Opposition multiple objective symbiotic organisms search (OMOSOS) for time, cost, quality and work continuity tradeoff in repetitive projects

Duc-Hoc Tran,Long Luong-Duc,Minh-Tin Duong,Trong-Nhan Le,Anh-Duc Pham 한국CDE학회 2018 Journal of computational design and engineering Vol.5 No.2

Construction managers often face with projects containing multiple units wherein activities repeat from unit to unit. Therefore effective resource management is crucial in terms of project duration, cost and quality. Accordingly, researchers have developed several models to aid planners in developing practical and near-optimal schedules for repetitive projects. Despite their undeniable benefits, such models lack the ability of pure simultaneous optimization because existing methodologies optimize the schedule with respect to a single factor, to achieve minimum duration, total cost, resource work breaks or various combinations, respectively. This study introduces a novel approach called ‘‘opposition multiple objective symbiotic organisms search” (OMOSOS) for scheduling repetitive projects. The proposed algorithm used an opposition-based learning technique for population initialization and for generation jumping. Further, this study integrated a scheduling module (M1) to determine all project objectives including time, cost, quality and interruption. The proposed algorithm was implemented on two application examples in order to demonstrate its capabilities in optimizing the scheduling of repetitive construction projects. The results indicate that the OMOSOS approach is a powerful optimization technique and can assist project managers in selecting appropriate plan for project.

Nondestructive crack detection in metal structures using impedance responses and artificial neural networks

Ho, Duc-Duy,Luu, Tran-Huu-Tin,Pham, Minh-Nhan Techno-Press 2022 Structural monitoring and maintenance Vol.9 No.3

Among nondestructive damage detection methods, impedance-based methods have been recognized as an effective technique for damage identification in many kinds of structures. This paper proposes a method to detect cracks in metal structures by combining electro-mechanical impedance (EMI) responses and artificial neural networks (ANN). Firstly, the theories of EMI responses and impedance-based damage detection methods are described. Secondly, the reliability of numerical simulations for impedance responses is demonstrated by comparing to pre-published results for an aluminum beam. Thirdly, the proposed method is used to detect cracks in the beam. The RMSD (root mean square deviation) index is used to alarm the occurrence of the cracks, and the multi-layer perceptron (MLP) ANN is employed to identify the location and size of the cracks. The selection of the effective frequency range is also investigated. The analysis results reveal that the proposed method accurately detects the cracks' occurrence, location, and size in metal structures.

The effects of BMS-470539 on lipopolysaccharideinduced acute lung injury

장은아,김진영,tran duc tin,송지아,이성헌,곽상현 대한중환자의학회 2019 Acute and Critical Care Vol.34 No.2

Background: Overactivation of inflammatory cells, including macrophages and neutrophils, is associated with acute lung injury. BMS-470539 is a selective agonist of melanocortin 1 receptor, which triggers the inhibition of proinflammatory responses, suppressing neutrophil infiltration and protecting tissue. This study evaluated the effects of BMS-470539 on lipopolysaccharide-induced acute lung injury in a mouse model. Methods: Mice received a subcutaneous injection of saline or BMS-470539 (18.47 mg/kg) 1 hour before an intratracheal injection of saline or lipopolysaccharide (20 μg). Mice were sacrificed to analyze the severity of pulmonary edema (lung wet-to-dry weight [W/D] ratio) and inflammatory responses (level of leukocytes, polymorphonuclear neutrophils [PMNs] and tumor necrosis factor alpha [TNF-α] in bronchoalveolar lavage fluid [BALF]), and neutrophil infiltration (myeloperoxidase activity). TNF-α activation was also measured in neutrophils from bone marrow. Survival was investigated in a second-hit sepsis mouse model. Results: BMS-470539 improved sepsis-induced pulmonary edema, as demonstrated by a decreased W/D ratio (5.76% ± 0.83% to 3.81% ± 0.86%, P < 0.05). The inflammatory response also improved, as shown by decreased levels of leukocytes (551 ± 116 to 357 ± 86 × 10²/mm³, P < 0.05), PMNs (51.52% ± 16.23% to 18.41% ± 7.25%, P < 0.01), and TNF-α (550 ± 338 to 128 ± 52 pg/ml, P < 0.01) in the BALF. BMS-470539 also improved the inflammatory response, as shown by TNF-α levels (850 ± 158 to 423 ± 59 pg/ml, P < 0.01) in neutrophils. BMS-470539 downregulated neutrophil infiltration in the lung (myeloperoxidase: 654 ± 98 to 218 ± 89 U/g, P < 0.001). Lastly, BMS improved the survival rate (0% to 70%, P < 0.01) in a mice multiple organ failure model. Conclusions: BMS-470539 improved lipopolysaccharide-induced acute lung injury and mortality in mice by affecting the inflammatory response.

The manufacturing of sintered bricks from clay and red mud derived from the alumina processing plant

Ngoc Tuyen Tran,Duc Vu Quyen Nguyen,Van Minh Hai Ho,Xuan Tin Dang,Ngoc Quang Tran 한양대학교 청정에너지연구소 2017 Journal of Ceramic Processing Research Vol.18 No.5

In this study, the manufacturing of sintered bricks from clay and red mud was presented. The initial materials and obtainedbricks were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope(TEM), X-ray fluorescence (XRF), and differential scanning calorimetry-thermal gravimetry (DSC-TG). The compressivestrength, water absorption, bulk density and sintering shrinkage of sintered bricks were performed. The effects of componentsof raw materials, sintering temperature and time on physico-mechanical properties of the products was investigated. Theresults showed that the bricks prepared at 1000 oC for 1 hr with raw material containing up to 50% of red mud providedexcellent physico-mechanical properties. The obtained brick met the Vietnam standard VS1451-1998 and was satisfied theconstruction material requirements that were safe to human’s health and friendly with environment in terms of alkalineleaching and radioactivity indexes.

Protective role of curcumin against lipopolysaccharide-induced inflammation and apoptosis in human neutrophil

조규범,박천희,김정민,Tran Duc Tin,곽상현 대한마취통증의학회 2020 Anesthesia and pain medicine Vol.15 No.1

Background: Sepsis, an uncontrolled host response to infection, may be life-threatening organ injury. Neutrophils play a critical role in regulation of host immune response to infection. Curcumin, known as a spice and food coloring agent, possesses anti-inflammatory properties. In this study, we investigated the effects of curcumin on lipopolysaccharide (LPS)-induced neutrophil activation with its signaling pathways. Methods: Isolated human neutrophils were incubated without or with LPS and curcumin, and the expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-8 were assessed by enzyme-linked immunosorbent assays. The expression of mitogen-activated protein kinases such as p38, extracellularsignal- regulated kinase (ERK)1/2, and c-Jun N-terminal kinase (JNK) were evaluated by Western blot analysis. Neutrophil apoptosis was also measured by fluorescenceactivated cell sorting (annexin V/propidium iodide) in LPS-stimulated neutrophils under treatment with curcumin. Results: Curcumin attenuated expression of TNF-α, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils. Additionally, curcumin restored the delayed neutrophil apoptosis by LPS-stimulated neutrophils(19.7 ± 3.2 to 38.2 ± 0.5%, P < 0.05). Conclusions: Our results reveal the underlying mechanism of how curcumin attenuate neutrophil activation and suggest potential clinic applications of curcumin supplementation for patients with severe sepsis and septic shock. Additional clinical studies are required to confirm these in vitro findings.

Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation

이승훈,Wan Ju,Tran Duc Tin,김정민,이정석,박천희,곽상현 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.2

Background: BMS-470539, a recently introduced selective agonist of the melanocortin 1 receptor, is known to have anti-inflammatory properties. In this study, we investigated the effects of BMS-470539 on lipopolysaccharide (LPS)-induced inflammatory responses and delayed apoptosis with its signaling pathways in human neutrophils. Methods: Isolated human neutrophils were incubated with various concentrations of BMS-470539 (1, 10, and 100 μM) in the presence or absence of LPS (100 ng/ml), and the expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin (IL)-6, and IL-1β, were assessed. The effects of BMS-470539 on the expression of mitogen-activated protein kinases (MAPKs), such as p38, extracellular-signal-regulated kinase 1/2, and c-Jun N-terminal kinase, and the expression of nuclear factor kappa B (NF-κB) in LPS-stimulated human neutrophils, were evaluated by enzyme-linked immunosorbent assay. Neutrophil apoptosis was also measured by fluorescence-activated cell sorting (annexin V/propidium iodide) in LPS-stimulated neutrophils under treatment with BMS-470539. Results: BMS-470539 attenuated LPS-induced expression of pro-inflammatory cytokines, and phosphorylation of MAPKs and NF-κB. LPS stimulation reduced neutrophil apoptosis compared to the controls; however, BMS-470539 significantly inhibited the reduction of neutrophil apoptosis. Conclusions: BMS-470539 can suppress the inflammatory responses of LPS-stimulated neutrophils by inhibition of MAPK pathways or NF-κB pathway, and it can also inhibit LPS-delayed neutrophil apoptosis.

The Effect of Caffeic Acid Phenethyl Ester (CAPE) on Phagocytic activity of septic Neutrophil in vitro

장은아,Hui-Jing Han,tran duc tin,조은예,이성헌,곽상현 대한의생명과학회 2023 Biomedical Science Letters Vol.29 No.4

Caffeic acid phenethyl ester (CAPE) is an active component of propolis obtained from honeybee hives. CAPE possesses anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory activities in diverse systems, which know as displays antioxidant activity and inhibits lipoxygenase activities, protein tyrosine kinase, and nuclear factor kappa B (NF-κB) activation. This study aimed to investigate the effect of CAPE on lipopolysaccharide (LPS)-induced human neutrophil phagocytosis. Human neutrophils were cultured with various concentrations of CAPE (1, 10, and 100 μM) with or without LPS. The pro-inflammatory proteins (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6 and IL-8) levels were measured after 4 h incubation. To investigate the intracellular signaling pathway, we measured the levels of mitogen-activated protein kinases (MAPK), including phosphorylation of p38, extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and c-Jun N-terminal kinase (JNK). Next, to evaluate the potential phagocytosis, neutrophils were labeled with iron particles of superparamagnetic iron oxide nanoparticles (SPIONs, 40 nm) for 1 h in culture medium containing 5 mg/mL of iron. The labeling efficiency was determined by Prussian blue staining for intracellular iron and 3T-wighted magnetic resonance imaging. CAPE decreased the activation of intracellular signaling pathways, including ERK1/2 and c-Jun, and expression of pro-inflammatory cytokines, including TNF-α and IL-6, but had no effect on the signaling pathways of p38 and cytokine IL-8. Furthermore, images obtained after mannan-coated SPION treatment suggested that CAPE induced significantly higher signal intensities than the control or LPS group. Together, these results suggest that CAPE regulates LPS-mediated activation of human neutrophils to reduce phagocytosis.

The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats

Shi Young Chung,Jinyoung Kim,Hong Bum Bae,Tran Duc Tin,Wan Ju,Sang Hyun Kwak 대한중환자의학회 2018 Acute and Critical Care Vol.33 No.1

Background: Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action is contended. We determined the effects of flecainide acetate on lipopolysaccharide (LPS)-stimulated human neutrophils in vitro and on mortality in a septic rat model. Methods: Neutrophils from human blood were cultured with varying concentrations of flecainide acetate (1 μM, 10 μM, or 100 μM) with or without LPS (100 ng/ml). To assess neutrophil activation, the protein levels of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 and IL-8 were measured after a 4-hour culture period. To assess the intracellular signaling pathways, the levels of phosphorylation of p38 mitogen-activated protein kinase (p38), extracellular signal-regulated kinase (ERK) 1/2, and c-Jun N-terminal kinase (JNK) were measured after a 30-minute culture period, and the nuclear translocation of nuclear factor (NF)-κB was measured after a 1-hour culture period. Additionally, the survival rate was investigated in a rat sepsis model. Results: Flecainide acetate down-regulated the activation of proinflammatory cytokines, including TNF-α and IL-6 and IL-8, and intracellular signaling pathways including ERK 1/2 and NF-κB. Flecainide acetate also improved the survival rate in the rat sepsis model. Conclusions: Collectively, these findings indicate that flecainide acetate can improve survival in a rat sepsis model by attenuating LPS-induced neutrophil responses. We therefore suggest that flecainide acetate plays an important role in modulating inflammatoryimmune responses.