were detected in hematologic and neurologic toxicities between the two groups (P>0.05). However, nausea, vomiting and hypersensitive reactions were significantly lower in group A than in group B (P<0.05). Conclusion: Paclitaxel liposomes are as effective as paclitaxel when combined with tegafur and oxaliplation in treating patients with advanced gastric cancer, but adverse reactions with paclitaxel liposomes are less common.
Surface nanocrystallization and its properties of a rare earth magnesium alloy induced by HVOF―SMB
Kai-dong Xu,Ji-na Wang,Ai-hua Wang,Hua Yan,Xiang-lin Zhang,Zao-wen Huang 한국물리학회 2011 Current Applied Physics Vol.11 No.3
The nanocrystalline microstructure in the surface of a rare earth magnesium alloy induced by a new process named HVOF―SMB (high velocity oxygen-fuel flame supersonic microparticles bombarding) has been characterized by means of X-ray diffractometry (XRD) and high-resolution transmission electron microscopy (HRTEM). The effects of HVOF―SMB on mechanical properties and corrosion resistance of the magnesium alloy have been investigated by microhardness distribution and polarization curves, and the cross-sectional observation of the treated Mg alloy sample has been characterized by optical microscopy (OM). Results showed that HVOF―SMB can induce surface nanocrystallization with a grain size level less than 20 nm at topmost surface layer, and the microhardness at the top surface layer increases up to about 170 HV_0.025 which is twice more than that of the substrate. The grain size increases as well as the microhardness decreases gradually with the depth varying from surface to substrate. The potentiodynamic polarization curves indicate that the HVOF―SMB treated surfaces show lower corrosion resistance in comparison with the untreated magnesium alloy in 3.5% NaCl solution. The underlying mechanism of the electrochemical properties on the nanocrystalline Mg-based alloy’s surface induced by severe plastic deformation in corrosion resistance is discussed.
Wei-dong Wang,Li-hua Zhang,Jia-Yan Ni,Xiong-ying Jiang,Dong Chen,Yao-ting Chen,Hong-liang Sun,Jiang-hong Luo,Lin-feng Xu 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.4
Objective: To meta-analytically compare combined transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) and surgical resection (SR) for the treatment of hepatocellular carcinoma (HCC) within the Milan criteria. Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for studies comparing these two therapies that were published between January 2006 and August 2017. Overall survival rate (OS), recurrence-free survival rate (RFS), major complications and the average length of hospital stay were compared between these two therapies. Metaanalytic pooled odds ratio (OR) was calculated using TACE plus RFA as the base category. Results: Seven case-control studies and one randomized trial were identified. Meta-analytic results revealed that, compared with SR, TACE plus RFA had significantly higher 1-year OS (OR for survival = 0.50, p = 0.009) and lower major complications (OR = 1.88, p = 0.02) after therapy. Three studies reported on the length of hospital stay. The average length ± standard deviation reported in individual studies for SR and TACE plus RFA groups was 19.8 ± 8.4 days and 7.4 ± 2.2 days, respectively; 18.7 ± 4.9 days and 11.5 ± 6.9 days, respectively; and 16.6 ± 6.7 days and 8.5 ± 4.1 days, respectively (p < 0.0001 for all studies). Three or 5-year OS and 1-, 3-, or 5-year RFS did not significantly differ between the two therapies. Conclusion: Combined TACE plus RFA may be an alternative to SR for the treatment of patients with HCC within Milan the criteria. Non-randomized design in most of the original studies was a limitation.
Sheng, Xu-Dong,Chen, Hu,Wang, Hui,Ding, Zhi-Bin,Xu, Gang-Zhu,Zhang, Jun-Feng,Lu, Wen-Chao,Wu, Tao,Zhao, Ling Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Fibulin-5 has recently been considered as a potential tumor suppressor in human cancers. Several studies have shown that it is down-regulated in a variety of tumor types and inhibits tumor growth and metastasis. This study was aimed to investigate the clinical significance of fibulin-5 in glioma and its role in cell proliferation and invasion. We found that the expression of fibulin-5 in glioma tissues was significantly lower than those in normal brain (NB) tissues. Negative expression was significantly correlated with advanced clinical stage (grade III+IV). Furthermore, Fibulin-5 negative expression was correlated with a shorter overall survival of glioma patients. Multivariate Cox repression analysis indicated that fibulin-5 was an independent factor for predicting overall survival of glioma patients. Overexpression obviously inhibited cell proliferation in U251 and U87 cells. Furthermore, it significantly reduced the number of migrating and invading glioma cells. In conclusion, impaired expression of fibulin-5 is correlated with the advanced tumor stage in glioma. Otherwise, Fibulin-5 is an independent prognostic marker for predicting overall survival of glioma patients. Mechanistically, it may function as a tumor suppressor via inhibiting cell proliferation and invasion in gliomas.