Lithium-ion batteries remaining useful life prediction using Wiener process and unscented particle filter

Wang, Ranran,Feng, Hailin The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.1

Remaining useful life (RUL) prediction plays an important role in the prognosis and health management of lithium-ion batteries (LIBs). This paper proposes a new method based on the Wiener process for the RUL prediction of LIBs. Firstly, a state-space model based on the Wiener process is constructed to describe the LIBs degradation process, which considers the four variability sources of the degradation process simultaneously. Then, the model parameters are initialized using maximum likelihood estimation (MLE) and dynamically estimated by an unscented particle filter (UPF) algorithm. Finally, through comparison with other models, the proposed method shows its effectiveness and superiority in describing the degradation process and RUL prediction of LIBs.

Identification of loci and genes for growth related traits from a genome-wide association study in a slow- 3 fast-growing broiler chicken cross

Ranran Liu,Yanfa Sun,Guiping Zhao,Hongyang Wang,Maiqing Zheng,Peng Li,Li Liu,Jie Wen 한국유전학회 2015 Genes & Genomics Vol.37 No.10

Identification of functional genes for multifactorial traits is an ongoing priority. A genome-wide association study and gene expression study for weight and carcass composition traits is presented here using a F2 resource population derived from a cross between slowand fast-growing chicken breeds. For weight traits, eight SNPs on GGA4 plus one SNP on GGA27 were significantly associated with two or more target traits, including body weight (BW) at day 56, BW93, carcass weight, eviscerated weight, breast weight (BrW), thigh muscle weight (ThW) and wing weight. Of 11candidate genes identified near significant SNPs, three were shown by Q-PCR to be differentially expressed in breast muscle between chickens selected from phenotypic extremes of carcass weight and BrW, including ligand dependent nuclear receptor corepressor-like protein and LIM domainbinding factor 2. For major carcass composition traits, nine significant SNPs on GGA1, GGAZ and GGA6 were identified as being associated with BrW and/or percentage. The wings apart-like homolog (Drosophila, WAPAL) on GGA6 had the most significant association with percentage of ThW.

Developmental Hypothyroidism Influences the Development of the Entorhinal-Dentate Gyrus Pathway of Rat Offspring

Ting Jin,Ranran Wang,Shiqiao Peng,Xin Liu,Hanyi Zhang,Xue He,Weiping Teng,Xiaochun Teng 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.2

Background: Developmental hypothyroidism impairs learning and memory in offspring, which depend on extensive neuronal circuits in the entorhinal cortex, together with the hippocampus and neocortex. The entorhinal-dentate gyrus pathway is the main entrance of memory circuits. We investigated whether developmental hypothyroidism impaired the morphological development of theentorhinal-dentate gyrus pathway. Methods: We examined the structure and function of the entorhinal-dentate gyrus pathway in response to developmental hypothyroidism induced using 2-mercapto-1-methylimidazole. Results: 1,1´-Dioctadecyl-3,3,3´,3´-tetramethylindocarbocyanine perchlorate tract tracing indicated that entorhinal axons showeddelayed growth in reaching the outer molecular layer of the dentate gyrus at postnatal days 2 and 4 in hypothyroid conditions. Theproportion of fibers in the outer molecular layer was significantly smaller in the hypothyroid group than in the euthyroid group atpostnatal day 4. At postnatal day 10, the pathway showed a layer-specific distribution in the outer molecular layer, similar to the euthyroid group. However, the projected area of entorhinal axons was smaller in the hypothyroid group than in the euthyroid group. Anelectrophysiological examination showed that hypothyroidism impaired the long-term potentiation of the perforant and the cornuammonis 3–cornu ammonis 1 pathways. Many repulsive axon guidance molecules were involved in the formation of the entorhinaldentate gyrus pathway. The hypothyroid group had higher levels of erythropoietin-producing hepatocyte ligand A3 and semaphorin3A than the euthyroid group. Conclusion: We demonstrated that developmental hypothyroidism might influence the development of the entorhinal-dentate gyruspathway, contributing to impaired long-term potentiation. These findings improve our understanding of neural mechanisms formemory function.

Identification of Histone Deacetylase 2 as a Functional Gene for Skeletal Muscle Development in Chickens

Shahjahan, Md.,Liu, Ranran,Zhao, Guiping,Wang, Fangjie,Zheng, Maiqing,Zhang, Jingjing,Song, Jiao,Wen, Jie Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.4

A previous genome-wide association study (GWAS) exposed histone deacetylase 2 (HDAC2) as a possible candidate gene for breast muscle weight in chickens. The present research has examined the possible role of HDAC2 in skeletal muscle development in chickens. Gene expression was measured by quantitative polymerase chain reaction in breast and thigh muscles during both embryonic (four ages) and post-hatch (five ages) development and in cultures of primary myoblasts during both proliferation and differentiation. The expression of HDAC2 increased significantly across embryonic days (ED) in breast (ED 14, 16, 18, and 21) and thigh (ED 14 and 18, and ED 14 and 21) muscles suggesting that it possibly plays a role in myoblast hyperplasia in both breast and thigh muscles. Transcript abundance of HDAC2 identified significantly higher in fast growing muscle than slow growing in chickens at d 90 of age. Expression of HDAC2 during myoblast proliferation in vitro declined between 24 h and 48 h when expression of the marker gene paired box 7 (PAX7) increased and cell numbers increased throughout 72 h of culture. During induced differentiation of myoblasts to myotubes, the abundance of HDAC2 and the marker gene myogenic differentiation 1 (MYOD1), both increased significantly. Taken together, it is suggested that HDAC2 is most likely involved in a suppressive fashion in myoblast proliferation and may play a positive role in myoblast differentiation. The present results confirm the suggestion that HDAC2 is a functional gene for pre-hatch and post-hatch (fast growing muscle) development of chicken skeletal muscle.

Inhibition of Wnt/β-catenin signaling by monensin in cervical cancer

Fu Bingbing,Fang Lixia,Wang Ranran,Zhang Xueling 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.1

The challenging clinical outcomes associated with advanced cervical cancer underscore the need for a novel therapeutic approach. Monensin, a polyether antibiotic, has recently emerged as a promising candidate with anti-cancer properties. In line with these ongoing efforts, our study presents compelling evidence of monensin's potent efficacy in cervical cancer. Monensin exerts a pronounced inhibitory impact on proliferation and anchorage-independent growth. Additionally,monensin significantly inhibited cervical cancer growth in vivo without causing any discernible toxicity in mice. Mechanism studies show that monensin's anti-cervical cancer activity can be attributed to its capacity to inhibit the Wnt/β -catenin pathway, rather than inducing oxidative stress. Monensin effectively reduces both the levels and activity of β -catenin, and we identify Akt, rather than CK1, as the key player in-volved in monensin-mediated Wnt/β-catenin inhibition. Rescue studies using Wnt activator and β-catenin-overexpressing cells confirmed that β-catenin inhibition is the mechanism of monensin’s action. As expected, cervical cancer cells exhibiting heightened Wnt/ β-catenin activity display increased sensitivity to monensin treat-ment. In conclusion, our findings provide pre-clinical evidence that supports further exploration of monensin's potential for repurposing in cervical cancer therapy, par - ticularly for patients exhibiting aberrant Wnt/ β -catenin activation

Investigation of the origin of abnormal grain growth in the sintering process of Sr0.5Ba0.5Nb2O6 ceramics without eutectic liquid-phase

Sui Wanmei,Luan Shijun,Song Ranran,Wang Chunlong 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.6

Abnormal grain growth in the traditional sintering process of (SrxBax−1)Nb2O6 limites its application and the localized liquidphase exsisting is regarded the main reason for the presence of abnormal grain growth. To prevent the presence of a localized liquid-phase, the sol-gel method was employed to synthesize nano-sized powders of Sr0.5Ba0.5Nb2O6, which was followed by a pure solid-phase sintering process of nano-sized powders to observe the evolution of the grain morphology. SEM observation revealed that the abnormal and preferential rod-like grain growth along the c-axis existed in the pure state-phase sintering for the Sr0.5Ba0.5Nb2O6 material companied with some of the smaller grains being diminished or consumed. This behavior would exist in the traditional solid-phase sintering with or without the localized liquid-phase. This would be another important factor to aid the abnormal grain growth and should be prevented in the manufacturing process. The effects of grain sizes on the dielectric constant, Tc and diffuse phase transion (DPT) were observed in the Sr0.5Ba0.5Nb2O6 ceramics.