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( Vinay G Zanwar ),( Sunil V Pawar ),( Pravir A Gambhire ),( Samit S Jain ),( Ravindra G Surude ),( Vinaya B Shah ),( Qais Q Contractor ),( Pravin M Rathi ) 대한장연구학회 2016 Intestinal Research Vol.14 No.4
Background/Aims: The existence of non-celiac gluten sensitivity has been debated. Indeed, the intestinal and extra-intestinal symptoms of many patients with irritable bowel syndrome (IBS) but without celiac disease or wheat allergy have been shown to improve on a gluten-free diet. Therefore, this study set out to evaluate the effects of gluten on IBS symptoms. Methods: We performed a double-blind randomized placebo-controlled rechallenge trial in a tertiary care hospital with IBS patients who fulfilled the Rome III criteria. Patients with celiac disease and wheat allergy were appropriately excluded. The participants were administered a gluten-free diet for 4 weeks and were asked to complete a symptom-based questionnaire to assess their overall symptoms, abdominal pain, bloating, wind, and tiredness on the visual analog scale (0-100) at the baseline and every week thereafter. The participants who showed improvement were randomly assigned to one of two groups to receive either a placebo (gluten-free breads) or gluten (whole cereal breads) as a rechallenge for the next 4 weeks. Results: In line with the protocol analysis, 60 patients completed the study. The overall symptom score on the visual analog scale was significantly different between the two groups (P <0.05). Moreover, the patients in the gluten intervention group scored significantly higher in terms of abdominal pain, bloating, and tiredness (P <0.05), and their symptoms worsened within 1 week of the rechallenge. Conclusions: A gluten diet may worsen the symptoms of IBS patients. Therefore, some form of gluten sensitivity other than celiac disease exists in some of them, and patients with IBS may benefit from gluten restrictions. (Intest Res 2016;14:343-350)
Acute Pancreatitis: A Rare Post-Colonoscopy Sequela
Sujit P. Nair,Prasanta Debnath,Suhas Udgirkar,Parmeshwar Junare,Sanjay Chandnani,Shubham Jain,Vinay B. Pawar,Pravin M. Rathi 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.5
Abdominal pain is a common but benign symptom after colonoscopy. We report a case of acute pancreatitis that occurred just after anelective screening colonoscopy; this is a rare event with very few reported cases. A healthy, asymptomatic male underwent screeningcolonoscopy at our center and developed abdominal pain and emesis after the procedure. An abdominal X-ray ruled out perforation but laboratory tests revealed elevated levels of amylase and lipase. The patient had no etiological risk factors for pancreatitis. Thepresumed mechanism of pancreatitis in this case is mechanical and pressure trauma from excessive insuffation, external abdominal pressure, and repeated withdrawal of the colonoscope due to tight angulation of the splenic flexure, a structure that is in close proximityto the pancreatic tail. Acute pancreatitis should be considered in the differential diagnosis of patients who present with abdominal painafter colonoscopy once more common etiologies have been excluded.