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      • KCI등재

        Identification of loci and genes for growth related traits from a genome-wide association study in a slow- 3 fast-growing broiler chicken cross

        Ranran Liu,Yanfa Sun,Guiping Zhao,Hongyang Wang,Maiqing Zheng,Peng Li,Li Liu,Jie Wen 한국유전학회 2015 Genes & Genomics Vol.37 No.10

        Identification of functional genes for multifactorial traits is an ongoing priority. A genome-wide association study and gene expression study for weight and carcass composition traits is presented here using a F2 resource population derived from a cross between slowand fast-growing chicken breeds. For weight traits, eight SNPs on GGA4 plus one SNP on GGA27 were significantly associated with two or more target traits, including body weight (BW) at day 56, BW93, carcass weight, eviscerated weight, breast weight (BrW), thigh muscle weight (ThW) and wing weight. Of 11candidate genes identified near significant SNPs, three were shown by Q-PCR to be differentially expressed in breast muscle between chickens selected from phenotypic extremes of carcass weight and BrW, including ligand dependent nuclear receptor corepressor-like protein and LIM domainbinding factor 2. For major carcass composition traits, nine significant SNPs on GGA1, GGAZ and GGA6 were identified as being associated with BrW and/or percentage. The wings apart-like homolog (Drosophila, WAPAL) on GGA6 had the most significant association with percentage of ThW.

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