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RISS 인기검색어
- 검색키워드
- 저자 : Uk Ho Bae (검색결과 235 건)
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Bae, Gi-Sang,Kim, Dong-Goo,Jo, Il-Joo,Choi, Sun-Bok,Kim, Myoung-Jin,Shin, Joon Yeon,Kim, Dong-Uk,Song, Ho-Joon,Joo, Myungsoo,Park, Sung-Joo ELSEVIER 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.69 No.-
<P><B>Abstract</B></P> <P>Heme oxygenase-1 (HO-1) has an anti-inflammatory action in acute pancreatitis (AP). However, its mechanism of action and natural compounds/drugs to induce HO-1 in pancreas are not well understood. In this study, we investigated the regulatory mechanisms of HO-1 during AP using desoxo-narchinol-A (DN), the natural compound inducing HO-1 in the pancreas. Female C57/BL6 Mice were intraperitoneally injected with supramaximal concentrations of cerulein (50 μg/kg) hourly for 6 h to induce AP. DMSO or DN was administered intraperitoneally, then mice were sacrificed 6 h after the final cerulein injection. Administration of DN increased pancreatic HO-1 expression through activation of activating protein-1, mediated by mitogen-activated protein kinases. Furthermore, DN treatment reduced the pancreatic weight-to-body weight ratio as well as production of digestive enzymes and pro-inflammatory cytokines. Inhibition of HO-1 by tin protoporphyrin IX abolished the protective effects of DN on pancreatic damage. Additionally, DN treatment inhibited neutrophil infiltration into the pancreas via regulation of chemokine (C-X-C motif) ligand 2 (CXCL2) by HO-1. Our results suggest that DN is an effective inducer of HO-1 in the pancreas, and that HO-1 regulates neutrophil infiltration in AP via CXCL2 inhibition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Desoxo-narchinol-A (DN) is a natural compound of HO-1 inducer in pancreas. </LI> <LI> Mechanism of DN-induced HO-1 is mediated by MAPK/Activator Protein-1/HO-1 signaling. </LI> <LI> DN-induced HO-1 blocks neutrophil infiltration into pancreas via inhibition of CXCL2. </LI> <LI> DN inhibits cerulein-induced acute pancreatitis (AP) and AP-associated lung injury. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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시간 스케일러빌리티를 이용한 MPEG-4 FGS 비디오 부호화 기법
김종욱,이배호 전남대학교 전자통신기술연구소 2002 전자통신기술논문지 Vol.5 No.1
The paper shows MPEG-4 FGS(Fine Granularity Scalability) using the scalable video encoding technique that is adapted by MPEG-4 standard and a scheme to improve its efficiency. MPEG-4 FGS is the encoding technique that has the good flexibility for various property of devices and bandwidth variation over the internet. To improve MPEG-4 FGS coding efficiency, we applied an encoding technique with temporal scalability. In other words, the base layer is encoded with the same technique as the typical MPEG-4 FGS and the enhancement layer is encoded by adding temporal scalability property In test results, we could know that had better coding efficiency in the case of adding temporal scalability for the enhancement layer.
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Bae, Jun-Seok,Jang, Jee-Soo,Lee, Sang-Ho,Kim, Jin-Uk The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.51 No.1
Objective : To compare radiographic analysis on the sagittal lumbar curve when standing, sitting on a chair, and sitting on the floor. Methods : Thirty asymptomatic volunteers without a history of spinal pathology were recruited. The study population comprised 11 women and 19 men with a mean age of 29.8 years. An independent observer assessed whole lumbar lordosis (WL) and segmental lordosis (SL) between L1 and S1 using the Cobb's angle on lateral radiographs of the lumbar spine obtained from normal individuals when standing, sitting on a chair, and sitting on the floor. WL and SL at each segment were compared for each position. Results : WL when sitting on the floor was reduced by 72.9% than the average of that in the standing position. Of the total decrease in WL, 78% occurred between L4 to S1. There were significant decreases in SL at all lumbar spinal levels, except L1-2, when sitting on the floor as compared to when standing and sitting on a chair. Changes in WL between the positions when sitting on a chair and when sitting on the floor were mostly contributed by the loss of SL at the L4-5 and L5-S1 levels. Conclusion : When sitting on the floor, WL is relatively low; this is mostly because of decreasing lordosis at the L4-5 and L5-S1 levels. In the case of lower lumbar fusion, hyperflexion is expected at the adjacent segment when sitting on the floor. To avoid this, sitting with a lordotic lumbar curve is important. Surgeons should remember to create sufficient lordosis when performing lower lumbar fusion surgery in patients with an oriental life style.
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배병욱,박진호,임경호,정연구,양해진 大田大學校 産業技術硏究所 2002 산업기술연구소 論文集 Vol.13 No.2
Batch-type thickening experiments were conducted to investigate the thickening characteristics of sludge produced from. drinking water treatment plants (WTPs). For this purpose, 8 water treatment plants in both upper and downstream, portions of four large rivers were selected as model facilities. Half the WTPs take raw water from rivers, while the other half takes water from. reservoirs or near dams. The limiting solid flux (SFL) varied remarkably according to water supply and season. For WTPs taking raw water from rivers, the value of SFL was in the range of 6.0 to 180 kg TS/㎡·d. On the other hand, WTPs taking raw water from reservoirs had much lower SFL. Especially in the case of Chungju and Hwasun WTPs, the SFL of sludge was lower than 10 TS/㎡·d during all seasons. Since the gravitational sludge thickeners of both WTPs were designed on the present guideline of 10 to 20 kg TS/㎡·d, it expected that both plants might suffer from operational problems caused by insufficient thickening area. This result strongly suggests that the gravitational sludge thickeners should be designed after considering the type of water supply and the thickening characteristics of the sludge to be generated at each specific WTP.
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Bae, Sung Uk,Park, Won-Jin,Jeong, Woon Kyung,Baek, Seong Kyu,Lee, Hye-Won,Lee, Jae-Ho,Yang., Hua Williams & Wilkins Co 2019 Medicine Vol.98 No.14
<P><B>Abstract</B></P><P>Telomeres are transcribed into long, noncoding telomeric repeat-containing RNAs (TERRA) that have been implicated in the regulation of telomerase, the enzyme that lengthens telomeres, in heterochromatin formation at telomeres, and in telomere stability. This study aimed to evaluate the correlation between TERRA expression and long-term oncologic outcomes in colorectal cancer (CRC).</P><P>We evaluated 18p TERRA expression and telomere length using quantitative real-time PCR in 60 patients who underwent surgical resection for CRC between June 2008 and November 2010.</P><P>Patients were grouped according to 18p TERRA expression, with 29 (48.3%) and 31 (51.7%) patients in the low and high TERRA expression groups, respectively. The median follow-up period was 80 months (range 2–103). The 18p TERRA expression was marginally significantly associated with preoperative carcinoembryonic antigen (CEA; <I>P</I> = .082) and was significantly associated with telomere length (<I>P</I> < .05). Multivariate analysis revealed that preoperative CEA (hazard ratio [HR], 2.728; 95% confidence interval [CI], 0.832–8.944, <I>P</I> = .098) and 18p TERRA expression (HR, 0.113; 95% CI, 0.011–1.126, <I>P</I> = .071) were marginally significant independent prognostic factors for overall survival (OS), whereas preoperative CEA (HR, 4.254; 95% CI, 1.394–12.985, <I>P</I> = .011) and 18p TERRA expression (HR, 0.108; 95% CI, 0.011–1.037, <I>P</I> = .054) were significant independent prognostic factors for disease-free survival (DFS). According to our prognostic model with 2 prognostic factors, the OS and DFS rate increased to 76.2% and 80.63%, respectively, in patients with high 18p TERRA expression and CEA levels ≤5 (<I>P</I> = .178, <I>P</I> = .057, respectively).</P><P>18p TERRA expression was marginally significantly associated with preoperative CEA and significantly associated with telomere length, rendering it a potential prognostic factor for long-term oncologic outcomes in CRC.</P>
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추적자 실험을 이용한 응집/침전지 수리학적 특성의 동시평가
배병욱,김영일,박진호 大田大學校 環境問題硏究所 2002 환경문제연구소 논문집 Vol.6 No.-
추적자 실험은 정수당 단위공정들의 수리학적 특성을 평가하기 위한 방법으로 사용되어 왔으나, 정수장의 각 단위공정들은 규모가 크고 처리 유량이 많아 실험이 용이하지 않고 결과의 해석도 쉽지 않다. 이에 본 연구에서는 실제 정수장 3곳의 응접지와 침전지를 대상으로 동시에 추적자 실험을 수행하는 방법과 결과의 해석기법(index법, Rebhun and Argaman이 제시한 도식해법)에 대해서 소개하였다. 추적자 실험 결과 대부분 정수장의 응집지는 실제 체류시간이 이론적 체류시간과 거의 유사했으나, 침전지의 경우에는 실제 체류시간이 이론적 체류시간에 훨씬 미치지 못하는 것으로 나타났다. 이는 침전지 하부의 슬러지와 밀도류에 의한 것으로 판단되며, 이로 인해 플락이 침강하기 전에 웨어로 유출되어 여과지의 지속시간 단축, 역세척시 탁질 누출 등의 여과지에 악영향을 미칠 수 있을 것으로 생각된다. 또한, 추적자 실험결과에 의해 동일한 정수장에 위치한 2개의 응집지와 침전지에 유량이 분배되는 특성도 알 수 있었다. 결론적으로 기존의 index법을 이용하여 응집지와 침전지의 수리학적 유체흐름 특성(back mixing, short-circuiting)을 파악할 수 있었으며, Rebhun과 Argaman이 제시한 수학적인 방법을 사용하여 압출형 흐름 분율(p). 완전혼합 흐름 분율(1-p), 그리고 사수부(m) 분율을 정량적으로 제시할 수 있었다. The tracer tests were used to evaluate for hydraulic characteristics of the unit process in water treatment plant(WTP). But, the tracer tests were difficult to analysis of results and to conducted for the test because of large flow and huge scale of unit processes in WTP. In order to introduce simultaneous performance to tracer test and analysis method of results(index method, Rebhun and Argaman method), the three real WTPs(CJ. DS, and DW) which have the flocculation and sedimentation basin were investigated. The actual detention time of flocculation basin in the majority WTPs were almost similar to theoretical detention time. But, that of sedimentation basin were far more short than theoretical detention time. This phenomenon might be due to the volume reduction of sedimentation basin by sludge and density flow (short-circuiting) under the sedimentation basin. Thereby the flocs, which carried over the weir before settle in sedimentation basin, were bad effect for downstream unit process such as filtration according to reduction of filter run time and turbidity breakthrough after filter back wash. According to the result of tracer test and flow distribution characteristics were evaluated between two flocculation and sedimentation basins in WTP. The hydraulic characteristics(back mixing, short-circuiting) of flocculation and sedimentation basin using the conventional index method were evaluated and the plug flow fraction(p), complete flow fraction(1-p), and the extent of dead spaces(m) were quantitatively determined using the mathematical and experimental analyses by Rebhun and Argaman method.
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임경호,박영오,배병욱 공주대학교 방재연구센터 1998 공주대학교 방재연구센터 논문집 Vol.2 No.-
Rapid sand filters in water treatment plants(WTP) is one of the most important step in order to remove fine particle including pathogens such as Criptosporidium and Giardia. Filters should be assessed based on their capability to achieve a treated water quality of less than 0.1 ntu on a continuous basis to ensure the integrity of the filtration process as a viable barrier in the treatment schme. This is less than the 1.0 ntu standard, but operation of filters to produce filterd water quality confidence that pathogens are being removed prior to the last barrier, disinfection. In this study, to optimize existing filtraiton unit process, rapid sand filteres-woking in S-WTP were evaluated for various factors. The results of comprehensive performance evaluation were followings. From the filter media analysis, effctive size and uniformity coefficient of media was 0.90~1.0 mm and 1.44~1.47, respectively. Therefore, the replacement of media is needed to optimize filter performance. Media loss was caused by air binding in the filter ed and improper operation of backwashing process. The ratio of the water used for filter washing to the amount of filtered waster was 2.5~3% curing the winter and 1~2 % in the summer. At teh beginning of a filter run, filtered water turbidity was over 0.5 ntu during about 20 min. Shorter filter run lengths was attributed to an overabundance of filter clogging algae(Synedra sp), air binding, and too much floc in the filter influent.
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