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강호림,Seog-Jin Seo,Takashi Hoshiba,Toshihiro Akaike,조종수 한국생체재료학회 2008 생체재료학회지 Vol.12 No.3
Galactose moiety was covalently coupled with chitosan to improve hepatocyte adhesion and heparin was immobilized to the galactosylated chitosan (GC) to enhancing hepatocyte function. Hepatocyte adhesion to heparin immobilized GC (GCH)-casted polystyrene (PS) dish was higher than that to chitosan-casted PS dish although it was slightly lower than GC-casted PS dish owing to the hydrated GCH-casted PS dish. Spreading of hepatocytes attached onto GCH-casted PS dish was increased with an increase of heparin for the GCH in the presence of hepatocyte growth factor (HGF). Also, DNA synthesis of the hepatocyte adhered to GCH-casted PS dish was increased with an increase of heparin in the GCH. Higher levels of albumin secretion were maintained on the GCH-casted PS dish than chitosan- or GC-casted PS dishes.
Shusuke Yagi,Ken-ichi Aihara,Masashi Akaike,Daiju Fukuda,Hotimah Masdan Salim,Masayoshi Ishida,Tomomi Matsuura,Takayuki Ise,Koji Yamaguchi,Takashi Iwase,Hirotsugu Yamada,Takeshi Soeki,Tetsuzo Wakatsuk 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.4
Background: Predictive factors for the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors for lowering glycosylated hemoglobin (HbA1c) remain unclear in patients with type 2 diabetes mellitus. The aim of this study is therefore to clarify predictive factors of the efficacy of DPP-4 inhibitors for lowering HbA1c after 12 months of treatment. Methods: A total of 191 consecutive type 2 diabetic patients (male sex 55%, mean age, 68.3±35.8 years), who had been treated with DPP-4 inhibitors for 12 months, were enrolled in this study and evaluated retrospectively. Results: After 12 months of DPP-4 inhibitor treatment, random blood glucose level, and HbA1c level, decreased from 167±63 to 151±49 mg/dL (P<0.01), and from 7.5%±1.3% to 6.9%±0.9% (P<0.01) respectively, without severe side effects. Multiple regression analysis showed that predictors of DPP-4 inhibitor treatment efficacy in lowering HbA1c level after 12 months were a decrease in HbA1c level after 3 months of treatment, a high baseline HbA1c level, a low baseline body mass index, and the absence of coronary artery disease. Conclusion: Most suitable candidates for treatment with DPP-4 inhibitors are diabetics who are not obese and do not have coronary artery disease. In addition, long-term efficacy of DPP-4 inhibitors can be predicted by decrement of HbA1c after 3 months of treatment.
Effects of Electric Field on Raman Spectra in SrTi16O3 and SrTi18O3
Kohji Abe,Mitsuru Itoh,Osamu Sanaka,Ruiping Wang,Takashi Akaike,Takeshi Shigenari,Tomohiko Takemoto 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.1
Proton ordering phase transition of ice crystal was studied by Raman pectroscopy. The difference of the vibrational modes between Ih and XI phase were detected for the rst time in the translation region and in the libration region. Below Tc(= 72K), in the translation region a new intense peak was observed at 236 cm1 and the peak at 315 cm1 in Ih phase shifted to 325 cm1. In the libration region several new peaks were observed. Assignments of these modes are discussed from the polarization dependence.