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A Complex Search Technique for Solving the Quadratic Assignment Problem
Ider Tseveendorj,Catherine Roucairol,Bazarragchaa Barsbold,Enkhbat Rentsen,Bertrand Le Cun,Francois Galea 한국멀티미디어학회 2009 한국멀티미디어학회 국제학술대회 Vol.2009 No.-
An algorithm recently developed by Enkhbat et al. based on continuous relaxation of the quadratic assignment problem generates suboptimal solution of good quality on average giving no sufficient enough verification on global optimality of the generated solution, whereas a branch and bound method provides a solution with verified global optimality, taking on input an upper bound close to global optimality. In this research we investigated possibility for combining these two techniques, so that firstly upper bound is obtained from the relaxed problem using a continuous global optimization, then a branch and bound procedure is taken to solve the problem completely.
몽골 특수교육의 문제점과 개선 방향에 대한 특수학교 교사의 인식
아리우나체벤도르지 ( Ariunaa Tseveendorj ),박남수 ( Park Nam-su ),강종구 ( Kang Jong-gu ) 대구대학교 특수교육재활과학연구소 2021 특수교육재활과학연구 Vol.60 No.4
[목적] 본 연구의 목적은 몽골 특수교육의 문제점과 개선 방향에 대한 교사들의 인식을 알아보는 것이다. [방법] 이를 위해 몽골의 특수학교에 근무하는 5명의 교사를 대상으로 심층 인터뷰를 진행한 다음 그 결과를 범주별로 유목화하여 분석하였다. [결론] 첫째, 특수학교 교사들은 전문성을 지닌 교사 및 인력의 부족, 열악한 학습 환경, 장애아동에게 적합하지 않은 교육과정 및 지속적인 개선의 미흡을 특수교육의 문제점으로 인식하고 있다. 둘째, 특수학교 교사들은 전문성을 지닌 교사 양성 및 연수를 통한 특수교사의 전문성 향상, 재정지원을 통한 적절한 학습 환경의 구비, 장애아동에게 적합한 교육과정 개발 및 지속적 개선이 필요하다고 인식하고 있다. [함의] 이러한 결론은 몽골 특수교육의 문제점 해결 및 개선방향의 실현을 위해서는 특수교육에 대한 정부의 적극적인 정책과 그 실현을 위한 재정적 지원에 더 많은 관심을 기울일 필요가 있음을 시사하고 있다. [Purpose] The purpose of this study was to investigate the special school teachers' perception about the problems and improvement directions of Mongolia’s special education. [Method] For this purpose, in-depth interviews were conducted with 5 teachers and the results were analyzed by categorizing them. [Conclusion] First, as the problems in special education, special education teachers recognized the lack of professional teachers and human resources, the poor learning environment, the curriculum not suitable for children with disabilities, and the lack of continuous improvement. Second, special school teachers recognized the need to secure professional teachers, improvement special teachers' expertise through training, establishment of an appropriate learning environment through financial support, and development and improvement of curriculum suitable for children with disabilities. [Implication] In order to solve the problems of these problems and realize the improvement direction, it is necessary to pay more attention to the government's active policy on special education and financial support for its realization.
An integrative model for the identification of key players of cancer networks
Amgalan, Bayarbaatar,Tseveendorj, Ider,Lee, Hyunju Elsevier 2018 Applied mathematical modelling Vol.58 No.-
<P><B>Abstract</B></P> <P>Uncovering miscoordination in a biological network is essential for the understanding of cellular malfunctions in cancer. Integrative analysis across multiple cellular levels may provide an opportunity to elucidate the miscoordination between the regulatory mechanisms in cancer cells.</P> <P>Here, we propose an integrative model for the identification of key players of the cancer-activated Multi-Type Interaction (MTI) gene network (KPOCN). To measure the functional associations between genes, using DNA copy number aberrations (CNAs) and gene expressions (GEs), we constructed three interacting weighted graphs: GEs affected by CNAs, CNAs by CNAs, and GEs by GEs. These three weighted graphs were mapped onto a single graph, in order to construct a MTI gene network by using their optimal combination. Finally, the effect of a single gene was determined by using the centrality and betweenness of node scores in the MTI network.</P> <P>We first tested KPOCN using simulated datasets, and afterward, we applied this model to the real breast cancer datasets. KPOCN was shown to identify successfully key regulators with their corresponding response variables (targets) when using the simulated data, and identified well-known breast cancer oncogenes. These results demonstrated that our model can be used for an efficient identification of key genes that affect cancer development. Source codes are available at http://gcancer.org/KPOCN.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A computational method for identification of cancer driver genes is proposed. </LI> <LI> Non-differentiable convex optimization identifies relationships between genes. </LI> <LI> Contributions of genomic data to cancer are formulated by convex maximization. </LI> <LI> Gene expression, copy number, and gene interaction are used to analyze breast cancer. </LI> </UL> </P>