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Muhammad Ashraf Javid,Toshiyuki Okamura,Fumihiko Nakamura,Shinji Tanaka,Rui Wang 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.1
This paper aims to identify the relationships between people’s attitudes on service quality attributes of private car and public transport, and intentions to use public transport under situational constraints, mobility restrictions on car use, public transport incentives and moral obligation. A questionnaire survey was conducted in Lahore and 354 usable samples obtained. Results revealed that people’s intentions to use public transport vary under different situations and mobility restrictions. The fiscal restrictions and policy of car entry restriction have significant influence on changing people’s intentions. Modeling results revealed that social/ aesthetic, personal and instrumental attitudinal aspects of private car and public transport are underlying factors in determining the people’s intentions towards public transport under stated conditions. It is argued that social/aesthetic and personal dimensions of public transport should have equal importance in making improvements along with instrumental dimensions. This study implicates that improvement in service quality of public transport need to integrate with mobility restrictions on car use for effective change of travel behavior. The findings of this study would be helpful for concerned authorities in considering the appropriate attributes of public transport for improvement, and other related policy measures to make significant promotion from car to public transport.
Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.
Nakayama, Masafumi,Kurokawa, Kenji,Nakamura, Kyohei,Lee, Bok Luel,Sekimizu, Kazuhisa,Kubagawa, Hiromi,Hiramatsu, Keiichi,Yagita, Hideo,Okumura, Ko,Takai, Toshiyuki,Underhill, David M,Aderem, Alan,Ogas American Association of Immunologists 2012 Journal of Immunology Vol. No.
<P>The innate immune system has developed to acquire a wide variety of pattern-recognition receptors (PRRs) to identify potential pathogens, whereas pathogens have also developed to escape host innate immune responses. ITIM-bearing receptors are attractive targets for pathogens to attenuate immune responses against them; however, the in vivo role of the inhibitory PRRs in host-bacteria interactions remains unknown. We demonstrate in this article that Staphylococcus aureus, a major Gram-positive bacteria, exploits inhibitory PRR paired Ig-like receptor (PIR)-B on macrophages to suppress ERK1/2 and inflammasome activation, and subsequent IL-6 and IL-1β secretion. Consequently, Pirb(-/-) mice infected with S. aureus showed enhanced inflammation and more effective bacterial clearance, resulting in resistance to the sepsis. Screening of S. aureus mutants identified lipoteichoic acid (LTA) as an essential bacterial cell wall component required for binding to PIR-B and modulating inflammatory responses. In vivo, however, an LTA-deficient S. aureus mutant was highly virulent and poorly recognized by macrophages in both wild-type and Pirb(-/-) mice, demonstrating that LTA recognition by PRRs other than PIR-B mediates effective bacterial elimination. These results provide direct evidence that bacteria exploit the inhibitory receptor for virulence, and host immune system counterbalances the infection.</P>
NASU Keiko,KINJO Yasuko,ISARIDA Toshiko,NAKAMURA Mieko,OJIMA Toshiyuki 아시아아동지원학회 2012 아시아아동지원연구 Vol.3 No.-
The consistency between 3 to 5-year-old children’s choice of facial expression stickers and the choices made by nursery school teachers and parents in health evaluations over a 4.5.month period were evaluated at 21 nursery schools in Japan. Children at the nursery schools chose facial expression stickers at health checks conducted immediately after arr?val at school a nd as they were leaving. For selected students, the teachers cond ucted health checks and chose a fac?al expression st?cker corresponding to their evaluation of the child’s cond?tion. At home, after the even?ng meal, the children and their parents conducted daily health checks, and each chose an appropriate facial expression sticker. Consistency rates and Cohen’s Kappa were calculated by age group for school arr?val and departure, and total arrivalsl departures for all sampled children throughout the entire study period. There was moderate consistency between ch?ldren and teachers ?mmediately after school arr?val, but cons?stency was lower at school departure, except for 5.yearold children. Levels of cons?stency were higher at home than at school for every age group. Using facial expression stickers in health checks could be a useful method for 3. to 5.year.old children, who may find it difficult to express their physical condition verbally
Karthik Paneer Selvam,Taichi Nagahata,Kosuke Kato,Mayuko Koreishi,Toshiyuki Nakamura,Yoshimasa Nakamura,Takeshi Nishikawa,Ayano Satoh,Yasuhiko Hayashi 한국생체재료학회 2020 생체재료학회지 Vol.24 No.4
Background: Conductive sheets of cellulose and carbon nanomaterials and its human skin applications are an interesting research aspect as they have potential for applications for skin compatibility. Hence it is needed to explore the effects and shed light on these applications. Method: To fabricate wearable, portable, flexible, lightweight, inexpensive, and biocompatible composite materials, carbon nanohorns (CNHs) and hydroxyethylcellulose (HEC) were used as precursors to prepare CNH-HEC (Cnh-cel) composite sheets. Cnh-cel sheets were prepared with different loading concentrations of CNHs (10, 20 50,100 mg) in 200 mg cellulose. To fabricate the bio-compatible sheets, a pristine composite of CNHs and HEC was prepared without any pretreatment of the materials. Results: The obtained sheets possess a conductivity of 1.83 × 10− 10 S/m and bio-compatible with human skin. Analysis for skin-compatibility was performed for Cnh-cel sheets by h-CLAT in vitro skin sensitization tests to evaluate the activation of THP-1 cells. It was found that THP-1 cells were not activated by Cnh-cel; hence Cnh-cel is a safe biomaterial for human skin. It was also found that the composite allowed only a maximum loading of 100 mg to retain the consistent geometry of free-standing sheets of < 100 μm thickness. Since CNHs have a unique arrangement of aggregates (dahlia structure), the composite is homogeneous, as verified by transmission electron microscopy (TEM) and, scanning electron microscopy (SEM), and other functional properties investigated by Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), conductivity measurement, tensile strength measurement, and skin sensitization. Conclusion: It can be concluded that cellulose and CNHs sheets are conductive and compatible to human skin applications.