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Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis and Their Cytotoxic Activity
Do Thi Ha,Quan Cheng Chen,Tran Manh Hung,Tran Minh Ngoc,Phuong Thien Thuong,김홍진,성연희,민병선,배기환,윤의중 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-ε -viniferin (3), gnetinH (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)- ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC50 values ranging from 15.7 ± 2.1 to 30.9 ± 1.8 μM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC50 values of 30.6 ± 4.1 and 28.7 ± 2.81μM, respectively) and K562 (IC50 values of 38.6 ± 0.82 and 24.6 ± 0.76 μM, respectively). Gnetin H (4)showed only weak cytotoxic activity against L1210 with an IC50 value of 40.1 ± 4.23 μM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-ε -viniferin (3), (+)-ampelopsin F (7), and piceatannol(9) exhibited no activity on three cancer cell lines.
To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
The Role of Zn Doping on the Catalytic Activity of the Nanoparticle Perovskite La0.7Sr0.3MnO3
Tran Thi Minh Nguyet,Nguyen Quang Huan,Tran Que Chi,Do The Chan,Nguyen Doan Thai,Nguyen Cong Trang,Luu Tien Hung,Le Van Tiep,Nguyen Van Qui 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
The nanometer complex oxide La0:7Sr0.3Mn0.6Zn0.₄O₃ was prepared by using a Sol-Gel method with citric acid as a ligand. The in uence of Zn doping of La0.7Sr0.₃MnO₃ on the structure, the morphology, the surface properties and on the catalytic activity of material was studied by using X-ray diraction (XRD), transmission electron microscopy (TEM), a high-resolution images and selected area electron diraction (SAED), physical adsorption and temperature programmed surface reaction (TPSR) methods. The results showed that perovskite La0:7Sr0:3Mn0:6. Zn0.₄O₃ could well catalyse propene oxidation in the temperature range 190 { 280 ℃, which was reduced to 100 { 120 ℃ for catalyst La1-χSrχMnO₃ The nanometer complex oxide La0:7Sr0.3Mn0.6Zn0.₄O₃ was prepared by using a Sol-Gel method with citric acid as a ligand. The in uence of Zn doping of La0.7Sr0.₃MnO₃ on the structure, the morphology, the surface properties and on the catalytic activity of material was studied by using X-ray diraction (XRD), transmission electron microscopy (TEM), a high-resolution images and selected area electron diraction (SAED), physical adsorption and temperature programmed surface reaction (TPSR) methods. The results showed that perovskite La0:7Sr0:3Mn0:6. Zn0.₄O₃ could well catalyse propene oxidation in the temperature range 190 { 280 ℃, which was reduced to 100 { 120 ℃ for catalyst La1-χSrχMnO₃
Hung Thuan Tran,Young-Joo Park,Mi-Kyeoung Cho,김동진,안대희 한국생물공학회 2006 Biotechnology and Bioprocess Engineering Vol.11 No.3
The purpose of this work was to evaluate the development of the anammox process by the use of granular sludge selected from a digestion reactor as a potential seed source in a lab-scale UASB (upflow anaerobic sludge blanket) reactor system. The reactor was operated for approximately 11 months and was fed by synthetic wastewater. After 200 days of feeding with NH4+ and NO2- as the main substrates, the biomass showed steady signs of ammonium consumption, resulting in over 60% of ammonium nitrogen removal. This report aims to present the results and to more closely examine what occurs after the onset of anammox activity, while the previous work described the start-up experiment and the presence of anammox bacteria in the enriched community using the fluorescence in situ hybridization (FISH) technique. By the last month of operation, the consumed NO2--N/NH4+-N ratio in the UASB reactor was close to 1.32, the stoichiometric ratio of the anammox reaction. The obtained results from the influent-shutdown test suggested that nitrite concentration would be one key parameter that promotes the anammox reaction during the start-up enrichment of anammox bacteria from granular sludge. During the study period, the sludge color gradually changed from black to red-brownish.
Tran-Hung Lam,Dard Michel 대한치과이식임플란트학회 2021 The Korean Academy of Implant Dentistry Vol.40 No.3
Purpose: These in-line clinical case series aim to assess the cumulative implant and definitive prosthesis survival rate of full edentulous arches in periodontally compromised patients using 4 to 6 Bone Level Tapered (BLT) implants (Straumann, Basel, Switzerland) for up to 3 years of loading. Materials and Methods: Ninety-four implants were placed in 20 patients under the full controlled principle of in-line clinical case series (14 successive days of surgery). Each subject received an immediate loaded and complete-arch provisional prosthesis during 24 hours after implant surgery. The definitive prostheses were delivered within 6 to 8 weeks after implant insertion. A life table method was used to determine implant cumulative survival rate. Results: Up to 3 years of loading, our results demonstrated a cumulative implant survival rate of 98.94%. The definitive prosthesis survival rate was 100%. Conclusions: These results support the use of BLT implants according to the ProArch concept for immediate placement and immediate loading of full edentulous arches in periodontally compromised patients. These in-line case series need to be followed by long-term clinical evaluations.
Development of Population Pharmacokinetic Model for Ethambutol in Korean Patients with Tuberculosis
( Tran Minh Hung ),( Nguyen Phuoc Long ),( Pham Quang Hoa ),( Tae-won Jang ),( Jusang Kim ),( Jee Youn Oh ),( Hyun Kuk Kim ),( Ji Joung Kang ),( Yong-soon Cho ),( Jae-gook Shin ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background Ethambutol (EMB) is one of the four drugs to treat drug-susceptibility tuberculosis (TB). Therapeutic drug monitoring (TDM) is suggested to establish the safe and effective dosing of drugs in TB treatment. The population pharmacokinetic (PK) model provides a helpful tool for individualizing the treatment to minimize therapeutic failure and toxicity. This study was designed to evaluate the EMB PK parameters, characterize the interindividual variability of EMB PK parameters in Korean patients. Methods Data were collected from patients in the prospective cohort from the Center for Personalized Precision Medicine of Tuberculosis research center. The data were randomly divided into training and test sets with a ratio of 4:1. The model was developed using NONMEM version 4.7.1. Non-parametric bootstrapping and prediction-corrected visual predictive checks were used to validate the final model. Additionally, the model performance was evaluated on the test set. Results A model with two-compartment, one transit compartment prior to first-order absorption and elimination adequately described the PK profile of EMB. The estimates were 69.3 L/h for apparent clearance (CL/F), 154 L/h for apparent intercompartment clearance (Q/F), 98.8 L for apparent volume of central compartment (Vc/F), 849 L for apparent volume of peripheral compartment (Vp/F), 0.446 h-1 for rate constant of first-order absorption (Ka) and 0.719 h for mean transit time (MTT). Body weight significantly influenced CL/F and Q/F, and eGFR markedly affected CL/F. The internal and external validations indicated a satisfactory descriptive and predictive performance of the model, respectively. Conclusions We successfully established a population PK model to predict EMB concentrations for Korean TB patients. Internal and external validation confirmed that our model showed a good performance. Our model may be a valuable tool to support dose optimization according to individual patients' body weight and renal function in clinical management.
Tran, Hung-Thuan,Park, Young-Joo,Cho, Mi-Kyeoung,Kim, Dong-Jin,Ahn, Dae-Hee The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.3
The purpose of this work was to evaluate the development of the anammox process by the use of granular sludge selected from a digestion reactor as a potential seed source in a lab-scale UASB (upflow anaerobic sludge blanket) reactor system. The reactor was operated for approximately 11 months and was fed by synthetic wastewater. After 200 days of feeding with $NH_4^+\;and\;NO_2^-$ as the main substrates, the biomass showed steady signs of ammonium consumption, resulting in over 60% of ammonium nitrogen removal. This report aims to present the results and to more closely examine what occurs after the onset of anammox activity, while the previous work described the start-up experiment and the presence of anammox bacteria in the enriched community using the fluorescence in situ hybridization (FISH) technique. By the last month of operation, the consumed $NO_2^--N/NH_4^+-N$ ratio in the UASB reactor was close to 1.32, the stoichiometric ratio of the anammox reaction. The obtained results from the influent-shutdown test suggested that nitrite concentration would be one key parameter that promotes the anammox reaction during the start-up enrichment of anammox bacteria from granular sludge. During the study period, the sludge color gradually changed from black to red-brownish.
Antioxidant Effect of Flavonoids Isolated from the Root of Clematis trichotoma Nakai
Hung, Tran Manh,Thuong, Phuong Thien,Bae, Ki-Hwan The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.5
The antioxidant effect of methanol extract (ME) and water extract (WE) from Clematis trichotoma was evaluated as primary study to scavenge stable 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), inhibited iron-induce lipid peroxidation in linoleic acid emulsion, peroxidation of liposome induced by $Fe^{3+}/H_2O_2/ascorbie$ acid, and on $Fe^{2+}/H_2O_2$ induced the mitochondrial lipid peroxidation. In secondary study, five flavonoids as luteolin (1), quercetin (2), apigenin (3), hirsutrin (4), kaempferol-3-O-glucoside were isolated (5). Among them, compounds 1 and 2 showed good activities in all the model systems. Compound 3 exhibited moderate antioxidant activities in both radical scavenging and these lipid peroxidation systems tested. Compound 4 showed significant inhibitions in liposome peroxidation and compound 5 displayed weak inhibition in all four tested systems. All the results presented herein indicate that products of C. trichotoma maybe useful in inhibiting membrane lipid peroxidation and preventing free radical-linked diseases.