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Primary copper-associated chronic hepatitis without COMMD1 mutation in a Dalmatian: a case report
Sumin Yun,Dohee Lee,Jimin Oh,Yeon Chae,Taesik Yun,Yoonhoi Koo,Mhan-Pyo Yang,Byeong-Teck Kang,Hakhyun Kim 대한수의학회 2022 大韓獸醫學會誌 Vol.62 No.4
A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.
Cutaneous angiomatosis in a dog: a case report
Koo, Yoonhoi,Yun, Taesik,Chae, Yeon,Lee, Dohee,Kim, Hakhyun,Yang, Mhan-Pyo,Kang, Byeong-Teck The Korean Society of Veterinary Science 2021 大韓獸醫學會誌 Vol.61 No.3
A 1-year-old castrated mixed-breed dog presented with diffuse, purple lesions arranged in an irregular patchy pattern, with a slight elevation on the right hindlimb extending from the tarsus joint to the upper region of the thigh. Dermatological examinations and fungal and bacterial cultures revealed no infectious agents. The therapeutic response to antibiotics and antifungal agents was negative. A histopathology examination of the lesion revealed vascular proliferation with vasodilation and numerous varying-sized vessels. Mast-cell-dominated perivascular cuffing was also noted. The dog was diagnosed with cutaneous angiomatosis due to diffuse lesions and the histopathology findings of hemangioma.