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- 검색키워드
- 저자 : Sikhumbuzo Charles Kunene (검색결과 3 건)
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Sikhumbuzo Charles Kunene,KUEN-SONG LIN,Meng-Tzu Weng,Maria Janina Carrera Espinoza,Chun-Ming Wu 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
In this study, a series of thermo- and pH-dependent doxorubicin (DOX) carriers based on magnetic graphenenanosheets (MGNSs), functionalized by poly(N-isopropylacrylamide) (PNIPAM) and polyethylenemine(PEI) nanogel, targeting liver cancer cells were formulated. The temperature phase transitions of thecarriers can be tuned as a function of pH to the intended value in the range of 38–42 C. In vitro studiesshowed a high cell viability of above 90% at all doses of MGNSs and MGNS-nanogel against HEK293T normaland HepG2 cancerous cells, confirming the biocompatibility and nontoxicity of the carriers. In comparison,the MGNS-nanogel-DOX demonstrated a sufficient therapeutic effect towards HepG2 cell line. The cell viability results showed enhanced efficacy of the drug released by means of applied magneticfield (AMF). Moreover, an efficient cellular intake of the carriers into the HepG2 cells was achieved. Additionally, the achieved low DOX release at a lower temperature and neutral pH can retain the drugin the carriers until reaching the targeted sites. Nevertheless, the high drug release showed that therelease was triggered by high temperature and acidic pH. Hence, the developed thermo- and pHtunableMGNS-nanogel-DOX showed a high potential for microenvironment stimulus-prompted drugdelivery and cancer cell suppression.
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Sikhumbuzo Charles Kunene,Kuen-Song Lin,Meng-Tzu Weng,Maria Janina Carrera Espinoza,You-Sheng Lin,Yi-Ting Lin 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
In this study, versatile homotypic-targeting and PEGylated magnetite hollow nanostructures (MHNs) thatare pH-responsive used as doxorubicin (DOX) nanocarriers are demonstrated. Cancer cell membrane(CM) and polyethylene glycol (PEG) functionalization through benzoic imine bonds endows DOXconjugatednanocarriers with enhanced tumor accumulation and penetration, biomimetic-targetingspecificity, as well as on-demand drug release, which improves their antitumor efficacy. The characteristicdiffraction peaks of magnetite nanocarriers at 35 indexed as (311) plane of magnetite can beobserved. Hierarchical mesoporous nanostructures with specific pore size distributions of approximately99.9, 97.2, and 95.6%, were developed. In vitro studies revealed that drug-free nanostructures exhibitedexcellent biocompatibility with more than 95% cell viability. In contrast, drug-conjugated nanostructuresdemonstrated high therapeutic effect, pH-responsive drug release, and enhanced intracellular uptake inHepG2 cells. In vivostudies showed that the MHNC–DOX–PEG/CM formulations displayed the best antitumorefficacy, with the lowest tumor volume and weight. Furthermore, significantly large apoptotic andnecrotic areas were identified in the tumor tissues from the DOX-conjugated groups, but no noticeableinflammation or hemorrhage was observed in the main organs. Therefore, these results suggest thatthe formulated nanostructures have great potential for cancer therapies.
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Maria Janina Carrera Espinoza,KUEN-SONG LIN,Meng-Tzu Weng,Sikhumbuzo Charles Kunene,Shin-Yun Liu,You-Sheng Lin 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
The current study presents the synthesis and characterization of magnetic silica nanocomposites(MSNCs) decorated with Pluronic F127. The nanocomposites were loaded with doxorubicin (DOX) forhepatocellular carcinoma (HCC) therapy. The X-ray diffraction (XRD) patterns proved that the nanocompositeswere crystalline with diffraction peaks at 2h = 35.44 corresponding to (311) plane of Fe3O4. Thein vitro test demonstrated cell viability of above 90% revealing that MSNCs-F127 were biocompatible andnontoxic to the HEK293T and HepG2 cell lines; however, the MSNCs-F127-DOX formulations exhibited asignificant therapeutic effect against HepG2 cells. A pH-responsive drug release was detected, showing aHiguchi kinetic model at acidic and physiological conditions which demonstrated the best correlationcoefficient with R2 values of 0.969, and 0.932, respectively. The highest level of cell inhibitory rate, necrosis,and apoptosis in mice treated with MSNCs-F127-DOX was achieved by in vivo experiment, hematoxylinand eosin (H&E), and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)staining. The in vivo experiment revealed a significant tumor inhibition after treatment with MSNCs-F127-DOX. The prepared MSNCs-F127-DOX formulations could be utilized as an innovative drug deliverysystem (DDS) for anticancer therapy for several cancer types.
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