韓國人의 위달抗體價 調査報告

鄭泰華,全南昊,尹尙五,柳榮海 國立保健硏究院 1974 국립보건연구원보 Vol.11 No.-

소아의 연령별 Propionibacterium acnes에 대한 균체응집항체 및 동종혈구응집항체간의 비교연구

정화영,정상인,최철순,양용태 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.3

In general, the concentration of maternal IgG globulin in serum of the neonates falls rapidly within the first few months after birth and the production of IgM globulin develops in the maturing infants during the course of exposure to various antigens in the environment. The development of natural antibodies, ie., isohemagglutinins, IgM class, to ABO blood group substances and agglutinins, Ig class, to normal flora, in the early stage of life is important since not only they may act as bactericidal substances in nonspecific manners, but also could be immunological barometers on the normal function of humoral immune system. The high concentration of isohemagglutinins to human A or B blood group antigens and agglutinating antibodies to some of normal flora such as Propionibacterium acnes or Staphylococcus aureus were observed in normal human sera. It has been known that the serum concentration of IgM globulin usually reached adult levels by one year of age, while that of IgG globulins by five to six years of age. However, the levels of isohemagglutinins to A and B group substances and agglutinating to Propionibacterium acnes in children's sera and the ages in which the concentrations of their antibodies reached to abult levels are not clarified. In this study, the concentrations of isohemagglutinins to A and B blood group antigens and agglutinating antibodies to P.acnes serotype Ⅰ and serotype Ⅱ in the sera of 163 normal children, ranged from 0 day to 15 years of age, were measured by means of microtitration technique. The results obtained are as follows: 1. In the sera of 163 children under 15 years of age, there observed no significant difference in the titers of agglutinating antibodies to P. acnes serotype Ⅰ andⅡ. 2. Of 75 sera of children under one year of age, the numbers of sera in which agglutinating antibodies were not detectable or less than 1:4 to P. acnes serotype Ⅰ were 67(89.6%) and to serotype Ⅱ 53(70.7%), respectively. 3. Agglutinating antibody to P. acnes serotype Ⅰ in the children's sera reached adult levels by 7 years of age, but 100 percentages of antibody detection was observed only in the age group of 15 years old, whereas the adult levels of isohemagglutinins to A and B blood group antigens were observed in the age group of 6 months old. 4. No correlation were observed in normal children's sera between agglutinating antibody titre to P. acnes serotype Ⅰ and isohemagglutinin titre. These results indicated that the isohemagglutinins to ABO blood substances appeared in the earlier stage of life than did agglutinating antibodies to P. acnes.

GPS-X 시뮬레이션을 이용한 2단탈질 공정에서 외부탄소원 적용성 평가

정창화,심유섭,김태형,박철휘 대한상하수도학회 2004 상하수도학회지 Vol.18 No.1

The purpose of this study was to evaluate adaptability of external carbon source using GPS-X program in pilot plant composed with 2-stage denitrification process. The result from analysis of pilot plant operation and GPS-X simulation showed that effluent concentration could be simulated similarly by modifying operation conditions, such as DO concentration, C/N ratio and other calibrated parameter. In order to satisfy the standard of the effluent water quality on T-N of 20㎎/L, it required approximately 3.1 of C/N ratio and 50% of nitrogen removal efficiency when influent T-N is 36.9㎎/L. To maintain the stable water quality of the receiving water, the effluent T-N concentration should be less than 10-15㎎/L and the appropriate C/N ratio to remove nitrogen was 4.27-6.82. The analysis of sensitivity to kinetic coefficient and reaction constant showed that Y_(H) and μ_(mAUT) were most sensitive to nitrate and ammonia nitrogen, relatively and sensitivity coefficient of their were 1.32, 1.98. It was concluded that as Y_(H) decreased and μ_(mAUT) increased, the reaction rates of denitrification and nitrification increased and the removal efficiencies of NO₃^(-)-N and NH₄^(+)-N improved.

우리 나라의 장티브스 發生에 對한 疫學的 考察

鄭泰華 건국대학교 1975 論文集 Vol.2 No.1

An epidemiological study of Typhoid Fever in Korea(1961∼1970) Typhoid fever is one of the most serious health hazard in Korea. Although the incidence rate has been assumed to be very high. This study was copied out using the records of the acute communicable disease reported to the Ministry of Health and Social Affairs during past 10 years from 1961 to 1970 The results are summarized as follows 1.Typhoid fever cases were 60.2 percent of the class 1 communicable disease cases in the past 10 years in Korea 2.The morbidity rate for typhoid fever was 14.9 based on 100,000 population and the cases fatality rate was 2.1 percent. 3.The high epidemic period is from May to October each year. The frequencey of incidence was highed in July. 4.The incidence in higher in the rural areas lower in urban area but lowest in mountainous districts. 5.The number of typhoid fever morbidity was higher among males than females and the higher incidence age group was the 10 to 35 age groups (Medion 22.35 years standard deviation 12.50) 6.Most typhoid fever cases were diagnosed by clinical dispensary (clinical dispansary diagnosis 71.3% , serogical examination 24.3% , bacteriological examenation 4.4% 7.The expenditure on typhoid vaccine averaged 20.8 perecnt of population based on 0.5ml doses given to the whole population. 8.Piped mineral water supply ratio was 24.0 percent based on the total number of houses in Korea in 1970. The authors recommended the need for nationwide health education and increased safety of drinking water supply system in the rural areas. The control and detection of carriers should be processed bacteriologically and serological diagnosis and annually vaccination should he given to the age group from 9 to 35 years season ally in March or April.

대안교육 분야 특성화고등학교 교육의 과정 평가

徐廷華,金太淵 홍익대학교 인문과학연구소 2006 人文科學 Vol.14 No.-

The purpose of this study was to make a self-evaluation of the educational process of specialty high schools in the field of alternative education in an attempt to boost the accountability of charter of teachers and to have the quality of educational process in control. An evaluation model was used to assess specialty high schools according to evaluation standard and criteria that were selected in light of the diversity and variableness of alternative school curriculum. As a result, 'the ideals and objects of alternative education(64.5%),' 'school management structure(57.0%),' 'school performance(54.4%),' and 'an intensity of efforts for finding workable alternatives(44.3%)' rated high. When a posttest was conducted, the opinions of the teachers investigated were statistically significantly different at the p<.05 level of significance from those of the assistant principles and principals investigated about 'the publicness-oriented objectives of school foundation and school charter' and 'a perpetual search by teachers for alternatives.' According to the findings of the study, it's required to offer a variety of 'alternative courses' and develop systematic teaching materials in order to provide more specialized speciality alternative education. Teachers should take pride in providing speciality alternative education and have a firm belief in it, and a diagnosis of accountability is requested in relation to making an exception to the operation of specialty high schools providing alternative education and of schools that are given a free hand in offering that education. Besides, it should clearly be specified that the goal of specialty high school evaluation in the area of alternative education is improving accountability of charter. As for the direction for and content of assessment, that should be done in pursuit of good alternative civilization, excellent alternative education, higher specialty and democratic school management. An organization that administers the assessment should be supervised by a third research institute or alternative education council. In regard to evaluation method, a quantitative evaluation that just focuses on outward accomplishments should be avoided, and the kind of method that is supportive, encouraging and presents feasible alternatives should be adopted.

일 도농복합지역 저소득층 노인의 건강문제 분석 : 보건소 방문간호사업 대상자 중심으로

고일선,,이태화,이경자,이정렬,임미혜,천의영,주윤미,이계철 노인간호학회 2005 노인간호학회지 Vol.7 No.2

Purpose: The purpose of this study was to analyze the health problems of low-income aged with chronic illness living in urban-rural composite area. Method: The sample consisted of 440 aged who were receiving home care services from a public health center. MDS-HC was applied to analyze the health problems of the aged. Data were collected through a face- to-face interview by six trained interviewers from June 28 to July 15, 2004. Result: Subjects had average number of 8 health problems in both urban and rural area. Lack of preventive health care measure, pain, and visual function were the most frequent health problem. The rural aged had more pain, bowel management problems, compared to the urban aged having more urinary incontinence and indwelling catheter. There were many health problems related to falls and pressure ulcers with middle-old aged in urban, and old-old aged in rural area. Conclusion: The results of this study showed strategies for care intervention of low-income elderly to put in practice. Therefore, tailored-service for each subject should be provided.

과도한 운동으로 발생한 횡문근융해증에 의한 급성신부전증 1예

문철호,류보열,모성환,김태종,기장도,박용관,김용환,정종훈 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Rhabdomyolysis may be defined as a clinical and laboratory syndrome which releases muscle cell contents into the plasma, such as creatine phosphokinase, due to skeletal muscle injuries. It can be the result of many diverse causes including muscle disease, ischemia, genetic disorder, metabolic disorder, infectious disease, drugs, comatose state, trauma or vigorous exercise that can lead to acute renal failure as a complication. Since first reported in 1941, rhabdomyolysis-induced acute renal failure has been documented many times, and the major causes of this disease are carbon monoxide poisoning, snake bites, and etc in Korea Reports of acute renal failure after exercise-related rhabdomyolysis with myoglobinemia are rare. We report a case of acute renal failure caused by exercise-related rhabdomyolysis in a 20 year old man.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-

The cytotoxic T lymphocyte(CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the ClassⅠ MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface proteion that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs. Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectantn T2 cells showed what 3 out of 4 synthetic peptides enhaced the expression of HLA-A2 molemule on T2 cell surface. Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding. Structural chacteristics of the peptides addressed by molecular dynamics simulation was analysed and compared. These peptides also parially triggerd CTL isolatied frmo human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-specific. These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by thier immunogenicity among natural T cell repertoire.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

The cytotoxic T lymphocyte (CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the Class I MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface protein that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs.Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectant T2 cells showed that 3 out of 4 synthetic peptides enhanced the expression of HLA-A2 molecule on T2 cell surface.Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding.Structural. characteristics of the peptides addressed by molecular dynamics simulation was analysed and compared.These peptides also partially triggered CTL isolated from human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-spcific.These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by their immunogenicity among natural T cell repertoire.

족관절 골절의 임상적 고찰

정준화(Joon Wha Chung),정태영(Tae Young Chung),이영구(Young Koo Lee),권칠수(Chil Soo Kwon),서광윤(Kwang Yoon Seo) 대한정형외과학회 1978 대한정형외과학회지 Vol.13 No.3