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Tung Nguyen-Thach,Nguyen Canh-Hung,Nguyen Van-Duong,Nguyen Thi-Hong-Thuy,Nguyen Van-Lam,Tran Cao-Son,Pham Thi-Minh-Hue 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.4
Purpose The study aimed firstly to determine the release behavior of the model drug (berberine chloride) from the dry coated tablets. The second objective of this study was to evaluate the exact location of the dry coated tablets in in vivo. Methods The colon targeting tablets were developed by dry powder coating technique on pan coater. The drug release behavior was determined in the three continuous mediums: pH 1.2; 7.4 and 6.8 plus pectinase. The location of the dry coated tablets in the gastrointestinal tract of human volunteers was observed through the X-ray imaging of the dry coated tablets containing the optimized radiocontrast agents. Results The release kinetics of berberine chloride from the dry coated tablets was mainly controlled by erosion and enzyme sensitive mechanism. The optimum dry coated tablets having the coating powders of pectin 102:HPMC K4 M (2:1) with the coating level of 200%, and the tablet core with BaSO4 10% and iobitridol 30% as radiocontrast agents were observed in the caecum and ascending colon of human volunteers after 5–6 h of oral administration. Conclusion The successful development of these dosage forms is believed to have a high potential in precisely monitoring the release of highly potent drugs such as anti-inflammatory drugs in bowel diseases.
Binh Hai Nguyen,Binh Thanh Nguyen,Hanh Van Vu,Chuc Van Nguyen,Dzung Tuan Nguyen,Loc Thai Nguyen,Thu Thi Vu,Lam Dai Tran 한국물리학회 2016 Current Applied Physics Vol.16 No.2
In this work, a lactose biosensor was developed by co-immobilizing b-galactosidase (b-Gal) and glucose oxidase (GOx) on microelectrodes pre-modified with Pt/graphene/P(1,5-DAN) for estimation of lactose in dairy products to prevent lactose intolerance. The Pt microelectrode was modified with graphene and 1,5-polydiaminonaphthalene film. Graphene was synthesized by chemical vapor deposition on copper tape and manually transferred to the electrode surface. Polymeric P(1,5-DAN) was grafted on top of the graphene film by electropolymerization. Modified surface of the electrode was characterized by Raman spectra analysis, FE-SEM, AFM and cyclic voltammetry. The results indicated that deposition graphene film on electrode surface induced considerable enhancement in current signal, over 20 times as high as the uncoated electrode surface. The developed sensor was successfully used to determine lactose in model samples with sensitivity, correlation coefficient (R2) and limit of detection (LOD) estimated to be 1.33 mA/(mgml1), 0.995 and 1.3 mg/ml, respectively. The combined graphene and conductive P(1,5-DAN) could serve as a novel sensing platform on electrochemical sensors with superior sensitivity.
Nguyen, Tuan Lam,Pham, Thi Quynh Nga,Hoang, Van Minh,Kim, Bao Giang,Phan, Thi Hai,Doan, Thu Huyen,Nguyen, Thuy Linh,Duong, Khanh Van,Luong, Ngoc Khue Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1
Second-hand tobacco smoke (SHS) exposure at home, especially among children, is a serious issue in Viet Nam. During the past decade, much effort has been taken for tobacco control in the country, including various prgorammes aiming to reduce SHS exposure among adults and children. This article analysed trends and factors associated with SHS exposure at home among school children aged 13-15 in Viet Nam, using the Global Youth Tobacco Surveys conducted in 2007 and 2014. Descriptive and inferential statistical methods with logistic regression were applied. Overall, there was a significant reduction in the level of exposure, from 58.5% (95%CI: 57.6-59.3) in 2007 to 47.1% (95%CI: 45.4-48.8) in 2014. Of the associated factors, having one or both parents smoking was significantly associated with the highest odds of SHS exposure at home (OR=5.0; 95%CI: 4.2-6.1). Conversely, having a mother with a college or higher education level was found to be a protective factor (OR=0.5; 95%CI: 0.3-0.8).
Nguyen Van Dung,유영준,이영백,Nguyen Thanh Tung,Bui Son Tung,Vu Dinh Lam 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.1
The influence of lattice constants on the electromagnetic behavior of a cut-wire-pair (CWP)structure has been elucidated. In this report, we performed both simulations and experiments todetermine the influence of polarization on the metamagnetic resonance of the CWP structure. Thekey finding is the result of an investigation on the plasmon hybridization between the two CWs,which showed that the polarization of the incident wave was affected. Good agreement betweennumerical simulation and measurement is achieved.
Van-Anh Nguyen,Huy L. Nguyen,Dzung T. Nguyen,Quan P. Do,Lam D. Tran 한국물리학회 2017 Current Applied Physics Vol.17 No.11
In this paper, an electrosynthesized bilayer film of polypyrrole nanowire and poly(1,5- diaminonaphthalene) on a disposable screen-printing carbon ink electrode is presented. The inner polypyrrole nanowire layer had a large surface-to-volume ratio and high conductivity in the neutral medium, whereas the outer layer of poly(1,5diaminonaphthalene) had functional amino groups on the polymer chains. The combination of polypyrrole nanowire and poly(1,5diaminonaphthalene) showed a promising material for electrochemical biosensing. Here we reported an electrochemical immunosensor based on this approach for the purpose of detecting breast cancer biomarkers. The bilayer could enhance the surface coverage of antibody anti-CA 15-3 and consequently improve the sensitivity and stability of the immunosensors. The magnetic beads were used as carriers of labeled antibody anti-CA15-3 and HRP (horseradish peroxidase) in order to achieve an amplification of the signal. Under optimized conditions, the linear range of the immunoassay was 0.05e20 U mL1 with a detection limit of 0.02 U mL1 CA 15-3 antigen.
Nguyen, Thanh Huong,Nguyen, Trung Kien,Kim, Bao Giang,Hoang, Van Minh,Phan, Thi Hai,Doan, Thu Huyen,Luong, Ngoc Khue,Nguyen, Thuy Linh,Nguyen, Tuan Lam,Pham, Thi Quynh Nga Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1
Studies have shown that smoking is a learnt behavior, often initiated during adolescence. This paper aims to describe tobacco-related knowledge, attitude and associations among school adolescents aged 13-15 with exposure to anti-smoking information. Using data from the Global Youth Tobacco Survey (GYTS) in Viet Nam, 2014, knowledge was measured through 4 questions about tobacco use, and attitude was assessed through 3 questions on personal, social and environmental aspects. Students giving most anti-tobacco responses to all questions were considered as having correct knowledge or appropriate attitude or both. Access to anti-smoking information was determined by exposure to any media messages on tobacco control during the past 30 days and teaching in school about the danger of tobacco use during the past 12 months. A substantial percentage of students thought that being near others who smoke might be harmful to them and smoking is harmful to health (89.4% and 89.6% respectively). However, only 46.4% reported that it is definitely difficult to quit smoking and 66.9% thought that smoking for only 1 or 2 years, once stopped, is harmful to health. Slightly more than half of the respondents reported appropriate attitude that young smokers have fewer friends than others and smoking makes them less attractive and less comfortable at social events. Noticing anti-smoking messages in the media together with having lessons in school about the dangers of tobacco substantially increased the likelihood of having correct knowledge, appropriate attitude and both. Despite relatively high awareness about smoking harms, effective educational communication is still highly needed to improve the level of comprehensive knowledge and an appropriate attitude regarding tobacco use.
Dung Van Nguyen,Thuy Le Lam Nguyen,Yujin Jin,Lila Kim,Chang-Seon Myung,Kyung-Sun Heo 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.11
Disruption of the endothelial barrier functionand reduction in cell migration leads to endothelial dysfunction. One of the most abundant human milk oligosaccharides,6′-sialylactose (6′-SL), is reported to exert variousbiological functions related to infl ammatory responses. Inthis study, we evaluated the eff ects of 6′-SL on lipopolysaccharide(LPS)-induced infl ammation caused by endothelialbarrier damage. Our results showed that LPS at 500 ng/mLstrongly not only abolished cell migration but also hyperactivatedMAPK and NF-κB pathways. 6′-SL suppressedLPS-induced endothelial infl ammation via ERK1/2, p38,and JNK MAPK pathways. 6′-SL supported endothelialjunctions by upregulating PECAM-1 expression and mRNAlevels of tight junctions, such as ZO-1 and occludin, whichwere downregulated by LPS stimulation. It signifi cantlyinhibited the nuclear translocation of NF-κB, along withthe downregulation of infl ammatory cytokines, includingTNF-α, IL-1β, MCP-1, VCAM-1, and ICAM-1. Furthermore,6′-SL abolished NF-κB-mediated STAT3 in controllingendothelial migration and hyperpermeability viadownregulating STAT3 activation and nuclear translocation. Finally, LPS induced over-expression of VCAM-1 and ZO-1disassembly in both atheroprone and atheroprotective areasof mouse aorta, which were reversed by 6′-SL treatment. Altogether, our fi ndings suggest that 6′-SL is a potent therapeuticagent for modulating infl ammatory responses andendothelial hyperpermeability.
Chinh, Nguyen Duc,Hien, Truong Thi,Do Van, Lam,Hieu, Nguyen Minh,Quang, Nguyen Duc,Lee, Seung-Mo,Kim, Chunjoong,Kim, Dojin Elsevier 2019 Sensors and actuators. B, Chemical Vol.281 No.-
<P><B>Abstract</B></P> <P>ZnO thin-films with precisely controlled thicknesses were fabricated by the atomic layer deposition and their <I>NO</I> gas sensing properties were investigated at different temperatures, and in particular, under light irradiation of various energy and intensity at room temperature with and without Au catalyst. The molecular dynamics of <I>NO</I> and <I>O</I> <SUB>2</SUB> during the response and recovery cycles in relation with the <I>NO</I> sensing performance in air environment was elaborated using the energy diagram modelled for adsorption and desorption kinetics of the gas molecules. The blue light irradiation combined with Au catalytic effect greatly enhanced the <I>NO</I> response rate, but delayed the recovery rate in the air environment via molecular dynamic interference from the environmental oxygen. The optimum condition for <I>NO</I> sensing was obtained for the film thickness, light energy and intensity. Critical issues for the stable sensor operation such as concentration dependence, gas selectivity, and humidity effect were also reported.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Gas sensing response/recovery kinetics of NO sensing by ZnO with light irradiation and Au catalytic effect at room temperature. </LI> <LI> Molecular dynamics consideration for adsorption and desorption to explain the detection of ppm level gas concentrations. </LI> <LI> The nano-effect in varying thicknesses of ZnO. </LI> </UL> </P>