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Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
The planning strategy of robotics technology for nuclear decommissioning in Taiwan
Tu Chung Yi,Chen Kuen Tsann,Ting Kuen,Yang Sheng Chin 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.1
According to the market research report, the nuclear decommissioning services market is currently experiencing considerable growth, with a projected Compound Annual Growth Rate (CAGR) of nearly 13% during the 2020–2024 forecast period. This expansion is primarily fueled by the advancement of Industry 4.0, in conjunction with the emergence of cutting-edge technologies such as the Internet of Things, big data, artificial intelligence, and 5G. Even though the fact that robots have already been utilized in the nuclear industry, their adoption has been hindered by conservative regulations. However, the nuclear decommissioning market presents an opportunity for the advancement of robotics technology. The British have already invested heavily in encouraging the use of intelligent robots for nuclear decommissioning, and other countries, such as Taiwan, should follow suit. Taiwan’s flourishing robotics development industry in manufacturing, logistics, and other domains can be leveraged to introduce advanced robotics in the decommissioning of its nuclear power plants. By doing so, Taiwan can establish itself as a competitive player in the nuclear decommissioning services market for the next two decades.
Sikhumbuzo Charles Kunene,Kuen-Song Lin,Meng-Tzu Weng,Maria Janina Carrera Espinoza,You-Sheng Lin,Yi-Ting Lin 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
In this study, versatile homotypic-targeting and PEGylated magnetite hollow nanostructures (MHNs) thatare pH-responsive used as doxorubicin (DOX) nanocarriers are demonstrated. Cancer cell membrane(CM) and polyethylene glycol (PEG) functionalization through benzoic imine bonds endows DOXconjugatednanocarriers with enhanced tumor accumulation and penetration, biomimetic-targetingspecificity, as well as on-demand drug release, which improves their antitumor efficacy. The characteristicdiffraction peaks of magnetite nanocarriers at 35 indexed as (311) plane of magnetite can beobserved. Hierarchical mesoporous nanostructures with specific pore size distributions of approximately99.9, 97.2, and 95.6%, were developed. In vitro studies revealed that drug-free nanostructures exhibitedexcellent biocompatibility with more than 95% cell viability. In contrast, drug-conjugated nanostructuresdemonstrated high therapeutic effect, pH-responsive drug release, and enhanced intracellular uptake inHepG2 cells. In vivostudies showed that the MHNC–DOX–PEG/CM formulations displayed the best antitumorefficacy, with the lowest tumor volume and weight. Furthermore, significantly large apoptotic andnecrotic areas were identified in the tumor tissues from the DOX-conjugated groups, but no noticeableinflammation or hemorrhage was observed in the main organs. Therefore, these results suggest thatthe formulated nanostructures have great potential for cancer therapies.
New Single-Phase Power Converter Topology for Frequency Changing of AC Voltage
Hurng-Liahng Jou,Jinn-Chang Wu,Kuen-Der Wu,Ting-Feng Huang,Szu-Hsiang Wei 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3
This paper proposes a new single-phase power converter topology for changing the frequency of AC voltage. The proposed single-phase frequency converter (SFC) includes a T-type multi-level power converter (TMPC), a frequency decoupling transformer (FDT) and a digital signal processor (DSP). The TMPC can convert a 60 Hz AC voltage to a DC voltage and then convert the DC voltage to a 50 Hz AC voltage. Therefore, the output currents of the two T-type power switch arms have 50 Hz and 60 Hz components. The FDT is used to decouple the 50 Hz and 60 Hz components. The salient feature of the proposed SFC is that only one power electronic converter stage is used since the functions of the AC-DC and DC-AC power conversions are integrated into the TMPC. Therefore, the proposed SFC can simplify both the power circuit and the control circuit. In order to verify the functions of the proposed SFC, a hardware prototype is established. Experimental results verify that the performance of the proposed SFC is as expected.
New Single-Phase Power Converter Topology for Frequency Changing of AC Voltage
Jou, Hurng-Liahng,Wu, Jinn-Chang,Wu, Kuen-Der,Huang, Ting-Feng,Wei, Szu-Hsiang The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3
This paper proposes a new single-phase power converter topology for changing the frequency of AC voltage. The proposed single-phase frequency converter (SFC) includes a T-type multi-level power converter (TMPC), a frequency decoupling transformer (FDT) and a digital signal processor (DSP). The TMPC can convert a 60 Hz AC voltage to a DC voltage and then convert the DC voltage to a 50 Hz AC voltage. Therefore, the output currents of the two T-type power switch arms have 50 Hz and 60 Hz components. The FDT is used to decouple the 50 Hz and 60 Hz components. The salient feature of the proposed SFC is that only one power electronic converter stage is used since the functions of the AC-DC and DC-AC power conversions are integrated into the TMPC. Therefore, the proposed SFC can simplify both the power circuit and the control circuit. In order to verify the functions of the proposed SFC, a hardware prototype is established. Experimental results verify that the performance of the proposed SFC is as expected.