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Yang, Ui-Jeong,Maeng, Hyojin,Park, Tae-Sik,Shim, Soon-Mi Mary Ann Liebert, Inc 2015 Journal of medicinal food Vol.18 No.9
<P>Vascular function is mediated by various regulatory molecules, including endothelial nitric oxide (NO), which regulates the vasodilation of smooth muscle cells. We investigated whether standardized Houttuynia cordata extract (SHCE) could improve physical endurance performance by regulating the endothelial production of NO. For the standardization of Houttuynia cordata (HC) extract, its bioactive components were identified and quantified using ultraperformance liquid chromatography-mass spectrometry. Bioaccessibility and biological activity were measured by the in vitro digestion model system and free radical scavenging capacity, respectively. The vascular function in the endothelium was assessed by the phosphorylation of endothelial nitric oxide synthase (eNOS). A preliminary clinical trial was carried out to assess the physical endurance performance. HC extract was standardized to bioactive components, including chlorogenic acid, rutin, and quercitrin, with the concentration of 5.53, 6.09, and 16.15?mg from 1?g of dry weight, respectively. Bioaccessibility was 33.17%, 31.67%, and 11.18% for chlorogenic acid, rutin, and quercitrin, respectively. Antioxidant activities of SHCE were expressed as vitamin C equivalent antioxidant capacity in 55.81 and 17.23?mg/g of HC extract using ABTS and DPPH scavenging assay, respectively. In human aortic endothelial cells, insulin-mediated phosphorylation of eNOS was increased by SHCE in the presence of palmitate. However, the expression of blood pressure-regulating genes was not altered. The level of blood lactate concentration and the heart rate of subjects who drank SHCE were lower than those of subjects who drank plain water. Oxygen uptake from subjects drinking SHCE was slightly higher than that from those who drank plain water. This study demonstrated that SHCE decreased heart rate and blood lactate, increased oxygen uptake, and improved physical performance, presumably due to the increased NO production.</P>
Yang, Ui-Jeong,Ko, Sanghoon,Shim, Soon-Mi The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.2
Inhibitory effects of water extract of water spinach (WEWS) on cytotoxicity and oxidative stress induced by heavy metals were examined. Antioxidant activities of WEWS were expressed as vitamin C equivalent antioxidant capacity in 238 mg/100 g of water spinach using $ABTS^{{\bullet}-}$ scavenging assay. Vitamin C was identified as a major bioactive component in WEWS by using UPLC/MS. The content of vitamin C was 42 mg from 100 g of dried powder. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (a yellow tetrazole) assay and dichlorofluorescein assay were conducted to measure cytotoxicity and generation of reactive oxygen species (ROS) caused by heavy metals, respectively. Cytotoxicity was inhibited at the concentrations of 1.06, 1.06, 1.06, and 2.65 mg/L of WEWS for Cd, As, Pb, and Hg, respectively. Pretreatment of WEWS in HepG2 cell attenuated the generation of ROS in a dose-dependent manner. Results of present study suggest that WEWS mainly containing vitamin C could be effective dietary source for reducing cytotoxicity and oxidative stress-induced heavy metals in HepG2 cell.
Yang, Ui-Jeong,Park, Tae-Sik,Shim, Soon-Mi Taylor Francis 2013 Journal of toxicology and environmental health. Pa Vol.76 No.23
<P>The purpose of this study was to examine the inhibitory effects of ethanol extract of water spinach (EEWS) containing chlorophyll and lycopene on cytotoxicity and oxidative stress in liver induced by heavy metals. The (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT assay and dichlorofluorescein (DCF) assay were conducted to measure cytotoxicity and inhibition of reactive oxygen species (ROS), respectively. Cytotoxicity was prevented at a concentration of 11.7 mg/L of EEWS. Both sodium copper chlorophyllin (SCC) and lycopene in EEWS were identified by ultraperformance liquid chromatography-photodiode array-electrospray ionization-mass spectroscopy (UPLC-PDA-ESI-MS/MSn) as major components at m/z 722.64 and 535.45, respectively. The concentrations of SCC and lycopene were 0.12 and 0.04 mg from 100 g of dried powder, respectively. Approximately 99% cytotoxicity induced by Cd was inhibited by EEWS. However, the inhibitory effect attributed to generation of ROS was similar with SCC, lycopene, and EEWS. Our results indicated that EEWS was effective in reducing cytotoxicity and oxidative stress produced by heavy metals in a HepG2 cell. Data suggest that the possible mechanism underlying the preventive action of SCC might be associated with diminished absorption of metal ions by chelating and blocking metal-mediated generation of ROS, while lycopene effects may be attributed to its high number of conjugated dienes that act as most potent singlet oxygen quenchers.</P>
Ui-Sik Jeong,Choong-Ki Kim,Hagyoul Bae,Dong-Il Moon,Tewook Bang,Ji-Min Choi,Jae Hur,Yang-Kyu Choi Institute of Electrical and Electronics Engineers 2016 IEEE transactions on electron devices Vol.63 No.5
<P>Low-frequency noise (LFN) behaviors, characterized with an SONOS-based gate-all-around junctionless nanowire (JLNW), are investigated to determine the suitability of this type of NW as a memory cell structure. LFN exhibits a 1/f-shape and is described by a carrier number fluctuation noise model. It is found that the proposed device structure shows a low level of device-to-device variation and high immunity against Fowler-Nordheim tunneling stress. Due to the centered conduction path in the JLNW device, the impact of correlated mobility fluctuations on the LFN is insignificant. The trapped charge in the nitride layer of the Silicon(Poly-Si)-oxide(SiO2)-nitride(SiNx)oxide(SiO2)-silicon(Single-crystalline) (SONOS) device also negligibly influences the LFN. The NW width-dependence is clarified in terms of the effects of the oxide trap density and source/drain series resistance under a fresh and a programmed state.</P>
포스터 발표 : 포스터 연제 ; 혈액 투석시 발생하는 저혈압의 예방에 대한 amezinium methylsulfate의 유용성
박정희 ( Park Jeong Hui ),김병수 ( Kim Byeong Su ),신영신 ( Sin Yeong Sin ),박철휘 ( Park Cheol Hwi ),김영옥 ( Kim Yeong Og ),송호철 ( Song Ho Cheol ),최의진 ( Choe Ui Jin ),양철우 ( Yang Cheol U ),김용수 ( Kim Yong Su ),방병기 ( 대한신장학회 1999 춘계학술대회 초록집 Vol.18 No.2